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Adam J. Hartigan
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Journal Articles

CD117 Antibody Conditioning and Multiplex Base Editing Enable Rapid and Robust Fetal Hemoglobin Reactivation in a Rhesus Autologous Transplantation Model

Selami Demirci, Nandini Mondal, Wayne Austin, Henna Butt, Evan London, Shruti Sathish, Kathy Zhang, Jeffrey Wong, Hugh Kromer, Alexander Harmon, Jeremy Decker, Anh Le, Khaled Essawi, Allen E Krouse, N Seth Linde, Aylin Bonifacino, Theresa Engels, Justin Golomb, So Gun Hong, Naoya Uchida, Nicole Gaudelli, Adam J. Hartigan, Charlotte F McDonagh, S Haihua Chu, Robert E Donahue, John Tisdale
Journal: Blood
Blood (2024) 144 (Supplement 1): 516.
https://doi.org/10.1182/blood-2024-204403
Published: 2024
Journal Articles

Initial Results from the BEACON Clinical Study: A Phase 1/2 Study Evaluating the Safety and Efficacy of a Single Dose of Autologous CD34+ Base Edited Hematopoietic Stem Cells (BEAM-101) in Patients with Sickle Cell Disease with Severe Vaso-Occlusive Crises

Ashish O. Gupta, Akshay Sharma, Haydar Frangoul, Jignesh Dalal, Julie Kanter, Asif Alavi, John DiPersio, Mary Eapen, Jennifer J. Jaroscak, Ernesto Ayala, Edward D. Ziga, Stacey Rifkin-Zenenberg, Alex C. Minella, Guo Chen, Yinzhong Chen, Priya S. Chockalingam, Ling Lin, Marcelyne Joseney-Antoine, Leanne Ianniello, Beth Gardner, Adam J. Hartigan, Giuseppe Ciaramella, Sunita Goyal, Amy Simon, Alexis Thompson, Matthew M. Heeney
Journal: Blood
Blood (2024) 144 (Supplement 1): 513.
https://doi.org/10.1182/blood-2024-204888
Published: 2024
Journal Articles

Engineered Stem Cell Antibody Paired Evasion-2 (ESCAPE-2): Paired HSC Epitope Engineering and Direct Editing of Sickle Allele for Antibody-Mediated Autologous Hematopoietic Stem Cell Therapy Conditioning for the Treatment of Sickle Cell Disease

S. Haihua Chu, Elizabeth Budak, Nandini Mondal, Kathy Zhang, Alexander Harmon, Jeffrey Wong, Dieter Lam, Corrina Lucini, Brent Coisman, Kangjian Qiao, Tao Bai, Jeremy Decker, Bob Gantzer, Kindo Lee, Maya Sen, Tanggis Bohnuud, Luis Barrera, Brian Cafferty, Seung-Joo Lee, Paul Kopesky, Nicole M. Gaudelli, Charlotte F McDonagh, Giuseppe Ciaramella, Adam J. Hartigan
Journal: Blood
Blood (2022) 140 (Supplement 1): 10213–10214.
https://doi.org/10.1182/blood-2022-169257
Published: 2022
Journal Articles

Engineered Stem Cell Antibody Paired Evasion 1 (ESCAPE-1): Paired HSC Epitope Engineering and Upregulation of Fetal Hemoglobin for Antibody-Mediated Autologous Hematopoietic Stem Cell Therapy Conditioning for the Treatment of Hemoglobinopathies

Nandini Mondal, Alexander Harmon, Elizabeth Budak, Kathy Zhang, Jeffrey Wong, Conrad Rinaldi, Jenny Olins, Kara Hoar, Archita Venugopal Menon, Moriah White, Faith Musenge, Adam Camblin, Adam Wolin, Brent Coisman, Tao Bai, Kangjian Qiao, Mudra Patel, Jeremy Decker, Bob Gantzer, Thomas Leete, Yi Yu, Tanggis Bohnuud, Seung-Joo Lee, Sarah Smith, Charlotte F McDonagh, Nicole M. Gaudelli, S. Haihua Chu, Adam J. Hartigan, Giuseppe Ciaramella
Journal: Blood
Blood (2022) 140 (Supplement 1): 4487–4488.
https://doi.org/10.1182/blood-2022-169120
Published: 2022
Journal Articles

Conversion of HbS to Hb G-Makassar By Adenine Base Editing Is Compatible with Normal Hemoglobin Function

S. Haihua Chu, Manuel Ortega, Paty Feliciano, Valerie Winton, Chavonna Xu, Daniel Haupt, Teresa McDonald, Salette Martinez, Alexander Liquori, Jeffrey Marshall, Daisy Lam, Jenny Olins, Conrad Rinaldi, Kyle Rehberger, Colin Lazarra, Jeremy Decker, Bob Gantzer, Tanggis Bohnuud, David Born, Luis Barrera, Bo Yan, Ian Slaymaker, Michael S. Packer, Sarah Smith, Carlo Zambonelli, Matt Lee, Nicole M. Gaudelli, Adam J. Hartigan, Giuseppe Ciaramella
Journal: Blood
Blood (2021) 138 (Supplement 1): 951.
https://doi.org/10.1182/blood-2021-150922
Published: 2021
Journal Articles

Adenine Base Editing of the Sickle Allele in CD34 + Hematopoietic Stem and Progenitor Cells Eliminates Hemoglobin S

S. Haihua Chu, PhD, Daisy Lam, Michael S. Packer, PhD, Jennifer Olins, Alexander Liquori, Jeffrey Marshall, PhD, Calvin Lee, Bo Yan, PhD, Jeremy Decker, Bob Gantzer, M.S., Scott J. Haskett, M.S., Tanggis Bohnuud, PhD, David Born, PhD, Luis Barrera, PhD, Ian Slaymaker, PhD, Nicole M. Gaudelli, PhD, Adam J. Hartigan, PhD, Giuseppe Ciaramella, PhD, B.Sc.
Journal: Blood
Blood (2020) 136 (Supplement 1): 47.
https://doi.org/10.1182/blood-2020-141805
Published: 2020
Journal Articles

Non-Genotoxic Conditioning Efficiently Depletes Host Hematopoietic Stem Cells and Facilitates Robust Multi-Lineage Engraftment in a Mouse Model of Fanconi Anemia

Meera Srikanthan, MD, Kevin G. Haworth, PhD, Christina M. Ironside, BS, Jerry Chen, Adam J. Hartigan, PhD, Rahul Palchaudhuri, PhD, Anthony E. Boitano, PhD, Michael P. Cooke, PhD, Hans-Peter Kiem, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2041.
https://doi.org/10.1182/blood-2018-99-116851
Published: 2018
Journal Articles

Non-Genotoxic Conditioning for Hematopoietic Stem Cell Transplant Using a Human Antibody Drug Conjugate Targeting C-KIT

Adam J. Hartigan, PhD, Bradley R. Pearse, PhD, Sean M. McDonough, Jennifer L. Proctor, BS, Hillary L. Adams, MS, Molly A. McShea, Megan D. Hoban, Rajiv Panwar, PhD, Sharon L. Hyzy, MS, Kevin A. Goncalves, PhD, Rahul Palchaudhuri, PhD BA, Anthony E. Boitano, PhD, Michael P. Cooke, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1894.
https://doi.org/10.1182/blood.V130.Suppl_1.1894.1894
Published: 2017
Journal Articles

CCR7 impairs hematopoiesis after hematopoietic stem cell transplantation increasing susceptibility to invasive aspergillosis

Adam J. Hartigan, Lara E. Kallal, Cory M. Hogaboam
Journal: Blood
Blood (2010) 116 (24): 5383–5393.
https://doi.org/10.1182/blood-2010-01-265454
Published: 2010
Includes: Supplemental data