Kathleen J. Helton,for the SWiTCH Investigators,Robert J. Adams,for the SWiTCH Investigators,Karen L. Kesler,for the SWiTCH Investigators,Alex Lockhart,for the SWiTCH Investigators,Banu Aygun,for the SWiTCH Investigators,Catherine Driscoll,for the SWiTCH Investigators,Matthew M. Heeney,for the SWiTCH Investigators,Sherron M. Jackson,for the SWiTCH Investigators,Lakshmanan Krishnamurti,for the SWiTCH Investigators,Scott T. Miller,for the SWiTCH Investigators,Sharada A. Sarnaik,for the SWiTCH Investigators,William H. Schultz,for the SWiTCH Investigators,Russell E. Ware,for the SWiTCH Investigators

View Articletitled, Magnetic resonance imaging/angiography and transcranial Doppler velocities in sickle cell anemia: results from the SWiTCH trial

Supplemental data

A phase 2 single-center study of carfilzomib 56 mg/m² with or without low-dose dexamethasone in relapsed multiple myeloma
Clinical Trials & Observations

Nikoletta Lendvai,Patrick Hilden,Sean Devlin,Heather Landau,Hani Hassoun,Alexander M. Lesokhin,Ioanna Tsakos,Kaitlyn Redling,Guenther Koehne,David J. Chung,Wendy L. Schaffer,Sergio A. Giralt

View Articletitled, A phase 2 single-center study of carfilzomib 56 mg/m2 with or without low-dose dexamethasone in relapsed multiple myeloma

Supplemental data

Trends in survival of patients with primary plasma cell leukemia: a population-based analysis
Clinical Trials & Observations

Wilson I. Gonsalves,S. Vincent Rajkumar,Ronald S. Go,Angela Dispenzieri,Vinay Gupta,Preet P. Singh,Francis K. Buadi,Martha Q. Lacy,Prashant Kapoor,David Dingli,John A. Lust,Steven R. Zeldenrust,Suzanne R. Hayman,Robert A. Kyle,Morie A. Gertz,Shaji K. Kumar

View Articletitled, Trends in survival of patients with primary plasma cell leukemia: a population-based analysis

GENE THERAPY

Rapamycin relieves lentiviral vector transduction resistance in human and mouse hematopoietic stem cells

Cathy X. Wang,Blythe D. Sather,Xuefeng Wang,Jennifer Adair,Iram Khan,Swati Singh,Shanshan Lang,Amie Adams,Gabrielle Curinga,Hans-Peter Kiem,Carol H. Miao,David J. Rawlings,Bruce E. Torbett

View Articletitled, Rapamycin relieves lentiviral vector transduction resistance in human and mouse hematopoietic stem cells

Supplemental data

HEMATOPOIESIS AND STEM CELLS

A motif in LILRB2 critical for Angptl2 binding and activation

Mi Deng,Zhigang Lu,Junke Zheng,Xuan Wan,Xiaoli Chen,Kouyuki Hirayasu,Hanzi Sun,Yeeling Lam,Liping Chen,Qihui Wang,Chun Song,Niu Huang,George F. Gao,Youxing Jiang,Hisashi Arase,Cheng Cheng Zhang

View Articletitled, A motif in LILRB2 critical for Angptl2 binding and activation

Supplemental data

MYELOID NEOPLASIA

TBLR1 fuses to retinoid acid receptor α in a variant t(3;17)(q26;q21) translocation of acute promyelocytic leukemia

Yirui Chen,Shouyun Li,Chunlin Zhou,Chengwen Li,Kun Ru,Qing Rao,Haiyan Xing,Zheng Tian,Kejing Tang,Yingchang Mi,Baohong Wang,Min Wang,Jianxiang Wang

View Articletitled, TBLR1 fuses to retinoid acid receptor α in a variant t(3;17)(q26;q21) translocation of acute promyelocytic leukemia

Supplemental data

PLATELETS AND THROMBOPOIESIS

Platelet diameters in inherited thrombocytopenias: analysis of 376 patients with all known disorders
e-blood

Patrizia Noris,Ginevra Biino,Alessandro Pecci,Elisa Civaschi,Anna Savoia,Marco Seri,Federica Melazzini,Giuseppe Loffredo,Giovanna Russo,Valeria Bozzi,Lucia Dora Notarangelo,Paolo Gresele,Paula G. Heller,Nuria Pujol-Moix,Shinji Kunishima,Marco Cattaneo,James Bussel,Erica De Candia,Claudia Cagioni,Ugo Ramenghi,Serena Barozzi,Fabrizio Fabris,Carlo L. Balduini

View Articletitled, Platelet diameters in inherited thrombocytopenias: analysis of 376 patients with all known disorders

RED CELLS, IRON, AND ERYTHROPOIESIS

Heme-bound iron activates placenta growth factor in erythroid cells via erythroid Krüppel-like factor

Xunde Wang,Laurel Mendelsohn,Heather Rogers,Susan Leitman,Nalini Raghavachari,Yanqin Yang,Yu Ying Yau,Michael Tallack,Andrew Perkins,James G. Taylor, VI,Constance Tom Noguchi,Gregory J. Kato

View Articletitled, Heme-bound iron activates placenta growth factor in erythroid cells via erythroid Krüppel-like factor

THROMBOSIS AND HEMOSTASIS

Rates, management, and outcome of rivaroxaban bleeding in daily care: results from the Dresden NOAC registry
Clinical Trials & Observations

Jan Beyer-Westendorf,Kati Förster,Sven Pannach,Franziska Ebertz,Vera Gelbricht,Christoph Thieme,Franziska Michalski,Christina Köhler,Sebastian Werth,Kurtulus Sahin,Luise Tittl,Ulrike Hänsel,Norbert Weiss

View Articletitled, Rates, management, and outcome of rivaroxaban bleeding in daily care: results from the Dresden NOAC registry

Supplemental data

TRANSPLANTATION

Bone marrow T-cell infiltration during acute GVHD is associated with delayed B-cell recovery and function after HSCT

Angela Mensen,Korinna Jöhrens,Ioannis Anagnostopoulos,Sonya Demski,Maike Oey,Andrea Stroux,Philipp Hemmati,Jörg Westermann,Olga Blau,Friedrich Wittenbecher,Kamran Movassaghi,Martin Szyska,Sybill Thomas,Bernd Dörken,Carmen Scheibenbogen,Renate Arnold,Il-Kang Na

View Articletitled, Bone marrow T-cell infiltration during acute GVHD is associated with delayed B-cell recovery and function after HSCT

Supplemental data

In utero depletion of fetal hematopoietic stem cells improves engraftment after neonatal transplantation in mice

S. Christopher Derderian,P. Priya Togarrati,Charmin King,Patriss W. Moradi,Damien Reynaud,Agnieszka Czechowicz,Irving L. Weissman,Tippi C. MacKenzie

View Articletitled, In utero depletion of fetal hematopoietic stem cells improves engraftment after neonatal transplantation in mice

Supplemental data

ERRATA

Kantarjian HM, Cortes JE, Kim D-W, et al. Bosutinib safety and management of toxicity in leukemia patients with resistance or intolerance to imatinib and other tyrosine kinase inhibitors. Blood. 2014;123(9):1309-1318.

View Articletitled, Kantarjian HM, Cortes JE, Kim D-W, et al. Bosutinib safety and management of toxicity in leukemia patients with resistance or intolerance to imatinib and other tyrosine kinase inhibitors. Blood. 2014;123(9):1309-1318.

Pandrea I, Cornell E, Wilson C, et al. Coagulation biomarkers predict disease progression in SIV-infected nonhuman primates. Blood. 2012;120(7):1357-1366.

View Articletitled, Pandrea I, Cornell E, Wilson C, et al. Coagulation biomarkers predict disease progression in SIV-infected nonhuman primates. Blood. 2012;120(7):1357-1366.

Giona F, Teofili L, Capodimonti S, et al. CALR mutations in patients with essential thrombocythemia diagnosed in childhood and adolescence. Blood. 2014;123(23):3677-3679.

View Articletitled, Giona F, Teofili L, Capodimonti S, et al. CALR mutations in patients with essential thrombocythemia diagnosed in childhood and adolescence. Blood. 2014;123(23):3677-3679.

Zhou Z, Sehn LH, Rademaker AW, et al. An enhanced International Prognostic Index (NCCN-IPI) for patients with diffuse large B-cell lymphoma treated in the rituximab era. Blood. 2014;123(6):837-842.

View Articletitled, Zhou Z, Sehn LH, Rademaker AW, et al. An enhanced International Prognostic Index (NCCN-IPI) for patients with diffuse large B-cell lymphoma treated in the rituximab era. Blood. 2014;123(6):837-842.

RETRACTIONS

Aprikyan AAG, Liles WC, Rodger E, Jonas M, Chi EY, Dale DC. Impaired survival of bone marrow hematopoietic progenitor cells in cyclic neutropenia. Blood. 2001;97(1):147-153.

View Articletitled, Aprikyan AAG, Liles WC, Rodger E, Jonas M, Chi EY, Dale DC. Impaired survival of bone marrow hematopoietic progenitor cells in cyclic neutropenia. Blood. 2001;97(1):147-153.

Cover Image

Cover Image

Heterodimerization with RXRα is important for RARα fusion proteins to bind retinoic acid responsive elements. In the image, 293T cells are transfected with the novel RXT and Flag-tagged TBLR1-RARα to determine whether the novel fusion protein could associate with RXRα to form heterodimers and whether all-trans retinoid acid (ATRA) affected heterodimer formation. Immunofluorescence assay demonstrates that the novel TBLR1-RARα fusion protein (red) co-localizes with RXRα (green) to form heterodimers, and the treatment of 1μM ATRA for 48h could not completely disassociate the TBLR1-RARα/RXRα complexes. See the article by Chen et al on page 936.
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Table of Contents

INSIDE BLOOD COMMENTARIES

Haploidentical transplantation: the search for the best donor Clinical Trials & Observations

Understanding sickle cell brain drain Clinical Trials & Observations

BLOOD WORK

Massive hemolysis and erythrophagocytosis in severe sepsis Clinical Trials & Observations

PLENARY PAPER

Who is the best donor for a related HLA haplotype-mismatched transplant? Clinical Trials & Observations

PLENARY PAPER

PERSPECTIVES

BLOOD SPOTLIGHT

REVIEW ARTICLE

Impact of iron overload and potential benefit from iron chelation in low-risk myelodysplastic syndrome Clinical Trials & Observations

HOW I TREAT

CLINICAL TRIALS AND OBSERVATIONS

Magnetic resonance imaging/angiography and transcranial Doppler velocities in sickle cell anemia: results from the SWiTCH trial Clinical Trials & Observations

A phase 2 single-center study of carfilzomib 56 mg/m2 with or without low-dose dexamethasone in relapsed multiple myeloma Clinical Trials & Observations

Trends in survival of patients with primary plasma cell leukemia: a population-based analysis Clinical Trials & Observations

GENE THERAPY

HEMATOPOIESIS AND STEM CELLS

MYELOID NEOPLASIA

PLATELETS AND THROMBOPOIESIS

Platelet diameters in inherited thrombocytopenias: analysis of 376 patients with all known disorders e-blood

RED CELLS, IRON, AND ERYTHROPOIESIS

THROMBOSIS AND HEMOSTASIS

Rates, management, and outcome of rivaroxaban bleeding in daily care: results from the Dresden NOAC registry Clinical Trials & Observations

TRANSPLANTATION

ERRATA

RETRACTIONS

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ASH Publications

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This Feature Is Available To Subscribers Only

Haploidentical transplantation: the search for the best donor
Clinical Trials & Observations

Understanding sickle cell brain drain
Clinical Trials & Observations

Massive hemolysis and erythrophagocytosis in severe sepsis
Clinical Trials & Observations

Who is the best donor for a related HLA haplotype-mismatched transplant?
Clinical Trials & Observations

Impact of iron overload and potential benefit from iron chelation in low-risk myelodysplastic syndrome
Clinical Trials & Observations

Magnetic resonance imaging/angiography and transcranial Doppler velocities in sickle cell anemia: results from the SWiTCH trial
Clinical Trials & Observations

A phase 2 single-center study of carfilzomib 56 mg/m² with or without low-dose dexamethasone in relapsed multiple myeloma
Clinical Trials & Observations

Trends in survival of patients with primary plasma cell leukemia: a population-based analysis
Clinical Trials & Observations

Platelet diameters in inherited thrombocytopenias: analysis of 376 patients with all known disorders
e-blood

Rates, management, and outcome of rivaroxaban bleeding in daily care: results from the Dresden NOAC registry
Clinical Trials & Observations