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Issue Archive

Volume 122, Issue 26
December 19 2013
Issue Cover

Table of Contents

INSIDE BLOOD

INSIDE BLOOD
IL-7Rα: Mr Hyde’s twists and turns
João T. Barata
View Articletitled, IL-7Rα: Mr Hyde’s twists and turns
INSIDE BLOOD
Activated DDR1 increases RS cell survival
Antonino Carbone,Annunziata Gloghini
View Articletitled, Activated DDR1 increases RS cell survival
INSIDE BLOOD
A novel prognostic scoring system for NLPHL
Michelle Fanale
View Articletitled, A novel prognostic scoring system for NLPHL
INSIDE BLOOD
Cyclophosphamide for CLL: to be or not CYP2B activated?
Christian H. Geisler
View Articletitled, Cyclophosphamide for CLL: to be or not CYP2B activated?
THROMBOSIS & HEMOSTASIS
A new view of integrin αIIbβ3 bound to membrane
Jun Qin,Edward F. Plow
View Articletitled, A new view of integrin αIIbβ3 bound to membrane
THROMBOSIS & HEMOSTASIS
Superficial venous thrombosis: recognizing the risk
Shannon M. Bates
View Articletitled, Superficial venous thrombosis: recognizing the risk
THROMBOSIS & HEMOSTASIS
Factor VIII inhibitor epitopes and an enigma
Gary E. Gilbert
View Articletitled, Factor VIII inhibitor epitopes and an enigma

BLOOD WORK

Leishmania amastigotes visualized on bone marrow aspirate in a leishmaniasis and HIV coinfected patient presenting with pancytopenia
Christopher Dittus,Dana Semmel
View Articletitled, <em>Leishmania</em> amastigotes visualized on bone marrow aspirate in a leishmaniasis and HIV coinfected patient presenting with pancytopenia
Value of the peripheral blood film: megakaryocytic fragments misidentified by automated counter
David Sanford,Cyrus Hsia
View Articletitled, Value of the peripheral blood film: megakaryocytic fragments misidentified by automated counter

PLENARY PAPER

Three-dimensional reconstruction of intact human integrin αIIbβ3: new implications for activation-dependent ligand binding
Won-Seok Choi,William J. Rice,David L. Stokes,Barry S. Coller
View Articletitled, Three-dimensional reconstruction of intact human integrin αIIbβ3: new implications for activation-dependent ligand binding
Supplemental data

REVIEW ARTICLE

Smoldering multiple myeloma requiring treatment: time for a new definition?
Angela Dispenzieri,A. Keith Stewart,Asher Chanan-Khan,S. Vincent Rajkumar,Robert A. Kyle,Rafael Fonseca,Prashant Kapoor,P. Leif Bergsagel,Arleigh McCurdy,Morie A. Gertz,Martha Q. Lacy,John A. Lust,Stephen J. Russell,Steven R. Zeldenrust,Craig Reeder,Vivek Roy,Francis Buadi,David Dingli,Suzanne R. Hayman,Nelson Leung,Yi Lin,Joseph Mikhael,Shaji K. Kumar
View Articletitled, Smoldering multiple myeloma requiring treatment: time for a new definition?

HOW I TREAT

How I treat nodular lymphocyte predominant Hodgkin lymphoma
Ranjana H. Advani,Richard T. Hoppe
View Articletitled, How I treat nodular lymphocyte predominant Hodgkin lymphoma

CLINICAL TRIALS AND OBSERVATIONS

Human and viral interleukin-6 and other cytokines in Kaposi sarcoma herpesvirus-associated multicentric Castleman disease
Clinical Trials & Observations
Mark N. Polizzotto,Thomas S. Uldrick,Victoria Wang,Karen Aleman,Kathleen M. Wyvill,Vickie Marshall,Stefania Pittaluga,Deirdre O’Mahony,Denise Whitby,Giovanna Tosato,Seth M. Steinberg,Richard F. Little,Robert Yarchoan
View Articletitled, Human and viral interleukin-6 and other cytokines in Kaposi sarcoma herpesvirus-associated multicentric Castleman disease
Supplemental data

HEMATOPOIESIS AND STEM CELLS

Chromatin looping defines expression of TAL1, its flanking genes, and regulation in T-ALL
Yan Zhou,Sreenivasulu Kurukuti,Peter Saffrey,Milica Vukovic,Alison M. Michie,Ruslan Strogantsev,Adam G. West,David Vetrie
View Articletitled, Chromatin looping defines expression of <em>TAL1</em>, its flanking genes, and regulation in T-ALL
Supplemental data

IMMUNOBIOLOGY

Human proT-cells generated in vitro facilitate hematopoietic stem cell-derived T-lymphopoiesis in vivo and restore thymic architecture
Génève Awong,Jastaranpreet Singh,Mahmood Mohtashami,Maria Malm,Ross N. La Motte-Mohs,Patricia M. Benveniste,Pablo Serra,Elaine Herer,Marcel R. van den Brink,Juan Carlos Zúñiga-Pflücker
View Articletitled, Human proT-cells generated in vitro facilitate hematopoietic stem cell-derived T-lymphopoiesis in vivo and restore thymic architecture
Supplemental data

LYMPHOID NEOPLASIA

The Myc-miR-17-92 axis amplifies B-cell receptor signaling via inhibition of ITIM proteins: a novel lymphomagenic feed-forward loop
James N. Psathas,Patrick J. Doonan,Pichai Raman,Bruce D. Freedman,Andy J. Minn,Andrei Thomas-Tikhonenko
View Articletitled, The Myc-miR-17-92 axis amplifies B-cell receptor signaling via inhibition of ITIM proteins: a novel lymphomagenic feed-forward loop
Supplemental data
Eradication of non-Hodgkin lymphoma through the induction of tumor-specific T-cell immunity by CD20-Flex BiFP
Lei Zhao,Qin Tong,Weizhu Qian,Bohua Li,Dapeng Zhang,Tuo Fu,Shuyan Duan,Xueguang Zhang,Jian Zhao,Jianxin Dai,Hao Wang,Sheng Hou,Yajun Guo
View Articletitled, Eradication of non-Hodgkin lymphoma through the induction of tumor-specific T-cell immunity by CD20-Flex BiFP
Supplemental data
The EBV oncogene LMP1 protects lymphoma cells from cell death through the collagen-mediated activation of DDR1
Fathima Zumla Cader,Martina Vockerodt,Shikha Bose,Eszter Nagy,Marie-Anne Brundler,Pamela Kearns,Paul G. Murray
View Articletitled, The EBV oncogene LMP1 protects lymphoma cells from cell death through the collagen-mediated activation of DDR1
Supplemental data
The prognostic impact of variant histology in nodular lymphocyte-predominant Hodgkin lymphoma: a report from the German Hodgkin Study Group (GHSG)
CME
Sylvia Hartmann,Dennis A. Eichenauer,Annette Plütschow,Anja Mottok,Roshanak Bob,Karoline Koch,Heinz-Wolfram Bernd,Sergio Cogliatti,Michael Hummel,Alfred C. Feller,German Ott,Peter Möller,Andreas Rosenwald,Harald Stein,Martin-Leo Hansmann,Andreas Engert,Wolfram Klapper
View Articletitled, The prognostic impact of variant histology in nodular lymphocyte-predominant Hodgkin lymphoma: a report from the German Hodgkin Study Group (GHSG)
Supplemental data
CYP2B6*6 is an independent determinant of inferior response to fludarabine plus cyclophosphamide in chronic lymphocytic leukemia
Gillian G. Johnson,Ke Lin,Trevor F. Cox,Melanie Oates,David R. Sibson,Richard Eccles,Bryony Lloyd,Laura-Jayne Gardiner,Daniel F. Carr,Munir Pirmohamed,Jonathan C. Strefford,David G. Oscier,David Gonzalez de Castro,Monica Else,Daniel Catovsky,Andrew R. Pettitt
View Articletitled, <em>CYP2B6*6</em> is an independent determinant of inferior response to fludarabine plus cyclophosphamide in chronic lymphocytic leukemia
Supplemental data
In vivo leukemogenic potential of an interleukin 7 receptor α chain mutant in hematopoietic stem and progenitor cells
Brief Report
Kazuaki Yokoyama,Nozomi Yokoyama,Kiyoko Izawa,Ai Kotani,Akira Harashima,Katsuto Hozumi,Arinobu Tojo
View Articletitled, In vivo leukemogenic potential of an interleukin 7 receptor α chain mutant in hematopoietic stem and progenitor cells
Supplemental data

THROMBOSIS AND HEMOSTASIS

The risk of venous thrombosis in individuals with a history of superficial vein thrombosis and acquired venous thrombotic risk factors
Rachel E. J. Roach,Willem M. Lijfering,Astrid van Hylckama Vlieg,Frans M. Helmerhorst,Frits R. Rosendaal,Suzanne C. Cannegieter
View Articletitled, The risk of venous thrombosis in individuals with a history of superficial vein thrombosis and acquired venous thrombotic risk factors
Structure of the factor VIII C2 domain in a ternary complex with 2 inhibitor antibodies reveals classical and nonclassical epitopes
Justin D. Walter,Rachel A. Werther,Caileen M. Brison,Rebecca K. Cragerud,John F. Healey,Shannon L. Meeks,Pete Lollar,P. Clint Spiegel, Jr
View Articletitled, Structure of the factor VIII C2 domain in a ternary complex with 2 inhibitor antibodies reveals classical and nonclassical epitopes
Supplemental data

TRANSPLANTATION

Allogeneic hematopoietic stem cell transplantation in Fanconi anemia: the European Group for Blood and Marrow Transplantation experience
Régis Peffault de Latour,Raphael Porcher,Jean-Hugues Dalle,Mahmoud Aljurf,Elisabeth T. Korthof,Johanna Svahn,Roelof Willemze,Cristina Barrenetxea,Valerie Mialou,Jean Soulier,Mouhab Ayas,Rosi Oneto,Andrea Bacigalupo,Judith C. W. Marsh,Christina Peters,Gerard Socie,Carlo Dufour,on behalf of the FA Committee of the Severe Aplastic Anemia Working Party and the Pediatric Working Party of the European Group for Blood and Marrow Transplantation
View Articletitled, Allogeneic hematopoietic stem cell transplantation in Fanconi anemia: the European Group for Blood and Marrow Transplantation experience
Supplemental data

CORRESPONDENCE

Resolution of thrombocytopenia with JAK2 mutation in a patient with Gaucher disease
Clinical Trials & Observations
Dominick Amato,Chen Wang
View Articletitled, Resolution of thrombocytopenia with JAK2 mutation in a patient with Gaucher disease
Treatment of NLPHL
Clinical Trials & Observations
Joseph M. Connors
View Articletitled, Treatment of NLPHL
Homozygosity by descent of a 3Mb chromosome 17 haplotype causes coinheritance of Glanzmann thrombasthenia and primary ciliary dyskinesia
Giovanna D'Andrea,Michele Schiavulli,Claudia Dimatteo,Rosa Santacroce,Egidio Guerra,Vittoria A. C. Longo,Elvira Grandone,Maurizio Margaglione
View Articletitled, Homozygosity by descent of a 3Mb chromosome 17 haplotype causes coinheritance of Glanzmann thrombasthenia and primary ciliary dyskinesia

CONTINUING MEDICAL EDUCATION (CME) QUESTIONS

Histopathologic variants in NLPHL
CME
View Articletitled, Histopathologic variants in NLPHL
  • Cover Image

    Cover Image

    issue cover

    The anti-C2 domain immune response to factor VIII. The X-ray crystal structure of factor VIII is represented by electrostatic surface potential, and three different inhibitory antibodies are represented as ribbon diagrams (cyan: 3E6 classical antibody, green: G99 non-classical antibody, orange: BO2C11 classical antibody). Each inhibitory antibody recognizes discrete regions of the factor VIII C2 domain, predominantly through electrostatic interactions (blue surface: positive charge, red surface: negative charge). See the article by Walter et al on page 4270.

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