Francisco Cervantes,on behalf of the COMFORT-II investigators,Alessandro M. Vannucchi,on behalf of the COMFORT-II investigators,Jean-Jacques Kiladjian,on behalf of the COMFORT-II investigators,Haifa Kathrin Al-Ali,on behalf of the COMFORT-II investigators,Andres Sirulnik,on behalf of the COMFORT-II investigators,Viktoriya Stalbovskaya,on behalf of the COMFORT-II investigators,Mari McQuitty,on behalf of the COMFORT-II investigators,Deborah S. Hunter,on behalf of the COMFORT-II investigators,Richard S. Levy,on behalf of the COMFORT-II investigators,Francesco Passamonti,on behalf of the COMFORT-II investigators,Tiziano Barbui,on behalf of the COMFORT-II investigators,Giovanni Barosi,on behalf of the COMFORT-II investigators,Claire N. Harrison,on behalf of the COMFORT-II investigators,Laurent Knoops,on behalf of the COMFORT-II investigators,Heinz Gisslinger,on behalf of the COMFORT-II investigators

View Articletitled, Three-year efficacy, safety, and survival findings from COMFORT-II, a phase 3 study comparing ruxolitinib with best available therapy for myelofibrosis

Supplemental data

IMMUNOBIOLOGY

Angiogenic capacity of M1- and M2-polarized macrophages is determined by the levels of TIMP-1 complexed with their secreted proMMP-9

Ewa Zajac,Bernhard Schweighofer,Tatyana A. Kupriyanova,Anna Juncker-Jensen,Petra Minder,James P. Quigley,Elena I. Deryugina

View Articletitled, Angiogenic capacity of M1- and M2-polarized macrophages is determined by the levels of TIMP-1 complexed with their secreted proMMP-9

Supplemental data

LYMPHOID NEOPLASIA

Germline and somatic genetic variations of TNFAIP3 in lymphoma complicating primary Sjögren’s syndrome

Gaetane Nocturne,Saida Boudaoud,Corinne Miceli-Richard,Say Viengchareun,Thierry Lazure,Joanne Nititham,Kimberly E. Taylor,Averil Ma,Florence Busato,Judith Melki,Christopher J. Lessard,Kathy L. Sivils,Jean-Jacques Dubost,Eric Hachulla,Jacques Eric Gottenberg,Marc Lombès,Jorg Tost,Lindsey A. Criswell,Xavier Mariette

View Articletitled, Germline and somatic genetic variations of TNFAIP3 in lymphoma complicating primary Sjögren’s syndrome

Supplemental data

Deep sequencing of the T-cell receptor repertoire in CD8⁺ T-large granular lymphocyte leukemia identifies signature landscapes

Michael J. Clemente,Bartlomiej Przychodzen,Andres Jerez,Brittney E. Dienes,Manuel G. Afable,Holleh Husseinzadeh,Hanna L. M. Rajala,Marcin W. Wlodarski,Satu Mustjoki,Jaroslaw P. Maciejewski

View Articletitled, Deep sequencing of the T-cell receptor repertoire in CD8+ T-large granular lymphocyte leukemia identifies signature landscapes

Supplemental data

MYELOID NEOPLASIA

A DNMT3A mutation common in AML exhibits dominant-negative effects in murine ES cells
Brief Report

Soo Jin Kim,Hongbo Zhao,Swanand Hardikar,Anup Kumar Singh,Margaret A. Goodell,Taiping Chen

View Articletitled, A DNMT3A mutation common in AML exhibits dominant-negative effects in murine ES cells

Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

Genome-wide methylation analyses of primary human leukocyte subsets identifies functionally important cell-type–specific hypomethylated regions
e-blood

Matthias Zilbauer,Tim F. Rayner,Christine Clark,Alison J. Coffey,Chris J. Joyce,Priit Palta,Aarno Palotie,Paul A. Lyons,Kenneth G. C. Smith

View Articletitled, Genome-wide methylation analyses of primary human leukocyte subsets identifies functionally important cell-type–specific hypomethylated regions

Supplemental data

PLATELETS AND THROMBOPOIESIS

Enrichment of FLI1 and RUNX1 mutations in families with excessive bleeding and platelet dense granule secretion defects
Brief Report

Jacqueline Stockley,on behalf of the UK Genotyping and Phenotyping of Platelets Study Group,Neil V. Morgan,on behalf of the UK Genotyping and Phenotyping of Platelets Study Group,Danai Bem,on behalf of the UK Genotyping and Phenotyping of Platelets Study Group,Gillian C. Lowe,on behalf of the UK Genotyping and Phenotyping of Platelets Study Group,Marie Lordkipanidzé,on behalf of the UK Genotyping and Phenotyping of Platelets Study Group,Ban Dawood,on behalf of the UK Genotyping and Phenotyping of Platelets Study Group,Michael A. Simpson,on behalf of the UK Genotyping and Phenotyping of Platelets Study Group,Kirsty Macfarlane,on behalf of the UK Genotyping and Phenotyping of Platelets Study Group,Kevin Horner,on behalf of the UK Genotyping and Phenotyping of Platelets Study Group,Vincenzo C. Leo,on behalf of the UK Genotyping and Phenotyping of Platelets Study Group,Katherine Talks,on behalf of the UK Genotyping and Phenotyping of Platelets Study Group,Jayashree Motwani,on behalf of the UK Genotyping and Phenotyping of Platelets Study Group,Jonathan T. Wilde,on behalf of the UK Genotyping and Phenotyping of Platelets Study Group,Peter W. Collins,on behalf of the UK Genotyping and Phenotyping of Platelets Study Group,Michael Makris,on behalf of the UK Genotyping and Phenotyping of Platelets Study Group,Steve P. Watson,on behalf of the UK Genotyping and Phenotyping of Platelets Study Group,Martina E. Daly,on behalf of the UK Genotyping and Phenotyping of Platelets Study Group

View Articletitled, Enrichment of FLI1 and RUNX1 mutations in families with excessive bleeding and platelet dense granule secretion defects

Supplemental data

THROMBOSIS AND HEMOSTASIS

Desmolaris, a novel factor XIa anticoagulant from the salivary gland of the vampire bat (Desmodus rotundus) inhibits inflammation and thrombosis in vivo

Dongying Ma,Daniella M. Mizurini,Teresa C. F. Assumpção,Yuan Li,Yanwei Qi,Michail Kotsyfakis,José M. C. Ribeiro,Robson Q. Monteiro,Ivo M. B. Francischetti

View Articletitled, Desmolaris, a novel factor XIa anticoagulant from the salivary gland of the vampire bat (Desmodus rotundus) inhibits inflammation and thrombosis in vivo

Supplemental data

Altered glycosylation of platelet-derived von Willebrand factor confers resistance to ADAMTS13 proteolysis
Brief Report

Rachel T. McGrath,Maartje van den Biggelaar,Barry Byrne,Jamie M. O’Sullivan,Orla Rawley,Richard O’Kennedy,Jan Voorberg,Roger J. S. Preston,James S. O’Donnell

View Articletitled, Altered glycosylation of platelet-derived von Willebrand factor confers resistance to ADAMTS13 proteolysis

TRANSPLANTATION

Long-term outcome and prospective validation of NIH response criteria in 39 patients receiving imatinib for steroid-refractory chronic GVHD
Clinical Trials & Observations

Attilio Olivieri,Michele Cimminiello,Paolo Corradini,Nicola Mordini,Roberta Fedele,Carmine Selleri,Francesco Onida,Francesca Patriarca,Enzo Pavone,Silvia Svegliati,Armando Gabrielli,Paola Bresciani,Roberta Nuccorini,Sara Pascale,Sabrina Coluzzi,Fabrizio Pane,Antonella Poloni,Jacopo Olivieri,Pietro Leoni,Andrea Bacigalupo

View Articletitled, Long-term outcome and prospective validation of NIH response criteria in 39 patients receiving imatinib for steroid-refractory chronic GVHD

Supplemental data

The histone methyltransferase Ezh2 is a crucial epigenetic regulator of allogeneic T-cell responses mediating graft-versus-host disease

Shan He,Fang Xie,Yongnian Liu,Qing Tong,Kazuhiro Mochizuki,Philip E. Lapinski,Ram-Shankar Mani,Pavan Reddy,Izumi Mochizuki,Arul M. Chinnaiyan,Shin Mineishi,Philip D. King,Yi Zhang

View Articletitled, The histone methyltransferase Ezh2 is a crucial epigenetic regulator of allogeneic T-cell responses mediating graft-versus-host disease

Supplemental data

Donor-derived CD19-targeted T cells cause regression of malignancy persisting after allogeneic hematopoietic stem cell transplantation

James N. Kochenderfer,Mark E. Dudley,Robert O. Carpenter,Sadik H. Kassim,Jeremy J. Rose,William G. Telford,Frances T. Hakim,David C. Halverson,Daniel H. Fowler,Nancy M. Hardy,Anthony R. Mato,Dennis D. Hickstein,Juan C. Gea-Banacloche,Steven Z. Pavletic,Claude Sportes,Irina Maric,Steven A. Feldman,Brenna G. Hansen,Jennifer S. Wilder,Bazetta Blacklock-Schuver,Bipulendu Jena,Michael R. Bishop,Ronald E. Gress,Steven A. Rosenberg

View Articletitled, Donor-derived CD19-targeted T cells cause regression of malignancy persisting after allogeneic hematopoietic stem cell transplantation

Supplemental data

VASCULAR BIOLOGY

A critical role for Lyn kinase in strengthening endothelial integrity and barrier function

Jingyan Han,Guoying Zhang,Emily J. Welch,Ying Liang,Jian Fu,Stephen M. Vogel,Clifford A. Lowell,Xiaoping Du,David A. Cheresh,Asrar B. Malik,Zhenyu Li

View Articletitled, A critical role for Lyn kinase in strengthening endothelial integrity and barrier function

Supplemental data

Cover Image

Cover Image

Immunohistochemical staining of the colon demonstrates gut-associated lymphoid reconstitution of a TKO-BLT mouse 22 weeks after humanization. Shown is a transverse section of the large intestine, containing human class I MHC expressing leukocytes (brown) interspersed within the murine intestinal mucosa (blue). See the article by Lavender et al on page 4013.
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INSIDE BLOOD

BLOOD WORK

PLENARY PAPER

PERSPECTIVES

REVIEW ARTICLE

CLINICAL TRIALS AND OBSERVATIONS

Three-year efficacy, safety, and survival findings from COMFORT-II, a phase 3 study comparing ruxolitinib with best available therapy for myelofibrosis Clinical Trials & Observations

IMMUNOBIOLOGY

LYMPHOID NEOPLASIA

MYELOID NEOPLASIA

A DNMT3A mutation common in AML exhibits dominant-negative effects in murine ES cells Brief Report

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

Genome-wide methylation analyses of primary human leukocyte subsets identifies functionally important cell-type–specific hypomethylated regions e-blood

PLATELETS AND THROMBOPOIESIS

Enrichment of FLI1 and RUNX1 mutations in families with excessive bleeding and platelet dense granule secretion defects Brief Report

THROMBOSIS AND HEMOSTASIS

Altered glycosylation of platelet-derived von Willebrand factor confers resistance to ADAMTS13 proteolysis Brief Report

TRANSPLANTATION

Long-term outcome and prospective validation of NIH response criteria in 39 patients receiving imatinib for steroid-refractory chronic GVHD Clinical Trials & Observations

VASCULAR BIOLOGY

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Three-year efficacy, safety, and survival findings from COMFORT-II, a phase 3 study comparing ruxolitinib with best available therapy for myelofibrosis
Clinical Trials & Observations

A DNMT3A mutation common in AML exhibits dominant-negative effects in murine ES cells
Brief Report

Genome-wide methylation analyses of primary human leukocyte subsets identifies functionally important cell-type–specific hypomethylated regions
e-blood

Enrichment of FLI1 and RUNX1 mutations in families with excessive bleeding and platelet dense granule secretion defects
Brief Report

Altered glycosylation of platelet-derived von Willebrand factor confers resistance to ADAMTS13 proteolysis
Brief Report

Long-term outcome and prospective validation of NIH response criteria in 39 patients receiving imatinib for steroid-refractory chronic GVHD
Clinical Trials & Observations