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Comparison of Myeloablative (CyTBI, BuCy) Versus Reduced-Intensity (FluBu2TBI400) Peripheral Blood Stem Cell Transplantation in Acute Myeloid Leukemia Patients with Low WT1 Expression Level at Transplant

Silvia Park, GI June MIN, MD, Sung-Soo Park, Seung-Ah Yahng, MD PhD, Young-Woo Jeon, MD PhD, Seung-Hwan Shin, MD PhD, Jae-Ho Yoon, MD PhD, Sung-Eun Lee, MD, Byung-Sik Cho, MD, Ki-Seong Eom, MD PhD, Yoo-Jin Kim, MD PhD, Seok Lee, MD PhD, Chang Ki Min, MD PhD, Seok-Goo Cho, MD PhD, Dong-Wook Kim, Jong-Wook Lee, MD PhD, Hee-Je Kim, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1973.
https://doi.org/10.1182/blood-2019-128306
Published: 2019
Journal Articles

DC Vaccination Induces Antigen Specific Immune Responses in AML Patients: A 1-Year Interim Assessment

Judith Eckl, PhD, Silke Raffegerst, PhD, Frauke Schnorfeil, PhD, Petra Prinz-Schulz, PhD, Christiane Fingerhut, Yngvar Floisand, MD PhD, Dag Josefsen, Iris Bigalke, MD, Kai Pinkernell, MDMBA, Gunnar Kvalheim, MD PhD, Dolores Schendel, Prof., Anna Tafuri, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3923.
https://doi.org/10.1182/blood-2019-129749
Published: 2019
Journal Articles

Targeting Intracellular WT1 in AML Utilizing a T Cell Bispecific Antibody Construct: Augmenting Efficacy through Combination with Lenalidomide

Christian Klein, PhD, Christian Augsberger, Wei Xu, MD PhD, Christina Heitmüller, PhD, Lydia Hanisch, PhD, Johannes Sam, PhD, Vesna Pulko, PhD, Anne Schönle, John Challier, PhD, Alejandro Carpy, PhD, Nikola Konstandin, PhD, Maurine Rothe, Gerulf Hänel, Veit Bücklein, MD, Felix S. Lichtenegger, MD, Antje Tunger, PhD, Marc Schmitz, MD, Michael von Bergwelt, Karsten Spiekermann, MD, Pablo Umana, PhD, Marion Subklewe, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4450.
https://doi.org/10.1182/blood-2019-130121
Published: 2019
Journal Articles

Isoform Specific Regulation of Acute Myeloid Leukemia Maintenance By Wilms Tumor 1

Sandeep Potluri, MA, MBBChir, MRCP, Salam A. Assi, PhD, Suyin Paulynn Chin, PhD, Anetta Ptasinska, PhD, Daniel Coleman, PhD, Peter Cockerill, PhD, Constanze Bonifer, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1232.
https://doi.org/10.1182/blood-2019-122533
Published: 2019
Journal Articles

Treatment‐Related Acute Myeloid Leukemia in Children

Katharina Waack, Katharina Röllecke, PhD, Mareike Rasche, MD, Christiane Walter, MSc, Ursula Creutzig, MD PhD, Dirk Reinhardt, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1322.
https://doi.org/10.1182/blood-2019-131911
Published: 2019
Journal Articles

A Phase I Study Evaluating the Safety and Persistence of Allorestricted WT1-TCR Gene Modified Autologous T Cells in Patients with High-Risk Myeloid Malignancies Unsuitable for Allogeneic Stem Cell Transplantation

Emma C Morris, Rita Tendeiro-Rego, Rachel Richardson, MSc, Thomas A Fox, BSc, MSc, MRCP, Francesca Sillito, BSc, MRCP, FRCPath, Angelika Holler, Sharyn Thomas, Shao-An Xue, Irma Alicia Martínez-Dávila, Emma Nicholson, Mandana Ahmadi, Judith King, Panagiotis Kottaridis, Ronjon Chakraverty, BMBS, PhD, Kirsty Thomson, Stephen Robinson, MBBS, PhD BSc, Andres E. Virchis, FRCP, FRCPath, Asim Khwaja, Michelle Quaye, Hong Zhan, Waseem Qasim, MBBS, PhD, Nourredine Himoudi, Jacqueline Barry, Natalie Mount, PhD, Terri Gaskell, Michaela Sharpe, Shannon M Inman, Kurt C. Gunter, MD, Hans Stauss
Journal: Blood
Blood (2019) 134 (Supplement_1): 1367.
https://doi.org/10.1182/blood-2019-128044
Published: 2019
Journal Articles

Phase II Trial of a Peptide Vaccine, Ocv-501 in Elderly Patients with Acute Myeloid Leukemia

Masaki Yamaguchi, MD PhD, Naoki Takezako, MD PhD, Toru Kiguchi, MD PhD, Shuichi Miyawaki, MD PhD, Yuji Heike, MD PhD, Kaori Mitsuki, Takahiro Yoshida, PhD, Ei Leen Liew, PhD MS, Tomoki Naoe, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 29.
https://doi.org/10.1182/blood-2018-99-110013
Published: 2018
Journal Articles

Predictive Response Biomarkers for BET Inhibitors in AML

Joseph J Saad, MSc, BSc, Juho Miettinen, PhD, Dimitrios Tsallos, BSc(Hons),MSc, Samuli Eldfors, PhD, Mika Kontro, MD, Krister Wennerberg, PhD, Olli Kallioniemi, MD PhD, Kimmo Porkka, MD PhD, Jing Tang, PhD, Caroline A Heckman, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2749.
https://doi.org/10.1182/blood-2018-99-118363
Published: 2018
Journal Articles

Characterization of Pathogenic Variants and Clinical Phenotypes in 117 Japanese Fanconi Anemia Patients

Minako Mori, MD, Asuka Hira, MD PhD, Kenichi Yoshida, MD PhD, Hideki Muramatsu, MD PhD, Yusuke Okuno, MD PhD, Michiko Anmae, MS, Kazuo Tamura, MD PhD, Jun Yasuda, MD PhD, Tomoo Osumi, MD, Yasushi Noguchi, MD, Souichi Adachi, MD PhD, Hiroshi Kawabata, MD PhD, Akifumi Takaori-Kondo, MD PhD, Seiji Kojima, MD PhD, Seishi Ogawa, MD PhD, Hiromasa Yabe, MD, PhD, Miharu Yabe, MD PhD, Minoru Takata, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3860.
https://doi.org/10.1182/blood-2018-99-110362
Published: 2018
Journal Articles

The Proportional Association between WT1 mRNA Level in Peripheral Blood before Allogeneic Hematopoietic Cell Transplantation and Risk of Mortality in Acute Myeloid Leukemia Not in Remission

Kentaro Ido, MD, Mika Nakamae, MDPhD, Hideo Koh, MDPhD, Hiroshi Okamura, Satoru Nanno, MD PhD, Mitsutaka Nishimoto, MDPhD, Yoshinori Hashimoto, MD, Yasunobu Takeoka, MDPhD, Asao Hirose, MDPhD, Yasuhiro Nakashima, MDPhD, Takahiko Nakane, MD PhD, Masayuki Hino, MDPhD, Hirohisa Nakamae, MDPhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4665.
https://doi.org/10.1182/blood-2018-99-111834
Published: 2018
Journal Articles

The interaction of ENL with PAF1 mitigates polycomb silencing and facilitates murine leukemogenesis

Katrin Hetzner, Maria-Paz Garcia-Cuellar, Christian Büttner, Robert K. Slany
Journal: Blood
Blood (2018) 131 (6): 662–673.
https://doi.org/10.1182/blood-2017-11-815035
Published: 2018
Includes: Supplemental data
Journal Articles

Identification of Cross-Reactive Targets of TCR-Based Therapeutic Agents within the Human Proteome

Ron S Gejman, BA, Tao Dao, MDPhD, David A. Scheinberg, MDPhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3188.
https://doi.org/10.1182/blood.V130.Suppl_1.3188.3188
Published: 2017
Journal Articles

Wt1 Haploinsufficiency Induces an Age-Dependent Enhancement in Stem Cell Self-Renewal and Cooperates with FLT3-ITD to Drives Leukemogenesis

Elodie Pronier, PhD, Justin T Whitfield, Tiffany Merlinsky, Jihae Ahn, Raajit K. Rampal, MD PhD, Benjamin H Durham, MD BS, Ari Melnick, MD, Ross L. Levine, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1214.
https://doi.org/10.1182/blood.V130.Suppl_1.1214.1214
Published: 2017
Journal Articles

Expression of the Tumor Suppressor WT1 Is Induced By PML-Rara in Acute Promyelocytic Leukemia. Â

Matt Christopher, MD PhD, Andrew Menssen, Margery Gang, Anand Upadhyaya, Lukas D Wartman, MD, Timothy James J Ley, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2508.
https://doi.org/10.1182/blood.V130.Suppl_1.2508.2508
Published: 2017
Journal Articles

A Blood Dendritic Cell Vaccine for Acute Myeloid Leukemia Expands Anti-Tumour T Cell Responses at Remission

Derek NJ Hart, PhD FRCPA, FRACP, MB, Jennifer L Hsu, Christian E Bryant, Michael S Papadimitrious, Benjamin Kong, Robin E Gasiorowski, Daniel W Orellana, Helen McGuire, Barbara Fazekas de St Groth, Douglas E. Joshua, Phoebe Joy Ho, Stephen R Larsen, Harry J Iland, John Gibson, Georgina J Clark, Phillip D Fromm
Journal: Blood
Blood (2017) 130 (Supplement 1): 2648.
https://doi.org/10.1182/blood.V130.Suppl_1.2648.2648
Published: 2017
Journal Articles

Evaluating Cyclin A1 As an Immunotherapeutic Target in Acute Myeloid Leukemia (AML)

Premal Lulla, MBBS, Ifigeneia Tzannou, MD, Daniel Brenner, Helen E. Heslop, MDDSc, Juan F. Vera, MD, Ann M. Leen, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1907.
https://doi.org/10.1182/blood.V130.Suppl_1.1907.1907
Published: 2017
Journal Articles

A Moderate Increase in the WT1 mRNA Copy Number in Peripheral Blood of Patients with Long-Standing Acquired Aplastic Anemia without Apparent Signs of Myelodysplastic Syndrome

Ken Ishiyama, MD PhD, Takeshi Yoroidaka, MD, Noriharu Nakagawa, MD, Hiroki Mizumaki, MD, Tatsuya Imi, MD, Kohei Hosokawa, Hirohito Yamazaki, MD PhD, Seishi Ogawa, MD PhD, Shinji Nakao, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2462.
https://doi.org/10.1182/blood.V130.Suppl_1.2462.2462
Published: 2017
Journal Articles

Safety and persistence of WT1-specific T-cell receptor gene−transduced lymphocytes in patients with AML and MDS

Clinical Trials & Observations
Isao Tawara, Shinichi Kageyama, Yoshihiro Miyahara, Hiroshi Fujiwara, Tetsuya Nishida, Yoshiki Akatsuka, Hiroaki Ikeda, Kazushi Tanimoto, Seitaro Terakura, Makoto Murata, Yoko Inaguma, Masahiro Masuya, Naoki Inoue, Tomohide Kidokoro, Sachiko Okamoto, Daisuke Tomura, Hideto Chono, Ikuei Nukaya, Junichi Mineno, Tomoki Naoe, Nobuhiko Emi, Masaki Yasukawa, Naoyuki Katayama, Hiroshi Shiku
Journal: Blood
Blood (2017) 130 (18): 1985–1994.
https://doi.org/10.1182/blood-2017-06-791202
Published: 2017
Includes: Supplemental data
Journal Articles

Dendritic cell vaccination as postremission treatment to prevent or delay relapse in acute myeloid leukemia

Clinical Trials & Observations
Sébastien Anguille, Ann L. Van de Velde, Evelien L. Smits, Viggo F. Van Tendeloo, Gunnar Juliusson, Nathalie Cools, Griet Nijs, Barbara Stein, Eva Lion, Ann Van Driessche, Irma Vandenbosch, Anke Verlinden, Alain P. Gadisseur, Wilfried A. Schroyens, Ludo Muylle, Katrien Vermeulen, Marie-Berthe Maes, Kathleen Deiteren, Ronald Malfait, Emma Gostick, Martin Lammens, Marie M. Couttenye, Philippe Jorens, Herman Goossens, David A. Price, Kristin Ladell, Yoshihiro Oka, Fumihiro Fujiki, Yusuke Oji, Haruo Sugiyama, Zwi N. Berneman
Journal: Blood
Blood (2017) 130 (15): 1713–1721.
https://doi.org/10.1182/blood-2017-04-780155
Published: 2017
Includes: Supplemental data
Journal Articles

Preliminary Results from a Phase 1/2 Study of DSP-7888, a Novel WT1 Peptide-Based Vaccine, in Patients with Myelodysplastic Syndrome (MDS)

Shigesaburo Miyakoshi, MD PhD, Kensuke Usuki, MD PhD, Itaru Matsumura, MD PhD, Yasunori Ueda, MD PhD, Hiromi Iwasaki, MD PhD, Toshihiro Miyamoto, MD PhD, Makoto Origuchi, Shuzo Tagashira, Ichiro Naoi, Tomoki Naoe, MD PhD, Masahiro Kizaki, MD PhD, Yuji Heike, MD PhD, Koichi Akashi, MD PhD, Yasushi Miyazaki, MD PhD
Journal: Blood
Blood (2016) 128 (22): 4335.
https://doi.org/10.1182/blood.V128.22.4335.4335
Published: 2016