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Safety and Tolerability of AZD0466 As Monotherapy for Patients with Advanced Hematologic Malignancies. Results from a Phase I/II Trial

Shukaib Arslan, Giovanni Marconi, Giovanni Martinelli, Shaun Fleming, Antonio Curti, Shira N. Dinner, James S Blachly, Matteo Giovanni Della Porta, Ashish Bajel, Tim Sauer, Martina Crysandt, Arnaud Pigneux, Lars Fransecky, Claudia D Baldus, Marina Y. Konopleva, Yotvat Marmor, Shringi Sharma, Nairouz Elgeioushi, Patricia Cheung, Emily Rowe, Ekaterina Jahn, Ting Yu, Jamal Saeh, Raoul Tibes, Fathima Zumla Cader, Nitin Jain
Journal: Blood
Blood (2023) 142 (Supplement 1): 5907.
https://doi.org/10.1182/blood-2023-179168
Published: 2023
Journal Articles

Single-Cell RNA Sequencing Reveals the Interplay between Circulating CD4 + T Cells, B Cells and Cancer-Associated Monocytes in Classic Hodgkin Lymphoma Treated with PD-1 Blockade

Julia Paczkowska, Ming Tang, Kyle T. Wright, Li Song, Kelsey Luu, Vignesh Shanmugam, Emma L. Welsh, Jason L. Weirather, Kathleen Pfaff, Robert A. Redd, Zumla Cader, Elisa Mandato, Jing Ouyang, Gali Bai, Lee N. Lawton, Philippe Armand, Scott Rodig, Xiaole Shirley Liu, Margaret A. Shipp
Journal: Blood
Blood (2023) 142 (Supplement 1): 173.
https://doi.org/10.1182/blood-2023-187038
Published: 2023
Journal Articles

Safety and Tolerability of AZD0466 As Monotherapy for Patients with Advanced Hematological Malignancies. Preliminary Results from an Ongoing Phase I/II Trial

Shukaib Arslan, Shaun Fleming, Nitin Jain, Giovanni Martinelli, Anthony S. Stein, James S. Blachly, Ashish Bajel, Antonio Curti, Giovanni Marconi, Giulia Fabbri, Yotvat Marmor, Shringi Sharma, Nairouz Elgeioushi, Natalia Couto-Francisco, Jamal Saeh, Raoul Tibes, Fathima Zumla Cader, Marina Konopleva
Journal: Blood
Blood (2022) 140 (Supplement 1): 9091–9093.
https://doi.org/10.1182/blood-2022-166192
Published: 2022
Journal Articles

NIMBLE: A Phase I/II Study of AZD0466 Monotherapy or in Combination in Patients with Advanced Hematological Malignancies

Marina Konopleva, Nitin Jain, Courtney L Andersen, Natalia Couto Francisco, Nairouz Elgeioushi, Rosalind Hobson, Martin Scott, John Stone, Shringi Sharma, Pablo Morentin Gutierrez, Raoul Tibes, Barry Davies, Thomas Winkler, Giulia Fabbri, Fathima Zumla Cader, Nicole McNeer
Journal: Blood
Blood (2021) 138 (Supplement 1): 2353.
https://doi.org/10.1182/blood-2021-147482
Published: 2021
Journal Articles

Comparative Genomic Analyses Defines Shared and Unique Features of cHL and PMBL and New Mechanisms of Sensitivity to PD-1 Blockade

Kirsty Wienand, PhD, Bjoern Chapuy, MD PhD, Chip Stewart, PhD, Andrew Dunford, MS, David Wu, MD PhD, Jaegil Kim, PhD, Atanas Kamburov, PhD, Timothy Wood, Fathima Zumla Cader, MD PhD MRCP, Matthew D. Ducar, MS, Aaron R. Thorner, PhD, Anwesha Nag, PhD, Gabriel K Griffin, MD, Pei-Hsuan Chen, Alexander T Heubeck, BS, Michael J Buonopane, BS, Kamil Bojarczuk, PhD, Claire McEwen Cote, Lee N. Lawton, PhD, Philippe Armand, MD PhD, Scott J Rodig, MD PhD, Jonathan R. Fromm, MD PhD, Gad Getz, PhD, Margaret A. Shipp, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1493.
https://doi.org/10.1182/blood-2019-131904
Published: 2019
Journal Articles

Comprehensive Genomic Analysis of Flow-Sorted Hodgkin Reed Sternberg Cells Reveals Additional Genetic Bases of Immune Evasion

Kirsty Wienand, PhD, Bjoern Chapuy, MDPhD, Chip Stewart, PhD, Andrew Dunford, MS, David Wu, MD PhD, Jaegil Kim, PhD, Atanas Kamburov, PhD, Fathima Zumla Cader, MD PhD MRCP, Matthew D. Ducar, MS, Aaron R. Thorner, PhD, Alexander T Heubeck, BS, Michael J Buonopane, BS, Philippe Armand, MD PhD, Scott J Rodig, MD, Jonathan R. Fromm, MD PhD, Gad Getz, PhD, Margaret A. Shipp, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1559.
https://doi.org/10.1182/blood-2018-99-118453
Published: 2018
Journal Articles

Mass cytometry of Hodgkin lymphoma reveals a CD4 + regulatory T-cell–rich and exhausted T-effector microenvironment

Fathima Zumla Cader, Ron C. J. Schackmann, Xihao Hu, Kirsty Wienand, Robert Redd, Bjoern Chapuy, Jing Ouyang, Nicole Paul, Evisa Gjini, Mikel Lipschitz, Philippe Armand, David Wu, Jonathan R. Fromm, Donna Neuberg, X. Shirley Liu, Scott J. Rodig, Margaret A. Shipp
Journal: Blood
Blood (2018) 132 (8): 825–836.
https://doi.org/10.1182/blood-2018-04-843714
Published: 2018
Includes: Multimedia, Supplemental data
Journal Articles

Expression of Major Histocompatibility Complex (MHC) Class II, but Not MHC Class I, Predicts Outcome in Patients with Classical Hodgkin Lymphoma (cHL) Treated with Nivolumab (Programmed Death-1 [PD-1] Blockade)

Margaretha G.M. Roemer, MSc, Robert A. Redd, MS, Fathima Zumla Cader, MD PhD MRCP, Christine J. Pak, Sara Abdelrahman, Jing Ouyang, Stephanie Sasse, MD, Anas Younes, MD, Michelle A. Fanale, MD, Armando Santoro, MD, Pier Luigi Zinzani, MD, John M Timmerman, MD, Graham Collins, MD PhD, Rod Ramchandren, MD, Jonathon B Cohen, MDMS, Jan Paul De Boer, MD PhD, John Kuruvilla, MD, Kerry J Savage, BSc, MD MSc, Marek Trneny, MD, Stephen M Ansell, MD PhD, Mariana Sacchi, Benedetto Farsaci, MD, Anne Sumbul, Philippe Armand, MD PhD, Donna S. Neuberg, ScD, Geraldine S. Pinkus, Azra H. Ligon, Scott J. Rodig, MDPhD, Margaret A. Shipp, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1450.
https://doi.org/10.1182/blood.V130.Suppl_1.1450.1450
Published: 2017
Journal Articles

The EBV oncogene LMP1 protects lymphoma cells from cell death through the collagen-mediated activation of DDR1

Fathima Zumla Cader, Martina Vockerodt, Shikha Bose, Eszter Nagy, Marie-Anne Brundler, Pamela Kearns, Paul G. Murray
Journal: Blood
Blood (2013) 122 (26): 4237–4245.
https://doi.org/10.1182/blood-2013-04-499004
Published: 2013
Includes: Supplemental data
Journal Articles

The EBV Oncogene LMP1 Protects Lymphoma Cells From Cell Death Through The Collagen-Mediated Activation Of Discoidin Domain Receptor 1

Fathima Zumla Cader, PhD, MBChB, MRCPCH, Martina Vockerodt, PhD, Shikha Bose, PhD, Eszter Nagy, BSc, Marie-Anne Brundler, MD, Pamela R Kearns, MBChB, PhD, FRCPCH, Paul G Murray, PhD
Journal: Blood
Blood (2013) 122 (21): 4241.
https://doi.org/10.1182/blood.V122.21.4241.4241
Published: 2013