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Cover Image

Pictured are adult zebrafish (Danio rerio) superimposed on a background of zebrafish erythrocytes, which are nucleated like those of most vertebrates, in contrast to mammalian erythrocytes. The genetic programs for hematopoiesis and lineage differentiation are highly conserved, making zebrafish an excellent model organism for studying the genetics and developmental biology of the blood system. Here, researchers show the function of friend of GATA-1 (FOG-1) in blood lineage differentiation and its regulation by GATA-1 in the zebrafish. See the article by Amigo et al on page 4654. Artwork and photograph courtesy of Lisa Sherman and A. Joseph Dalton.
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Targeting DOT1L and EZH2 synergizes in breaking the germinal center identity of Diffuse Large B-cell Lymphoma

High-throughput drug screening identifies SMAC mimetics as enhancers of NK cell cytotoxicity in chronic myeloid leukemia

Donor Regulatory T-Cell Therapy to Prevent Graft-Versus-Host Disease

Epcoritamab plus GemOx in transplant-ineligible relapsed/refractory DLBCL: results from the EPCORE NHL-2 trial

Doubling down on GPRC5D in multiple myeloma

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Table of Contents

INSIDE BLOOD

Macrophage fusion cuisine

IG genes and hairy cell leukemia

Cracking the platelet WIP

REVIEW ARTICLES

Mechanisms underlying neutrophil-mediated monocyte recruitment

HOW I TREAT

How I treat postthrombotic syndrome

CLINICAL TRIALS AND OBSERVATIONS

Serum ferritin level changes in children with sickle cell disease on chronic blood transfusion are nonlinear and are associated with iron load and liver injury
Clinical Trials & Observations

Relationship of erythropoietin, fetal hemoglobin, and hydroxyurea treatment to tricuspid regurgitation velocity in children with sickle cell disease
Clinical Trials & Observations

HEMATOPOIESIS AND STEM CELLS

Identification of novel regulators of hematopoietic stem cell development through refinement of stem cell localization and expression profiling

The role and regulation of friend of GATA-1 (FOG-1) during blood development in the zebrafish

IMMUNOBIOLOGY

Alternatively activated macrophages engage in homotypic and heterotypic interactions through IL-4 and polyamine-induced E-cadherin/catenin complexes

LYMPHOID NEOPLASIA

High TCL1 levels are a marker of B-cell receptor pathway responsiveness and adverse outcome in chronic lymphocytic leukemia

VH4-34⁺ hairy cell leukemia, a new variant with poor prognosis despite standard therapy

Hairy cell leukemias with unmutated IGHV genes define the minor subset refractory to single-agent cladribine and with more aggressive behavior

TAPP2 links phosphoinositide 3-kinase signaling to B-cell adhesion through interaction with the cytoskeletal protein utrophin: expression of a novel cell adhesion-promoting complex in B-cell leukemia

Follicular lymphoma cells induce T-cell immunologic synapse dysfunction that can be repaired with lenalidomide: implications for the tumor microenvironment and immunotherapy

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

The transcription factors STAT5A/B regulate GM-CSF–mediated granulopoiesis

PLATELETS AND THROMBOPOIESIS

Platelet-associated IgAs and impaired GPVI responses in platelets lacking WIP

THROMBOSIS AND HEMOSTASIS

Platelet protein disulfide isomerase is localized in the dense tubular system and does not become surface expressed after activation
Brief Report

A role for thrombin in the initiation of the immune response to therapeutic factor VIII

Mutation of the H-bond acceptor S119 in the ADAMTS13 metalloprotease domain reduces secretion and substrate turnover in a patient with congenital thrombotic thrombocytopenic purpura
Brief Report

CORRESPONDENCE

Limited role of MHC class I chain–related gene A (MICA) typing in assessing graft-versus-host disease risk after fully human leukocyte antigen–matched unrelated donor transplantation

Response: MHC class I chain–related gene A (MICA) in unrelated donor transplantation

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Table of Contents

INSIDE BLOOD

REVIEW ARTICLES

HOW I TREAT

CLINICAL TRIALS AND OBSERVATIONS

Serum ferritin level changes in children with sickle cell disease on chronic blood transfusion are nonlinear and are associated with iron load and liver injury Clinical Trials & Observations

Relationship of erythropoietin, fetal hemoglobin, and hydroxyurea treatment to tricuspid regurgitation velocity in children with sickle cell disease Clinical Trials & Observations

HEMATOPOIESIS AND STEM CELLS

IMMUNOBIOLOGY

LYMPHOID NEOPLASIA

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

PLATELETS AND THROMBOPOIESIS

THROMBOSIS AND HEMOSTASIS

Platelet protein disulfide isomerase is localized in the dense tubular system and does not become surface expressed after activation Brief Report

Mutation of the H-bond acceptor S119 in the ADAMTS13 metalloprotease domain reduces secretion and substrate turnover in a patient with congenital thrombotic thrombocytopenic purpura Brief Report

CORRESPONDENCE

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ASH Publications

American Society of Hematology

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Serum ferritin level changes in children with sickle cell disease on chronic blood transfusion are nonlinear and are associated with iron load and liver injury
Clinical Trials & Observations

Relationship of erythropoietin, fetal hemoglobin, and hydroxyurea treatment to tricuspid regurgitation velocity in children with sickle cell disease
Clinical Trials & Observations

Platelet protein disulfide isomerase is localized in the dense tubular system and does not become surface expressed after activation
Brief Report

Mutation of the H-bond acceptor S119 in the ADAMTS13 metalloprotease domain reduces secretion and substrate turnover in a patient with congenital thrombotic thrombocytopenic purpura
Brief Report