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Journal Articles

Loss of a 7q gene, CUX1 , disrupts epigenetically driven DNA repair and drives therapy-related myeloid neoplasms

Free
Molly K. Imgruet, Julian Lutze, Ningfei An, Bonnie Hu, Saira Khan, Jeffrey Kurkewich, Tanner C. Martinez, Donald Wolfgeher, Sandeep K. Gurbuxani, Stephen J. Kron, Megan E. McNerney
Journal: Blood
Blood (2021) 138 (9): 790–805.
https://doi.org/10.1182/blood.2020009195
Published: 2021
Includes: Supplemental data
Journal Articles

Single-cell transcriptomics dissects hematopoietic cell destruction and T-cell engagement in aplastic anemia

Free
Caiying Zhu, Yu Lian, Chenchen Wang, Peng Wu, Xuan Li, Yan Gao, Sibin Fan, Lanlan Ai, Liwei Fang, Hong Pan, Tao Cheng, Jun Shi, Ping Zhu
Journal: Blood
Blood (2021) 138 (1): 23–33.
https://doi.org/10.1182/blood.2020008966
Published: 2021
Includes: Supplemental data
Journal Articles

Radiation-induced bystander effects impair transplanted human hematopoietic stem cells via oxidative DNA damage

Free
Linping Hu, Xiuxiu Yin, Yawen Zhang, Aiming Pang, Xiaowei Xie, Shangda Yang, Caiying Zhu, Yapu Li, Biao Zhang, Yaojin Huang, Yunhong Tian, Mei Wang, Wenbin Cao, Shulian Chen, Yawei Zheng, Shihui Ma, Fang Dong, Sha Hao, Sizhou Feng, Yongxin Ru, Hui Cheng, Erlie Jiang, Tao Cheng
Journal: Blood
Blood (2021) 137 (24): 3339–3350.
https://doi.org/10.1182/blood.2020007362
Published: 2021
Includes: Supplemental data
Journal Articles

Genomic and transcriptomic correlates of Richter transformation in chronic lymphocytic leukemia

Free
Jenny Klintman, Niamh Appleby, Basile Stamatopoulos, Katie Ridout, Toby A. Eyre, Pauline Robbe, Laura Lopez Pascua, Samantha J. L. Knight, Helene Dreau, Maite Cabes, Niko Popitsch, Mats Ehinger, Jose I. Martín-Subero, Elías Campo, Robert Månsson, Davide Rossi, Jenny C. Taylor, Dimitrios V. Vavoulis, Anna Schuh
Journal: Blood
Blood (2021) 137 (20): 2800–2816.
https://doi.org/10.1182/blood.2020005650
Published: 2021
Includes: Supplemental data
Journal Articles

Venetoclax and dexamethasone synergize with inotuzumab ozogamicin–induced DNA damage signaling in B-lineage ALL

Free
Brief Report
Hanna Kirchhoff, Uemran Karsli, Caroline Schoenherr, Karin Battmer, Sergej Erschow, Steven R. Talbot, Doris Steinemann, Michael Heuser, Olaf Heidenreich, Denise Hilfiker-Kleiner, Arnold Ganser, Matthias Eder, Michaela Scherr
Journal: Blood
Blood (2021) 137 (19): 2657–2661.
https://doi.org/10.1182/blood.2020008544
Published: 2021
Includes: Supplemental data
Journal Articles

Analysis of disease model iPSCs derived from patients with a novel Fanconi anemia–like IBMFS ADH5/ALDH2 deficiency

Free
Anfeng Mu, Asuka Hira, Akira Niwa, Mitsujiro Osawa, Kenichi Yoshida, Minako Mori, Yusuke Okamoto, Kazuko Inoue, Keita Kondo, Masato T. Kanemaki, Tomonari Matsuda, Etsuro Ito, Seiji Kojima, Tatsutoshi Nakahata, Seishi Ogawa, Keigo Tanaka, Keitaro Matsuo, Megumu K. Saito, Minoru Takata
Journal: Blood
Blood (2021) 137 (15): 2021–2032.
https://doi.org/10.1182/blood.2020009111
Published: 2021
Includes: Supplemental data
Journal Articles

LUBAC accelerates B-cell lymphomagenesis by conferring resistance to genotoxic stress on B cells

Free
Tomoyasu Jo, Momoko Nishikori, Yasunori Kogure, Hiroshi Arima, Katsuhiro Sasaki, Yoshiteru Sasaki, Tomoko Nakagawa, Fumie Iwai, Shuji Momose, Aki Shiraishi, Hiroshi Kiyonari, Noritaka Kagaya, Tetsuo Onuki, Kazuo Shin-ya, Minoru Yoshida, Keisuke Kataoka, Seishi Ogawa, Kazuhiro Iwai, Akifumi Takaori-Kondo
Journal: Blood
Blood (2020) 136 (6): 684–697.
https://doi.org/10.1182/blood.2019002654
Published: 2020
Includes: Supplemental data
Journal Articles

Epidermal growth factor receptor–dependent DNA repair promotes murine and human hematopoietic regeneration

Free
Tiancheng Fang, Yurun Zhang, Vivian Y. Chang, Martina Roos, Christina M. Termini, Lia Signaevskaia, Mamle Quarmyne, Paulina K. Lin, Amara Pang, Jenny Kan, Xiao Yan, Anna Javier, Katherine Pohl, Liman Zhao, Peter Scott, Heather A. Himburg, John P. Chute
Journal: Blood
Blood (2020) 136 (4): 441–454.
https://doi.org/10.1182/blood.2020005895
Published: 2020
Includes: Supplemental data
Journal Articles

CYT-0853, a Novel RAD51 Inhibitor, Modulates Immunoregulatory B-Lymphocytes

Free
Tamar Aprahamian, PhD, ED Keniston, Jane Branca, Muneer G Hasham, PhD, Melinda Day, PhD, Kevin Mills, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2330.
https://doi.org/10.1182/blood-2019-131311
Published: 2019
Journal Articles

ILF2 Antisense Oligonucleotide Therapy and a CRISPR/Cas9-Based Screening for DNA Repair Effectors Identify Synthetic Lethal Approaches Enhancing Myeloma Cells Sensitivity to DNA Damage

Free
Natthakan Thongon, PhD, Christopher Jackson, BS, Pamela Lockyer, MS, Jintan Liu, Andrea Santoni, PhD, Ashley Rose, BS, Guillermo Garcia-Manero, MD, Simona Colla, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 685.
https://doi.org/10.1182/blood-2019-129286
Published: 2019
Journal Articles

Influence of Bone Marrow Stromal and Leukemic Cells on Cytarabine Chemo-Toxicity in Acute Myeloid Leukemia (AML)

Free
Liana E Gynn, BSc, Elizabeth Anderson, PhD, Gareth M Robinson, PhD, Sarah Anne Wexler, MBBS, MRCP, FRCPath, Gillian Upstill-Goddard, Christine Cox, Rhys Gareth Morgan, PhD, Jennifer E May, PhD BSc
Journal: Blood
Blood (2019) 134 (Supplement_1): 2492.
https://doi.org/10.1182/blood-2019-122891
Published: 2019
Journal Articles

PARP Inhibitors Are Effective in IDH1/2 Mutant MDS and AML Resistant to Targeted IDH Inhibitors

Free
Rana Gbyli, MS, Yuanbin Song, MD, Wei Liu, PhD, Yimeng Gao, PhD, Namrata S Chandhok, MD, Xiaoying Fu, MD, Xiaman Wang, MD PhD, Amisha Patel, MS, Ranjini Sundaram, PhD, Toma Tebaldi, PhD, Giulia Biancon, PhD, Anastasia Ardasheva, BS, Ashley Qin, Mukhtar Sadykov, MD, Padmavathi Mamillapalli, BS, Richard Flavell, PhD, Thomas Prebet, MD PhD, Ranjit Bindra, MD PhD, Stephanie Halene, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4222.
https://doi.org/10.1182/blood-2019-130814
Published: 2019
Journal Articles

A Randomized, Open-Label, Multicenter, Phase 2 Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of KRT-232 Compared with Ruxolitinib in Patients with Phlebotomy-Dependent Polycythemia Vera

Free
Jason Gotlib, MD MS, Nashat Gabrail, MD, Casey L. O'Connell, MD, Regina Garcia-Delgado, MD, Timothy Sbardellati, Wayne M. Rothbaum, Jesse McGreivy, Claire N Harrison, Professor, Jean-Jacques Kiladjian, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4168.
https://doi.org/10.1182/blood-2019-123546
Published: 2019
Journal Articles

Synthetic Lethal Interaction between Apto-253 and IDH1/2 Mutations

Free
Cheng-Yu Tsai, PhD, Hongying Zhang, MD PhD, William G Rice, PhD, Stephen B Howell, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5755.
https://doi.org/10.1182/blood-2019-123571
Published: 2019
Journal Articles

Simultaneous Inhibition of Mcl-1 and Induction of DNA Damage Accumulation By Chidamide, a Novel Selective HDACi, Potentiates the Cytotoxicity of ABT-199 in Acute Myeloid Leukemia

Free
Bing Xu, Kai Chen, Qianying Yang, Jie Zha, Haijun Zhao, Liying Feng, Xiaolei Chen, Guo Fu, Ken H. Young, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5767.
https://doi.org/10.1182/blood-2019-121721
Published: 2019
Journal Articles

Intrinsic and Extrinsic Factors Driving Hematopoietic Stem Cell Aging and Bone Marrow Failure

Free
Jennifer J. Trowbridge, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): SCI-35.
https://doi.org/10.1182/blood-2019-121044
Published: 2019
Journal Articles

Dynamic Immune Modulation Seen By Single Cell RNA-Sequencing of Serial Lymphoma Biopsies in Patients Undergoing in Situ Vaccination

Free
Tanaya Shree, MD PhD, Sarah Haebe, MD, Anuja Sathe, PhD, Grady Day, HoJoon Lee, PhD, Debra K. Czerwinski, BA, Susan Grimes, BSc, Hanlee Ji, MD, Ronald Levy, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1479.
https://doi.org/10.1182/blood-2019-131684
Published: 2019
Journal Articles

Targeting Homologous Recombination in Lymphoid Malignancies: Evaluation of Four Small Molecule Inhibitors of RAD51

Free
Melinda Day, PhD, Tyler Maclay, Amber Cyr, Muneer G Hasham, PhD, Kin-hoe Chow, ED Keniston, Kevin Mills, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2080.
https://doi.org/10.1182/blood-2019-131747
Published: 2019
Journal Articles

Ripk3 Signaling Regulates Hematopoietic Stem Cell Number and Function during Stress

Free
Lei Zhang, PhD, Huacheng Luo, PhD, Jing Li, Hong-Min Ni, Mark Sellin, Feng Zhang, Jun Zhang, Peter Breslin, PhD, Wei Wei, William Small, Jr., Wen-Xin Ding, Suming Huang, PhD, Jiwang Zhang, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3714.
https://doi.org/10.1182/blood-2019-131332
Published: 2019
Journal Articles

High Burden of Clonal Hematopoiesis in First Responders Exposed to the World Trade Center Disaster

Free
Sakshi Jasra, MD, Orsi Giricz, PhD, Rachel Zeig-Owens, M.P.H, David Goldfarb, M.P.H, Angelica Barreto-Galvez, Kith Pradhan, PhD, Jiahao Chen, PhD, Gaurav S Choudhary, PhD, Srinivas Aluri, Tushar D Bhagat, PhD, Aditi Shastri, MD, Victor Thiruthuvanathan, M.S, Hiroki Goto, MD PhD, Jeannine Gerhardt, PhD, Shanisha Gordon, Arul Veerappan, PhD, Syed Hissam Haider, MD, Matthias Bartenstein, MD, George Nwankwo, Ola Landgren, MD PhD, Michael Weiden, MD, Frederick Fletcher, Lee Greenberger, PhD, Benjamin L. Ebert, MD PhD, Ulrich G. Steidl, MD PhD, Britta Will, PhD, Anna Nolan, MD MS, David Prezant, MD, Advaitha Madireddy, PhD, Amit Verma, MBBS
Journal: Blood
Blood (2019) 134 (Supplement_1): 3720.
https://doi.org/10.1182/blood-2019-129276
Published: 2019