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Charlotte F. McDonagh
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Journal Articles

Engineered Stem Cell Antibody Paired Evasion-2 (ESCAPE-2): Paired HSC Epitope Engineering and Direct Editing of Sickle Allele for Antibody-Mediated Autologous Hematopoietic Stem Cell Therapy Conditioning for the Treatment of Sickle Cell Disease

S. Haihua Chu, Elizabeth Budak, Nandini Mondal, Kathy Zhang, Alexander Harmon, Jeffrey Wong, Dieter Lam, Corrina Lucini, Brent Coisman, Kangjian Qiao, Tao Bai, Jeremy Decker, Bob Gantzer, Kindo Lee, Maya Sen, Tanggis Bohnuud, Luis Barrera, Brian Cafferty, Seung-Joo Lee, Paul Kopesky, Nicole M. Gaudelli, Charlotte F McDonagh, Giuseppe Ciaramella, Adam J. Hartigan
Journal: Blood
Blood (2022) 140 (Supplement 1): 10213–10214.
https://doi.org/10.1182/blood-2022-169257
Published: 2022
Journal Articles

Engineered Stem Cell Antibody Paired Evasion 1 (ESCAPE-1): Paired HSC Epitope Engineering and Upregulation of Fetal Hemoglobin for Antibody-Mediated Autologous Hematopoietic Stem Cell Therapy Conditioning for the Treatment of Hemoglobinopathies

Nandini Mondal, Alexander Harmon, Elizabeth Budak, Kathy Zhang, Jeffrey Wong, Conrad Rinaldi, Jenny Olins, Kara Hoar, Archita Venugopal Menon, Moriah White, Faith Musenge, Adam Camblin, Adam Wolin, Brent Coisman, Tao Bai, Kangjian Qiao, Mudra Patel, Jeremy Decker, Bob Gantzer, Thomas Leete, Yi Yu, Tanggis Bohnuud, Seung-Joo Lee, Sarah Smith, Charlotte F McDonagh, Nicole M. Gaudelli, S. Haihua Chu, Adam J. Hartigan, Giuseppe Ciaramella
Journal: Blood
Blood (2022) 140 (Supplement 1): 4487–4488.
https://doi.org/10.1182/blood-2022-169120
Published: 2022
Journal Articles

Single Agent CD45-Targeted Antibody Drug Conjugate Enables Full Mismatch Allogeneic Hematopoietic Stem Cell Transplantation in a Murine HSCT Model

Sharon L. Hyzy, MS, Jennifer L Proctor, BS, Geoff O Gillard, PhD, Katelyn J. Hammond, BS, Ganapathy N. Sarma, PhD, Asim Saha, PhD, Nicholas Clark, PhD, Anjali Bhat, MS, Tahirih L Lamothe, BS, Rahul Palchaudhuri, PhD, Bradley R Pearse, PhD, Charlotte F McDonagh, PhD, Hans-Peter Kiem, MDPhD, John E Wagner, MD, Bruce R. Blazar, MD, Anthony E Boitano, PhD, Michael P Cooke, PhD, John C. Davis, Jr., MD MPH, MS
Journal: Blood
Blood (2020) 136 (Supplement 1): 31.
https://doi.org/10.1182/blood-2020-140489
Published: 2020
Journal Articles

A Single Dose of CD117 Antibody Drug Conjugate Enables Autologous Gene-Modified Hematopoietic Stem Cell Transplant (Gene Therapy) in Nonhuman Primates

John F. Tisdale, MD, Robert E. Donahue, VMD, Naoya Uchida, MD, Bradley R Pearse, PhD, Sean M McDonough, MS, Jennifer L Proctor, BS, Allen Krouse, Nathaniel S. Linde, Aylin C. Bonifacino, Rajiv Panwar, PhD, Ganapathy N. Sarma, PhD, Lena Kien, BS, Kellie Latimer, Junia Dushime, BS, Sharon L. Hyzy, MS, Melissa L. Brooks, BS, Rahul Palchaudhuri, PhD, Qing Li, PhD, Pranoti Sawant, MS, Charlotte F McDonagh, PhD, Anthony E. Boitano, PhD, Michael P. Cooke, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 610.
https://doi.org/10.1182/blood-2019-125968
Published: 2019
Journal Articles

CD117-Amanitin Antibody Drug Conjugates Effectively Deplete Human and Non-Human Primate HSCs: Proof of Concept As a Targeted Strategy for Conditioning Patients for Bone Marrow Transplant

Bradley R Pearse, PhD, Sean M McDonough, MS, Jennifer L Proctor, BS, Rajiv Panwar, PhD, Ganapathy Sarma, PhD, Molly A McShea, MS, Lena Kien, BS, Junia Dushime, BS, Hillary L Adams, MS, Sharon L. Hyzy, MS, Melissa L. Brooks, BS, Rahul Palchaudhuri, PhD, Qing Li, PhD, Nathan M Kallen, BA, Pranoti Sawant, MS, Charlotte F McDonagh, PhD, Anthony E. Boitano, PhD, Michael P. Cooke, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3314.
https://doi.org/10.1182/blood-2018-99-114881
Published: 2018
Journal Articles

Single Doses of Antibody Drug Conjugates (ADCs) Targeted to CD117 or CD45 Have Potent In Vivo Anti-Leukemia Activity and Survival Benefit in Patient Derived AML Models

Jennifer L Proctor, BS, Sharon L. Hyzy, MS, Hillary L Adams, MS, Melissa L. Brooks, BS, Andrew D Gabros, Sean M McDonough, MS, Lena Kien, BS, Sharon Aslanian, MS, Bradley R Pearse, PhD, Rahul Palchaudhuri, PhD, Qing Li, PhD, Nathan M Kallen, BA, Ganapathy Sarma, PhD, Molly A McShea, MS, Danielle Ladwig, MS, Junia Dushime, BS, Rajiv Panwar, PhD, Charlotte F McDonagh, PhD, Anthony E. Boitano, PhD, Michael P. Cooke, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3316.
https://doi.org/10.1182/blood-2018-99-112726
Published: 2018
Journal Articles

Targeting CD45 with an Amanitin Antibody-Drug Conjugate Effectively Depletes Human HSCs and Immune Cells for Transplant Conditioning

Rahul Palchaudhuri, PhD, Bradley R Pearse, PhD, Jennifer L Proctor, BS, Sharon L. Hyzy, MS, Sharon Aslanian, MS, Sean M McDonough, MS, Ganapathy Sarma, PhD, Melissa L. Brooks, BS, Anjali Bhat, MS, Danielle Ladwig, MS, Molly A McShea, MS, Nathan M Kallen, BA, Qing Li, PhD, Rajiv Panwar, PhD, Junia Dushime, BS, Pranoti Sawant, MS, Hillary L Adams, MS, Patrick C. Falahee, PhD, Tahirih L Lamothe, Andrew D Gabros, Lena Kien, BS, Geoff Gillard, PhD, Charlotte F McDonagh, PhD, Anthony E. Boitano, PhD, Michael P. Cooke, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4526.
https://doi.org/10.1182/blood-2018-99-117167
Published: 2018
Journal Articles

Antibody Drug Conjugates Targeted to CD45 or CD117 Enable Allogeneic Hematopoietic Stem Cell Transplantation in Animal Models

Rahul Palchaudhuri, PhD, Sharon L. Hyzy, MS, Jennifer L Proctor, BS, Hillary L Adams, MS, Bradley R Pearse, PhD, Ganapathy Sarma, PhD, Sharon Aslanian, MS, Geoff Gillard, PhD, Tahirih L Lamothe, Olga Burenkova, BS, Melissa L. Brooks, BS, Andrew D Gabros, Charlotte F McDonagh, PhD, Anthony E. Boitano, PhD, Michael P. Cooke, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3324.
https://doi.org/10.1182/blood-2018-99-119432
Published: 2018
Journal Articles

Potent antitumor activity of the anti-CD19 auristatin antibody drug conjugate hBU12-vcMMAE against rituximab-sensitive and -resistant lymphomas

Hans-Peter Gerber, May Kung-Sutherland, Ivan Stone, Carol Morris-Tilden, Jamie Miyamoto, Renee McCormick, Stephen C. Alley, Nicole Okeley, Brad Hayes, Francisco J. Hernandez-Ilizaliturri, Charlotte F. McDonagh, Paul J. Carter, Dennis Benjamin, Iqbal S. Grewal
Journal: Blood
Blood (2009) 113 (18): 4352–4361.
https://doi.org/10.1182/blood-2008-09-179143
Published: 2009
Includes: Supplemental data
Journal Articles

SGN-70, a Humanized Anti-CD70 Antibody, Targets CD70-Expressing Hematologic Tumors.

Julie A. McEarchern, PhD, Charlotte F. McDonagh, Ph.D., Leia M. Smith, Ph.D., Kerry Klussman, B.S., Ezogelin Oflazoglu, Ph.D., Carol Morris-Tilden, B.S., Ivan Stone, B.S., Renee McCormick, B.S., Paul Carter, Ph.D., Hanspeter Gerber, Ph.D., Iqbal S. Grewal, Ph.D., Che-Leung Law, Ph.D.
Journal: Blood
Blood (2006) 108 (11): 2492.
https://doi.org/10.1182/blood.V108.11.2492.2492
Published: 2006
Journal Articles

Engineered anti-CD70 antibody with multiple effector functions exhibits in vitro and in vivo antitumor activities

Julie A. McEarchern, Ezogelin Oflazoglu, Leigh Francisco, Charlotte F. McDonagh, Kristine A. Gordon, Ivan Stone, Kerry Klussman, Eileen Turcott, Nico van Rooijen, Paul Carter, Iqbal S. Grewal, Alan F. Wahl, Che-Leung Law
Journal: Blood
Blood (2006) 109 (3): 1185–1192.
https://doi.org/10.1182/blood-2006-07-034017
Published: 2006