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Issue Archive

Volume 113, Issue 7
February 12 2009
Issue Cover

Table of Contents

INSIDE BLOOD

HEMATOPOIESIS & STEM CELLS
MLL5 governs hematopoiesis: a step closer
Han Liu,Todd D. Westergard,James J.-D. Hsieh
View Articletitled, MLL5 governs hematopoiesis: a step closer
PHAGOCYTES & GRANULOCYTES
Interleukin-33: a regulator of basophils
Peter Valent
View Articletitled, Interleukin-33: a regulator of basophils
VASCULAR BIOLOGY
Fishing for platelets
Daniel F. Cutler
View Articletitled, Fishing for platelets

REVIEW ARTICLES

TLRs and innate immunity
Bruce A. Beutler
View Articletitled, TLRs and innate immunity

CLINICAL TRIALS AND OBSERVATIONS

Improvement in survival in younger patients with acute lymphoblastic leukemia from the 1980s to the early 21st century
Clinical Trials & Observations
Dianne Pulte,Adam Gondos,Hermann Brenner
View Articletitled, Improvement in survival in younger patients with acute lymphoblastic leukemia from the 1980s to the early 21st century
Phase 1/2 study of fractionated 131I-rituximab in low-grade B-cell lymphoma: the effect of prior rituximab dosing and tumor burden on subsequent radioimmunotherapy
Clinical Trials & Observations
Tim M. Illidge,Mike Bayne,Nicholas S. Brown,Samantha Chilton,Mark S. Cragg,Martin J. Glennie,Yong Du,Valerie Lewington,James Smart,James Thom,Maureen Zivanovic,Peter W. M. Johnson
View Articletitled, Phase 1/2 study of fractionated <sup>131</sup>I-rituximab in low-grade B-cell lymphoma: the effect of prior rituximab dosing and tumor burden on subsequent radioimmunotherapy

GENE THERAPY

Engineering human hematopoietic stem/progenitor cells to produce a broadly neutralizing anti-HIV antibody after in vitro maturation to human B lymphocytes.
Xin M. Luo,Emily Maarschalk,Ryan M. O'Connell,Pin Wang,Lili Yang,David Baltimore
View Articletitled, Engineering human hematopoietic stem/progenitor cells to produce a broadly neutralizing anti-HIV antibody after in vitro maturation to human B lymphocytes.
Supplemental data

HEMATOPOIESIS AND STEM CELLS

Loss of Mll5 results in pleiotropic hematopoietic defects, reduced neutrophil immune function, and extreme sensitivity to DNA demethylation
Michael Heuser,Damian B. Yap,Malina Leung,Teresa Ruiz de Algara,Alaeddin Tafech,Steven McKinney,John Dixon,Rosemary Thresher,Bill Colledge,Mark Carlton,R. Keith Humphries,Samuel A. Aparicio
View Articletitled, Loss of Mll5 results in pleiotropic hematopoietic defects, reduced neutrophil immune function, and extreme sensitivity to DNA demethylation
Supplemental data
Impaired function of primitive hematopoietic cells in mice lacking the Mixed-Lineage-Leukemia homolog Mll5
Vikas Madan,Babita Madan,Urszula Brykczynska,Frédéric Zilbermann,Kevin Hogeveen,Konstanze Döhner,Hartmut Döhner,Odile Weber,Carmen Blum,Hans-Reimer Rodewald,Paolo Sassone-Corsi,Antoine H. F. M. Peters,Hans Jörg Fehling
View Articletitled, Impaired function of primitive hematopoietic cells in mice lacking the Mixed-Lineage-Leukemia homolog Mll5
Supplemental data
Mll5 contributes to hematopoietic stem cell fitness and homeostasis
Yan Zhang,Jasmine Wong,Mark Klinger,Mary T. Tran,Kevin M. Shannon,Nigel Killeen
View Articletitled, Mll5 contributes to hematopoietic stem cell fitness and homeostasis
Supplemental data

IMMUNOBIOLOGY

FcγRIIB signals inhibit BLyS signaling and BCR-mediated BLyS receptor up-regulation
Jenni E. Crowley,Jason E. Stadanlick,John C. Cambier,Michael P. Cancro
View Articletitled, FcγRIIB signals inhibit BLyS signaling and BCR-mediated BLyS receptor up-regulation
Supplemental data
SWAP-70 regulates RhoA/RhoB-dependent MHCII surface localization in dendritic cells
Carlos Ocana-Morgner,Christine Wahren,Rolf Jessberger
View Articletitled, SWAP-70 regulates RhoA/RhoB-dependent MHCII surface localization in dendritic cells
Supplemental data

LYMPHOID NEOPLASIA

BLNK suppresses pre–B-cell leukemogenesis through inhibition of JAK3
Joji Nakayama,Mutsumi Yamamoto,Katsuhiko Hayashi,Hitoshi Satoh,Kenji Bundo,Masato Kubo,Ryo Goitsuka,Michael A. Farrar,Daisuke Kitamura
View Articletitled, BLNK suppresses pre–B-cell leukemogenesis through inhibition of JAK3
Supplemental data
Imaging spontaneous tumorigenesis: inflammation precedes development of peripheral NK tumors
Dan Rauch,Shimon Gross,John Harding,Stefan Niewiesk,Michael Lairmore,David Piwnica-Worms,Lee Ratner
View Articletitled, Imaging spontaneous tumorigenesis: inflammation precedes development of peripheral NK tumors
Splenic plasma cells can serve as a source of amyloidogenic light chains
Brief Report
Alan Solomon,Sallie D. Macy,Craig Wooliver,Deborah T. Weiss,Per Westermark
View Articletitled, Splenic plasma cells can serve as a source of amyloidogenic light chains

MYELOID NEOPLASIA

CXCR4 expression and biologic activity in acute myeloid leukemia are dependent on oxygen partial pressure
Michael Fiegl,Ismael Samudio,Karen Clise-Dwyer,Jared K. Burks,Zakar Mnjoyan,Michael Andreeff
View Articletitled, CXCR4 expression and biologic activity in acute myeloid leukemia are dependent on oxygen partial pressure
Targeting PKC: a novel role for beta-catenin in ER stress and apoptotic signaling
Marc S. Raab,Iris Breitkreutz,Giovanni Tonon,Jing Zhang,Patrick J. Hayden,Thu Nguyen,Johannes H. Fruehauf,Boris K. Lin,Dharminder Chauhan,Teru Hideshima,Nikhil C. Munshi,Kenneth C. Anderson,Klaus Podar
View Articletitled, Targeting PKC: a novel role for beta-catenin in ER stress and apoptotic signaling
Supplemental data
Activity of the BH3 mimetic ABT-737 on polycythemia vera erythroid precursor cells
Brief Report
Ann Zeuner,Francesca Pedini,Federica Francescangeli,Michele Signore,Gabriella Girelli,Agostino Tafuri,Ruggero De Maria
View Articletitled, Activity of the BH3 mimetic ABT-737 on polycythemia vera erythroid precursor cells
Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

Human basophils and eosinophils are the direct target leukocytes of the novel IL-1 family member IL-33
Tatjana Pecaric-Petkovic,Svetlana A. Didichenko,Sacha Kaempfer,Nicole Spiegl,Clemens A. Dahinden
View Articletitled, Human basophils and eosinophils are the direct target leukocytes of the novel IL-1 family member IL-33
Supplemental data

PLATELETS AND THROMBOPOIESIS

Increased expression of urokinase plasminogen activator in Quebec platelet disorder is linked to megakaryocyte differentiation
D. Kika Veljkovic,Georges E. Rivard,Maria Diamandis,Jessica Blavignac,Elisabeth M. Cramer-Bordé,Catherine P. M. Hayward
View Articletitled, Increased expression of urokinase plasminogen activator in Quebec platelet disorder is linked to megakaryocyte differentiation
Quebec platelet disorder is linked to the urokinase plasminogen activator gene (PLAU) and increases expression of the linked allele in megakaryocytes
Maria Diamandis,Andrew D. Paterson,Johanna M. Rommens,D. Kika Veljkovic,Jessica Blavignac,Dennis E. Bulman,John S. Waye,Francine Derome,Georges E. Rivard,Catherine P. M. Hayward
View Articletitled, Quebec platelet disorder is linked to the urokinase plasminogen activator gene (<em>PLAU</em>) and increases expression of the linked allele in megakaryocytes
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

An insulator with barrier-element activity promotes α-spectrin gene expression in erythroid cells
Patrick G. Gallagher,Douglas G. Nilson,Laurie A. Steiner,Yelena D. Maksimova,Jolinta Y. Lin,David M. Bodine
View Articletitled, An insulator with barrier-element activity promotes α-spectrin gene expression in erythroid cells
Supplemental data
Regulation of growth differentiation factor 15 expression by intracellular iron
Samira Lakhal,Nick P. Talbot,Alexi Crosby,Chantal Stoepker,Alain R. M. Townsend,Peter A. Robbins,Christopher W. Pugh,Peter J. Ratcliffe,David R. Mole
View Articletitled, Regulation of growth differentiation factor 15 expression by intracellular iron

TRANSFUSION MEDICINE

A randomized controlled trial comparing standard- and low-dose strategies for transfusion of platelets (SToP) to patients with thrombocytopenia
Nancy M. Heddle,Richard J. Cook,Alan Tinmouth,C. Tom Kouroukis,Tor Hervig,Ellen Klapper,Joseph M. Brandwein,Zbigniew M. Szczepiorkowski,James P. AuBuchon,Rebecca L. Barty,Ker-Ai Lee,for the SToP Study investigators of the BEST Collaborative
View Articletitled, A randomized controlled trial comparing standard- and low-dose strategies for transfusion of platelets (SToP) to patients with thrombocytopenia

TRANSPLANTATION

Keratinocyte growth factor enhances DNA plasmid tumor vaccine responses after murine allogeneic bone marrow transplantation
Robert R. Jenq,Christopher G. King,Christine Volk,David Suh,Odette M. Smith,Uttam K. Rao,Nury L. Yim,Amanda M. Holland,Sydney X. Lu,Johannes L. Zakrzewski,Gabrielle L. Goldberg,Adi Diab,Onder Alpdogan,Olaf Penack,Il-Kang Na,Lucy W. Kappel,Jedd D. Wolchok,Alan N. Houghton,Miguel-Angel Perales,Marcel R. M. van den Brink
View Articletitled, Keratinocyte growth factor enhances DNA plasmid tumor vaccine responses after murine allogeneic bone marrow transplantation
CTLA4 blockade with ipilimumab to treat relapse of malignancy after allogeneic hematopoietic cell transplantation
Asad Bashey,Bridget Medina,Sue Corringham,Mildred Pasek,Ewa Carrier,Linda Vrooman,Israel Lowy,Scott R. Solomon,Lawrence E. Morris,H. Kent Holland,James R. Mason,Edwin P. Alyea,Robert J. Soiffer,Edward D. Ball
View Articletitled, CTLA4 blockade with ipilimumab to treat relapse of malignancy after allogeneic hematopoietic cell transplantation

VASCULAR BIOLOGY

Integrin αvβ3 on human endothelial cells binds von Willebrand factor strings under fluid shear stress
Jing Huang,Robyn Roth,John E. Heuser,J. Evan Sadler
View Articletitled, Integrin α<sub>v</sub>β<sub>3</sub> on human endothelial cells binds von Willebrand factor strings under fluid shear stress
Supplemental data
Heme oxygenase-1 expression enhances vascular endothelial resistance to complement-mediated injury through induction of decay-accelerating factor: a role for increased bilirubin and ferritin
Anne R. Kinderlerer,Isabel Pombo Gregoire,Shahir S. Hamdulay,Faisal Ali,Rivka Steinberg,Gabriela Silva,Nadira Ali,Bufei Wang,Dorian O. Haskard,Miguel P. Soares,Justin C. Mason
View Articletitled, Heme oxygenase-1 expression enhances vascular endothelial resistance to complement-mediated injury through induction of decay-accelerating factor: a role for increased bilirubin and ferritin
Supplemental data

CORRESPONDENCE

Antibiotics may impair hematopoietic recovery after cytotoxic myeloablation
Marc Tjwa,Lieve Moons,Catherine Verfaillie,Peter Carmeliet
View Articletitled, Antibiotics may impair hematopoietic recovery after cytotoxic myeloablation
Granule-mediated death by cytotoxic lymphocytes does not require mitochondrial polarization toward the immunologic synapse in target cells
Olivia Susanto,Karin Sedelies,Joe Trapani,Nigel Waterhouse
View Articletitled, Granule-mediated death by cytotoxic lymphocytes does not require mitochondrial polarization toward the immunologic synapse in target cells
Response: Movement of mitochondria during CTL-mediated killing
Ing Swie Goping,R. Chris Bleackley
View Articletitled, Response: Movement of mitochondria during CTL-mediated killing

ERRATUM

Diakos et al. RNAi-mediated silencing of TEL/AML1 reveals a heat-shock protein– and survivin-dependent mechanism for survival. Blood. 2007;109:2607-2610.
View Articletitled, Diakos et al. RNAi-mediated silencing of <em>TEL/AML1</em> reveals a heat-shock protein– and survivin-dependent mechanism for survival. Blood. 2007;109:2607-2610.
Luciano et al. Nur77 converts phenotype of Bcl-B, an antiapoptotic protein expressed in plasma cells and myeloma. Blood. 2007;109:3849-3855.
View Articletitled, Luciano et al. Nur77 converts phenotype of Bcl-B, an antiapoptotic protein expressed in plasma cells and myeloma. Blood. 2007;109:3849-3855.
Khouri et al. Eight-year experience with allogeneic stem cell transplantation for relapsed follicular lymphoma after nonmyeloablative conditioning with fludarabine, cyclophosphamide, and rituximab. Blood. 2008;111:5530-5536.
View Articletitled, Khouri et al. Eight-year experience with allogeneic stem cell transplantation for relapsed follicular lymphoma after nonmyeloablative conditioning with fludarabine, cyclophosphamide, and rituximab. Blood. 2008;111:5530-5536.
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