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Issue Archive

Volume 1, Issue 19
August 22 2017
Issue Cover

Table of Contents

EXCEPTIONAL CASE REPORTS

Maternal iAMP21 acute lymphoblastic leukemia detected on prenatal cell-free DNA genetic screening
Clinical Trials & Observations
Marlise R. Luskin,Marie N. Discenza,Sarah Rae Easter,Paola Dal Cin,Renius Owen,Bernard Ilagan,Meredith Masiello,Andrew A. Lane
View Articletitled, Maternal iAMP21 acute lymphoblastic leukemia detected on prenatal cell-free DNA genetic screening
Ruxolitinib for treatment of refractory hemophagocytic lymphohistiocytosis
Clinical Trials & Observations
Larisa Broglie,Lauren Pommert,Sridhar Rao,Monica Thakar,Rachel Phelan,David Margolis,Julie Talano
View Articletitled, Ruxolitinib for treatment of refractory hemophagocytic lymphohistiocytosis

STIMULUS REPORTS

MLL-AF9 leukemias are sensitive to PARP1 inhibitors combined with cytotoxic drugs
Silvia Maifrede,Esteban Martinez,Margaret Nieborowska-Skorska,Daniela Di Marcantonio,Michael Hulse,Bac Viet Le,Huaqing Zhao,Katarzyna Piwocka,Italo Tempera,Stephen M. Sykes,Tomasz Skorski
View Articletitled, MLL-AF9 leukemias are sensitive to PARP1 inhibitors combined with cytotoxic drugs
Supplemental data
Intragenic amplification of PAX5: a novel subgroup in B-cell precursor acute lymphoblastic leukemia?
Claire Schwab,Karin Nebral,Lucy Chilton,Cristina Leschi,Esmé Waanders,Judith M. Boer,Markéta Žaliová,Rosemary Sutton,Ingegerd Ivanov Öfverholm,Kentaro Ohki,Yuka Yamashita,Stefanie Groeneveld-Krentz,Eva Froňková,Marleen Bakkus,Joelle Tchinda,Thayana da Conceição Barbosa,Grazia Fazio,Wojciech Mlynarski,Agata Pastorczak,Giovanni Cazzaniga,Maria S. Pombo-de-Oliveira,Jan Trka,Renate Kirschner-Schwabe,Toshihiko Imamura,Gisela Barbany,Martin Stanulla,Andishe Attarbaschi,Renate Panzer-Grümayer,Roland P. Kuiper,Monique L. den Boer,Hélène Cavé,Anthony V. Moorman,Christine J. Harrison,Sabine Strehl,on behalf of the International Berlin-Frankfurt-Münster (I-BFM) Study Group,on behalf of the International Berlin-Frankfurt-Münster (I-BFM) Study Group,on behalf of the International Berlin-Frankfurt-Münster (I-BFM) Study Group,on behalf of the International Berlin-Frankfurt-Münster (I-BFM) Study Group,on behalf of the International Berlin-Frankfurt-Münster (I-BFM) Study Group,on behalf of the International Berlin-Frankfurt-Münster (I-BFM) Study Group,on behalf of the International Berlin-Frankfurt-Münster (I-BFM) Study Group,on behalf of the International Berlin-Frankfurt-Münster (I-BFM) Study Group,on behalf of the International Berlin-Frankfurt-Münster (I-BFM) Study Group,on behalf of the International Berlin-Frankfurt-Münster (I-BFM) Study Group,on behalf of the International Berlin-Frankfurt-Münster (I-BFM) Study Group,on behalf of the International Berlin-Frankfurt-Münster (I-BFM) Study Group,on behalf of the International Berlin-Frankfurt-Münster (I-BFM) Study Group,on behalf of the International Berlin-Frankfurt-Münster (I-BFM) Study Group,on behalf of the International Berlin-Frankfurt-Münster (I-BFM) Study Group,on behalf of the International Berlin-Frankfurt-Münster (I-BFM) Study Group,on behalf of the International Berlin-Frankfurt-Münster (I-BFM) Study Group,on behalf of the International Berlin-Frankfurt-Münster (I-BFM) Study Group,on behalf of the International Berlin-Frankfurt-Münster (I-BFM) Study Group,on behalf of the International Berlin-Frankfurt-Münster (I-BFM) Study Group,on behalf of the International Berlin-Frankfurt-Münster (I-BFM) Study Group,on behalf of the International Berlin-Frankfurt-Münster (I-BFM) Study Group,on behalf of the International Berlin-Frankfurt-Münster (I-BFM) Study Group,on behalf of the International Berlin-Frankfurt-Münster (I-BFM) Study Group,on behalf of the International Berlin-Frankfurt-Münster (I-BFM) Study Group,on behalf of the International Berlin-Frankfurt-Münster (I-BFM) Study Group,on behalf of the International Berlin-Frankfurt-Münster (I-BFM) Study Group,on behalf of the International Berlin-Frankfurt-Münster (I-BFM) Study Group,on behalf of the International Berlin-Frankfurt-Münster (I-BFM) Study Group,on behalf of the International Berlin-Frankfurt-Münster (I-BFM) Study Group,on behalf of the International Berlin-Frankfurt-Münster (I-BFM) Study Group,on behalf of the International Berlin-Frankfurt-Münster (I-BFM) Study Group,on behalf of the International Berlin-Frankfurt-Münster (I-BFM) Study Group,on behalf of the International Berlin-Frankfurt-Münster (I-BFM) Study Group
View Articletitled, Intragenic amplification of <em>PAX5</em>: a novel subgroup in B-cell precursor acute lymphoblastic leukemia?
Supplemental data

REVIEW ARTICLES

Pharmacotherapeutical strategies in the prevention of acute, vaso-occlusive pain in sickle cell disease: a systematic review
Clinical Trials & Observations
Joep W. R. Sins,David J. Mager,Shyrin C. A. T. Davis,Bart J. Biemond,Karin Fijnvandraat
View Articletitled, Pharmacotherapeutical strategies in the prevention of acute, vaso-occlusive pain in sickle cell disease: a systematic review
Supplemental data
Patient-centered care coordination in hematopoietic cell transplantation
Nandita Khera,Patricia Martin,Kristen Edsall,Anthony Bonagura,Linda J. Burns,Mark Juckett,Olivia King,C. Frederick LeMaistre,Navneet S. Majhail
View Articletitled, Patient-centered care coordination in hematopoietic cell transplantation

CLINICAL TRIALS AND OBSERVATIONS

A phase 2 study of panobinostat with lenalidomide and weekly dexamethasone in myeloma
Clinical Trials & Observations
Ajai Chari,Hearn J. Cho,Amishi Dhadwal,Gillian Morgan,Lisa La,Katarzyna Zarychta,Donna Catamero,Erika Florendo,Nadege Stevens,Daniel Verina,Elaine Chan,Violetta Leshchenko,Alessandro Laganà,Deepak Perumal,Anna Huo-Chang Mei,Kaity Tung,Jami Fukui,Sundar Jagannath,Samir Parekh
View Articletitled, A phase 2 study of panobinostat with lenalidomide and weekly dexamethasone in myeloma
Supplemental data
Near-tetraploidy is associated with Richter transformation in chronic lymphocytic leukemia patients receiving ibrutinib
Clinical Trials & Observations
Cecelia R. Miller,Amy S. Ruppert,Nyla A. Heerema,Kami J. Maddocks,Jadwiga Labanowska,Heather Breidenbach,Gerard Lozanski,Weiqiang Zhao,Amber L. Gordon,Jeffrey A. Jones,Joseph M. Flynn,Samantha M. Jaglowski,Leslie A. Andritsos,Kristie A. Blum,Farrukh T. Awan,Kerry A. Rogers,Michael R. Grever,Amy J. Johnson,Lynne V. Abruzzo,Erin K. Hertlein,James S. Blachly,Jennifer A. Woyach,John C. Byrd
View Articletitled, Near-tetraploidy is associated with Richter transformation in chronic lymphocytic leukemia patients receiving ibrutinib
Supplemental data

MYELOID NEOPLASIA

A 4-lncRNA scoring system for prognostication of adult myelodysplastic syndromes
Clinical Trials & Observations
Chi-Yuan Yao,Ching-Hsuan Chen,Huai-Hsuan Huang,Hsin-An Hou,Chien-Chin Lin,Mei-Hsuan Tseng,Chein-Jun Kao,Tzu-Pin Lu,Wen-Chien Chou,Hwei-Fang Tien
View Articletitled, A 4-lncRNA scoring system for prognostication of adult myelodysplastic syndromes
Supplemental data
Co-occurrence of FLT3-TKD and NPM1 mutations defines a highly favorable prognostic AML group
Clinical Trials & Observations
Prajwal Boddu,Hagop Kantarjian,Gautam Borthakur,Tapan Kadia,Naval Daver,Sherry Pierce,Michael Andreeff,Farhad Ravandi,Jorge Cortes,Steven M. Kornblau
View Articletitled, Co-occurrence of <em>FLT3</em>-TKD and <em>NPM1</em> mutations defines a highly favorable prognostic AML group
Supplemental data
Patient-derived antibody recognizes a unique CD43 epitope expressed on all AML and has antileukemia activity in mice
Marijn A. Gillissen,Greta de Jong,Martijn Kedde,Etsuko Yasuda,Sophie E. Levie,Gemma Moiset,Paul J. Hensbergen,Arjen Q. Bakker,Koen Wagner,Jullien Villaudy,Pauline M. van Helden,Hergen Spits,Mette D. Hazenberg
View Articletitled, Patient-derived antibody recognizes a unique CD43 epitope expressed on all AML and has antileukemia activity in mice
Supplemental data

PLATELETS AND THROMBOPOIESIS

Platelet dense granules begin to selectively accumulate mepacrine during proplatelet formation
Hayley A. Hanby,Jialing Bao,Ji-Yoon Noh,Danuta Jarocha,Mortimer Poncz,Mitchell J. Weiss,Michael S. Marks
View Articletitled, Platelet dense granules begin to selectively accumulate mepacrine during proplatelet formation
Supplemental data
Fibrin and D-dimer bind to monomeric GPVI
Marie-Blanche Onselaer,Alexander T. Hardy,Clare Wilson,Ximena Sanchez,Amir K. Babar,Jeanette L. C. Miller,Callum N. Watson,Stephanie K. Watson,Arkadiusz Bonna,Helen Philippou,Andrew B. Herr,Diego Mezzano,Robert A. S. Ariëns,Steve P. Watson
View Articletitled, Fibrin and D-dimer bind to monomeric GPVI
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Erythropoiesis-stimulating agents in elderly patients with anemia: response and cardiovascular outcomes
Clinical Trials & Observations
Zachary Gowanlock,Swetha Sriram,Alison Martin,Anargyros Xenocostas,Alejandro Lazo-Langner
View Articletitled, Erythropoiesis-stimulating agents in elderly patients with anemia: response and cardiovascular outcomes
Supplemental data

THROMBOSIS AND HEMOSTASIS

The impact of von Willebrand factor on factor VIII memory immune responses
Juan Chen,Jocelyn A. Schroeder,Xiaofeng Luo,Qizhen Shi
View Articletitled, The impact of von Willebrand factor on factor VIII memory immune responses
Supplemental data

TRANSPLANTATION

IAPs protect host target tissues from graft-versus-host disease in mice
Tomomi Toubai,Corinne Rossi,Katherine Oravecz-Wilson,Chen Liu,Cynthia Zajac,Shin-Rong Julia Wu,Yaping Sun,Hideaki Fujiwara,Hiroya Tamaki,Daniel Peltier,Mary Riwes,Israel Henig,Stuart Brabbs,Colin S. Duckett,Shaomeng Wang,Pavan Reddy
View Articletitled, IAPs protect host target tissues from graft-versus-host disease in mice
Supplemental data
The number of CD56dim NK cells in the graft has a major impact on risk of disease relapse following allo-HSCT
Clinical Trials & Observations
Luke Maggs,Francesca Kinsella,Y. L. Tracey Chan,Suzy Eldershaw,Duncan Murray,Jane Nunnick,Joanne Bird,Charles Craddock,Jianmin Zuo,Ram Malladi,Paul Moss
View Articletitled, The number of CD56<sup>dim</sup> NK cells in the graft has a major impact on risk of disease relapse following allo-HSCT
Supplemental data

ERRATUM

Jayappa KD, Portell CA, Gordon VL, et al. Microenvironmental agonists generate de novo phenotypic resistance to combined ibrutinib plus venetoclax in CLL and MCL. Blood Adv. 2017;1(14):933-946.
View Articletitled, Jayappa KD, Portell CA, Gordon VL, et al. Microenvironmental agonists generate de novo phenotypic resistance to combined ibrutinib plus venetoclax in CLL and MCL. <em>Blood Adv.</em> 2017;1(14):933-946.
  • Cover Image

    Cover Image

    issue cover

    COVER FIGURE
    Bone marrow metaphase fluorescence in situ hybridization demonstrating multiple signals from a RUNX1 probe (21q22, red) consistent with a diagnosis of iAMP21 B-cell acute lymphoblastic leukemia. See the article by Luskin et al.

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