Andrea Pession,for the AIEOP AML Study Group,Riccardo Masetti,for the AIEOP AML Study Group,Carmelo Rizzari,for the AIEOP AML Study Group,Maria Caterina Putti,for the AIEOP AML Study Group,Fiorina Casale,for the AIEOP AML Study Group,Franca Fagioli,for the AIEOP AML Study Group,Matteo Luciani,for the AIEOP AML Study Group,Luca Lo Nigro,for the AIEOP AML Study Group,Giuseppe Menna,for the AIEOP AML Study Group,Concetta Micalizzi,for the AIEOP AML Study Group,Nicola Santoro,for the AIEOP AML Study Group,Anna Maria Testi,for the AIEOP AML Study Group,Marco Zecca,for the AIEOP AML Study Group,Andrea Biondi,for the AIEOP AML Study Group,Martina Pigazzi,for the AIEOP AML Study Group,Sergio Rutella,for the AIEOP AML Study Group,Roberto Rondelli,for the AIEOP AML Study Group,Giuseppe Basso,for the AIEOP AML Study Group,Franco Locatelli,for the AIEOP AML Study Group

View Articletitled, Results of the AIEOP AML 2002/01 multicenter prospective trial for the treatment of children with acute myeloid leukemia

GENE THERAPY

Positive selection of mC46-expressing CD4⁺ T cells and maintenance of virus specific immunity in a primate AIDS model

Patrick M. Younan,Patricia Polacino,John P. Kowalski,Christopher W. Peterson,Nicholas J. Maurice,Nathaniel P. Williams,On Ho,Grant D. Trobridge,Dorothee Von Laer,Martin Prlic,Brian C. Beard,Stephen DeRosa,Shiu-Lok Hu,Hans-Peter Kiem

View Articletitled, Positive selection of mC46-expressing CD4+ T cells and maintenance of virus specific immunity in a primate AIDS model

Supplemental data

HEMATOPOIESIS AND STEM CELLS

WT1 regulates murine hematopoiesis via maintenance of VEGF isoform ratio
Brief Report

Thomas J. Cunningham,Ilaria Palumbo,Michela Grosso,Nicholas Slater,Colin G. Miles

View Articletitled, WT1 regulates murine hematopoiesis via maintenance of VEGF isoform ratio

Supplemental data

IMMUNOBIOLOGY

Dynamic imaging reveals promiscuous crosspresentation of blood-borne antigens to naïve CD8⁺ T cells in the bone marrow

Idan Milo,Anita Sapoznikov,Vyacheslav Kalchenko,Orna Tal,Rita Krauthgamer,Nico van Rooijen,Diana Dudziak,Steffen Jung,Guy Shakhar

View Articletitled, Dynamic imaging reveals promiscuous crosspresentation of blood-borne antigens to naïve CD8+ T cells in the bone marrow

Supplemental data

Naturally secreted immunoglobulins limit B1 and MZ B-cell numbers through a microbiota-independent mechanism

Andreia C. Lino,Elodie Mohr,Jocelyne Demengeot

View Articletitled, Naturally secreted immunoglobulins limit B1 and MZ B-cell numbers through a microbiota-independent mechanism

Supplemental data

LYMPHOID NEOPLASIA

Global methylation analysis identifies prognostically important epigenetically inactivated tumor suppressor genes in multiple myeloma

Martin F. Kaiser,David C. Johnson,Ping Wu,Brian A. Walker,Annamaria Brioli,Fabio Mirabella,Christopher P. Wardell,Lorenzo Melchor,Faith E. Davies,Gareth J. Morgan

View Articletitled, Global methylation analysis identifies prognostically important epigenetically inactivated tumor suppressor genes in multiple myeloma

Supplemental data

MYELOID NEOPLASIA

Tyrosine kinase inhibitors impair B-cell immune responses in CML through off-target inhibition of kinases important for cell signaling

Hugues de Lavallade,Ahmad Khoder,Melanie Hart,Anushruti Sarvaria,Takuya Sekine,Abdullah Alsuliman,Stephan Mielke,Alexandra Bazeos,Kate Stringaris,Sara Ali,Dragana Milojkovic,Letizia Foroni,Aristeidis Chaidos,Nichola Cooper,Ian Gabriel,Jane Apperley,Sarah Belsey,Robert J. Flanagan,John Goldman,Elizabeth J. Shpall,Peter Kelleher,David Marin,Katayoun Rezvani

View Articletitled, Tyrosine kinase inhibitors impair B-cell immune responses in CML through off-target inhibition of kinases important for cell signaling

Supplemental data

FLT3 inhibitor-induced neutrophilic dermatosis
Brief Report

Amir T. Fathi,Long Le,Robert P. Hasserjian,Hossein Sadrzadeh,Mark Levis,Yi-Bin Chen

View Articletitled, FLT3 inhibitor-induced neutrophilic dermatosis

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

A role for miR-155 in enabling tumor-infiltrating innate immune cells to mount effective antitumor responses in mice

Erika Zonari,Ferdinando Pucci,Massimo Saini,Roberta Mazzieri,Letterio S. Politi,Bernhard Gentner,Luigi Naldini

View Articletitled, A role for miR-155 in enabling tumor-infiltrating innate immune cells to mount effective antitumor responses in mice

Supplemental data

PLATELETS AND THROMBOPOIESIS

Activated platelets can deliver mRNA regulatory Ago2•microRNA complexes to endothelial cells via microparticles

Benoit Laffont,Aurélie Corduan,Hélène Plé,Anne-Claire Duchez,Nathalie Cloutier,Eric Boilard,Patrick Provost

View Articletitled, Activated platelets can deliver mRNA regulatory Ago2•microRNA complexes to endothelial cells via microparticles

Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Gain-of-function Lyn induces anemia: appropriate Lyn activity is essential for normal erythropoiesis and Epo receptor signaling

Neli S. Slavova-Azmanova,Nicole Kucera,Jiulia Satiaputra,Leah Stone,Aaron Magno,Mhairi J. Maxwell,Cathy Quilici,Wendy Erber,S. Peter Klinken,Margaret L. Hibbs,Evan Ingley

View Articletitled, Gain-of-function Lyn induces anemia: appropriate Lyn activity is essential for normal erythropoiesis and Epo receptor signaling

Supplemental data

THROMBOSIS AND HEMOSTASIS

Complex formation with nucleic acids and aptamers alters the antigenic properties of platelet factor 4

Miriam E. Jaax,Krystin Krauel,Thomas Marschall,Sven Brandt,Julia Gansler,Birgitt Fürll,Bettina Appel,Silvia Fischer,Stephan Block,Christiane A. Helm,Sabine Müller,Klaus T. Preissner,Andreas Greinacher

View Articletitled, Complex formation with nucleic acids and aptamers alters the antigenic properties of platelet factor 4

VASCULAR BIOLOGY

Complement activation by heme as a secondary hit for atypical hemolytic uremic syndrome

Marie Frimat,Fanny Tabarin,Jordan D. Dimitrov,Caroline Poitou,Lise Halbwachs-Mecarelli,Veronique Fremeaux-Bacchi,Lubka T. Roumenina

View Articletitled, Complement activation by heme as a secondary hit for atypical hemolytic uremic syndrome

CORRESPONDENCE

The NCI common toxicity criteria and treatment-associated mortality in acute myeloid leukemia

Joshua R. Veatch,Vicky Sandhu,Pamela S. Becker,John M. Pagel,Frederick R. Appelbaum,Elihu Estey

View Articletitled, The NCI common toxicity criteria and treatment-associated mortality in acute myeloid leukemia

MGUS prevalence in a cohort of AML patients

S. Peter Wu,Rene Costello,Jonathan N. Hofmann,Neha Korde,Sham Mailankody,Mark Purdue,Ola Landgren

View Articletitled, MGUS prevalence in a cohort of AML patients

BDCA-2 (CD303): a highly specific marker for normal and neoplastic plasmacytoid dendritic cells

Leonardo Boiocchi,Silvia Lonardi,William Vermi,Simona Fisogni,Fabio Facchetti

View Articletitled, BDCA-2 (CD303): a highly specific marker for normal and neoplastic plasmacytoid dendritic cells

Molecular characterization of a transformation from primary myelofibrosis into polycythemia vera: a case report

Matthew J. Butler,Paul I. Roda,Patrick Dorion

View Articletitled, Molecular characterization of a transformation from primary myelofibrosis into polycythemia vera: a case report

Donor-derived acute myeloid leukemia in a kidney transplant recipient

Sabine Girsberger,Caroline Wehmeier,Patrizia Amico,Stephan Dirnhofer,Elizabeth Marti,Jörg P. Halter,Jakob R. Passweg,Christoph M. Bucher

View Articletitled, Donor-derived acute myeloid leukemia in a kidney transplant recipient

Cerebrospinal leukemoid reaction secondary to VZV meninigoencephalitis in an AML patient post allogeneic bone marrow transplantation

Ramesh K. Bhagat,Arthur W. Zieske,Rammurti T. Kamble

View Articletitled, Cerebrospinal leukemoid reaction secondary to VZV meninigoencephalitis in an AML patient post allogeneic bone marrow transplantation

RETRACTIONS

Mizutani A, Okajima K, Uchiba M, Noguchi T. Activated protein C reduces ischemia/reperfusion-induced renal injury in rats by inhibiting leukocyte activation. Blood. 2000;95(12):3781-3787. Mizutani A, Okajima K, Uchiba M, Isobe H, Harada N, Mizutani S, Noguchi T. Antithrombin reduces ischemia/reperfusion-induced renal injury in rats by inhibiting leukocyte activation through promotion of prostacyclin production. Blood. 2003;101(8):3029-3036.

View Articletitled, Mizutani A, Okajima K, Uchiba M, Noguchi T. Activated protein C reduces ischemia/reperfusion-induced renal injury in rats by inhibiting leukocyte activation. Blood. 2000;95(12):3781-3787. Mizutani A, Okajima K, Uchiba M, Isobe H, Harada N, Mizutani S, Noguchi T. Antithrombin reduces ischemia/reperfusion-induced renal injury in rats by inhibiting leukocyte activation through promotion of prostacyclin production. Blood. 2003;101(8):3029-3036.

Cover Image

Cover Image

The paths of CD8⁺ T cells (yellow) and B cells (blue) were followed using 2-photon microscopy in the bone marrow cavities of a live mouse. T cells cover longer distances than B cells in this organ. See the article by Milo et al on page 193.
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