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Shown to the left is the ¹H-¹⁵N NMR correlation spectrum of the von Willebrand factor TIL′E′ domains. On the right is the 3-dimensional structure of TIL′E′ with the 2 domains colored pale blue (TIL′) and salmon (E′). The locations of the type 2N von Willebrand disease missense mutations are shown in green (noncysteine) and black (cysteine) on the structure. See the article by Shiltagh et al on page 4143.