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Journal Articles

A Phase I Study of Nivolumab in Combination with Ipilimumab for the Treatment of Patients with High Risk or Refractory/Relapsed Acute Myeloid Leukemia Following Allogeneic Stem Cell Transplantation

Blood (2024) 144 (Supplement 1): 1047.

https://doi.org/10.1182/blood-2024-211343

Published: 2024

Journal Articles

AML Immunotherapy Using a Novel Tcrm-Based Bispecific Antibody That Targets a Leader Sequence Peptide Derived from Cathepsin G

Chunhua Shi, Ze Tian, Jun Yan, Mao Zhang, Pariya Sukhumalchandra, Edward Chang, Guojun Yang, Junping You, Meng Cui, Qing Shi, Anne Philips, Na Qiao, Anna Sergeeva, Lisa St. John, Hong He, Dongxing Zha, Jeffrey J. Molldrem, Gheath Alatrash

Blood (2023) 142 (Supplement 1): 1415.

https://doi.org/10.1182/blood-2023-189514

Published: 2023

Journal Articles

Targeting Myeloid Leukemia Using Novel TCR-like Chimeric Antigen Receptor-T Cells Against Cathepsin G

Jun Yan, Ze Tian, Chunhua Shi, Mao Zhang, Pariya Sukhumalchandra, Guojan Yang, Qing Edward Chang, Junping You, Meng Cui, Qing Shi, Anne Philip, Na Qiao, Anna Sergeeva, Lisa St John, Hong He, Dongxing Zha, Jeffrey J. Molldrem, Gheath Alatrash

Blood (2022) 140 (Supplement 1): 7392–7393.

https://doi.org/10.1182/blood-2022-166488

Published: 2022

Journal Articles

Pembrolizumab in Combination with Antigen-Specific Cytotoxic T Lymphocytes Enhances Killing of Acute Myeloid Leukemia

Amber Gibson, Mao Zhang, Pariya Sukhumalchandra, Anne V. Philips, Na Qiao, Alexander A. Perakis, Celine Kerros, Lisa St. John, Karen Clise-Dwyer, Sijie Lu, Qing Ma, Jeffrey J. Molldrem, Gheath Alatrash

Blood (2021) 138 (Supplement 1): 2775.

https://doi.org/10.1182/blood-2021-149318

Published: 2021

Journal Articles

Pembrolizumab Enhances the Anti-Leukemia Activity of Antigen Specific Cytotoxic T Lymphocytes

Mao Zhang, MPH, Pariya Sukhumalchandra, BS, Anne V. Philips, PhD, Na Qiao, PhD, Celine Kerros, PhD, Lisa St. John, PhD, Alexander A. Perakis, BS, Karen Clise-Dwyer, PhD, Elizabeth Mittendorf, MD PhD, Naval G. Daver, MD, Jeffrey J. Molldrem, MD, Qing Ma, PhD, Gheath Alatrash, DO, PhD

Blood (2018) 132 (Supplement 1): 4542.

https://doi.org/10.1182/blood-2018-99-114864

Published: 2018

Journal Articles

Cathepsin G Is Expressed By B Cell Acute Lymphoblastic Leukemia and Is an Effective Immunotherapeutic Target

Maliha Khan, Selena Carmona, MS, Pariya Sukhumalchandra, Yihua Qiu, Alexander Perakis, Mao Zhang, MPH, Madhushree Zope, Anne Philip, Abdul Shah, Na Qiao, Lisa St. John, Jonathan Goldberg, Elizabeth Mittendorf, Jeffrey J. Molldrem, MD, Steven Kornblau, MD, Gheath Alatrash, DO, PhD

Blood (2017) 130 (Supplement 1): 1438.

https://doi.org/10.1182/blood.V130.Suppl_1.1438.1438

Published: 2017

Journal Articles

Characterizing the Mechanism of NE and P3 Cross-Presentation in B Cell-Acute Lymphoblastic Leukemia

Selena Carmona, MS, Celine Kerros, PhD, Alexander Perakis, Anne Philip, Pariya Sukhumalchandra, Anna Sergeeva, PhD, Lisa St. John, Mao Zhang, MPH, Na Qiao, Elizabeth Mittendorf, Gheath Alatrash, DO, PhD, Jeffrey J. Molldrem, MD

Blood (2017) 130 (Supplement 1): 3596.

https://doi.org/10.1182/blood.V130.Suppl_1.3596.3596

Published: 2017

Journal Articles

Cross-Presentation Is a Source of Tumor Antigens for Multiple Myeloma Immunotherapy

Alexander A. Perakis, BA, Haley L. Peters, PhD, Jason Roszik, PhD, Mao Zhang, MPH, Anna Sergeeva, PhD, Celine Kerros, PhD, Pariya Sukhumalchandra, BS, Anne V. Philips, PhD, Maria R. Khouri, Rahul U. Popat, Lisa St. John, PhD, Amjad Talukder, PhD, David H. Hawke, PhD, Greg Lizee, PhD, Elizabeth A. Mittendorf, MD PhD, Jeffrey J. Molldrem, MD, Gheath Alatrash, DO, PhD

Blood (2016) 128 (22): 2104.

https://doi.org/10.1182/blood.V128.22.2104.2104

Published: 2016

Journal Articles

Fucosylated Antigen-Specific Cytotoxic T Lymphocytes Demonstrate Enhanced Killing of Leukemia Targets

Gheath Alatrash, DO, PhD, Mao Zhang, MPH, Na Qiao, PhD, Pariya Sukhumalchandra, BS, Madhushree Zope, Anne V. Philips, PhD, Alexander Perakis, BA, Lisa St. John, PhD, Maria R. Khouri, Victor Gall, MD, Karen C. Dwyer, PhD, Jodie Polan, MS, Jeffrey J. Molldrem, MD, Elizabeth J. Shpall, MD, Elizabeth A. Mittendorf, MD PhD

Blood (2015) 126 (23): 1888.

https://doi.org/10.1182/blood.V126.23.1888.1888

Published: 2015

Journal Articles

PR1 Is Cross-Presented By Multiple Myeloma Cells in Patients and Renders Multiple Myeloma Susceptible to PR1-CTL and Anti-PR1/HLA-A2 Antibody

Gheath Alatrash, DO, PhD, Pariya Sukhumalchandra, BS, Mao Zhang, MPH, Celine Kerros, PhD, Anna Sergeeva, PhD, Amanda Cernosek, BS, Haroon Jakher, BS, Madhushree Zope, Rebecca Patenia, MS, Lisa St John, PhD, Alexander Perakis, BA, Karen Dwyer, PhD, Ken H. Young, MD PhD, Jinsheng Weng, PhD, Sijie Lu, PhD, Elizabeth A. Mittendorf, MD PhD, Larry W Kwak, MD PhD, Qing Ma, PhD, Jeffrey J. Molldrem, MD

Blood (2014) 124 (21): 2133.

https://doi.org/10.1182/blood.V124.21.2133.2133

Published: 2014

Journal Articles

Cathepsin G Is Broadly Expressed By AML and Is an Effective Immunotherapeutic Target Against AML in Vivo

Gheath Alatrash, DO, PhD, Mao Zhang, MPH, Pariya Sukhumalchandra, BS, Yihua Qiu, MD, Amjad H. Talukder, PhD, Vladimir Senyukov, PhD, Lisa S. St. John, PhD, Hong He, MD, Anna Sergeeva, PhD, Jason Roszik, PhD, Karen Clise-Dwyer, PhD, Sijie Lu, PhD, Qing Ma, PhD, Elizabeth A. Mittendorf, MD PhD, Dean A. Lee, MD PhD, David H Hawke, PhD, Lizee Gregory, PhD, Jeffrey J. Molldrem, Steven M. Kornblau, MD

Blood (2014) 124 (21): 3761.

https://doi.org/10.1182/blood.V124.21.3761.3761

Published: 2014

Journal Articles

RNA-Seq Expression Profiling of AML Stem Cells Reveals Differential Expression of Lineage Differentiation Markers and Novel Splice Variants.

Benjamin G Vincent, MD, Darshan Singh, MS, Michael Wu, PhD, Sally A. Hunsucker, PhD, Gheath Alatrash, DO, PhD, Kathryn Ruisaard, MS, Pariya Sukhumalchandra, BS, Karen Clise-Dwyer, PhD, Jonathan S Serody, MD, Jan F Prins, PhD, Jeffrey J. Molldrem, M.D., Paul M. Armistead, MD, PhD

Blood (2012) 120 (21): 2502.

https://doi.org/10.1182/blood.V120.21.2502.2502

Published: 2012

Journal Articles

Multiple Myeloma Cross-Presents Neutrophil Elastase and Proteinase 3 and Becomes Susceptible to PR1-Targeting Immunotherapy

Gheath Alatrash, DO, PhD, Pariya Sukhumalchandra, BS, Mao Zhang, MPH, Anna Sergeeva, PhD, Haroon Jakher, BS, Jinsheng Weng, Ph.D, Lisa S St. John, PhD, Kathryn Ruisaard, BS, Karen Clise-Dwyer, PhD, Sijie Lu, PhD, Jeffrey J. Molldrem, MD

Blood (2012) 120 (21): 4973.

https://doi.org/10.1182/blood.V120.21.4973.4973

Published: 2012

Journal Articles

Treatment with 8F4, An Anti-PR1/HLA-A2 T Cell Receptor-Like Antibody, Reduces Established Acute Myeloid Leukemia and Eliminates Leukemia Stem Cells in Mice

Anna Sergeeva, PhD, Hong He, MD, PhD, Kathryn Ruisaard, MS, Karen Clise-Dwyer, PhD, Lisa S St. John, PhD, Rebecca Patenia, Pariya Sukhumalchandra, BS, Gheath Alatrash, DO, PhD, William K Decker, PhD, Elizabeth J Shpall, MD, M. James You, MD, PhD, Qing Ma, PhD, Jeffrey J. Molldrem, MD

Blood (2011) 118 (21): 766.

https://doi.org/10.1182/blood.V118.21.766.766

Published: 2011

Journal Articles

A Novel HLA-A2 Restricted Peptide Derived From Cathepsin G Is An Effective Immunotherapeutic Target for Myeloid Leukemia

Mao Zhang, MPH, Pariya Sukhumalchandra, BS, Atim A. Enyenihi, PhD, Lisa S St. John, PhD, Sally A. Hunsucker, PhD, Kathryn Ruisaard, MS, Zein Al Atrache, Patricia A Ropp, PhD, Tania Rodriguez-Cruz, BS, Elizabeth Mittendorf, MD, Gregory Lizee, PhD, Karen Clise-Dwyer, PhD, Sijie Lu, PhD, Gary L. Glish, PhD, Jeffrey J. Molldrem, MD, Paul M Armistead, MD, PhD, Gheath Alatrash, D.O., Ph.D.

Blood (2011) 118 (21): 2986.

https://doi.org/10.1182/blood.V118.21.2986.2986

Published: 2011

Journal Articles

Peripheral Tolerance to PR1 Is Maintained After Uptake of Soluble Proteinas-3 and Neutrophil Elastase

Gheath Alatrash, DO, PhD, Yoko Ono, MD, Anna Sergeeva, PhD, Pariya Sukhumalchandra, BS, Mao Zhang, MPH, Kathryn Quintanilla, MS, Paul Armistead, MD, PhD, Hong He, MD, Tania Rodriguez-Cruz, BS, Karen Clise-Dwyer, PhD, Eric Wieder, PhD, Greg Lizee, PhD, Sijie Lu, PhD, Jeffrey J. Molldrem, MD

Blood (2010) 116 (21): 4301.

https://doi.org/10.1182/blood.V116.21.4301.4301

Published: 2010

Journal Articles

Soluble Inflammatory Mediators Proteinase-3 and Neutrophil Elastase Are Targeted by PR1-Specific Immunotherapy After Cellular Uptake and Cross Presentation of PR1 Peptide by Breast Cancer Cells

Gheath Alatrash, DO, PhD, Elizabeth Mittendorf, MD, Anna Sergeeva, PhD, Pariya Sukhumalchandra, BS, Na Qiao, PhD, Kathryn Quintanilla, MS, Mao Zhang, MPH, Lu Sijie, PhD, Karen Clise-Dwyer, PhD, Jeffrey J. Molldrem, MD

Blood (2010) 116 (21): 2089.

https://doi.org/10.1182/blood.V116.21.2089.2089

Published: 2010

Journal Articles

Cellular Uptake of Soluble Neutrophil Elastase Increases Cyclin E (CCNE) Isoform Expression and Significantly Augments Susceptibility of Breast Cancer Cells to Cytolysis by CCNE-Specific Cytotoxic T Lymphocytes

Elizabeth Mittendorf, M.D., Gheath Alatrash, Na Qiao, Pariya Sukhumalchandra, Sijie Lu, Kathryn Quintanilla, Karen Clise-Dwyer, PhD, Jeffrey J. Molldrem, MD

Blood (2010) 116 (21): 2090.

https://doi.org/10.1182/blood.V116.21.2090.2090

Published: 2010

Journal Articles

A Novel Strategy for Generation of Human Tumor-Specific T Cell Clones for Adoptive Transfer.

Seung-Tae Lee, MD, Shujuan Liu, Ph.D., Pariya Sukhumalchandra, Jeffrey Molldrem, M.D., Patrick Hwu, M.D., Yong-Jun Liu, M.D.,Ph.D., Larry W. Kwak, M.D.,Ph.D., Gregory Lizee, Ph.D., Sattva S. Neelapu, M.D.

Blood (2006) 108 (11): 3713.

https://doi.org/10.1182/blood.V108.11.3713.3713

Published: 2006

NARROW

A Phase I Study of Nivolumab in Combination with Ipilimumab for the Treatment of Patients with High Risk or Refractory/Relapsed Acute Myeloid Leukemia Following Allogeneic Stem Cell Transplantation

AML Immunotherapy Using a Novel Tcrm-Based Bispecific Antibody That Targets a Leader Sequence Peptide Derived from Cathepsin G

Targeting Myeloid Leukemia Using Novel TCR-like Chimeric Antigen Receptor-T Cells Against Cathepsin G

Pembrolizumab in Combination with Antigen-Specific Cytotoxic T Lymphocytes Enhances Killing of Acute Myeloid Leukemia

Pembrolizumab Enhances the Anti-Leukemia Activity of Antigen Specific Cytotoxic T Lymphocytes

Cathepsin G Is Expressed By B Cell Acute Lymphoblastic Leukemia and Is an Effective Immunotherapeutic Target

Characterizing the Mechanism of NE and P3 Cross-Presentation in B Cell-Acute Lymphoblastic Leukemia

Cross-Presentation Is a Source of Tumor Antigens for Multiple Myeloma Immunotherapy

Fucosylated Antigen-Specific Cytotoxic T Lymphocytes Demonstrate Enhanced Killing of Leukemia Targets

PR1 Is Cross-Presented By Multiple Myeloma Cells in Patients and Renders Multiple Myeloma Susceptible to PR1-CTL and Anti-PR1/HLA-A2 Antibody

Cathepsin G Is Broadly Expressed By AML and Is an Effective Immunotherapeutic Target Against AML in Vivo

RNA-Seq Expression Profiling of AML Stem Cells Reveals Differential Expression of Lineage Differentiation Markers and Novel Splice Variants.

Multiple Myeloma Cross-Presents Neutrophil Elastase and Proteinase 3 and Becomes Susceptible to PR1-Targeting Immunotherapy

Treatment with 8F4, An Anti-PR1/HLA-A2 T Cell Receptor-Like Antibody, Reduces Established Acute Myeloid Leukemia and Eliminates Leukemia Stem Cells in Mice

A Novel HLA-A2 Restricted Peptide Derived From Cathepsin G Is An Effective Immunotherapeutic Target for Myeloid Leukemia

Peripheral Tolerance to PR1 Is Maintained After Uptake of Soluble Proteinas-3 and Neutrophil Elastase

Soluble Inflammatory Mediators Proteinase-3 and Neutrophil Elastase Are Targeted by PR1-Specific Immunotherapy After Cellular Uptake and Cross Presentation of PR1 Peptide by Breast Cancer Cells

Cellular Uptake of Soluble Neutrophil Elastase Increases Cyclin E (CCNE) Isoform Expression and Significantly Augments Susceptibility of Breast Cancer Cells to Cytolysis by CCNE-Specific Cytotoxic T Lymphocytes

A Novel Strategy for Generation of Human Tumor-Specific T Cell Clones for Adoptive Transfer.

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American Society of Hematology

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