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Issue Archive

Volume 127, Issue 11
March 17 2016
Issue Cover

Table of Contents

BLOOD FLASHBACK

Giblett ER, Coleman DH, Pirzio-Biroli G, Donohue DM, Motulsky AG, Finch CA. Erythrokinetics: quantitative measurements of red cell production and destruction in normal subjects and patients with anemia. Blood. 1956;11(4):291-309.
View Articletitled, Giblett ER, Coleman DH, Pirzio-Biroli G, Donohue DM, Motulsky AG, Finch CA. Erythrokinetics: quantitative measurements of red cell production and destruction in normal subjects and patients with anemia. <em>Blood</em>. 1956;11(4):<span class="related-article">291-309</span>.

INSIDE BLOOD COMMENTARIES

INSIDE BLOOD COMMENTARY
Pediatric MDS: GATA screen the germline
Elliot Stieglitz,Mignon L. Loh
View Articletitled, Pediatric MDS: GATA screen the germline
INSIDE BLOOD COMMENTARY
Less menorrhagia for women with VTE
Clinical Trials & Observations
Sam Schulman
View Articletitled, Less menorrhagia for women with VTE
INSIDE BLOOD COMMENTARY
S1PR2 deficiency in DLBCL: a FOXy connection
Cosima T. Baldari
View Articletitled, S1PR2 deficiency in DLBCL: a FOXy connection
INSIDE BLOOD COMMENTARY
Release the hounds: virotherapy with immunotherapy
Tapan M. Kadia
View Articletitled, Release the hounds: virotherapy with immunotherapy
INSIDE BLOOD COMMENTARY
Arf6 arbitrates fibrinogen endocytosis
Matthew T. Rondina,Andrew S. Weyrich
View Articletitled, Arf6 arbitrates fibrinogen endocytosis
INSIDE BLOOD COMMENTARY
Down the repressors! Up the fetal hemoglobin!
Christopher H. Lowrey
View Articletitled, Down the repressors! Up the fetal hemoglobin!
INSIDE BLOOD COMMENTARY
An oxidase road to platelet adhesion
Diane S. Krause
View Articletitled, An oxidase road to platelet adhesion

PLENARY PAPER

Prevalence, clinical characteristics, and prognosis of GATA2-related myelodysplastic syndromes in children and adolescents
CME
Marcin W. Wlodarski,Shinsuke Hirabayashi,Victor Pastor,Jan Starý,Henrik Hasle,Riccardo Masetti,Michael Dworzak,Markus Schmugge,Marry van den Heuvel-Eibrink,Marek Ussowicz,Barbara De Moerloose,Albert Catala,Owen P. Smith,Petr Sedlacek,Arjan C. Lankester,Marco Zecca,Victoria Bordon,Susanne Matthes-Martin,Jonas Abrahamsson,Jörn Sven Kühl,Karl-Walter Sykora,Michael H. Albert,Bartlomiej Przychodzien,Jaroslaw P. Maciejewski,Stephan Schwarz,Gudrun Göhring,Brigitte Schlegelberger,Annámaria Cseh,Peter Noellke,Ayami Yoshimi,Franco Locatelli,Irith Baumann,Brigitte Strahm,Charlotte M. Niemeyer,for the EWOG-MDS,for the EWOG-MDS,for the EWOG-MDS,for the EWOG-MDS,for the EWOG-MDS,for the EWOG-MDS,for the EWOG-MDS,for the EWOG-MDS,for the EWOG-MDS,for the EWOG-MDS,for the EWOG-MDS,for the EWOG-MDS,for the EWOG-MDS,for the EWOG-MDS,for the EWOG-MDS,for the EWOG-MDS,for the EWOG-MDS,for the EWOG-MDS,for the EWOG-MDS,for the EWOG-MDS,for the EWOG-MDS,for the EWOG-MDS,for the EWOG-MDS,for the EWOG-MDS,for the EWOG-MDS,for the EWOG-MDS,for the EWOG-MDS,for the EWOG-MDS,for the EWOG-MDS,for the EWOG-MDS,for the EWOG-MDS,for the EWOG-MDS,for the EWOG-MDS,for the EWOG-MDS
View Articletitled, Prevalence, clinical characteristics, and prognosis of GATA2-related myelodysplastic syndromes in children and adolescents
Supplemental data

BLOOD FORUM

Strategies that delay or prevent the timely availability of affordable generic drugs in the United States
Clinical Trials & Observations
Gregory H. Jones,Michael A. Carrier,Richard T. Silver,Hagop Kantarjian
View Articletitled, Strategies that delay or prevent the timely availability of affordable generic drugs in the United States

REVIEW ARTICLE

A lymphomagenic role for HIV beyond immune suppression?
Riccardo Dolcetti,Annunziata Gloghini,Arnaldo Caruso,Antonino Carbone
View Articletitled, A lymphomagenic role for HIV beyond immune suppression?

CLINICAL TRIALS AND OBSERVATIONS

Phase 2 study of the bispecific T-cell engager (BiTE) antibody blinatumomab in relapsed/refractory diffuse large B-cell lymphoma
Clinical Trials & Observations
Andreas Viardot,Marie-Elisabeth Goebeler,Georg Hess,Svenja Neumann,Michael Pfreundschuh,Nicole Adrian,Florian Zettl,Martin Libicher,Cyrus Sayehli,Julia Stieglmaier,Alicia Zhang,Dirk Nagorsen,Ralf C. Bargou
View Articletitled, Phase 2 study of the bispecific T-cell engager (BiTE) antibody blinatumomab in relapsed/refractory diffuse large B-cell lymphoma
Supplemental data
Recurrent venous thromboembolism and abnormal uterine bleeding with anticoagulant and hormone therapy use
Clinical Trials & Observations
Ida Martinelli,Anthonie W. A. Lensing,Saskia Middeldorp,Marcel Levi,Jan Beyer-Westendorf,Bonno van Bellen,Henri Bounameaux,Timothy A. Brighton,Alexander T. Cohen,Mila Trajanovic,Martin Gebel,Phuong Lam,Philip S. Wells,Martin H. Prins
View Articletitled, Recurrent venous thromboembolism and abnormal uterine bleeding with anticoagulant and hormone therapy use

HEMATOPOIESIS AND STEM CELLS

Functional and molecular characterization of mouse Gata2-independent hematopoietic progenitors
Polynikis Kaimakis,Emma de Pater,Christina Eich,Parham Solaimani Kartalaei,Mari-Liis Kauts,Chris S. Vink,Reinier van der Linden,Martine Jaegle,Tomomasa Yokomizo,Dies Meijer,Elaine Dzierzak
View Articletitled, Functional and molecular characterization of mouse Gata2-independent hematopoietic progenitors
Supplemental data

LYMPHOID NEOPLASIA

The hematopoietic oncoprotein FOXP1 promotes tumor cell survival in diffuse large B-cell lymphoma by repressing S1PR2 signaling
Michael Flori,Corina A. Schmid,Eric T. Sumrall,Alexandar Tzankov,Charity W. Law,Mark D. Robinson,Anne Müller
View Articletitled, The hematopoietic oncoprotein FOXP1 promotes tumor cell survival in diffuse large B-cell lymphoma by repressing S1PR2 signaling
Supplemental data

MYELOID NEOPLASIA

Immunovirotherapy with vesicular stomatitis virus and PD-L1 blockade enhances therapeutic outcome in murine acute myeloid leukemia
Weiwei Shen,Mrinal M. Patnaik,Autumn Ruiz,Stephen J. Russell,Kah-Whye Peng
View Articletitled, Immunovirotherapy with vesicular stomatitis virus and PD-L1 blockade enhances therapeutic outcome in murine acute myeloid leukemia
Supplemental data

PLATELETS AND THROMBOPOIESIS

Arf6 controls platelet spreading and clot retraction via integrin αIIbβ3 trafficking
Yunjie Huang,Smita Joshi,Binggang Xiang,Yasunori Kanaho,Zhenyu Li,Beth A. Bouchard,Carole L. Moncman,Sidney W. Whiteheart
View Articletitled, Arf6 controls platelet spreading and clot retraction via integrin α<sub>IIb</sub>β<sub>3</sub> trafficking
Supplemental data
Synthesis and dephosphorylation of MARCKS in the late stages of megakaryocyte maturation drive proplatelet formation
Kellie R. Machlus,Stephen K. Wu,Deborah J. Stumpo,Thomas S. Soussou,David S. Paul,Robert A. Campbell,Hermann Kalwa,Thomas Michel,Wolfgang Bergmeier,Andrew S. Weyrich,Perry J. Blackshear,John H. Hartwig,Joseph E. Italiano, Jr
View Articletitled, Synthesis and dephosphorylation of MARCKS in the late stages of megakaryocyte maturation drive proplatelet formation
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Pomalidomide reverses γ-globin silencing through the transcriptional reprogramming of adult hematopoietic progenitors
Brian M. Dulmovits,Abena O. Appiah-Kubi,Julien Papoin,John Hale,Mingzhu He,Yousef Al-Abed,Sebastien Didier,Michael Gould,Sehba Husain-Krautter,Sharon A. Singh,Kyle W. H. Chan,Adrianna Vlachos,Steven L. Allen,Naomi Taylor,Philippe Marambaud,Xiuli An,Patrick G. Gallagher,Narla Mohandas,Jeffrey M. Lipton,Johnson M. Liu,Lionel Blanc
View Articletitled, Pomalidomide reverses γ-globin silencing through the transcriptional reprogramming of adult hematopoietic progenitors
Supplemental data

THROMBOSIS AND HEMOSTASIS

Lysyl oxidase is associated with increased thrombosis and platelet reactivity
Shinobu Matsuura,Rongjuan Mi,Milka Koupenova,Alexia Eliades,Shenia Patterson,Paul Toselli,Jonathan Thon,Joseph E. Italiano, Jr,Philip C. Trackman,Nikolaos Papadantonakis,Katya Ravid
View Articletitled, Lysyl oxidase is associated with increased thrombosis and platelet reactivity
Supplemental data

TRANSPLANTATION

Posttransplantation cyclophosphamide for prevention of graft-versus-host disease after HLA-matched mobilized blood cell transplantation
Clinical Trials & Observations
Marco Mielcarek,Terry Furlong,Paul V. O’Donnell,Barry E. Storer,Jeannine S. McCune,Rainer Storb,Paul A. Carpenter,Mary E. D. Flowers,Frederick R. Appelbaum,Paul J. Martin
View Articletitled, Posttransplantation cyclophosphamide for prevention of graft-versus-host disease after HLA-matched mobilized blood cell transplantation
Supplemental data

LETTERS TO BLOOD

Variability in the efficacy of the IL1 receptor antagonist anakinra for treating Erdheim-Chester disease
Clinical Trials & Observations
Fleur Cohen-Aubart,Philippe Maksud,David Saadoun,Aurélie Drier,Frédéric Charlotte,Philippe Cluzel,Zahir Amoura,Julien Haroche
View Articletitled, Variability in the efficacy of the IL1 receptor antagonist anakinra for treating Erdheim-Chester disease
Uncompromised 10-year survival of oldest old carrying somatic mutations in DNMT3A and TET2
Erik B. van den Akker,Steven J. Pitts,Joris Deelen,Matthijs H. Moed,Shobha Potluri,Jeroen van Rooij,H. Eka D. Suchiman,Nico Lakenberg,Wesley J. de Dijcker,André G. Uitterlinden,Robert Kraaij,Albert Hofman,Anton J. M. de Craen,Jeanine J. Houwing-Duistermaat,Gert-Jan B. van Ommen,on behalf of the Genome of The Netherlands Consortium,David R. Cox,Joyce B. J. van Meurs,Marian Beekman,Marcel J. T. Reinders,P. Eline Slagboom
View Articletitled, Uncompromised 10-year survival of oldest old carrying somatic mutations in <em>DNMT3A</em> and <em>TET2</em>
Supplemental data

BLOOD WORK

Circulating CD30-positive T-cell lymphoma with anaplastic morphology
Amanda E. Maskovyak,Megan O. Nakashima
View Articletitled, Circulating CD30-positive T-cell lymphoma with anaplastic morphology

ERRATA

Kim W, Klarmann KD, Keller JR. Gfi-1 regulates the erythroid transcription factor network through Id2 repression in murine hematopoietic progenitor cells. Blood. 2014;124(10):1586-1596.
View Articletitled, Kim W, Klarmann KD, Keller JR. Gfi-1 regulates the erythroid transcription factor network through <em>Id2</em> repression in murine hematopoietic progenitor cells. <em>Blood.</em> 2014;124(10):1586-1596.
Liu J, Zhu H-H, Jiang H, Jiang Q, Huang X-J. Varying responses of PML-RARA with different genetic mutations to arsenic trioxide. Blood. 2016;127(2):243-250.
View Articletitled, Liu J, Zhu H-H, Jiang H, Jiang Q, Huang X-J. Varying responses of PML-RARA with different genetic mutations to arsenic trioxide. <em>Blood.</em> 2016;127(2):243-250.

CONTINUING MEDICAL EDUCATION (CME) QUESTIONS

GATA2-related MDS
CME
View Articletitled, GATA2-related MDS
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