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Journal Articles

High-dose busulfan-melphalan vs melphalan and reinforced VRD for newly diagnosed multiple myeloma: a phase 3 GEM trial

Available to Purchase
Clinical Trials & Observations
Juan José Lahuerta, Jesús San-Miguel, Ana Jiménez-Ubieto, Rafael Alonso, Bruno Paiva, Noemí Puig, M. Teresa Cedena, Norma Carmen Gutierrez, María José Calasanz, Manuela Fernández Guijarro, Rafael Ríos Tamayo, Albert Oriol Rocafiguera, María Jesús Blanchard, Estrella Carrillo Cruz, Rafael Martínez-Martínez, Joan Bargay, Ana Sureda Balari, Javier de la Rubia, Miguel Teodoro Hernández García, Valentín Cabañas, Felipe Casado Montero, Luis Palomera Bernal, Yolanda González Montes, Joaquín Martínez-Lopez, Paula Rodriguez-Otero, Isabel Krisnik, José M. Arguiñano, María Esther Gonzalez García, Enrique M. Ocio, Javier de la Cruz, María Victoria Mateos, Laura Rosiñol, Joan Bladé
Journal: Blood
Blood (2025) 146 (15): 1747–1758.
https://doi.org/10.1182/blood.2025028313
Published: 2025
Includes: Supplemental data
Journal Articles

Reduction of Tumor Lysis Syndrome Risk after Debulking with Obinutuzumab in Patients Treated with Venetoclax-Obinutuzumab in the Randomized Phase 3 CRISTALLO Trial

Free
Paolo Sportoletti, Luca Laurenti, Emmanuelle Ferrant, Luis Felipe Casado Montero, Stephen P Mulligan, Rosemary Harrup, Stephen Opat, Adalberto Ibatici, Roberto Marasca, Marcus Lefebure, Michelle Boyer, Yanwen Jiang, Simona Barlera, Oscar Cazares, Franck Morschhauser, Jeff P. Sharman
Journal: Blood
Blood (2024) 144 (Supplement 1): 1873.
https://doi.org/10.1182/blood-2024-198372
Published: 2024
Journal Articles

Unraveling Long-Term Survival of Multiple Myeloma Patients, the GEM2000 Experience

Free
Rafael Alonso Fernandez, Andrés Arroyo Barea, Maria Teresa Cedena Romero, Laura Rosiñol Dachs, Javier de la Rubia, Sara Miqueleiz, Veronica Gonzalez-Calle, Felipe De Arriba, Luis Felipe Casado Montero, Miguel Teodoro Hernandez, Maria Mas Esteve, Pascual Fernandez, Paula Rodríguez-Otero, Carmen Calle Primo, Eugenia Abella, Paz Ribas, Adrian Alegre, Juan Miguel Bergua, Irene Gomez-Catalan, Jose Maria Arguiñano Perez, Luis Palomera, Enrique M Ocio, Maria Jose Busto Medina, Nieves Somolinos, Jose Maria Alonso Alonso, Aránzazu García Mateo, Joan Bargay, Pilar Delgado, Dunia De Miguel Llorente, Javier de la Cruz, Maria Victoria Mateos, Jesús F. San-Miguel, Joan Bladé, Juan-Jose Lahuerta Palacios, Joaquin Martinez Lopez
Journal: Blood
Blood (2024) 144 (Supplement 1): 1957.
https://doi.org/10.1182/blood-2024-211383
Published: 2024
Journal Articles

CRISTALLO: Results from a Phase III Trial of Venetoclax-Obinutuzumab Versus Fludarabine, Cyclophosphamide and Rituximab or Bendamustine-Rituximab in Patients with Untreated Chronic Lymphocytic Leukemia without Del(17p) or TP53 Mutations

Free
Jeff P. Sharman, Luca Laurenti, Emmanuelle Ferrant, Luis Felipe Casado Montero, Stephen P Mulligan, Rosemary Harrup, Stephen Opat, Adalberto Ibatici, Roberto Marasca, Paolo Sportoletti, Marcus Lefebure, Michelle Boyer, Yanwen Jiang, Simona Barlera, Oscar Cazares, Franck Morschhauser
Journal: Blood
Blood (2024) 144 (Supplement 1): 3237.
https://doi.org/10.1182/blood-2024-200632
Published: 2024
Journal Articles

Clinical Value of Peripheral Residual Disease (PRD) and Measurable Residual Disease (MRD) in Newly Diagnosed Elderly Patients in the GEM2017FIT Trial

Free
Noemi Puig, Bruno Paiva, María T Cedena, Cristina Agullo, Teresa Contreras, Sergio Castro, Ana Maria Sureda Balari, Veronica Gonzalez-Calle, Albert Oriol, Enrique M Ocio, Laura Rosiñol Dachs, Yolanda González-Montes, Joan Bargay, Esther González García, Miguel Teodoro Hernández Garcia, Angel Ramirez, Alexia Suarez-Cabrera, María-Jesús Blanchard, Sebastián Garzón, Luis Felipe Casado Montero, Valentin Cabanas Perianes, Jaime Perez de Oteyza, Mercedes Gironella, Joaquín Martínez-Lopez, Pilar Delgado, Elena Prieto, Juan-Jose Lahuerta Palacios, Joan Bladé, Jesús F. San-Miguel, Maria- Victoria Mateos
Journal: Blood
Blood (2024) 144 (Supplement 1): 365.
https://doi.org/10.1182/blood-2024-209748
Published: 2024
Journal Articles

Outcomes of Chronic Myeloid Leukemia Patients after Therapeutic Failure to Asciminib, a Multicenter Observational Study

Free
Lucía Pérez-Lamas, Adrian Segura Diaz, Elvira Mora, Marta Hidalgo Soto, Antonio Paz Coll, Natalia De Las Heras, Montse Cortes, Patricia Velez Tenza, Magdalena Sierra Pacho, María Alicia Senin, Anna Angona, Carlos Cervero, Raquel De Paz Arias, Araceli Salamanca Cuenca, Marta Santaliestra, Javier López Marin, Luis Felipe Casado Montero, Valentín García Gutiérrez
Journal: Blood
Blood (2023) 142 (Supplement 1): 3177.
https://doi.org/10.1182/blood-2023-187412
Published: 2023
Journal Articles

Efficacy of Consolidation Therapy with Ponatinib 15mg on Treatment-Free Remission Rate in Patients with Chronic Myeloid Leukemia. Results of the Ponazero Trial

Free
Lucía Pérez-Lamas, Juan Carlos Hernandez Boluda, Luis Felipe Casado Montero, Maria Teresa Gómez Casares, Rosa Ayala, Blanca Xicoy, Francisca Ferrer Marin, Guillermo Orti, Raquel De Paz Arias, Santiago Osorio Prendes, Raul Perez Lopez, Elvira Mora, Concepción Ruiz Nuño, Antonio Jimenez Velasco, Concepcion Boque, Magdalena Sierra Pacho, Joaquin Martinez Lopez, Valentin Garcia Gutierrez
Journal: Blood
Blood (2023) 142 (Supplement 1): 1795.
https://doi.org/10.1182/blood-2023-184989
Published: 2023
Journal Articles

GEM2017FIT Trial: Induction Therapy with Bortezomib-Melphalan and Prednisone (VMP) Followed By Lenalidomide and Dexamethasone (Rd) Versus Carfilzomib, Lenalidomide and Dexamethasone (KRd) Plus/Minus Daratumumab (D), 18 Cycles, Followed By Consolidation and Maintenance Therapy with Lenalidomide and Daratumumab: Phase III, Multicenter, Randomized Trial for Elderly Fit Newly Diagnosed Multiple Myeloma (NDMM) Patients Aged between 65 and 80 Years

Free
Maria-Victoria Mateos, Bruno Paiva, Maria Teresa Cedena Romero, Noemi Puig, Anna Maria Sureda Balari, Albert Oriol, Enrique M Ocio, Laura Rosiñol, Yolanda González-Montes, Juan Jose Bargay, Esther Gonzalez Garcia, Miguel Teodoro Hernández Garcia, Angel Ramirez, Alexia Suarez-Cabrera, María-Jesús Blanchard, Sebastián Garzón, Luis Felipe Casado Montero, Valentin Cabanas Perianes, Jaime Pérez De Oteyza, Mercedes Gironella, Joaquin Martinez-Lopez, Ana-Isabel -Teruel, Pilar Delgado, Elena Prieto, Juan Jose Lahuerta Palacios, Joan Bladé, Jesus San Miguel
Journal: Blood
Blood (2023) 142 (Supplement 1): 209.
https://doi.org/10.1182/blood-2023-179866
Published: 2023
Journal Articles

Sustained Recovery of Uninvolved Heavy/Light Chain Pair Immunoparesis during Maintenance Discriminates Patients with Sustained Negative Minimal Residual Disease

Free
Sunil Lakhwani, Laura Rosiñol, Noemi Puig, Miguel Angel Pico Picos, Laura Medina-González, Joaquin Martinez Lopez, Bruno Paiva, Maria Teresa Cedena Romero, Albert Oriol, Rafael Ríos, María Jesús Blanchard, Isidro Jarque, Joan Bargay, Jose Maria Moraleda, Estrella Carrillo-Cruz, Anna Maria Sureda Balari, Isabel Krsnik, Esther Gonzalez Garcia, Luis Felipe Casado Montero, Josep Maria Marti Tutusaus, Cristina Encinas Rodriguez, Felipe De Arriba, Luis Palomera, Antonia Sampol Mayol, Yolanda González-Montes, Cristina Motlló, Javier De la Cruz, Rafael Alonso Fernández, Maria-Victoria Mateos, Joan Blade Creixenti, Juan Jose Lahuerta Palacios, Jesus San Miguel, Miguel Teodoro Hernández Garcia
Journal: Blood
Blood (2023) 142 (Supplement 1): 1958.
https://doi.org/10.1182/blood-2023-179452
Published: 2023
Journal Articles

Liver Toxicity As Dose Limiting Toxicity of Bosutinib in Combination with Atezolizumab in Chronic Myeloid Leukemia. Results from the Phase Ib/II Zerolmc Trial

Free
Valentín García Gutiérrez, Luis Felipe Casado Montero, Raquel de Paz, María Teresa Gómez-Casares, Angel Ramírez Payer, Rosa Ayala, Raul Perez Lopez, Francisca Ferrer Marin, Blanca Xicoy, Juan Luis Steegmann, Fermin Sanchez-Guijo, Joaquín Martínez-López
Journal: Blood
Blood (2022) 140 (Supplement 1): 12206–12207.
https://doi.org/10.1182/blood-2022-165998
Published: 2022
Journal Articles

Dynamic Response Assesment Combining Liquid Biopsy MRD and PET/CT in Follicular Lymphoma Patients Including CAR-T Cell Therapy

Free
Alejandro Martín-Muñoz, María Poza, Gloria Figaredo, Sara Dorado, Yanira Ruiz-Heredia, Margarita Rodriguez, Laura Rufian, Antonia Rodriguez Izquierdo, Laura Parrilla-Navamuel, Chongwu Wang, Paula Toledo, Carlos Grande Garcia, Tycho Baumann, Maria Calbacho, Inmaculada Rapado, Miguel Gallardo, Miguel Canales, Pilar Sarandeses, Manuela Mollejo, Luis Felipe Casado Montero, Rosa Ayala, Joaquín Martínez-López, Santiago Barrio, Ana Jimenez-Ubieto
Journal: Blood
Blood (2022) 140 (Supplement 1): 3514–3515.
https://doi.org/10.1182/blood-2022-166372
Published: 2022
Journal Articles

Immunoparesis Recovery in Transplant-Ineligible Newly Diagnosis Multiple Myeloma Patients: An Independent Prognosis Factor That Could Complement Prognostic Value of Minimal Residual Disease

Free
Sunil Lakhwani, María Victoria Mateos, Joaquín Martínez-López, Bruno Paiva, Laura Rosinol Dachs, Rafael Martínez, Albert Oriol, Joan Bargay, Yolanda Gonzalez-Montes, Mercedes Gironella, Cristina Encinas, Jesus Martin, Isidro Jarque, Miquel Granell, Eugenia Abella, Aránzazu García Mateo, José Ángel Hernández-Rivas, Elena Ramila, Isabel Krsnik, Luis Felipe Casado Montero, Felipe De Arriba, Luis Palomera, Antonia Sampol, Jose Maria Moraleda, Maria Casanova, Pilar Delgado, Ana Lafuente, Elena Amutio, Aurelio Lopez Martínez, Albert Altés, M. Ángeles Ruíz, Lucia Lopez-Anglada, Joan Bladé Creixenti, Juan-José Lahuerta, Jesús San-Miguel, Miguel-Teodoro Hernández
Journal: Blood
Blood (2022) 140 (Supplement 1): 2344–2346.
https://doi.org/10.1182/blood-2022-166826
Published: 2022
Journal Articles

Real-World Data Analysis of the Molecular Response Kinetics within the Two First Years of the RELMC-NOVA Study in Newly Diagnosed Spanish CML-CP Patients Treated with Tirosin Kinasa Inhibitors (TKIs) in First Line

Free
Luis Felipe Casado Montero, Nuria Garcia-Ormeña, Manuel Perez Encinas, Santiago Osorio-Prendes, Francisca Ferrer Marin, Miguel Sagüés, Valentín Garcia-Gutiérrez, Fernando Marco De Lucas, Concepcion Boque, Soledad Noya, María Teresa Gomez Casares, Natalia Estrada, Maria Angeles Goñi, Angel Ramírez Payer, Maria Jose Requena, Sunil Lakhwani, Marcio Miguel Andrade Campos, Natalia De las Heras, María Ángeles Foncillas, Juan Luis Steegmann
Journal: Blood
Blood (2022) 140 (Supplement 1): 3908–3910.
https://doi.org/10.1182/blood-2022-169631
Published: 2022
Journal Articles

Recovery of Uninvolved Heavy/Light Chain Pair Immunoparesis during Maintenance Is an Independent Prognostic Factor for Multiple Myeloma and Could Complement Prognosis Value of Minimal Residual Disease

Free
Sunil Lakhwani, Laura Rosinol Dachs, Noemi Puig, Miguel Angel Pico Picos, Laura Medina-González, Joaquín Martínez-López, Bruno Paiva, Albert Oriol, Rafael Rios, María Jesús Blanchard, Isidro Jarque, Joan Bargay, Jose Maria Moraleda, Estrella Carrillo-Cruz, Anna Sureda, Isabel Krsnik, Esther González Garcia, Luis Felipe Casado Montero, Josep M Marti, Cristina Encinas, Felipe De Arriba, Luis Palomera, Antonia Sampol, Yolanda Gonzalez-Montes, Cristina Motllo, Javier De La Cruz, Rafael Alonso Fernández, María-Victoria Mateos, Joan Bladé Creixenti, Juan-José Lahuerta, Jesús San-Miguel, Miguel-Teodoro Hernández
Journal: Blood
Blood (2022) 140 (Supplement 1): 2101–2103.
https://doi.org/10.1182/blood-2022-167247
Published: 2022
Journal Articles

Safety and Efficacy Profile of Asciminib As Treatment in Chronic Myeloid Leukemia Patients after Several Tyrosine-Kinase Inhibitors Failure

Free
Alejandro Luna, MD, Natalia Estrada, Concepcion Boque, MD PhD, Blanca Xicoy, MD, Pilar Giraldo, PhD, Anna Angona, Alberto Alvarez-Larrán, MD PhD, Fermin Sanchez-Guijo, MD PhD, María José Ramírez, Juan M. Alonso-Domínguez, Elvira Mora, Patricia Vélez, MD, Ana Rosell, Mercedes Colorado Araujo, Beatriz Cuevas, MD, Miguel Sagüés, Montserrat Cortes, Manuel Perez Encinas, MD, Luis Felipe Casado Montero, MD, Melania Moreno Vega, Luis Serrano, Valle Gomez, Carmen Garcia-Hernandez, MD, Sunil Lakhwani Lakhwani, Antonio Paz Coll, Raquel de Paz, MD, Sara Suarez-Varela, Andrés Fernandez-Ruiz, Raul Perez Lopez, Almudena Ortiz-Fernández, Antonio Jiménez-Velasco, MD, Valentín Garcia-Gutiérrez, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 49–50.
https://doi.org/10.1182/blood-2020-138690
Published: 2020
Journal Articles

Different Clinical Implications of Kinase Domain BCR-ABL1 Variants Detected in Chronic Myeloid Leukemia and Acute Lymphoblastic Leukemia Patients

Free
Ricardo Sanchez, PhD MD, Rosa Ayala, MD PhD, Gonzalo Carreño Gomez-Tarragona, Espino Maria Jose, Beatriz Cuevas, MD, Vanegas Raul, Luis Felipe Casado Montero, MD, Nuria Garcia-Ormeña, jose Angel Hernandez, Pilar Bravo, Cristina Seri, Eduardo Anguita, Eva Barragán, Francisca Ferrer Marin, MD PhD, maria Dolores Monteagudo, sanchez-Calero Jorge, Julian Sevilla, MD PhD, Elena Ruiz, Lucia Villalon, PhD, maria Del Mar Herraez, Rosalia Riaza, Elena Magro, Juan Luis Steegmann, Valentín García Gutiérrez, PhD, Joaquin Martinez-Lopez, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5368.
https://doi.org/10.1182/blood-2019-127069
Published: 2019
Journal Articles

Preliminary Results of Ibrutinib Followed By Ofatumumab Consolidation in Previously Untreated Patients with Chronic Lymphocytic Leukemia (CLL): GELLC7 Trials from the Spanish Group of CLL (GELLC)

Free
Pau Abrisqueta, MD PhD, Eva González-Barca, MD PhD, Christelle M Ferra, Eduardo Ríos Herranz, MD, Margarita Fernandez, MD, Julio Delgado, MD, Rafael Andreu, MD, Jose Angel Hernandez-Rivas, MD PhD, Maria Jose Terol, Marcos González, Patricia Baltasar Tello, MD, Javier de la Serna, MD PhD, Angel Ramirez Payer, Carmen Ballester, MD, Carol Moreno, MD PhD, Jose A. Garcia-Marco, MD PhD, Raul Cordoba, MD PhD, Lucrecia Yanez San Segundo, MD PhD, Luis Felipe Casado Montero, MD, Francesc Bosch, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4296.
https://doi.org/10.1182/blood-2019-128470
Published: 2019
Journal Articles

A Conservative Tailoring of Ponatinib Dose in Chronic Myeloid Leukemia Patients Can Diminish Adverse Events While Maintaining Efficacy

Free
Valentín García Gutiérrez, PhD, Andrés Novo, MD, Antonio Jimenez-Velasco, Luis Felipe Casado Montero, MD, Fermin Sanchez-Guijo, MD PhD, Raul Perez Lopez, Santiago Osorio-Prendes, Sunil Lakhwani Lakhwani, Angel Ramirez Payer, Guillermo Orti, Maria Teresa Gomez-Casares, Juan Manuel Alonso, Manuel Pérez-Encinas, Rolando Vallansot, Ernesto Pérez Persona, Maria Angeles Portero Frias, María José Ramírez Sánchez, Maria Alicia Senin, Gonzalo Caballero, Soledad Noya, Concepcion Boque, Maribel Mata, Mario Romo, Juan Luis Steegmann, MD PhD, Juan Carlos Hernandez-Boluda, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1624.
https://doi.org/10.1182/blood.V130.Suppl_1.1624.1624
Published: 2017
Journal Articles

Real Life Long-Term Survival Analysis in Patients with Chronic Myeloid Leukemia Treated with Tkis in Spain

Free
Luis Felipe Casado Montero, Valentin Garcia Gutierrez, MD, Pilar Giraldo, MD PhD, Manuel Perez-Encinas, Raquel de Paz, Joaquin Martinez-Lopez, Guiomar Bautista, Santiago Osorio, Maria Jose Requena, Luis Palomera, MD PhD, Maria Jesús Peñarrubia, Carmen Calle, Jose Angel Hernandez-Rivas, Nuria García-Ormeña, Juan Luis Steegmann, MD PhD
Journal: Blood
Blood (2016) 128 (22): 3074.
https://doi.org/10.1182/blood.V128.22.3074.3074
Published: 2016
Journal Articles

Lenalidomide-Based Treatment for Newly Diagnosed Multiple Myeloma Patients, Ineligible for Transplant: A Healthcare Cost-Impact Analysis in Europe

Free
Stephen A Schey, Casado Montero, Chloe Stengel-Tosetti, Craig Gibson, Sujith Dhanasiri
Journal: Blood
Blood (2015) 126 (23): 3304.
https://doi.org/10.1182/blood.V126.23.3304.3304
Published: 2015