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No BS! Bleeding scores predict future bleeding
Valproic acid in combination with all-trans retinoic acid and intensive therapy for acute myeloid leukemia in older patients
The bleeding score predicts clinical outcomes and replacement therapy in adults with von Willebrand disease
Phase 2 randomized study of bortezomib-melphalan-prednisone with or without siltuximab (anti–IL-6) in multiple myeloma
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INSIDE BLOOD COMMENTARIES
INSIDE BLOOD COMMENTARY
No BS! Bleeding scores predict future bleeding
Clinical Trials & Observations
BLOOD WORK
PLENARY PAPER
HOW I TREAT
CLINICAL TRIALS AND OBSERVATIONS
Valproic acid in combination with all-trans retinoic acid and intensive therapy for acute myeloid leukemia in older patients
Clinical Trials & Observations
Michela Tassara,Konstanze Döhner,Peter Brossart,Gerhard Held,Katharina Götze,Heinz-A. Horst,Mark Ringhoffer,Claus-Henning Köhne,Stephan Kremers,Aruna Raghavachar,Gerald Wulf,Heinz Kirchen,David Nachbaur,Hans Günter Derigs,Mohammed Wattad,Elisabeth Koller,Wolfram Brugger,Axel Matzdorff,Richard Greil,Gerhard Heil,Peter Paschka,Verena I. Gaidzik,Martin Göttlicher,Hartmut Döhner,Richard F. Schlenk
The bleeding score predicts clinical outcomes and replacement therapy in adults with von Willebrand disease
Clinical Trials & Observations
Augusto B. Federici,Paolo Bucciarelli,Giancarlo Castaman,Maria G. Mazzucconi,Massimo Morfini,Angiola Rocino,Mario Schiavoni,Flora Peyvandi,Francesco Rodeghiero,Pier Mannuccio Mannucci
Phase 2 randomized study of bortezomib-melphalan-prednisone with or without siltuximab (anti–IL-6) in multiple myeloma
Clinical Trials & Observations
Jesús San-Miguel,Joan Bladé,Ofer Shpilberg,Sebastian Grosicki,Frédéric Maloisel,Chang-Ki Min,Marta Polo Zarzuela,Tadeusz Robak,Sripada V. S. S. Prasad,Yeow Tee Goh,Jacob Laubach,Andrew Spencer,María-Victoria Mateos,Antonio Palumbo,Tom Puchalski,Manjula Reddy,Clarissa Uhlar,Xiang Qin,Helgi van de Velde,Hong Xie,Robert Z. Orlowski
GENE THERAPY
Omental implantation of BOECs in hemophilia dogs results in circulating FVIII antigen and a complex immune response
Margareth C. Ozelo,Barbara Vidal,Christine Brown,Colleen Notley,Carol Hegadorn,Sandra Webster,Lori Harpell,James Ahlin,Andrew Winterborn,Janine Handforth,Valder R. Arruda,Christine Hough,David Lillicrap
HEMATOPOIESIS AND STEM CELLS
IMMUNOBIOLOGY
Leukocytes require ADAM10 but not ADAM17 for their migration and inflammatory recruitment into the alveolar space
Jessica Pruessmeyer,Franz Martin Hess,Henriette Alert,Esther Groth,Tobias Pasqualon,Nicole Schwarz,Stella Nyamoya,Jos Kollert,Emiel van der Vorst,Marjo Donners,Christian Martin,Stefan Uhlig,Paul Saftig,Daniela Dreymueller,Andreas Ludwig
LYMPHOID NEOPLASIA
Trisomy 12 chronic lymphocytic leukemia cells exhibit upregulation of integrin signaling that is modulated by NOTCH1 mutations
John C. Riches,Conor J. O’Donovan,Sarah J. Kingdon,Fabienne McClanahan,Andrew J. Clear,Donna S. Neuberg,Lillian Werner,Carlo M. Croce,Alan G. Ramsay,Laura Z. Rassenti,Thomas J. Kipps,John G. Gribben
C1013G/CXCR4 acts as a driver mutation of tumor progression and modulator of drug resistance in lymphoplasmacytic lymphoma
Aldo M. Roccaro,Antonio Sacco,Cristina Jimenez,Patricia Maiso,Michele Moschetta,Yuji Mishima,Yosra Aljawai,Ilyas Sahin,Michelle Kuhne,Pina Cardarelli,Lewis Cohen,Jesus F. San Miguel,Ramon Garcia-Sanz,Irene M. Ghobrial
THROMBOSIS AND HEMOSTASIS
ERRATA
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Cover Image
Cover Image
Shown to the left is the 1H-15N NMR correlation spectrum of the von Willebrand factor TIL′E′ domains. On the right is the 3-dimensional structure of TIL′E′ with the 2 domains colored pale blue (TIL′) and salmon (E′). The locations of the type 2N von Willebrand disease missense mutations are shown in green (noncysteine) and black (cysteine) on the structure. See the article by Shiltagh et al on page 4143.
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