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François Aguet
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Journal Articles

Single-Cell Profiling of ~1.7 Million Plasma Cells across >250 Individuals Reveals Transcriptional Signatures of Progression and Clonal Expansion in Multiple Myeloma and Its Precursor Stages

Junko Tsuji, Elizabeth D. Lightbody, Romanos Sklavenitis-Pistofidis, Ting Wu, Michael P. Agius, Danielle T. Firer, Mahshid Rahmat, Hadley Barr, Yoshinobu Konishi, Ankit K. Dutta, Jean-Baptiste Alberge, Nang Kham Su, Cody J. Boehner, Michelle P. Aranha, Laura Hevenor, Katherine Towle, Erica M. Horowitz, Maya Davis, Jacqueline F Perry, Francois Aguet, Ruitong Li, Sungjae Kim, Nicholas J. Haradhvala, Rebecca Boiarsky, Gad Getz, Irene Ghobrial
Journal: Blood
Blood (2024) 144 (Supplement 1): 4637.
https://doi.org/10.1182/blood-2024-206540
Published: 2024
Journal Articles

Single-Cell RNA-Sequencing of 370 Bone Marrow and Peripheral Blood Immune Cell Samples from Patients with MGUS and Smoldering Multiple Myeloma Reveal Significant Immune Dysregulation at the MGUS Stage, and Novel Interactions between Tumor and Immune Cells

Romanos Sklavenitis-Pistofidis, Ting Wu, Mahshid Rahmat, Yoshinobu Konishi, Elizabeth D. Lightbody, Michael Timonian, Junko Tsuji, Danielle T. Firer, Nicholas J. Haradhvala, Cinnie Yentia Soekojo, Xiyue Wang, Daniel Heilpern-Mallory, François Aguet, Gad Getz, Irene Ghobrial
Journal: Blood
Blood (2022) 140 (Supplement 1): 860–861.
https://doi.org/10.1182/blood-2022-168911
Published: 2022
Journal Articles

Single-Cell RNA-Sequencing of 245 Tumor Samples from Patients with MGUS and Smoldering Multiple Myeloma Reveals Novel Insights into Malignant Plasma Cell Biology

Junko Tsuji, Elizabeth D. Lightbody, Romanos Sklavenitis-Pistofidis, Michael P. Agius, Mahshid Rahmat, Hadley Barr, Yoshinobu Konishi, Ankit K. Dutta, Nang Kham Su, Cody J. Boehner, Danielle T. Firer, Ting Wu, Michelle P. Aranha, Laura Hevenor, Erica Horowitz, Jacqueline Perry, François Aguet, Nicholas J. Haradhvala, Rebecca Boiarsky, Gad Getz, Irene Ghobrial
Journal: Blood
Blood (2022) 140 (Supplement 1): 254–255.
https://doi.org/10.1182/blood-2022-167325
Published: 2022
Journal Articles

Single-Cell RNA-Sequencing Identifies Immune Biomarkers of Progression in Patients with High-Risk Smoldering Multiple Myeloma Treated with Immunotherapy

Romanos Sklavenitis-Pistofidis, Michelle P. Aranha, Nicholas J. Haradhvala, Shohreh Varmeh, Daniel Heilpern-Mallory, Ting Wu, Nang Kham Su, Elizabeth D. Lightbody, François Aguet, Oksana Zavidij, Sabrin Tahri, Tarek H. Mouhieddine, Gad Getz, Irene Ghobrial
Journal: Blood
Blood (2022) 140 (Supplement 1): 268–269.
https://doi.org/10.1182/blood-2022-168839
Published: 2022
Journal Articles

Single Cell Characterization of Myeloma and Its Precursor Conditions Reveals Transcriptional Signatures of Early Tumorigenesis

Rebecca Boiarsky, Nicholas Haradhvala, Romanos Sklavenitis-Pistofidis, Tarek H Mouhieddine, Jean-Baptiste Alberge, Oksana Zavidij, Danielle Firer, Shankara Anand, Habib El-Khoury, François Aguet, David Sontag, Irene M. Ghobrial, Gad Getz
Journal: Blood
Blood (2021) 138 (Supplement 1): 2219.
https://doi.org/10.1182/blood-2021-150889
Published: 2021
Journal Articles

Single-Cell RNA-Sequencing Identifies Immune Biomarkers of Response to Immunotherapy in Patients with High-Risk Smoldering Myeloma

Romanos Sklavenitis-Pistofidis, Ankit K. Dutta, Sylvia Ujwary, Robert A. Redd, Alexandra Savell, Léa Fléchon, François Aguet, Nicholas Haradhvala, Oksana Zavidij, Mark Bustoros, Sabrin Tahri, Tarek H Mouhieddine, Nang K. Su, Lily Ardente, Shankara Anand, Jacalyn Rosenblatt, Jeffrey A. Zonder, James J. Vredenburgh, Adam Boruchov, Manisha Bhutani, Saad Z. Usmani, Jeffrey V. Matous, Andrew J. Yee, Andrzej Jakubowiak, Claudia E. Paba-Prada, Julia Prescott, Jacob P. Laubach, Salomon Manier, Omar Nadeem, Paul G. Richardson, Ashraf Z. Badros, Lorenzo Trippa, Maria-Victoria Mateos, Gad Getz, Irene M. Ghobrial
Journal: Blood
Blood (2021) 138 (Supplement 1): 330.
https://doi.org/10.1182/blood-2021-147623
Published: 2021
Journal Articles

Genomic Profiling of Smoldering Multiple Myeloma Classifies Molecular Groups with Distinct Pathogenic Phenotypes and Clinical Outcomes

Shankara Anand, Mark Bustoros, Romanos Sklavenitis-Pistofidis, Robert A. Redd, Eileen M Boyle, Yu-Tzu Tai, Carl J Neuse, Selina J Chavda, Cody J. Boehner, Mahshid Rahmat, Benny Zhitomirsky, Andrew Dunford, Ankit K. Dutta, Chip Stewart, Lorenzo Trippa, Tineke Casneuf, Efstathios Kastritis, Brian A Walker, Faith E Davies, Meletios A. Dimopoulos, P. Leif Bergsagel, Kwee Yong, Gareth J. Morgan, François Aguet, Gad Getz, Irene M. Ghobrial
Journal: Blood
Blood (2021) 138 (Supplement 1): 723.
https://doi.org/10.1182/blood-2021-150767
Published: 2021
Journal Articles

The CLL-1100 Project: Towards Complete Genomic Characterization and Improved Prognostics for CLL

Binyamin A. Knisbacher, PhD, Ziao Lin, BS, Cynthia K. Hahn, MD PhD, Ferran Nadeu, Martí Duran-Ferrer, Kristen E. Stevenson, MS, Eugen Tausch, MD, Alex Barbera-Mourelle, Andrew Dunford, Shankara Anand, Julio Delgado, MD, Julian M. Hess, Amaro Taylor-Weiner, PhD, Helene Kretzmer, PhD, Pablo Bousquets Muñoz, Conner J. Shaughnessy, Stacey M. Fernandes, BS, Mariela Sivina, Laura Z. Rassenti, PhD, Alexander Meissner, PhD, Adrian Wiestner, MD PhD, Jan A. Burger, MD PhD, Thomas J. Kipps, MD PhD, Jennifer R Brown, MD PhD, Michael Hallek, François Aguet, PhD, Donna S. Neuberg, ScD, Xose S Puente, PhD, Chip Stewart, PhD, José I. Martín-Subero, PhD, Stephan Stilgenbauer, MD, Catherine J. Wu, MD, Elías Campo, MD PhD, Gad Getz, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 3–4.
https://doi.org/10.1182/blood-2020-140987
Published: 2020
Journal Articles

Cellular Mechanisms For Transferrin Receptor Endocytosis Vital For Terminal Erythroid Differentiation

Yuichi Ishikawa, M.D., Ph.D., Silvia K Tacheva-Grigorova, Manami Maeda, M.D., Ph.D., Francois Aguet, Ph.D., Sung-Uk Lee, Ph.D., Maria Ericsson, Tomas Kirchhausen, Ph.D., Takahiro Maeda, M.D., Ph.D.
Journal: Blood
Blood (2013) 122 (21): 3434.
https://doi.org/10.1182/blood.V122.21.3434.3434
Published: 2013