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Issue Archive

Volume 122, Issue 2
July 11 2013
Issue Cover

Table of Contents

INSIDE BLOOD

PLATELETS & THROMBOPOIESIS
Platelets deliver small packages of genetic function
John W. Semple
View Articletitled, Platelets deliver small packages of genetic function
THROMBOSIS & HEMOSTASIS
HIT: nucleic acid masquerading as heparin
Beng H. Chong,James J.-H. Chong
View Articletitled, HIT: nucleic acid masquerading as heparin

BLOOD WORK

POEMS syndrome and Castleman disease
Swati Andhavarapu,Liuyan Jiang
View Articletitled, POEMS syndrome and Castleman disease
Circulating plasma cells with Russell bodies in osteosclerotic myeloma
Mingyi Chen,Ralph Green
View Articletitled, Circulating plasma cells with Russell bodies in osteosclerotic myeloma

REVIEW ARTICLE

Implications of DPP4 modification of proteins that regulate stem/progenitor and more mature cell types
Xuan Ou,Heather A. O’Leary,Hal E. Broxmeyer
View Articletitled, Implications of DPP4 modification of proteins that regulate stem/progenitor and more mature cell types

CLINICAL TRIALS AND OBSERVATIONS

Results of the AIEOP AML 2002/01 multicenter prospective trial for the treatment of children with acute myeloid leukemia
Clinical Trials & Observations
Andrea Pession,Riccardo Masetti,Carmelo Rizzari,Maria Caterina Putti,Fiorina Casale,Franca Fagioli,Matteo Luciani,Luca Lo Nigro,Giuseppe Menna,Concetta Micalizzi,Nicola Santoro,Anna Maria Testi,Marco Zecca,Andrea Biondi,Martina Pigazzi,Sergio Rutella,Roberto Rondelli,Giuseppe Basso,Franco Locatelli,for the AIEOP AML Study Group
View Articletitled, Results of the AIEOP AML 2002/01 multicenter prospective trial for the treatment of children with acute myeloid leukemia

GENE THERAPY

Positive selection of mC46-expressing CD4+ T cells and maintenance of virus specific immunity in a primate AIDS model
Patrick M. Younan,Patricia Polacino,John P. Kowalski,Christopher W. Peterson,Nicholas J. Maurice,Nathaniel P. Williams,On Ho,Grant D. Trobridge,Dorothee Von Laer,Martin Prlic,Brian C. Beard,Stephen DeRosa,Shiu-Lok Hu,Hans-Peter Kiem
View Articletitled, Positive selection of mC46-expressing CD4<sup>+</sup> T cells and maintenance of virus specific immunity in a primate AIDS model
Supplemental data

HEMATOPOIESIS AND STEM CELLS

WT1 regulates murine hematopoiesis via maintenance of VEGF isoform ratio
Brief Report
Thomas J. Cunningham,Ilaria Palumbo,Michela Grosso,Nicholas Slater,Colin G. Miles
View Articletitled, WT1 regulates murine hematopoiesis via maintenance of VEGF isoform ratio
Supplemental data

IMMUNOBIOLOGY

Dynamic imaging reveals promiscuous crosspresentation of blood-borne antigens to naïve CD8+ T cells in the bone marrow
Idan Milo,Anita Sapoznikov,Vyacheslav Kalchenko,Orna Tal,Rita Krauthgamer,Nico van Rooijen,Diana Dudziak,Steffen Jung,Guy Shakhar
View Articletitled, Dynamic imaging reveals promiscuous crosspresentation of blood-borne antigens to naïve CD8<sup>+</sup> T cells in the bone marrow
Supplemental data
Naturally secreted immunoglobulins limit B1 and MZ B-cell numbers through a microbiota-independent mechanism
Andreia C. Lino,Elodie Mohr,Jocelyne Demengeot
View Articletitled, Naturally secreted immunoglobulins limit B1 and MZ B-cell numbers through a microbiota-independent mechanism
Supplemental data

LYMPHOID NEOPLASIA

Global methylation analysis identifies prognostically important epigenetically inactivated tumor suppressor genes in multiple myeloma
Martin F. Kaiser,David C. Johnson,Ping Wu,Brian A. Walker,Annamaria Brioli,Fabio Mirabella,Christopher P. Wardell,Lorenzo Melchor,Faith E. Davies,Gareth J. Morgan
View Articletitled, Global methylation analysis identifies prognostically important epigenetically inactivated tumor suppressor genes in multiple myeloma
Supplemental data

MYELOID NEOPLASIA

Tyrosine kinase inhibitors impair B-cell immune responses in CML through off-target inhibition of kinases important for cell signaling
Hugues de Lavallade,Ahmad Khoder,Melanie Hart,Anushruti Sarvaria,Takuya Sekine,Abdullah Alsuliman,Stephan Mielke,Alexandra Bazeos,Kate Stringaris,Sara Ali,Dragana Milojkovic,Letizia Foroni,Aristeidis Chaidos,Nichola Cooper,Ian Gabriel,Jane Apperley,Sarah Belsey,Robert J. Flanagan,John Goldman,Elizabeth J. Shpall,Peter Kelleher,David Marin,Katayoun Rezvani
View Articletitled, Tyrosine kinase inhibitors impair B-cell immune responses in CML through off-target inhibition of kinases important for cell signaling
Supplemental data
FLT3 inhibitor-induced neutrophilic dermatosis
Brief Report
Amir T. Fathi,Long Le,Robert P. Hasserjian,Hossein Sadrzadeh,Mark Levis,Yi-Bin Chen
View Articletitled, FLT3 inhibitor-induced neutrophilic dermatosis

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

A role for miR-155 in enabling tumor-infiltrating innate immune cells to mount effective antitumor responses in mice
Erika Zonari,Ferdinando Pucci,Massimo Saini,Roberta Mazzieri,Letterio S. Politi,Bernhard Gentner,Luigi Naldini
View Articletitled, A role for miR-155 in enabling tumor-infiltrating innate immune cells to mount effective antitumor responses in mice
Supplemental data

PLATELETS AND THROMBOPOIESIS

Activated platelets can deliver mRNA regulatory Ago2•microRNA complexes to endothelial cells via microparticles
Benoit Laffont,Aurélie Corduan,Hélène Plé,Anne-Claire Duchez,Nathalie Cloutier,Eric Boilard,Patrick Provost
View Articletitled, Activated platelets can deliver mRNA regulatory Ago2•microRNA complexes to endothelial cells via microparticles
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Gain-of-function Lyn induces anemia: appropriate Lyn activity is essential for normal erythropoiesis and Epo receptor signaling
Neli S. Slavova-Azmanova,Nicole Kucera,Jiulia Satiaputra,Leah Stone,Aaron Magno,Mhairi J. Maxwell,Cathy Quilici,Wendy Erber,S. Peter Klinken,Margaret L. Hibbs,Evan Ingley
View Articletitled, Gain-of-function Lyn induces anemia: appropriate Lyn activity is essential for normal erythropoiesis and Epo receptor signaling
Supplemental data

THROMBOSIS AND HEMOSTASIS

Complex formation with nucleic acids and aptamers alters the antigenic properties of platelet factor 4
Miriam E. Jaax,Krystin Krauel,Thomas Marschall,Sven Brandt,Julia Gansler,Birgitt Fürll,Bettina Appel,Silvia Fischer,Stephan Block,Christiane A. Helm,Sabine Müller,Klaus T. Preissner,Andreas Greinacher
View Articletitled, Complex formation with nucleic acids and aptamers alters the antigenic properties of platelet factor 4

VASCULAR BIOLOGY

Complement activation by heme as a secondary hit for atypical hemolytic uremic syndrome
Marie Frimat,Fanny Tabarin,Jordan D. Dimitrov,Caroline Poitou,Lise Halbwachs-Mecarelli,Veronique Fremeaux-Bacchi,Lubka T. Roumenina
View Articletitled, Complement activation by heme as a secondary hit for atypical hemolytic uremic syndrome

CORRESPONDENCE

The NCI common toxicity criteria and treatment-associated mortality in acute myeloid leukemia
Joshua R. Veatch,Vicky Sandhu,Pamela S. Becker,John M. Pagel,Frederick R. Appelbaum,Elihu Estey
View Articletitled, The NCI common toxicity criteria and treatment-associated mortality in acute myeloid leukemia
MGUS prevalence in a cohort of AML patients
S. Peter Wu,Rene Costello,Jonathan N. Hofmann,Neha Korde,Sham Mailankody,Mark Purdue,Ola Landgren
View Articletitled, MGUS prevalence in a cohort of AML patients
BDCA-2 (CD303): a highly specific marker for normal and neoplastic plasmacytoid dendritic cells
Leonardo Boiocchi,Silvia Lonardi,William Vermi,Simona Fisogni,Fabio Facchetti
View Articletitled, BDCA-2 (CD303): a highly specific marker for normal and neoplastic plasmacytoid dendritic cells
Molecular characterization of a transformation from primary myelofibrosis into polycythemia vera: a case report
Matthew J. Butler,Paul I. Roda,Patrick Dorion
View Articletitled, Molecular characterization of a transformation from primary myelofibrosis into polycythemia vera: a case report
Donor-derived acute myeloid leukemia in a kidney transplant recipient
Sabine Girsberger,Caroline Wehmeier,Patrizia Amico,Stephan Dirnhofer,Elizabeth Marti,Jörg P. Halter,Jakob R. Passweg,Christoph M. Bucher
View Articletitled, Donor-derived acute myeloid leukemia in a kidney transplant recipient
Cerebrospinal leukemoid reaction secondary to VZV meninigoencephalitis in an AML patient post allogeneic bone marrow transplantation
Ramesh K. Bhagat,Arthur W. Zieske,Rammurti T. Kamble
View Articletitled, Cerebrospinal leukemoid reaction secondary to VZV meninigoencephalitis in an AML patient post allogeneic bone marrow transplantation

RETRACTIONS

Mizutani A, Okajima K, Uchiba M, Noguchi T. Activated protein C reduces ischemia/reperfusion-induced renal injury in rats by inhibiting leukocyte activation. Blood. 2000;95(12):3781-3787. Mizutani A, Okajima K, Uchiba M, Isobe H, Harada N, Mizutani S, Noguchi T. Antithrombin reduces ischemia/reperfusion-induced renal injury in rats by inhibiting leukocyte activation through promotion of prostacyclin production. Blood. 2003;101(8):3029-3036.
View Articletitled, Mizutani A, Okajima K, Uchiba M, Noguchi T. Activated protein C reduces ischemia/reperfusion-induced renal injury in rats by inhibiting leukocyte activation. <em>Blood</em>. 2000;95(12):<span class="related-article">3781-3787</span>. Mizutani A, Okajima K, Uchiba M, Isobe H, Harada N, Mizutani S, Noguchi T. Antithrombin reduces ischemia/reperfusion-induced renal injury in rats by inhibiting leukocyte activation through promotion of prostacyclin production. <em>Blood</em>. 2003;101(8):<span class="related-article">3029-3036</span>.
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NOVEL THERAPEUTIC APPROACHES IN THALASSEMIAS, SICKLE CELL DISEASE AND OTHER RED CELL DISORDERS

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