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Volume 6, Issue 10
May 24 2022
Issue Cover

Table of Contents

STIMULUS REPORT

Regenerating islet-derived protein 3-α is a prognostic biomarker for gastrointestinal chronic graft-versus-host disease
Brittany Paige DePriest,Hong Li,Alan Bidgoli,Lynn Onstad,Daniel Couriel,Stephanie J. Lee,Sophie Paczesny
View Articletitled, Regenerating islet-derived protein 3-α is a prognostic biomarker for gastrointestinal chronic graft-versus-host disease
Supplemental data
Prognostic value of low-level MRD in adult acute lymphoblastic leukemia detected by low- and high-throughput methods
Michaela Kotrová,Johannes Koopmann,Heiko Trautmann,Nael Alakel,Joachim Beck,Kathrin Nachtkamp,Björn Steffen,Simon Raffel,Andreas Viardot,Klaus Wethmar,Nikos Darzentas,Claudia D. Baldus,Nicola Gökbuget,Monika Brüggemann
View Articletitled, Prognostic value of low-level MRD in adult acute lymphoblastic leukemia detected by low- and high-throughput methods
Supplemental data
Neurofilament light chain serum levels correlate with the severity of neurotoxicity after CAR T-cell treatment
Clinical Trials & Observations
Florian Schoeberl,Steffen Tiedt,Anita Schmitt,Viktoria Blumenberg,Philipp Karschnia,Vanessa Granja Burbano,Veit L. Bücklein,Kai Rejeski,Christian Schmidt,Galina Busch,Michael von Bergwelt-Baildon,Jörg-Christian Tonn,Michael Schmitt,Marion Subklewe,Louisa von Baumgarten
View Articletitled, Neurofilament light chain serum levels correlate with the severity of neurotoxicity after CAR T-cell treatment
Associating drug sensitivity with differentiation status identifies effective combinations for acute myeloid leukemia
Stephen E. Kurtz,Christopher A. Eide,Andy Kaempf,Nicola Long,Daniel Bottomly,Olga Nikolova,Brian J. Druker,Shannon K. McWeeney,Bill H. Chang,Jeffrey W. Tyner,Anupriya Agarwal
View Articletitled, Associating drug sensitivity with differentiation status identifies effective combinations for acute myeloid leukemia
Supplemental data
G6b-B regulates an essential step in megakaryocyte maturation
Isabelle C. Becker,Zoltan Nagy,Georgi Manukjan,Melanie Haffner-Luntzer,Maximilian Englert,Tobias Heib,Timo Vögtle,Carina Gross,Richa Bharti,Sascha Dietrich,Kristina Mott,Johannes Heck,Sebastian Stegmaier,Anke Baranowsky,Thorsten Schinke,Nicolas Schlegel,Tobias Heckel,David Stegner,Irina Pleines,Anita Ignatius,Harald Schulze,Bernhard Nieswandt
View Articletitled, G6b-B regulates an essential step in megakaryocyte maturation
Supplemental data

MYELOID NEOPLASIA

Patient-specific MDS-RS iPSCs define the mis-spliced transcript repertoire and chromatin landscape of SF3B1-mutant HSPCs
Georgios Asimomitis,André G. Deslauriers,Andriana G. Kotini,Elsa Bernard,Davide Esposito,Malgorzata Olszewska,Nikolaos Spyrou,Juan Arango Ossa,Teresa Mortera-Blanco,Richard Koche,Yasuhito Nannya,Luca Malcovati,Seishi Ogawa,Mario Cazzola,Stuart A. Aaronson,Eva Hellström-Lindberg,Elli Papaemmanuil,Eirini P. Papapetrou
View Articletitled, Patient-specific MDS-RS iPSCs define the mis-spliced transcript repertoire and chromatin landscape of <em>SF3B1</em>-mutant HSPCs
Supplemental data
Characteristics and outcomes of patients with blastic plasmacytoid dendritic cell neoplasm treated with frontline HCVAD
Naveen Pemmaraju,Nathaniel R. Wilson,Guillermo Garcia-Manero,Koji Sasaki,Joseph D. Khoury,Nitin Jain,Gautam Borthakur,Farhad Ravandi,Naval Daver,Tapan Kadia,Courtney DiNardo,Elias Jabbour,Sherry Pierce,Muzaffar Qazilbash,Marina Konopleva,Hagop Kantarjian
View Articletitled, Characteristics and outcomes of patients with blastic plasmacytoid dendritic cell neoplasm treated with frontline HCVAD
Supplemental data
Metalloproteinase inhibition reduces AML growth, prevents stem cell loss, and improves chemotherapy effectiveness
Chiara Pirillo,Flora Birch,Floriane S. Tissot,Sara Gonzalez Anton,Myriam Haltalli,Valentina Tini,Isabella Kong,Cécile Piot,Ben Partridge,Constandina Pospori,Karen Keeshan,Salvatore Santamaria,Edwin Hawkins,Brunangelo Falini,Andrea Marra,Delfim Duarte,Chiu Fan Lee,Edward Roberts,Cristina Lo Celso
View Articletitled, Metalloproteinase inhibition reduces AML growth, prevents stem cell loss, and improves chemotherapy effectiveness
Supplemental data
Molecular and cytogenetic characterization of myelodysplastic syndromes in cell-free DNA
Nieves Garcia-Gisbert,Sara Garcia-Ávila,Brayan Merchán,Marta Salido,Concepción Fernández-Rodríguez,Joan Gibert,Lierni Fernández-Ibarrondo,Laura Camacho,Marta Lafuente,Raquel Longarón,Blanca Espinet,Patricia Vélez,Ramon M. Pujol,Marcio Andrade-Campos,Leonor Arenillas,Antonio Salar,Xavier Calvo,Carles Besses,Beatriz Bellosillo
View Articletitled, Molecular and cytogenetic characterization of myelodysplastic syndromes in cell-free DNA
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Four AAs increase DMT1 abundance in duodenal brush-border membrane vesicles and enhance iron absorption in iron-deprived mice
Regina R. Woloshun,Yang Yu,Xiaodong Xu,Jennifer K. Lee,Sean Zhu,Jacob S. Shine,Pearl Ebea,Bruce R. Stevens,Sadasivan Vidyasagar,James F. Collins
View Articletitled, Four AAs increase DMT1 abundance in duodenal brush-border membrane vesicles and enhance iron absorption in iron-deprived mice
Supplemental data
Circulating primitive murine erythroblasts undergo complex proteomic and metabolomic changes during terminal maturation
Travis Nemkov,Paul D. Kingsley,Monika Dzieciatkowska,Jeffrey Malik,Kathleen E. McGrath,Kirk C. Hansen,Angelo D’Alessandro,James Palis
View Articletitled, Circulating primitive murine erythroblasts undergo complex proteomic and metabolomic changes during terminal maturation
Supplemental data

THROMBOSIS AND HEMOSTASIS

Lupus anticoagulant test persistence over time and its associations with future thrombotic events
Meaghan E. Colling,Cihan Ay,Daniel Kraemmer,Silvia Koder,Peter Quehenberger,Ingrid Pabinger,Florian Posch,Johanna Gebhart
View Articletitled, Lupus anticoagulant test persistence over time and its associations with future thrombotic events
Supplemental data
Validation of the Khorana score for predicting venous thromboembolism in 40 218 patients with cancer initiating chemotherapy
Thure Filskov Overvad,Anne Gulbech Ording,Peter Brønnum Nielsen,Flemming Skjøth,Ida Ehlers Albertsen,Simon Noble,Anders Krog Vistisen,Inger Lise Gade,Marianne Tang Severinsen,Gregory Piazza,Torben Bjerregaard Larsen
View Articletitled, Validation of the Khorana score for predicting venous thromboembolism in 40 218 patients with cancer initiating chemotherapy
Supplemental data
Management strategies following slightly out-of-range INRs: watchful waiting vs dose changes
Hallie B. Remer,Xiaokui Gu,Brian Haymart,Geoffrey D. Barnes,Mona A. Ali,Eva Kline-Rogers,Tina Alexandris-Souphis,Jay H. Kozlowski,James B. Froehlich,Vinay Shah,Gregory D. Krol,Scott Kaatz
View Articletitled, Management strategies following slightly out-of-range INRs: watchful waiting vs dose changes
Anti-HK antibody reveals critical roles of a 20-residue HK region for Aβ-induced plasma contact system activation
Zu-Lin Chen,Pradeep Kumar Singh,Katharina Horn,Sidney Strickland,Erin H. Norris
View Articletitled, Anti-HK antibody reveals critical roles of a 20-residue HK region for Aβ-induced plasma contact system activation
Supplemental data
Cost-effectiveness analysis of alternative anticoagulation in suspected heparin-induced thrombocytopenia
Aleksandra Tuleja,Dante Salvador, Jr,Taulant Muka,Sarah Bernhard,Armando Lenz,Iris Baumgartner,Marc Schindewolf
View Articletitled, Cost-effectiveness analysis of alternative anticoagulation in suspected heparin-induced thrombocytopenia
Supplemental data
Model for surface-dependent factor XII activation: the roles of factor XII heavy chain domains
Aleksandr Shamanaev,Ivan Ivanov,Mao-Fu Sun,Maxim Litvak,Priyanka Srivastava,Bassem M. Mohammed,Rabia Shaban,Ashoka Maddur,Ingrid M. Verhamme,Owen J. T. McCarty,Ruby H. P. Law,David Gailani
View Articletitled, Model for surface-dependent factor XII activation: the roles of factor XII heavy chain domains
Supplemental data
Racial disparities in cancer-associated thrombosis
Tatini Datta,Ann Brunson,Anjlee Mahajan,Theresa Keegan,Ted Wun
View Articletitled, Racial disparities in cancer-associated thrombosis
Supplemental data

TRANSPLANTATION

MicroRNA-31 regulates T-cell metabolism via HIF1α and promotes chronic GVHD pathogenesis in mice
Yongxia Wu,Corey Mealer,Steven Schutt,Carole L. Wilson,David Bastian,M. Hanief Sofi,Mengmeng Zhang,Zhenwu Luo,Hee-Jin Choi,Kaipo Yang,Linlu Tian,Hung Nguyen,Kris Helke,Lynn M. Schnapp,Honglin Wang,Xue-Zhong Yu
View Articletitled, MicroRNA-31 regulates T-cell metabolism via HIF1α and promotes chronic GVHD pathogenesis in mice
Supplemental data

RESEARCH LETTER

Myb drives B-cell neoplasms and myeloid malignancies in vivo
Tim Pieters,André Almeida,Sara T'Sas,Kelly Lemeire,Tino Hochepied,Geert Berx,Alex Kentsis,Steven Goossens,Pieter Van Vlierberghe
View Articletitled, Myb drives B-cell neoplasms and myeloid malignancies in vivo
Supplemental data
Letermovir reduces chronic GVHD risk in calcineurin inhibitor-free GVHD prophylaxis after hematopoietic cell transplantation
Francesca Lorentino,Elisabetta Xue,Sara Mastaglio,Fabio Giglio,Daniela Clerici,Francesca Farina,Simona Piemontese,Alessandro Bruno,Lorenzo Lazzari,Annalisa Ruggeri,Elena Guggiari,Francesca Lunghi,Andrea A. Assanelli,Sarah Marktel,Magda Marcatti,Matteo G. Carrabba,Massimo Bernardi,Consuelo Corti,Jacopo Peccatori,Fabio Ciceri,Raffaella Greco,Maria Teresa Lupo-Stanghellini
View Articletitled, Letermovir reduces chronic GVHD risk in calcineurin inhibitor-free GVHD prophylaxis after hematopoietic cell transplantation
Supplemental data
Blinatumomab induces complete response in refractory PTLD after hematopoietic cell transplantation
Clinical Trials & Observations
Sanyukta Janardan,Edwin Horwitz,Benjamin Watkins,Kirsten Williams,Shanmuganathan Chandrakasan,Muna Qayed,Suhag Parikh,Staci Arnold,Frank Keller,Adina Alazraki,Michelle Schoettler,Kathryn Leung
View Articletitled, Blinatumomab induces complete response in refractory PTLD after hematopoietic cell transplantation
Antibody response to mRNA vaccination for COVID-19 in patients with AML receiving hypomethylating agents alone or with venetoclax
Clinical Trials & Observations
Anna Candoni,Chiara Callegari,Maria Elena Zannier,Renato Fanin
View Articletitled, Antibody response to mRNA vaccination for COVID-19 in patients with AML receiving hypomethylating agents alone or with venetoclax
SMARCD1 negatively regulates myeloid differentiation of leukemic cells via epigenetic mechanisms
Subha Saha,Priyanka Samal,Swati Madhulika,Krushna Chandra Murmu,Sohini Chakraborty,Jhinuk Basu,Subhabrata Barik,Kautilya Kumar Jena,Asima Das,Santosh Chauhan,Punit Prasad
View Articletitled, SMARCD1 negatively regulates myeloid differentiation of leukemic cells via epigenetic mechanisms
Supplemental data
Childhood acute myeloid leukemia with 5q deletion and HNRNPH1-MLLT10 fusion: the first case report
Ko Kudo,Yasuo Kubota,Tsutomu Toki,Rika Kanezaki,Akie Kobayashi,Tomohiko Sato,Takuya Kamio,Shinya Sasaki,Norio Shiba,Daisuke Tomizawa,Souichi Adachi,Kenichi Yoshida,Seishi Ogawa,Masafumi Seki,Junko Takita,Etsuro Ito,Kiminori Terui
View Articletitled, Childhood acute myeloid leukemia with 5q deletion and <em>HNRNPH1-MLLT10</em> fusion: the first case report
Supplemental data
A genetically distinct pediatric subtype of primary CNS large B-cell lymphoma is associated with favorable clinical outcome
Ekin Güney,Calixto-Hope G. Lucas,Zhongxia Qi,Jingwei Yu,Ruth Zhang,Robert S. Ohgami,James L. Rubenstein,Daniel R. Boué,Kristian Schafernak,Gerald B. Wertheim,Sonika Dahiya,Lisa Giulino-Roth,Andishe Attarbaschi,Matthew J. Barth,Shalin Kothari,Oussama Abla,Adam L. Cohen,Joe S. Mendez,Andrew Bollen,Arie Perry,Tarik Tihan,Melike Pekmezci,David A. Solomon,Kwun Wah Wen
View Articletitled, A genetically distinct pediatric subtype of primary CNS large B-cell lymphoma is associated with favorable clinical outcome
Supplemental data

ERRATUM

Miles J, Bailey SL, Obenaus AM, et al. Storage temperature determines platelet GPVI levels and function in mice and humans. Blood Adv. 2021;5(19):3839-3849.
View Articletitled, Miles J, Bailey SL, Obenaus AM, et al. Storage temperature determines platelet GPVI levels and function in mice and humans. <em>Blood Adv</em>. 2021;5(19):3839-3849.
  • Cover Image

    Cover Image

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    Loss of microRNA-31 in donor T cells attenuates collagen deposition in recipient skin during development of chronic graft-versus-host disease. BALB/c mice were lethally irradiated and injected with bone marrow plus splenocytes isolated from B6 mice with or without microRNA-31 deficiency in T cells. Collagen deposition in recipient skin was evaluated with Masson’s trichrome stain on day 50 after bone marrow transplantation. See the article by Wu et al.

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