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James J.-D. Hsieh
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Journal Articles

The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations

Gang Huang, Xinghui Zhao, Lan Wang, Shannon Elf, Hao Xu, Xinyang Zhao, Goro Sashida, Yue Zhang, Yan Liu, Jennifer Lee, Silvia Menendez, Youyang Yang, Xiaomei Yan, Pu Zhang, Daniel G. Tenen, Motomi Osato, James J.-D. Hsieh, Stephen D. Nimer
Journal: Blood
Blood (2011) 118 (25): 6544–6552.
https://doi.org/10.1182/blood-2010-11-317909
Published: 2011
Includes: Supplemental data
Journal Articles

A Novel Function of MLL in the S Phase Checkpoint: MLL Is Phosphorylated by ATR Upon DNA Damage, Which Blocks Its Degradation by the SCF skp2 Proteasome, Leading to Its Accumulation That Directly Inhibits DNA Replication.

Han Liu, Shugaku Takeda, Rakesh Kumar, Todd Westergard, Tej Pandita, Emily Cheng, MD, PhD, James J.-D. Hsieh, MD, PhD
Journal: Blood
Blood (2009) 114 (22): 450.
https://doi.org/10.1182/blood.V114.22.450.450
Published: 2009
Journal Articles

MLL5 governs hematopoiesis: a step closer

Han Liu, Todd D. Westergard, James J.-D. Hsieh
Journal: Blood
Blood (2009) 113 (7): 1395–1396.
https://doi.org/10.1182/blood-2008-11-185801
Published: 2009
Journal Articles

The Role of MLL in DNA Damage Checkpoint and Its Implication in Leukemogenesis

Han Liu, PhD, Todd D Westergard, David Y Chen, Emily H.-Y. Cheng, MD, PhD, James J.-D. Hsieh, MD, PhD
Journal: Blood
Blood (2008) 112 (11): 5332.
https://doi.org/10.1182/blood.V112.11.5332.5332
Published: 2008
Journal Articles

Bimodal Degradation of MLL Protein by the Cell Cycle SCF Skp2 and APC Cdc20 E3 Lilgases Assures Cell Cycle Execution: A Critical Regulatory Circuit Lost in Leukemogenic MLL-Fusions.

Han Liu, PhD, David Chen, Todd Westergard, Shugaku Takeda, Satoru Sasagawa, PhD, Emily H.-Y. Cheng, MD PhD, James J.-D. Hsieh, MD, PhD
Journal: Blood
Blood (2007) 110 (11): 828.
https://doi.org/10.1182/blood.V110.11.828.828
Published: 2007