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Journal Articles

CD117 Antibody Conditioning and Multiplex Base Editing Enable Rapid and Robust Fetal Hemoglobin Reactivation in a Rhesus Autologous Transplantation Model

Selami Demirci, Nandini Mondal, Wayne Austin, Henna Butt, Evan London, Shruti Sathish, Kathy Zhang, Jeffrey Wong, Hugh Kromer, Alexander Harmon, Jeremy Decker, Anh Le, Khaled Essawi, Allen E Krouse, N Seth Linde, Aylin Bonifacino, Theresa Engels, Justin Golomb, So Gun Hong, Naoya Uchida, Nicole Gaudelli, Adam J. Hartigan, Charlotte F McDonagh, S Haihua Chu, Robert E Donahue, John Tisdale
Journal: Blood
Blood (2024) 144 (Supplement 1): 516.
https://doi.org/10.1182/blood-2024-204403
Published: 2024
Journal Articles

Non-Genotoxic Conditioning for Hematopoietic Stem Cell Transplant through Engineered Stem Cell Antibody Paired Evasion (ESCAPE)

Nandini Mondal, Alexander Harmon, Elizabeth Budak, Kathy Zhang, Jeffrey Wong, Archita Venugopal Menon, Adam Wolin, Moriah White, Faith Musenge, Adam Camblin, Brent Coisman, Corrina Lucini, Tao Bai, Kangjian Qiao, Wayne Austin, Michelle DeLelys, Hugh Kromer, Lisa Hardy, Megan Law, Raffi Manoukian, Rachel Goldsmith, Kiera Fallon, Mudra Patel, Antoinette Cozier, Colin Lazzara, Jeremy Decker, Rebecca Jenkins, Tanggis Bohnuud, Patricia Feliciano, Seung-Joo Lee, Paul Kopesky, Sarah Smith, Charlotte McDonagh, Nicole Gaudelli, S. Haihua Chu, Adam Hartigan, Gopi Shankar, Giuseppe Ciaramella
Journal: Blood
Blood (2023) 142 (Supplement 1): 7128.
https://doi.org/10.1182/blood-2023-182077
Published: 2023
Journal Articles

Engineered Stem Cell Antibody Paired Evasion-2 (ESCAPE-2): Paired HSC Epitope Engineering and Direct Editing of Sickle Allele for Antibody-Mediated Autologous Hematopoietic Stem Cell Therapy Conditioning for the Treatment of Sickle Cell Disease

S. Haihua Chu, Elizabeth Budak, Nandini Mondal, Kathy Zhang, Alexander Harmon, Jeffrey Wong, Dieter Lam, Corrina Lucini, Brent Coisman, Kangjian Qiao, Tao Bai, Jeremy Decker, Bob Gantzer, Kindo Lee, Maya Sen, Tanggis Bohnuud, Luis Barrera, Brian Cafferty, Seung-Joo Lee, Paul Kopesky, Nicole M. Gaudelli, Charlotte F McDonagh, Giuseppe Ciaramella, Adam J. Hartigan
Journal: Blood
Blood (2022) 140 (Supplement 1): 10213–10214.
https://doi.org/10.1182/blood-2022-169257
Published: 2022
Journal Articles

Engineered Stem Cell Antibody Paired Evasion 1 (ESCAPE-1): Paired HSC Epitope Engineering and Upregulation of Fetal Hemoglobin for Antibody-Mediated Autologous Hematopoietic Stem Cell Therapy Conditioning for the Treatment of Hemoglobinopathies

Nandini Mondal, Alexander Harmon, Elizabeth Budak, Kathy Zhang, Jeffrey Wong, Conrad Rinaldi, Jenny Olins, Kara Hoar, Archita Venugopal Menon, Moriah White, Faith Musenge, Adam Camblin, Adam Wolin, Brent Coisman, Tao Bai, Kangjian Qiao, Mudra Patel, Jeremy Decker, Bob Gantzer, Thomas Leete, Yi Yu, Tanggis Bohnuud, Seung-Joo Lee, Sarah Smith, Charlotte F McDonagh, Nicole M. Gaudelli, S. Haihua Chu, Adam J. Hartigan, Giuseppe Ciaramella
Journal: Blood
Blood (2022) 140 (Supplement 1): 4487–4488.
https://doi.org/10.1182/blood-2022-169120
Published: 2022
Journal Articles

Conversion of HbS to Hb G-Makassar By Adenine Base Editing Is Compatible with Normal Hemoglobin Function

S. Haihua Chu, Manuel Ortega, Paty Feliciano, Valerie Winton, Chavonna Xu, Daniel Haupt, Teresa McDonald, Salette Martinez, Alexander Liquori, Jeffrey Marshall, Daisy Lam, Jenny Olins, Conrad Rinaldi, Kyle Rehberger, Colin Lazarra, Jeremy Decker, Bob Gantzer, Tanggis Bohnuud, David Born, Luis Barrera, Bo Yan, Ian Slaymaker, Michael S. Packer, Sarah Smith, Carlo Zambonelli, Matt Lee, Nicole M. Gaudelli, Adam J. Hartigan, Giuseppe Ciaramella
Journal: Blood
Blood (2021) 138 (Supplement 1): 951.
https://doi.org/10.1182/blood-2021-150922
Published: 2021
Journal Articles

Adenine Base Editing of the Sickle Allele in CD34 + Hematopoietic Stem and Progenitor Cells Eliminates Hemoglobin S

S. Haihua Chu, PhD, Daisy Lam, Michael S. Packer, PhD, Jennifer Olins, Alexander Liquori, Jeffrey Marshall, PhD, Calvin Lee, Bo Yan, PhD, Jeremy Decker, Bob Gantzer, M.S., Scott J. Haskett, M.S., Tanggis Bohnuud, PhD, David Born, PhD, Luis Barrera, PhD, Ian Slaymaker, PhD, Nicole M. Gaudelli, PhD, Adam J. Hartigan, PhD, Giuseppe Ciaramella, PhD, B.Sc.
Journal: Blood
Blood (2020) 136 (Supplement 1): 47.
https://doi.org/10.1182/blood-2020-141805
Published: 2020
Journal Articles

Leukemia Cell of Origin Influences p53 Activity and Therapeutic Sensitivity Via an Evi1-Dependent Mechanism

Sheng F Cai, MD PhD, S Haihua Chu, PhD, Aaron D Goldberg, MD PhD, Salma Parvin, PhD, Richard Koche, PhD, Jacob L Glass, MD PhD, Eytan M. Stein, MD, Martin S. Tallman, MD, Filiz Sen, MD, Christopher Famulare, MS, Monica Cusan, MD, Chun-Hao Huang, PhD, Chun-Wei David Chen, PhD, Lihua Zou, PhD, Keith B Cordner, BS, Vidushi Durani, MS, Mitali Kini, BS, Madison Rex, Johannes Zuber, Timour Baslan, PhD, Scott W. Lowe, PhD, Hugh Young Rienhoff, Jr., MD, Ross L. Levine, MD, Scott A. Armstrong, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 109.
https://doi.org/10.1182/blood-2019-122483
Published: 2019
Journal Articles

The Lysine Histone Methyltransferase SETD2 Is Required for Appropriate Immunoglobulin VDJ Recombination

S. Haihua Chu, PhD, Jonathan Chabon, BS, Janna Minehart, BS, Chloe N Matovina, BS, Jian Zhang, Bo-Ruei Chen, PhD, Elsa Callen-Moreu, PhD, Putzer J Hung, Zhaohui Feng, BM, BS, Richard Koche, PhD, X. Shirley Liu, Jayanta Chaudhuri, Andre Nussenzweig, PhD, Barry Sleckman, Scott A. Armstrong, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 511.
https://doi.org/10.1182/blood-2018-99-111952
Published: 2018
Journal Articles

SETD2 alterations impair DNA damage recognition and lead to resistance to chemotherapy in leukemia

Brenton G. Mar, S. Haihua Chu, Josephine D. Kahn, Andrei V. Krivtsov, Richard Koche, Cecilia A. Castellano, Jacob L. Kotlier, Rebecca L. Zon, Marie E. McConkey, Jonathan Chabon, Ryan Chappell, Peter V. Grauman, James J. Hsieh, Scott A. Armstrong, Benjamin L. Ebert
Journal: Blood
Blood (2017) 130 (24): 2631–2641.
https://doi.org/10.1182/blood-2017-03-775569
Published: 2017
Includes: Supplemental data
Journal Articles

Targeting the DNA Damage Response Pathway in MLL- rearranged B-Acute Lymphoblastic Leukemias

S. Haihua Chu, PhD, Evelyn Junyao Song, BS, Jonathan Chabon, BS, Janna Minehart, BS, Zhaohui Feng, BM, BS, Kenneth Ross, PhD, Richard Koche, PhD, Andrei V. Krivtsov, PhD, Scott Armstrong, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3880.
https://doi.org/10.1182/blood.V130.Suppl_1.3880.3880
Published: 2017
Journal Articles

Loss of Lysine Histone Methyltransferase Setd2 Disrupts Normal Hematopoiesis, Lineage Commitment and Reveals a Novel Role for H3K36me3 in Immunoglobulin VDJ Recombination

S. Haihua Chu, PhD, Jonathan R Chabon, BS, Janna Minehart, BS, Richard Koche, PhD, Katie Li, BS, Matthew Witkin, BS, Andrei Krivtsov, PhD, Scott A. Armstrong, MD PhD
Journal: Blood
Blood (2016) 128 (22): 423.
https://doi.org/10.1182/blood.V128.22.423.423
Published: 2016
Journal Articles

Inhibition of MEK and DDR Pathways Induces Synergistic Killing of Novel Mll-Af4 B-ALL Model Harboring Activated Ras Mutations

Evelyn J Song, BS, S. Haihua Chu, PhD, Janna Minehart, BS, Jonathan Chabon, BS, Richard Koche, PhD, Andrei Krivtsov, PhD, Scott A. Armstrong, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1511.
https://doi.org/10.1182/blood.V128.22.1511.1511
Published: 2016
Journal Articles

An Epigenetic Regulator Screen Identifies Novel Targets That Sensitize MLL -Rearranged Leukemia to DOT1L Inhibition

Chun-Wei David Chen, PhD, Christopher Delaney, BS, Haiming Xu, PhD, Richard Koche, PhD, Amaya Lujambio Goizueta, PhD, Takayuki Hoshii, PhD, Monica Cusan, MD PhD, Jonathan Chabon, BS, Daria Gianina Valerio, MD, Michael Kuehn, MD, Xi Wang, BS, Sheng Cai, MD PhD, S. Haihua Chu, PhD, Yining Kevin Chen, Justin He, Chun-Hao Huang, PhD, Zhaohui Feng, BM, BS, Andrei Krivtsov, PhD, Jun Qi, PhD, James E. Bradner, MD, Scott W. Lowe, PhD, Scott A. Armstrong, MD PhD
Journal: Blood
Blood (2016) 128 (22): 571.
https://doi.org/10.1182/blood.V128.22.571.571
Published: 2016
Journal Articles

Genetic and Pharmacologic Notch4 Inhibition Synergizes with FLT3 Tyrosine Kinase Inhibition in Vitro to More Effectively Eliminate FLT3/ITD-Positive Leukemia Cells

Courtney M. Shirley, PhD, S. Haihua Chu, PhD, Yandan Yang, PhD, George W. Wright, PhD, Louis M. Staudt, MD PhD, Donald Small, MD PhD
Journal: Blood
Blood (2014) 124 (21): 3583.
https://doi.org/10.1182/blood.V124.21.3583.3583
Published: 2014
Journal Articles

FLT3-ITD Knock-in Impairs Hematopoietic Stem Cell Quiescence/Homeostasis, Leading to a Myeloproliferative Neoplasm

S. Haihua Chu, Diane Heiser, Li Li, PhD, Ian M Kaplan, PhD, David Huso, D.V.M., Ph.D., Curt I. Civin, MD, Donald Small, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 46.
https://doi.org/10.1182/blood.V118.21.46.46
Published: 2011
Journal Articles

Sorafenib Treatment Reverses Depletion of Primitive Hematopoietic Stem Cells and Resolves FLT3-ITD Driven Myeloproliferative Disease In a Mouse Model.

Diane Heiser, S. Haihua Chu, Li Li, PhD, Ian M Kaplan, Curt I. Civin, MD, Donald Small, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 1586.
https://doi.org/10.1182/blood.V116.21.1586.1586
Published: 2010
Journal Articles

FLT3 Internal Tandem Duplication (ITD) Mutations Disrupt Homeostasis in Hematopoietic Stem Cells.

S. Haihua Chu, BSE, Diane Heiser, BA, Li Li, MD, PhD, Ian M Kaplan, BS, Curt I. Civin, MD, Donald Small, MD, PhD
Journal: Blood
Blood (2009) 114 (22): 1420.
https://doi.org/10.1182/blood.V114.22.1420.1420
Published: 2009