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Journal Articles

Animal Models Demonstrate a Critical Role of Factor VIII in Par4- and Platelet-Mediated Pathology

Michelle Castillo, BS, Quihui Yang, MD PhD, Dosia McKinney, Qizhen Shi, MD PhD, Rashmi Sood, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1057.
https://doi.org/10.1182/blood-2019-123290
Published: 2019
Journal Articles

Extravascular coagulation in hematopoietic stem and progenitor cell regulation

T. Son Nguyen, Tsvee Lapidot, Wolfram Ruf
Journal: Blood
Blood (2018) 132 (2): 123–131.
https://doi.org/10.1182/blood-2017-12-768986
Published: 2018
Journal Articles

Cytoprotective activated protein C averts Nlrp3 inflammasome–induced ischemia-reperfusion injury via mTORC1 inhibition

Sumra Nazir, Ihsan Gadi, Moh’d Mohanad Al-Dabet, Ahmed Elwakiel, Shrey Kohli, Sanchita Ghosh, Jayakumar Manoharan, Satish Ranjan, Fabian Bock, Ruediger C. Braun-Dullaeus, Charles T. Esmon, Tobias B. Huber, Eric Camerer, Chris Dockendorff, John H. Griffin, Berend Isermann, Khurrum Shahzad
Journal: Blood
Blood (2017) 130 (24): 2664–2677.
https://doi.org/10.1182/blood-2017-05-782102
Published: 2017
Includes: Supplemental data
Journal Articles

On PAR with aPC to target inflammasomes

Steven R. Lentz
Journal: Blood
Blood (2017) 130 (24): 2579–2581.
https://doi.org/10.1182/blood-2017-09-806307
Published: 2017
Journal Articles

Signal integration at the PI3K-p85-XBP1 hub endows coagulation protease activated protein C with insulin-like function

Thati Madhusudhan, Hongjie Wang, Sanchita Ghosh, Wei Dong, Varun Kumar, Moh'd Mohanad Al-Dabet, Jayakumar Manoharan, Sumra Nazir, Ahmed Elwakiel, Fabian Bock, Shrey Kohli, Andi Marquardt, Ibrahim Sögüt, Khurrum Shahzad, Andreas J. Müller, Charles T. Esmon, Peter P. Nawroth, Jochen Reiser, Triantafyllos Chavakis, Wolfram Ruf, Berend Isermann
Journal: Blood
Blood (2017) 130 (12): 1445–1455.
https://doi.org/10.1182/blood-2017-02-767921
Published: 2017
Includes: Supplemental data
Journal Articles

Diabetic kidney disease: as easy as aPC?

James D. McFadyen, Mark E. Cooper
Journal: Blood
Blood (2017) 130 (12): 1390–1391.
https://doi.org/10.1182/blood-2017-08-798314
Published: 2017
Journal Articles

Coagulation factor V mediates inhibition of tissue factor signaling by activated protein C in mice

Hai Po H. Liang, Edward J. Kerschen, Sreemanti Basu, Irene Hernandez, Mark Zogg, Shuang Jia, Martin J. Hessner, Raffaella Toso, Alireza R. Rezaie, José A. Fernández, Rodney M. Camire, Wolfram Ruf, John H. Griffin, Hartmut Weiler
Journal: Blood
Blood (2015) 126 (21): 2415–2423.
https://doi.org/10.1182/blood-2015-05-644401
Published: 2015
Includes: Supplemental data
Journal Articles

Antibodies associated with heparin-induced thrombocytopenia (HIT) inhibit activated protein C generation: new insights into the prothrombotic nature of HIT

M. Anna Kowalska, Sriram Krishnaswamy, Lubica Rauova, Li Zhai, Vincent Hayes, Karine Amirikian, Jeffrey D. Esko, Daniel W. Bougie, Richard H. Aster, Douglas B. Cines, Mortimer Poncz
Journal: Blood
Blood (2011) 118 (10): 2882–2888.
https://doi.org/10.1182/blood-2011-02-335208
Published: 2011
Includes: Supplemental data
Journal Articles

Niessen F, Furlan-Freguia C, Fernández JA, Mosnier LO, Castellino FJ, Weiler H, Rosen H, Griffin JH, Ruf W. Endogenous EPCR/aPC-PAR1 signaling prevents inflammation-induced vascular leakage and lethality. Blood . 2009;113(12): 2859–2866 .

Journal: Blood
Blood (2011) 117 (26): 7188.
https://doi.org/10.1182/blood-2011-05-354621
Published: 2011
Journal Articles

The protein C pathway in tissue inflammation and injury: pathogenic role and therapeutic implications

Silvio Danese, Stefania Vetrano, Li Zhang, Victoria A. Poplis, Francis J. Castellino
Journal: Blood
Blood (2010) 115 (6): 1121–1130.
https://doi.org/10.1182/blood-2009-09-201616
Published: 2010
Journal Articles

Endogenous EPCR/aPC-PAR1 signaling prevents inflammation-induced vascular leakage and lethality

Frank Niessen, Christian Furlan-Freguia, José A. Fernández, Laurent O. Mosnier, Francis J. Castellino, Hartmut Weiler, Hugh Rosen, John H. Griffin, Wolfram Ruf
Journal: Blood
Blood (2009) 113 (12): 2859–2866.
https://doi.org/10.1182/blood-2008-12-192385
Published: 2009