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Journal Articles

Potent antitumor activity of the anti-CD19 auristatin antibody drug conjugate hBU12-vcMMAE against rituximab-sensitive and -resistant lymphomas

Hans-Peter Gerber, May Kung-Sutherland, Ivan Stone, Carol Morris-Tilden, Jamie Miyamoto, Renee McCormick, Stephen C. Alley, Nicole Okeley, Brad Hayes, Francisco J. Hernandez-Ilizaliturri, Charlotte F. McDonagh, Paul J. Carter, Dennis Benjamin, Iqbal S. Grewal

Blood (2009) 113 (18): 4352–4361.

https://doi.org/10.1182/blood-2008-09-179143

Published: 2009

Includes: Supplemental data

Journal Articles

CD27-CD70 interactions in the pathogenesis of Waldenström macroglobulinemia

Allen W. Ho, Evdoxia Hatjiharissi, Bryan T. Ciccarelli, Andrew R. Branagan, Zachary R. Hunter, Xavier Leleu, Olivier Tournilhac, Lian Xu, Kelly O'Connor, Robert J. Manning, Daniel Ditzel Santos, Mariana Chemaly, Christopher J. Patterson, Jacob D. Soumerai, Nikhil C. Munshi, Julie A. McEarchern, Che-Leung Law, Iqbal S. Grewal, Steven P. Treon

Blood (2008) 112 (12): 4683–4689.

https://doi.org/10.1182/blood-2007-04-084525

Published: 2008

Journal Articles

Macrophages contribute to the antitumor activity of the anti-CD30 antibody SGN-30

Ezogelin Oflazoglu, Ivan J. Stone, Kristine A. Gordon, Iqbal S. Grewal, Nico van Rooijen, Che-Leung Law, Hans-Peter Gerber

Blood (2007) 110 (13): 4370–4372.

https://doi.org/10.1182/blood-2007-06-097014

Published: 2007

Includes: Supplemental data

Journal Articles

The Humanized Anti-CD40 Monoclonal Antibody, SGN-40, Potentiates Chemotherapy Regimens in NHL Xenograft Models Via Pro-Apoptotic Signaling.

Timothy S. Lewis, PhD, Renee S. McCormick, B.S., Kim Kissler, B.S., Ivan J. Stone, B.S., Mechthild Jonas, Ph.D., May S.K. Sutherland, Ph.D., Hans-Peter Gerber, Ph.D., Jonathan G. Drachman, M.D., Iqbal S. Grewal, Ph.D., Che-Leung Law, Ph.D.

Blood (2007) 110 (11): 2342.

https://doi.org/10.1182/blood.V110.11.2342.2342

Published: 2007

Journal Articles

SGN-33, Lintuzumab, Demonstrates Anti-Leukemic Activity in Preclinical Models of AML.

May S.K. Sutherland, PhD, Changpu Yu, MD, Carol Morris-Tilden, Timothy S. Lewis, PhD, Jamie B. Miyamoto, Julie A. McEarchern, PhD, Ezogelin Oflazoglu, PhD, Hanspeter Gerber, PhD, Eric L. Sievers, MD, Iqbal S. Grewal, PhD, Che-Leung Law, PhD

Blood (2007) 110 (11): 919.

https://doi.org/10.1182/blood.V110.11.919.919

Published: 2007

Journal Articles

SGN-33 Modulates Cytokine and Chemokine Production by Activated Monocytes and Macrophages.

May S.K. Sutherland, PhD, Timothy S. Lewis, PhD, Changpu Yu, MD, Julie A. McEarchern, PhD, Jonathan G. Drachman, MD, Eric L. Sievers, MD, Iqbal S. Grewal, PhD, Che-Leung Law, PhD

Blood (2006) 108 (11): 1995.

https://doi.org/10.1182/blood.V108.11.1995.1995

Published: 2006

Journal Articles

Targeted Depletion and Inhibition of Activated T Lymphocytes with SGN-70, a Humanized Antibody Specific for the Activation Antigen CD70.

Julie A. McEarchern, PhD, Kerry Klussman, B.S., Tamar E. Boursalian, Ph.D., Iqbal S. Grewal, Ph.D., Che-Leung Law, Ph.D.

Blood (2006) 108 (11): 1728.

https://doi.org/10.1182/blood.V108.11.1728.1728

Published: 2006

Journal Articles

Preclinical In Vitro and In Vivo Evidence Support a Therapeutic Role for the CD70 Directed Monoclonal Antibody (SGN-70) in Waldenström’s Macroglobulinemia (WM).

Evdoxia Hatjiharissi, MD, Allen W. Ho, Lian Xu, Kelly E. O’Connor, Zachary R. Hunter, Daniel D. Santos, MD, Robert Manning, Xavier Leleu, MD, Anne-Sophie Moreau, MD, Christopher J. Patterson, Julie A. McEarchern, PhD, Che-Leung Law, PhD, Iqbal S. Grewal, PhD, Nikhil C. Munshi, MD, PhD, Steven P. Treon, MD, PhD

Blood (2006) 108 (11): 2490.

https://doi.org/10.1182/blood.V108.11.2490.2490

Published: 2006

Journal Articles

SGN-70, a Humanized Anti-CD70 Antibody, Targets CD70-Expressing Hematologic Tumors.

Julie A. McEarchern, PhD, Charlotte F. McDonagh, Ph.D., Leia M. Smith, Ph.D., Kerry Klussman, B.S., Ezogelin Oflazoglu, Ph.D., Carol Morris-Tilden, B.S., Ivan Stone, B.S., Renee McCormick, B.S., Paul Carter, Ph.D., Hanspeter Gerber, Ph.D., Iqbal S. Grewal, Ph.D., Che-Leung Law, Ph.D.

Blood (2006) 108 (11): 2492.

https://doi.org/10.1182/blood.V108.11.2492.2492

Published: 2006

Journal Articles

The Humanized Anti-CD40 Antibody, SGN-40, Promotes Apoptosis Signaling and Is Effective in Combination with Standard Therapies in Lymphoma Xenograft Models.

Timothy S. Lewis, PhD, May S.K. Sutherland, Ph.D., Mechthild Jonas, Ph.D., Charles G. Cerveny, M.S., Renee McCormick, B.S., Alan F. Wahl, Ph.D., Jonathan G. Drachman, M.D., Iqbal S. Grewal, Ph.D., Che-Leung Law, Ph.D.

Blood (2006) 108 (11): 2499.

https://doi.org/10.1182/blood.V108.11.2499.2499

Published: 2006

Journal Articles

Engineered anti-CD70 antibody with multiple effector functions exhibits in vitro and in vivo antitumor activities

Julie A. McEarchern, Ezogelin Oflazoglu, Leigh Francisco, Charlotte F. McDonagh, Kristine A. Gordon, Ivan Stone, Kerry Klussman, Eileen Turcott, Nico van Rooijen, Paul Carter, Iqbal S. Grewal, Alan F. Wahl, Che-Leung Law

Blood (2006) 109 (3): 1185–1192.

https://doi.org/10.1182/blood-2006-07-034017

Published: 2006

Journal Articles

The Humanized Anti-CD40 Monoclonal Antibody SGN-40 Targets Hodgkin’s Disease Cells through Multiple Mechanisms.

Che-Leung Law, PhD, Julie A. McEarchern, PhD, Charles G. Cerveny, MS, Leia M. Smith, PhD, Albina Nesterova, MS, Kristine A. Gordon, BS, Iqbal S. Grewal, PhD, Alan F. Wahl, PhD

Blood (2005) 106 (11): 1476.

https://doi.org/10.1182/blood.V106.11.1476.1476

Published: 2005

Journal Articles

A Humanized Anti-CD70 Monoclonal Antibody Targets CD70-Expressing Multiple Myeloma.

Julie A. McEarchern, PhD, Charlotte McDonagh, PhD, Allen Ho, BA, Yu-Tzu Tai, PhD, Leigh Francisco, BS, Kerry Klussman, BS, Carol Morris-Tilden, BS, Kristine Gordon, BS, Ezogelin Oflazoglu, PhD, Kim Kissler, Nikhil Munshi, MD, Kenneth C. Anderson, MD, Steven P. Treon, MD, PhD, Paul Carter, PhD, Alan F. Wahl, PhD, Iqbal S. Grewal, PhD, Che-Leung Law, PhD

Blood (2005) 106 (11): 1591.

https://doi.org/10.1182/blood.V106.11.1591.1591

Published: 2005

NARROW

Potent antitumor activity of the anti-CD19 auristatin antibody drug conjugate hBU12-vcMMAE against rituximab-sensitive and -resistant lymphomas

CD27-CD70 interactions in the pathogenesis of Waldenström macroglobulinemia

Macrophages contribute to the antitumor activity of the anti-CD30 antibody SGN-30

The Humanized Anti-CD40 Monoclonal Antibody, SGN-40, Potentiates Chemotherapy Regimens in NHL Xenograft Models Via Pro-Apoptotic Signaling.

SGN-33, Lintuzumab, Demonstrates Anti-Leukemic Activity in Preclinical Models of AML.

SGN-33 Modulates Cytokine and Chemokine Production by Activated Monocytes and Macrophages.

Targeted Depletion and Inhibition of Activated T Lymphocytes with SGN-70, a Humanized Antibody Specific for the Activation Antigen CD70.

Preclinical In Vitro and In Vivo Evidence Support a Therapeutic Role for the CD70 Directed Monoclonal Antibody (SGN-70) in Waldenström’s Macroglobulinemia (WM).

SGN-70, a Humanized Anti-CD70 Antibody, Targets CD70-Expressing Hematologic Tumors.

The Humanized Anti-CD40 Antibody, SGN-40, Promotes Apoptosis Signaling and Is Effective in Combination with Standard Therapies in Lymphoma Xenograft Models.

Engineered anti-CD70 antibody with multiple effector functions exhibits in vitro and in vivo antitumor activities

The Humanized Anti-CD40 Monoclonal Antibody SGN-40 Targets Hodgkin’s Disease Cells through Multiple Mechanisms.

A Humanized Anti-CD70 Monoclonal Antibody Targets CD70-Expressing Multiple Myeloma.

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American Society of Hematology

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American Society of Hematology

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