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Issue Archive

Volume 120, Issue 18
November 1 2012
Issue Cover

Table of Contents

Inside Blood

CLINICAL TRIALS
Are 25 antibodies better than 1?
Adam Cuker
View Articletitled, Are 25 antibodies better than 1?
GENE THERAPY
Gene therapy for ADA-SCID: defining the factors for successful outcome
H. Bobby Gaspar
View Articletitled, Gene therapy for ADA-SCID: defining the factors for successful outcome
HEMATOPOIESIS & STEM CELLS
Transcription factor dose links development to disease
Mikael Sigvardsson
View Articletitled, Transcription factor dose links development to disease

Blood Work

Metastatic alveolar rhabdomyosarcoma to the bone marrow mimicking acute leukemia
Jennifer N. Stall,Nathanael G. Bailey
View Articletitled, Metastatic alveolar rhabdomyosarcoma to the bone marrow mimicking acute leukemia
Plasma cell leukemia in pregnancy
Bushra Moiz,Syed Sarwar Ali
View Articletitled, Plasma cell leukemia in pregnancy

Plenary Paper

CLINICAL TRIALS AND OBSERVATIONS
Gene therapy for adenosine deaminase–deficient severe combined immune deficiency: clinical comparison of retroviral vectors and treatment plans
Clinical Trials & Observations
Fabio Candotti,Kit L. Shaw,Linda Muul,Denise Carbonaro,Robert Sokolic,Christopher Choi,Shepherd H. Schurman,Elizabeth Garabedian,Chimene Kesserwan,G. Jayashree Jagadeesh,Pei-Yu Fu,Eric Gschweng,Aaron Cooper,John F. Tisdale,Kenneth I. Weinberg,Gay M. Crooks,Neena Kapoor,Ami Shah,Hisham Abdel-Azim,Xiao-Jin Yu,Monika Smogorzewska,Alan S. Wayne,Howard M. Rosenblatt,Carla M. Davis,Celine Hanson,Radha G. Rishi,Xiaoyan Wang,David Gjertson,Otto O. Yang,Arumugam Balamurugan,Gerhard Bauer,Joanna A. Ireland,Barbara C. Engel,Gregory M. Podsakoff,Michael S. Hershfield,R. Michael Blaese,Robertson Parkman,Donald B. Kohn
View Articletitled, Gene therapy for adenosine deaminase–deficient severe combined immune deficiency: clinical comparison of retroviral vectors and treatment plans
Supplemental data

Perspectives

Sickle cell pain: a critical reappraisal
Samir K. Ballas,Kalpna Gupta,Patricia Adams-Graves
View Articletitled, Sickle cell pain: a critical reappraisal
Supplemental data

How I Treat

How I treat transfusional iron overload
A. Victor Hoffbrand,Ali Taher,Maria Domenica Cappellini
View Articletitled, How I treat transfusional iron overload

Gene Therapy

Gene therapy/bone marrow transplantation in ADA-deficient mice: roles of enzyme-replacement therapy and cytoreduction
Denise A. Carbonaro,Xiangyang Jin,Xingchao Wang,Xiao-Jin Yu,Nora Rozengurt,Michael L. Kaufman,Xiaoyan Wang,David Gjertson,Yang Zhou,Michael R. Blackburn,Donald B. Kohn
View Articletitled, Gene therapy/bone marrow transplantation in ADA-deficient mice: roles of enzyme-replacement therapy and cytoreduction
Supplemental data

Hematopoiesis and Stem Cells

Biphenotypic B-lymphoid/myeloid cells expressing low levels of Pax5: potential targets of BAL development
Szandor Simmons,Marko Knoll,Christopher Drewell,Ingrid Wolf,Hans-Joachim Mollenkopf,Corinne Bouquet,Fritz Melchers
View Articletitled, Biphenotypic B-lymphoid/myeloid cells expressing low levels of Pax5: potential targets of BAL development
Supplemental data

Immunobiology

Cytosolic sensing of extracellular self-DNA transported into monocytes by the antimicrobial peptide LL37
Georgios Chamilos,Josh Gregorio,Stephan Meller,Roberto Lande,Dimitrios P. Kontoyiannis,Robert L. Modlin,Michel Gilliet
View Articletitled, Cytosolic sensing of extracellular self-DNA transported into monocytes by the antimicrobial peptide LL37
Supplemental data
Neutralizing antibodies inhibit HIV-1 transfer from primary dendritic cells to autologous CD4 T lymphocytes
Bin Su,Ke Xu,Alexandre Lederle,Maryse Peressin,Marina Elizabeth Biedma,Géraldine Laumond,Sylvie Schmidt,Thomas Decoville,Alizé Proust,Mélanie Lambotin,Vincent Holl,Christiane Moog
View Articletitled, Neutralizing antibodies inhibit HIV-1 transfer from primary dendritic cells to autologous CD4 T lymphocytes
Supplemental data
Regulating type 1 IFN effects in CD8 T cells during viral infections: changing STAT4 and STAT1 expression for function
M. Pilar Gil,Mickaël J. Y. Ploquin,Wendy T. Watford,Seung-Hwan Lee,Kwangsin Kim,Xin Wang,Yuka Kanno,John J. O'Shea,Christine A. Biron
View Articletitled, Regulating type 1 IFN effects in CD8 T cells during viral infections: changing STAT4 and STAT1 expression for function
Supplemental data
Super-resolution imaging of remodeled synaptic actin reveals different synergies between NK cell receptors and integrins
Alice C. N. Brown,Ian M. Dobbie,Juha-Matti Alakoskela,Ilan Davis,Daniel M. Davis
View Articletitled, Super-resolution imaging of remodeled synaptic actin reveals different synergies between NK cell receptors and integrins
Signaling through cannabinoid receptor 2 suppresses murine dendritic cell migration by inhibiting matrix metalloproteinase 9 expression
Sabina Adhikary,Virginia P. Kocieda,Jui-Hung Yen,Ronald F. Tuma,Doina Ganea
View Articletitled, Signaling through cannabinoid receptor 2 suppresses murine dendritic cell migration by inhibiting matrix metalloproteinase 9 expression
Supplemental data

Lymphoid Neoplasia

Atypical prediagnosis Epstein-Barr virus serology restricted to EBV-positive Hodgkin lymphoma
Lynn I. Levin,Ellen T. Chang,Richard F. Ambinder,Evelyne T. Lennette,Mark V. Rubertone,Risa B. Mann,Michael Borowitz,Edward G. Weir,Susan L. Abbondanzo,Nancy E. Mueller
View Articletitled, Atypical prediagnosis Epstein-Barr virus serology restricted to EBV-positive Hodgkin lymphoma
Hodgkin lymphoma requires stabilized NIK and constitutive RelB expression for survival
Stella M. Ranuncolo,Stefania Pittaluga,Moses O. Evbuomwan,Elaine S. Jaffe,Brian A. Lewis
View Articletitled, Hodgkin lymphoma requires stabilized NIK and constitutive RelB expression for survival
Supplemental data
Inactivation of ribosomal protein L22 promotes transformation by induction of the stemness factor, Lin28B
Shuyun Rao,Sang-Yun Lee,Alejandro Gutierrez,Jacqueline Perrigoue,Roshan J. Thapa,Zhigang Tu,John R. Jeffers,Michele Rhodes,Stephen Anderson,Tamas Oravecz,Stephen P. Hunger,Roman A. Timakhov,Rugang Zhang,Siddharth Balachandran,Gerard P. Zambetti,Joseph R. Testa,A. Thomas Look,David L. Wiest
View Articletitled, Inactivation of ribosomal protein L22 promotes transformation by induction of the stemness factor, Lin28B
Supplemental data
IL-21 in the bone marrow microenvironment contributes to IgM secretion and proliferation of malignant cells in Waldenstrom macroglobulinemia
Lucy S. Hodge,Steve C. Ziesmer,Zhi Zhang Yang,Frank J. Secreto,Morie A. Gertz,Anne J. Novak,Stephen M. Ansell
View Articletitled, IL-21 in the bone marrow microenvironment contributes to IgM secretion and proliferation of malignant cells in Waldenstrom macroglobulinemia
Role of the microenvironment in mantle cell lymphoma: IL-6 is an important survival factor for the tumor cells
Liang Zhang,Jing Yang,Jianfei Qian,Haiyan Li,Jorge E. Romaguera,Larry W. Kwak,Michael Wang,Qing Yi
View Articletitled, Role of the microenvironment in mantle cell lymphoma: IL-6 is an important survival factor for the tumor cells
Supplemental data

Myeloid Neoplasia

Commonly altered genomic regions in acute myeloid leukemia are enriched for somatic mutations involved in chromatin remodeling and splicing
e-blood
Anna Dolnik,Julia C. Engelmann,Maren Scharfenberger-Schmeer,Julian Mauch,Sabine Kelkenberg-Schade,Berit Haldemann,Tamara Fries,Jan Krönke,Michael W. M. Kühn,Peter Paschka,Sabine Kayser,Stephan Wolf,Verena I. Gaidzik,Richard F. Schlenk,Frank G. Rücker,Hartmut Döhner,Claudio Lottaz,Konstanze Döhner,Lars Bullinger
View Articletitled, Commonly altered genomic regions in acute myeloid leukemia are enriched for somatic mutations involved in chromatin remodeling and splicing
Supplemental data

Phagocytes, Granulocytes, and Myelopoiesis

Neutralization of the IL-17 axis diminishes neutrophil invasion and protects from ischemic stroke
Mathias Gelderblom,Anna Weymar,Christian Bernreuther,Joachim Velden,Priyadharshini Arunachalam,Karin Steinbach,Ellen Orthey,Thiruma V. Arumugam,Frank Leypoldt,Olga Simova,Vivien Thom,Manuel A. Friese,Immo Prinz,Christoph Hölscher,Markus Glatzel,Thomas Korn,Christian Gerloff,Eva Tolosa,Tim Magnus
View Articletitled, Neutralization of the IL-17 axis diminishes neutrophil invasion and protects from ischemic stroke
Supplemental data
Excess F-actin mechanically impedes mitosis leading to cytokinesis failure in X-linked neutropenia by exceeding Aurora B kinase error correction capacity
Dale A. Moulding,Emad Moeendarbary,Leo Valon,Julien Record,Guillaume T. Charras,Adrian J. Thrasher
View Articletitled, Excess F-actin mechanically impedes mitosis leading to cytokinesis failure in X-linked neutropenia by exceeding Aurora B kinase error correction capacity
Supplemental data

Platelets and Thrombopoiesis

Rozrolimupab, a mixture of 25 recombinant human monoclonal RhD antibodies, in the treatment of primary immune thrombocytopenia
Clinical Trials & Observations
Tadeusz Robak,Jerzy Windyga,Jacek Trelinski,Mario von Depka Prondzinski,Aristoteles Giagounidis,Chantal Doyen,Ann Janssens,María Teresa Álvarez-Román,Isidro Jarque,Javier Loscertales,Gloria Pérez Rus,Andrzej Hellmann,Wiesław Wiktor Jêdrzejczak,Kazimierz Kuliczkowski,Lana M. Golubovic,Dusica Celeketic,Andrei Cucuianu,Emanuil Gheorghita,Mihaela Lazaroiu,Ofer Shpilberg,Dina Attias,Elena Karyagina,Kalinina Svetlana,Kateryna Vilchevska,Nichola Cooper,Kate Talks,Mukhyaprana Prabhu,Prasad Sripada,T. P. R. Bharadwaj,Henrik Næsted,Niels J. Ø. Skartved,Torben P. Frandsen,Mimi F. Flensburg,Peter S. Andersen,Jørgen Petersen
View Articletitled, Rozrolimupab, a mixture of 25 recombinant human monoclonal RhD antibodies, in the treatment of primary immune thrombocytopenia
Induction of functional platelets from mouse and human fibroblasts by p45NF-E2/Maf
Yukako Ono,Yuhuan Wang,Hidenori Suzuki,Shinichiro Okamoto,Yasuo Ikeda,Mitsuru Murata,Mortimer Poncz,Yumiko Matsubara
View Articletitled, Induction of functional platelets from mouse and human fibroblasts by <em>p45NF-E2/Maf</em>
Supplemental data

Red Cells, Iron, and Erythropoiesis

Heme oxygenase-1 gene promoter polymorphism is associated with reduced incidence of acute chest syndrome among children with sickle cell disease
Christopher J. Bean,Sheree L. Boulet,Dorothy Ellingsen,Meredith E. Pyle,Emily A. Barron-Casella,James F. Casella,Amanda B. Payne,Jennifer Driggers,Heidi A. Trau,Genyan Yang,Kimberly Jones,Solomon F. Ofori-Acquah,W. Craig Hooper,Michael R. DeBaun
View Articletitled, Heme oxygenase-1 gene promoter polymorphism is associated with reduced incidence of acute chest syndrome among children with sickle cell disease
Supplemental data
Minihepcidins prevent iron overload in a hepcidin-deficient mouse model of severe hemochromatosis
Emilio Ramos,Piotr Ruchala,Julia B. Goodnough,Léon Kautz,Gloria C. Preza,Elizabeta Nemeth,Tomas Ganz
View Articletitled, Minihepcidins prevent iron overload in a hepcidin-deficient mouse model of severe hemochromatosis
Supplemental data

Thrombosis and Hemostasis

Prothrombin activation in blood coagulation: the erythrocyte contribution to thrombin generation
Matthew F. Whelihan,Vicentios Zachary,Thomas Orfeo,Kenneth G. Mann
View Articletitled, Prothrombin activation in blood coagulation: the erythrocyte contribution to thrombin generation
Supplemental data

Vascular Biology

TAK1 kinase signaling regulates embryonic angiogenesis by modulating endothelial cell survival and migration
Sho Morioka,Maiko Inagaki,Yoshihiro Komatsu,Yuji Mishina,Kunihiro Matsumoto,Jun Ninomiya-Tsuji
View Articletitled, TAK1 kinase signaling regulates embryonic angiogenesis by modulating endothelial cell survival and migration
Supplemental data

Correspondence

Helicobacter pylori eradication as exclusive treatment for limited-stage gastric diffuse large B-cell lymphoma: results of a multicenter phase 2 trial
Andrés J. M. Ferreri,Silvia Govi,Markus Raderer,Antonino Mulè,Alessandro Andriani,Daniele Caracciolo,Liliana Devizzi,Fiorella Ilariucci,Stefano Luminari,Edi Viale,Leonhard Müllauer,Stefania Dell'Oro,Paolo Giorgio Arcidiacono,Maurilio Ponzoni,Caterina Patti
View Articletitled, <em>Helicobacter pylori</em> eradication as exclusive treatment for limited-stage gastric diffuse large B-cell lymphoma: results of a multicenter phase 2 trial
Screening of novel genetic aberrations in pediatric acute myeloid leukemia: a report from the AIEOP AML-2002 study group
Martina Pigazzi,Elena Manara,Valeria Bisio,Sanja Aveic,Riccardo Masetti,Giuseppe Menna,Marco Zecca,Andrea Pession,Franco Locatelli,Giuseppe Basso
View Articletitled, Screening of novel genetic aberrations in pediatric acute myeloid leukemia: a report from the AIEOP AML-2002 study group
P-selectin glycoprotein ligand-1 inhibition blocks increased leukocyte-endothelial interactions associated with sickle cell disease in mice
Wei Luo,Andrew Campbell,Hui Wang,Chiao Guo,Kori Bradley,Jintao Wang,Daniel T. Eitzman
View Articletitled, P-selectin glycoprotein ligand-1 inhibition blocks increased leukocyte-endothelial interactions associated with sickle cell disease in mice
All Issues

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