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Shugaku Takeda
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Journal Articles

Targeting Myeloid Epithelial Tyrosine Kinase (MERTK) Receptor in Acute Myeloid Leukemia Using a Novel Antibody Drug Conjugate, Rgx-019-MMAE

Anudishi Tyagi, Maryam Siddiqui, Isabel Kurth, Shugaku Takeda, Amanda Eckstrom, Jenny Borgman, Abhishek Maiti, Venkata Lokesh Battula
Journal: Blood
Blood (2023) 142 (Supplement 1): 5955.
https://doi.org/10.1182/blood-2023-175048
Published: 2023
Journal Articles

A Novel Function of MLL in the S Phase Checkpoint: MLL Is Phosphorylated by ATR Upon DNA Damage, Which Blocks Its Degradation by the SCF skp2 Proteasome, Leading to Its Accumulation That Directly Inhibits DNA Replication.

Han Liu, Shugaku Takeda, Rakesh Kumar, Todd Westergard, Tej Pandita, Emily Cheng, MD, PhD, James J.-D. Hsieh, MD, PhD
Journal: Blood
Blood (2009) 114 (22): 450.
https://doi.org/10.1182/blood.V114.22.450.450
Published: 2009
Journal Articles

Bimodal Degradation of MLL Protein by the Cell Cycle SCF Skp2 and APC Cdc20 E3 Lilgases Assures Cell Cycle Execution: A Critical Regulatory Circuit Lost in Leukemogenic MLL-Fusions.

Han Liu, PhD, David Chen, Todd Westergard, Shugaku Takeda, Satoru Sasagawa, PhD, Emily H.-Y. Cheng, MD PhD, James J.-D. Hsieh, MD, PhD
Journal: Blood
Blood (2007) 110 (11): 828.
https://doi.org/10.1182/blood.V110.11.828.828
Published: 2007
Journal Articles

Proteolysis of MLL Family Proteins Is Essential for Taspase1−Orchestrated Cell Cycle Progression.

James J. Hsieh, Shugaku Takeda, David Y. Chen, Todd D. Westergard, Jill K. Fisher, Jeffrey A. Rubens, Satoru Sasagawa, Jason T. Kan, Stanley J. Korsmeyer, Emily H. Cheng
Journal: Blood
Blood (2006) 108 (11): 769.
https://doi.org/10.1182/blood.V108.11.769.769
Published: 2006