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Issue Archive

Volume 8, Issue 13
July 9 2024
Issue Cover

Table of Contents

INSIDE BLOOD ADVANCES

Understanding CAR-T therapy in myeloma: 1 cell at a time
Madhav V. Dhodapkar
View Articletitled, Understanding CAR-T therapy in myeloma: 1 cell at a time
Immune thrombocytopenia guidelines get an annual checkup
Paul M. Gallo,Michele P. Lambert
View Articletitled, Immune thrombocytopenia guidelines get an annual checkup

REVIEW ARTICLE

The 2022 review of the 2019 American Society of Hematology guidelines on immune thrombocytopenia
Cindy E. Neunert,Donald M. Arnold,Rachael F. Grace,Thomas Kuhne,Keith R. McCrae,Deirdra R. Terrell
View Articletitled, The 2022 review of the 2019 American Society of Hematology guidelines on immune thrombocytopenia
Venetoclax: a new player in the treatment of children with high-risk myeloid malignancies?
Riccardo Masetti,Francesco Baccelli,Davide Leardini,Franco Locatelli
View Articletitled, Venetoclax: a new player in the treatment of children with high-risk myeloid malignancies?

CLINICAL TRIALS AND OBSERVATIONS

Acalabrutinib-based regimens in frontline or relapsed/refractory higher-risk CLL: pooled analysis of 5 clinical trials
Clinical Trials & Observations
Matthew S. Davids,Jeff P. Sharman,Paolo Ghia,Jennifer A. Woyach,Toby A. Eyre,Wojciech Jurczak,Tanya Siddiqi,Paulo Miranda,Mina Shahkarami,Anna Butturini,Ugochinyere Emeribe,John C. Byrd
View Articletitled, Acalabrutinib-based regimens in frontline or relapsed/refractory higher-risk CLL: pooled analysis of 5 clinical trials
Supplemental data
DISPLACE study shows poor quality of transcranial doppler ultrasound for stroke risk screening in sickle cell anemia
Clinical Trials & Observations
Kimberly A. Davidow,Robin E. Miller,Shannon M. Phillips,Alyssa M. Schlenz,Martina Mueller,Monica L. Hulbert,Lewis L. Hsu,Neha Bhasin,Robert J. Adams,Julie Kanter
View Articletitled, DISPLACE study shows poor quality of transcranial doppler ultrasound for stroke risk screening in sickle cell anemia

GENE THERAPY

Blockage of BCL-XL overcomes venetoclax resistance across BCL2+ lymphoid malignancies irrespective of BIM status
Alexandra Dolnikova,Dmitry Kazantsev,Magdalena Klanova,Eva Pokorna,Dana Sovilj,Cristina Daniela Kelemen,Liliana Tuskova,Eva Hoferkova,Marek Mraz,Karel Helman,Nikola Curik,Katerina Machova Polakova,Ladislav Andera,Marek Trneny,Pavel Klener
View Articletitled, Blockage of BCL-XL overcomes venetoclax resistance across BCL2<sup>+</sup> lymphoid malignancies irrespective of BIM status
Supplemental data

HEALTH SERVICES AND OUTCOMES

Trends in volumes and survival after hematopoietic cell transplantation in racial/ethnic minorities
Nandita Khera,Sikander Ailawadhi,Ruta Brazauskas,Jinalben Patel,Benjamin Jacobs,Celalettin Ustun,Karen Ballen,Muhammad Bilal Abid,Miguel Angel Diaz Perez,A. Samer Al-Homsi,Hasan Hashem,Sanghee Hong,Reinhold Munker,Raquel M. Schears,Hillard M. Lazarus,Stefan Ciurea,Sherif M. Badawy,Bipin N. Savani,Baldeep Wirk,C. Fred LeMaistre,Neel S. Bhatt,Amer Beitinjaneh,Mahmoud Aljurf,Akshay Sharma,Jan Cerny,Jennifer M. Knight,Amar H. Kelkar,Jean A. Yared,Tamila Kindwall-Keller,Lena E. Winestone,Amir Steinberg,Staci D. Arnold,Sachiko Seo,Jaime M. Preussler,Nasheed M. Hossain,Warren B. Fingrut,Vaibhav Agrawal,Shahrukh Hashmi,Leslie E. Lehmann,William A. Wood,Hemalatha G. Rangarajan,Wael Saber,Theresa Hahn
View Articletitled, Trends in volumes and survival after hematopoietic cell transplantation in racial/ethnic minorities
Supplemental data
“Don't keep me waiting”: estimating the impact of reduced vein-to-vein time on lifetime US 3L+ LBCL patient outcomes
Sachin Vadgama,Marcelo C. Pasquini,Richard T. Maziarz,Zhen-Huan Hu,Markqayne Ray,Harry Smith,Ash Bullement,Mark Edmondson-Jones,Will Sullivan,Guillaume Cartron
View Articletitled, “Don't keep me waiting”: estimating the impact of reduced vein-to-vein time on lifetime US 3L+ LBCL patient outcomes
Supplemental data
Decision theoretical foundations of clinical practice guidelines: an extension of the ASH thrombophilia guidelines
Benjamin Djulbegovic,Iztok Hozo,Gordon Guyatt
View Articletitled, Decision theoretical foundations of clinical practice guidelines: an extension of the ASH thrombophilia guidelines
Supplemental data

IMMUNOBIOLOGY AND IMMUNOTHERAPY

Cotargeting EBV lytic as well as latent cycle antigens increases T-cell potency against lymphoma
Sandhya Sharma,Naren U. Mehta,Tim Sauer,Lisa A. Rollins,Dirk P. Dittmer,Cliona M. Rooney
View Articletitled, Cotargeting EBV lytic as well as latent cycle antigens increases T-cell potency against lymphoma
Supplemental data

Lysosomal degradation pathways regulate mutant CRT and cell surface MPL levels in mutant CRT-driven MPNs

Lysosomal degradation targets mutant calreticulin and the thrombopoietin receptor in myeloproliferative neoplasms
Amanpreet Kaur,Arunkumar Venkatesan,Malathi Kandarpa,Moshe Talpaz,Malini Raghavan
View Articletitled, Lysosomal degradation targets mutant calreticulin and the thrombopoietin receptor in myeloproliferative neoplasms
Supplemental data
HLA reduction of human T cells facilitates generation of immunologically multicompatible cellular products
Pascal M. Winterhalter,Linda Warmuth,Philipp Hilgendorf,Julius M. Schütz,Sarah Dötsch,Torsten Tonn,Luka Cicin-Sain,Dirk H. Busch,Kilian Schober
View Articletitled, HLA reduction of human T cells facilitates generation of immunologically multicompatible cellular products
Supplemental data
A research center’s experience of T-cell–redirecting therapies in triple-class refractory multiple myeloma
Borja Puertas,Adolfo Fernández-Sánchez,Elena Alejo,Beatriz Rey-Búa,Ana A. Martín-López,Estefanía Pérez-López,Miriam López-Parra,Lucía López-Corral,Norma C. Gutiérrez-Gutiérrez,Ramón García-Sanz,Noemi Puig,Verónica González-Calle,María-Victoria Mateos
View Articletitled, A research center’s experience of T-cell–redirecting therapies in triple-class refractory multiple myeloma
Supplemental data
CD4+ CAR T-cell exhaustion associated with early relapse of multiple myeloma after BCMA CAR T-cell therapy
Guy Ledergor,Zenghua Fan,Kai Wu,Elizabeth McCarthy,Axel Hyrenius-Wittsten,Alec Starzinski,Hewitt Chang,Mark Bridge,Serena Kwek,Alexander Cheung,Sophia Bylsma,Erik Hansen,Jeffrey Wolf,Sandy Wong,Nina Shah,Kole T. Roybal,Thomas Martin,Chun J. Ye,Lawrence Fong
View Articletitled, CD4<sup>+</sup> CAR T-cell exhaustion associated with early relapse of multiple myeloma after BCMA CAR T-cell therapy
Supplemental data

LYMPHOID NEOPLASIA

Defining primary refractory large B-cell lymphoma
Allison M. Bock,Raphael Mwangi,Yucai Wang,Arushi Khurana,Matthew J. Maurer,Amy Ayers,Brad S. Kahl,Peter Martin,Jonathon B. Cohen,Carla Casulo,Izidore S. Lossos,Umar Farooq,Sabarish Ayyappan,Tanner Reicks,Thomas M. Habermann,Thomas E. Witzig,Christopher R. Flowers,James R. Cerhan,Loretta J. Nastoupil,Grzegorz S. Nowakowski
View Articletitled, Defining primary refractory large B-cell lymphoma
Supplemental data
The CNS relapse in T-cell lymphoma index predicts CNS relapse in patients with T- and NK-cell lymphomas
Clinical Trials & Observations
Rahul S. Bhansali,Fredrik Ellin,Thomas Relander,Miao Cao,Wenrui Li,Qi Long,Nivetha Ganesan,Robert Stuver,Steven M. Horwitz,Kitsada Wudhikarn,Steven R. Hwang,N. Nora Bennani,Julio Chavez,Lubomir Sokol,Hayder Saeed,Frank Duan,Pierluigi Porcu,Priyanka Pullarkat,Neha Mehta-Shah,Jasmine M. Zain,Miguel Ruiz,Jonathan E. Brammer,Rishab Prakash,Swaminathan P. Iyer,Adam J. Olszewski,Ajay Major,Peter A. Riedell,Sonali M. Smith,Caroline Goldin,Bradley Haverkos,Bei Hu,Tony Z. Zhuang,Pamela B. Allen,Wael Toama,Murali Janakiram,Taylor R. Brooks,Deepa Jagadeesh,Nisha Hariharan,Aaron M. Goodman,Gabrielle Hartman,Paola Ghione,Fatima Fayyaz,Joanna M. Rhodes,Elise A. Chong,James N. Gerson,Daniel J. Landsburg,Sunita D. Nasta,Stephen J. Schuster,Jakub Svoboda,Mats Jerkeman,Stefan K. Barta
View Articletitled, The CNS relapse in T-cell lymphoma index predicts CNS relapse in patients with T- and NK-cell lymphomas
Supplemental data

MYELOID NEOPLASIA

Clonal hematopoiesis and inflammation in the vasculature: CHIVE, a prospective, longitudinal clonal hematopoiesis cohort and biorepository
Clinical Trials & Observations
Morgan L. Shannon,J. Brett Heimlich,Sydney Olson,Ariana Debevec,Zachary Copeland,Ashwin Kishtagari,Caitlyn Vlasschaert,Christina Snider,Alexander J. Silver,Donovan Brown,Travis Spaulding,Manasa Bhatta,Kelly Pugh,Shannon S. Stockton,Jessica Ulloa,Yaomin Xu,Muhamed Baljevic,Javid Moslehi,Eiman Jahangir,P. Brent Ferrell,David Slosky,Alexander G. Bick,Michael R. Savona
View Articletitled, Clonal hematopoiesis and inflammation in the vasculature: CHIVE, a prospective, longitudinal clonal hematopoiesis cohort and biorepository
Supplemental data
Treatment approach and outcomes of patients with accelerated/blast-phase myeloproliferative neoplasms in the current era
Anand A. Patel,James J. Yoon,Hannah Johnston,Marta B. Davidson,Rory M. Shallis,Evan C. Chen,Madelyn Burkart,Timothy S. Oh,Sunil G. Iyer,Ellen Madarang,Chandrasekar Muthiah,Iyana Gross,Raven Dean,Joshua Kassner,Auro Viswabandya,Rafael Madero-Marroquin,Raajit K. Rampal,Guru Subramanian Guru Murthy,Terrence Bradley,Yasmin Abaza,Jacqueline S. Garcia,Vikas Gupta,Kristen M. Pettit,John F. Cursio,Olatoyosi Odenike
View Articletitled, Treatment approach and outcomes of patients with accelerated/blast-phase myeloproliferative neoplasms in the current era
Supplemental data

PLASMA CELL DISORDERS

Clonal hematopoiesis of indeterminate potential in patients with immunoglobulin light-chain AL amyloidosis
Paolo Lopedote,Benjamin Evans,Alfredo Marchetti,Tianzeng Chen,Maria Moscvin,Samuel Boullt,Niccolò Bolli,Giada Bianchi
View Articletitled, Clonal hematopoiesis of indeterminate potential in patients with immunoglobulin light-chain AL amyloidosis

THROMBOSIS AND HEMOSTASIS

Essential role of glycoprotein Ibα in platelet activation
Rong Yan,Yue Xia,Kangxi Zhou,Jun Liu,Yueyue Sun,Chunyan He,Xinxin Ge,Mengnan Yang,Chenglin Sun,Liuxia Yuan,Shujun Li,Biao Yang,Fanbi Meng,Lijuan Cao,Changgeng Ruan,Kesheng Dai
View Articletitled, Essential role of glycoprotein Ibα in platelet activation
Supplemental data

TRANSPLANTATION

The MAGIC algorithm probability predicts treatment response and long-term outcomes to second-line therapy for acute GVHD
Zachariah DeFilipp,Haesook T. Kim,Nikolaos Spyrou,Nikolaos Katsivelos,Steven Kowalyk,Gilbert Eng,Stelios Kasikis,Rahnuma Beheshti,Janna Baez,Yu Akahoshi,Francis Ayuk,Hannah Choe,Aaron Etra,Stephan A. Grupp,Elizabeth O. Hexner,William J. Hogan,Carrie L. Kitko,Muna Qayed,Ran Reshef,Ingrid Vasova,Robert Zeiser,Rachel Young,Ernst Holler,James L. M. Ferrara,Ryotaro Nakamura,John E. Levine,Yi-Bin Chen
View Articletitled, The MAGIC algorithm probability predicts treatment response and long-term outcomes to second-line therapy for acute GVHD
Supplemental data

RESEARCH LETTERS

Unraveling facets of MECOM-associated syndrome: somatic genetic rescue, clonal hematopoiesis, and phenotype expansion
Parvathy Venugopal,Peer Arts,Lucy C. Fox,Annet Simons,Devendra K. Hiwase,Peter G. Bardy,Annette Swift,David M. Ross,Lize F. D. van Vulpen,Arjan Buijs,Kelly L. Bolton,Bartlomiej Getta,Eliska Furlong,Tina Carter,Ingrid Krapels,Marlijn Hoeks,Adila Al Kindy,Farah Al Kindy,Sonja de Munnik,Pamela Evans,Mahalia S. B. Frank,Adam M. Bournazos,Sandra T. Cooper,Thuong Thi Ha,Matilda R. Jackson,Luis Arriola-Martinez,Kerry Phillips,Yvonne Brennan,Madhura Bakshi,Karen Ambler,Song Gao,Karin S. Kassahn,Rosalie Kenyon,Kevin Hung,Milena Babic,Alan McGovern,Lesley Rawlings,Cassandra Vakulin,Lucas Dejong,Rema Fathi,Simon McRae,Nicholas Myles,Dariusz Ladon,Marjolijn Jongmans,Roland P. Kuiper,Nicola K. Poplawski,Pasquale Barbaro,Piers Blombery,Anna L. Brown,Christopher N. Hahn,Hamish S. Scott
View Articletitled, Unraveling facets of MECOM-associated syndrome: somatic genetic rescue, clonal hematopoiesis, and phenotype expansion
Supplemental data
CAR T-cell therapy in mantle cell lymphoma with secondary CNS involvement: a multicenter experience
Clinical Trials & Observations
Gulrayz Ahmed,Aseel Alsouqi,Aniko Szabo,Laura Samples,Mazyar Shadman,Farrukh T. Awan,Alexandra E. Rojek,Peter A. Riedell,Madiha Iqbal,Timothy S. Fenske,Mohamed A. Kharfan-Dabaja,Sawa Ito,Mehdi Hamadani
View Articletitled, CAR T-cell therapy in mantle cell lymphoma with secondary CNS involvement: a multicenter experience
Risk of T-cell malignancy after CAR T-cell therapy in children, adolescents, and young adults
Adam J. Lamble,Liora M. Schultz,Khanh Nguyen,Emily M. Hsieh,Kevin McNerney,Rayne H. Rouce,Rebecca A. Gardner,Sara Ghorashian,Nirali N. Shah,Shannon L. Maude
View Articletitled, Risk of T-cell malignancy after CAR T-cell therapy in children, adolescents, and young adults
Industry payments to American Society of Hematology Clinical Practice Guideline authors
Jeremy W. Jacobs,Garrett S. Booth,Laura D. Stephens,Brian D. Adkins,Amarilis A. Martin,George D. Lundberg,Raeshun T. Glover,Shazia S. Khan,Julie K. Silver,Jennifer S. Woo
View Articletitled, Industry payments to American Society of Hematology Clinical Practice Guideline authors
Supplemental data
Infections in patients with lymphoma treated with bispecific antibodies: a systematic review and meta-analysis
Clinical Trials & Observations
Gemma K. Reynolds,Marsali Maclean,Edward R. Scheffer Cliff,Benjamin W. Teh,Karin A. Thursky,Monica A. Slavin,Mary Ann Anderson,Eliza A. Hawkes
View Articletitled, Infections in patients with lymphoma treated with bispecific antibodies: a systematic review and meta-analysis
Supplemental data

COMMENTARIES

The clinical trials landscape in immunoglobulin light chain amyloidosis: a systematic review
Ramya Ramachandran,Darshi Shah,Catherine Luo,Veer Shah,Edward R. Scheffer Cliff,Vaishali Sanchorawala,Suzanne Lentzsch,Rajshekhar Chakraborty
View Articletitled, The clinical trials landscape in immunoglobulin light chain amyloidosis: a systematic review
Supplemental data
ASH Guideline Oversight Subcommittee Response to Jacobs et al regarding Industry Payments to ASH Guideline Panelists
Menaka Pai,Michael Byrne,Adam Cuker,Benjamin Djulbegovic,Jim George,Matthew Seftel,Deirdra R. Terrell,Robert Kunkle,Matthew C. Cheung
View Articletitled, ASH Guideline Oversight Subcommittee Response to Jacobs et al regarding Industry Payments to ASH Guideline Panelists
Supplemental data
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    Cover Image

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    3D rendering of T cells attacking and killing cancer cells. Image by Meletios Verras/iStock.

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