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Journal Articles

A Phase II Study to Assess the Sustained Response Off Treatment in Patients with ITP Receiving Eltrombopag, Who Had a Previous Insufficient Response to Corticosteroids (TAPER): A Recruitment Update

Free
Nichola Cooper, MD, Waleed Ghanima, Jens Haenig, James Lee, Masiur Rahman, Francesco Zaja
Journal: Blood
Blood (2020) 136 (Supplement 1): 37–38.
https://doi.org/10.1182/blood-2020-137398
Published: 2020
Journal Articles

ROR1-targeted delivery of miR-29b induces cell cycle arrest and therapeutic benefit in vivo in a CLL mouse model

Free
Chi-Ling Chiang, Swagata Goswami, Frank W. Frissora, Zhiliang Xie, Pearlly S. Yan, Ralf Bundschuh, Logan A. Walker, Xiaomeng Huang, Rajeswaran Mani, Xiaokui M. Mo, Sivasubramanian Baskar, Christoph Rader, Mitch A. Phelps, Guido Marcucci, John C. Byrd, L. James Lee, Natarajan Muthusamy
Journal: Blood
Blood (2019) 134 (5): 432–444.
https://doi.org/10.1182/blood.2018882290
Published: 2019
Includes: Supplemental data
Journal Articles

Immunoliposomal Delivery of Mir-29b By Targeting Tumor Antigen ROR1 Induces Epigenetic Reprograming in Human-ROR1-Expressed Mouse Model of Chronic Lymphocytic Leukemia

Free
Chi-Ling Chiang, Frank W Frissora, Zhiliang Xie, Xiaomeng Huang, Rajeswaran Mani, DVM, Sivasubramanian Baskar, Christoph Rader, Kenneth K. Chan, Guido Marcucci, MD, John C. Byrd, MD, L. James Lee, Natarajan Muthusamy, DVM, PhD
Journal: Blood
Blood (2015) 126 (23): 1743.
https://doi.org/10.1182/blood.V126.23.1743.1743
Published: 2015
Journal Articles

Tumor Antigen ROR1 Targeted Delivery Of FTY720 Derivative OSU-2S Prolongs Survival In ROR1 Engineered Mouse Model Of Chronic Lymphocytic Leukemia

Free
Rajeswaran Mani, DVM, Yicheng Mao, PhD, Frank W Frissora, M.S., Chi-ling Chiang, Jiang Wang, Yuan Zhao, Yun Wu, Bo Yu, Ph.D., Ribai Yan, Xiaokui Mo, PhD, Sivasubramanian Baskar, PhD, Christoph Rader, Ph.D., Mitch A. Phelps, PhD, Robert J. Lee, Ph.D, Ching-Shih Chen, PhD, James Lee, PhD, John C. Byrd, MD, Natarajan Muthusamy, DVM, Ph.D
Journal: Blood
Blood (2013) 122 (21): 4168.
https://doi.org/10.1182/blood.V122.21.4168.4168
Published: 2013
Journal Articles

A Novel Therapeutic Approach In Acute Myeloid Leukemia (AML): In Vivo Preclinical Pharmacokinetic (PK), Pharmacodynamic (PD) and Antileukemia Activities Of Synthetic 2’-O-Methylphosphorothioate Mir-29b

Free
Hongyan Wang, PhD, Ramasamy Santhanam, Ph.D, Zhiliang Xie, MD, Xiaomeng Huang, Ming Chiu, Mitch A. Phelps, PhD, Alison R Walker, MD, Michael A. Caligiuri, MD, Ramiro Garzon, MD, James Lee, PhD, Natarajan Muthusamy, DVM, Ph.D, Kenneth K. Chan, Ph.D, Guido Marcucci, MD
Journal: Blood
Blood (2013) 122 (21): 3933.
https://doi.org/10.1182/blood.V122.21.3933.3933
Published: 2013
Journal Articles

Lenalidomide-mediated enhanced translation of C/EBPα-p30 protein up-regulates expression of the antileukemic microRNA-181a in acute myeloid leukemia

Free
Christopher J. Hickey, Sebastian Schwind, Hanna S. Radomska, Adrienne M. Dorrance, Ramasamy Santhanam, Anjali Mishra, Yue-Zhong Wu, Houda Alachkar, Kati Maharry, Deedra Nicolet, Krzysztof Mrózek, Alison Walker, Anna M. Eiring, Susan P. Whitman, Heiko Becker, Danilo Perrotti, Lai-Chu Wu, Xi Zhao, Todd A. Fehniger, Ravi Vij, John C. Byrd, William Blum, L. James Lee, Michael A. Caligiuri, Clara D. Bloomfield, Ramiro Garzon, Guido Marcucci
Journal: Blood
Blood (2013) 121 (1): 159–169.
https://doi.org/10.1182/blood-2012-05-428573
Published: 2013
Includes: Supplemental data
Journal Articles

Targeted nanoparticle delivery overcomes off-target immunostimulatory effects of oligonucleotides and improves therapeutic efficacy in chronic lymphocytic leukemia

Free
Bo Yu, Yicheng Mao, Li-Yuan Bai, Sarah E. M. Herman, Xinmei Wang, Asha Ramanunni, Yan Jin, Xiaokui Mo, Carolyn Cheney, Kenneth K. Chan, David Jarjoura, Guido Marcucci, Robert J. Lee, John C. Byrd, L. James Lee, Natarajan Muthusamy
Journal: Blood
Blood (2013) 121 (1): 136–147.
https://doi.org/10.1182/blood-2012-01-407742
Published: 2013
Includes: Supplemental data
Journal Articles

Therapeutic Targeting of the RAS-Pathway by Synthetic Mir-181a Nanoparticles in Acute Myeloid Leukemia (AML).

Free
Xiaomeng Huang, Sebastian Schwind, MD, Ann-Kathrin Eisfeld, MD, Bo Yu, Ph.D, Ramasamy Santhanam, Ph.D, Pia Hoellerbauer, Yan Jin, Ph.D, Christopher Hickey, Ph.D, Jiuxia Pang, Kenneth K. Chan, Ph.D, Danilo Perrotti, MD, Ph.D, Natarajan Muthusamy, DVM, Ph.D, John C. Byrd, MD, William Blum, MD, Clara D. Bloomfield, MD, Shujun Liu, Ph.D, Ramiro Garzon, MD, Robert J. Lee, Ph.D, L. James Lee, Ph.D, Guido Marcucci, MD
Journal: Blood
Blood (2012) 120 (21): 2422.
https://doi.org/10.1182/blood.V120.21.2422.2422
Published: 2012
Journal Articles

Targeted Delivery of MicroRNA-29b by Nanoparticles Provides Antileukemic Activity and Increases Sensitivity to the Hypomethylating Agent Decitabine (DAC) in Acute Myeloid Leukemia (AML)

Free
Xiaomeng Huang, Sebastian Schwind, MD, Bo Yu, Ph.D, Jiuxia Pang, Ramasamy Santhanam, Ph.D, Kenneth K. Chan, Ph.D, Ramiro Garzon, MD, William Blum, MD, Clara D. Bloomfield, MD, Shujun Liu, Ph.D, Danilo Perrotti, MD, Ph.D, Robert J. Lee, Ph.D, John C. Byrd, MD, Natarajan Muthusamy, DVM, Ph.D, L. James Lee, Ph.D, Guido Marcucci, MD
Journal: Blood
Blood (2011) 118 (21): 81.
https://doi.org/10.1182/blood.V118.21.81.81
Published: 2011
Journal Articles

Tumor Specific T Cells Modified to Secrete IL-12 Eradicate Systemic Tumors in the Absence of Prior Toxic Chemotherapy Conditioning Regimens

Free
Hollie J. Pegram, PhD, James Lee, MD, Erik Hayman, BS, Gavin H Imperato, Thomas J. Tedder, PhD, Renier J Brentjens, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 3120.
https://doi.org/10.1182/blood.V118.21.3120.3120
Published: 2011
Journal Articles

Adoptive Therapy with Human CD19 (hCD19)-Targeted T Cells Further Modified to Express IL-12 Overcome the Need for Prior Lymphodepletion to Eradicate Established hCD19 + Tumors and Induce B Cell Aplasias In Immune Competent hCD19 + Transgenic Mice

Free
Erik Hayman, BS, James Lee, MD, Hollie J. Pegram, PhD, Renier Brentjens, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 2097.
https://doi.org/10.1182/blood.V116.21.2097.2097
Published: 2010
Journal Articles

Lenalidomide down-regulates the CD20 antigen and antagonizes direct and antibody-dependent cellular cytotoxicity of rituximab on primary chronic lymphocytic leukemia cells

Free
Rosa Lapalombella, Bo Yu, Georgia Triantafillou, Qing Liu, Jonathan P. Butchar, Gerard Lozanski, Asha Ramanunni, Lisa L. Smith, William Blum, Leslie Andritsos, Da-Sheng Wang, Amy Lehman, Ching-Shih Chen, Amy J. Johnson, Guido Marcucci, Robert J. Lee, L. James Lee, Susheela Tridandapani, Natarajan Muthusamy, John C. Byrd
Journal: Blood
Blood (2008) 112 (13): 5180–5189.
https://doi.org/10.1182/blood-2008-01-133108
Published: 2008
Journal Articles

Tumor-Targeted Human CD4 + CD25 hi Regulatory T Cells Effectively Inhibit T Cell –mediated Rejection of CD19 + Tumors in An in Vivo xenotransplant Tumor Model

Free
James Lee, Michel Sadelain, MD, PhD, Renier J. Brentjens, MD, PhD
Journal: Blood
Blood (2008) 112 (11): 3901.
https://doi.org/10.1182/blood.V112.11.3901.3901
Published: 2008
Journal Articles

Efficacy and Long Term Survival of Genetically Modified T Cells Targeting CD19 in a Syngeneic Immune Competent Transgenic Murine Tumor Model Is Dependent on Prior Lymphodepleting Chemotherapy.

Free
James Lee, BA, Yan Nikhamin, MS, Gavin Imperato, MS, Adam Cohen, MD, Michel Sadelain, MD/PhD, Renier Brentjens, MD/PhD
Journal: Blood
Blood (2007) 110 (11): 2754.
https://doi.org/10.1182/blood.V110.11.2754.2754
Published: 2007
Journal Articles

Hospital Mortality Due to Pulmonary Embolism (PE) and an Evaluation of the Usefulness of Preventative Interventions.

Free
Dimitrios Scarvelis, MD, CM, Laurie Davis, MD, Linn Petersson, MD, Tim Ramsay, PhD, Josdalyne Anderson, BSc, James Lee, MD, Melissa Forgie, MD, MSc, Philip S. Wells, MD, MSc
Journal: Blood
Blood (2006) 108 (11): 3297.
https://doi.org/10.1182/blood.V108.11.3297.3297
Published: 2006
Journal Articles

Risk for heparin-induced thrombocytopenia with unfractionated and low-molecular-weight heparin thromboprophylaxis: a meta-analysis

Free
Clinical Trials & Observations
Nadine Martel, James Lee, Philip S. Wells
Journal: Blood
Blood (2005) 106 (8): 2710–2715.
https://doi.org/10.1182/blood-2005-04-1546
Published: 2005
Journal Articles

ALCAM (CD166): its role in hematopoietic and endothelial development

Free
Osamu Ohneda, Kinuko Ohneda, Fumio Arai, James Lee, Takeshi Miyamoto, Yoshimi Fukushima, Donald Dowbenko, Laurence A. Lasky, Toshio Suda
Journal: Blood
Blood (2001) 98 (7): 2134–2142.
https://doi.org/10.1182/blood.V98.7.2134
Published: 2001