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Issue Archive

Volume 9, Issue 18
September 23 2025
Blood Advances Cover Image for Volume 9, Issue 18

Table of Contents

INSIDE BLOOD ADVANCES

A standardized metric to define a successful transition from pediatric to adult care in sickle cell disease
Galia Pollock,Susanna Curtis
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BaR-based cryo-EM of platelet integrin αIIbβ3
Sneha Singh,Arijit Biswas
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Weighing the evidence: apixaban for pediatric leukemia
Leslie Raffini,Hilary Whitworth
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Gene-edited CAR T cells: going the distance in B-ALL
Clinical Trials & Observations
John A. Ligon,Nirali N. Shah
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ADVANCES VIEWPOINT

Therapeutic innovations in hemophilia: the essential role of a positive reinvestment cycle
Cedric Hermans,Glenn F. Pierce
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Immunoglobulin prophylaxis should be initiated after bispecific antibody therapy in multiple myeloma, regardless of IgG levels
Rahul Banerjee,Meera Mohan,Kai Rejeski,Benjamin R. Puliafito,Diana D. Cirstea,Gurbakhash Kaur,Shonali Midha,Georgia J. McCaughan,Nikhil M. Kumar,Nikita Mehra,Bhausaheb Bagal,Noopur S. Raje
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CLINICAL TRIALS AND OBSERVATIONS

Efficacy and safety of BCMA nanobody CAR T-cell therapy in relapsed or refractory plasma cell myeloma
Clinical Trials & Observations
Xian Zhang,Lin Wang,Junfang Yang,Xiaona N. Hu,Hui Wang,Lina N. Zhang,Xiaoge Zhou,Ying Liu,Qinglong Wang,Pei H. Lu
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Supplemental data
Prospective study of immunogenicity to SARS-CoV-2 booster vaccines in multiple myeloma and Waldenström macroglobulinemia
Clinical Trials & Observations
Andrew R. Branagan,Clifton Mo,Matthew Lei,Joshua N. Gustine,Andrew J. Yee,Elizabeth O’Donnell,Jorge J. Castillo,Omar Nadeem,Catherine Flynn,Zachary Bernstein,Rie Nakamoto-Matsubara,Kirsten Meid,Rakesh Verma,Zachary R. Hunter,Maria L. Guerrera,Galit Alter,Jill Burke,Cynthia Harrington,Emerentia Agyemang,Marilyn Gammon,Kathleen Lively,Lisette Packer,Nora Horick,Jacob Laubach,Constantine S. Mitsiades,Nikhil Munshi,Kenneth C. Anderson,Steven P. Treon,Paul G. Richardson,Noopur S. Raje,Shayna R. Sarosiek
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Age-adjusted dosing of fludarabine for lymphodepletion in CAR T-cell therapy: a clinical trial simulation study
Clinical Trials & Observations
John C. Panetta,Aimee C. Talleur,Swati Naik,Stephen Gottschalk,Markos Leggas
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Supplemental data
Ibrutinib plus rituximab vs ibrutinib monotherapy in patients with Waldenström macroglobulinemia: a pooled analysis
Clinical Trials & Observations
Alberto Guijosa,Andres Ramirez-Gamero,Shayna Sarosiek,Andrew R. Branagan,Gottfried von Keudell,Steven P. Treon,Jorge J. Castillo
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HEALTH SERVICES AND OUTCOMES

Inequalities in CAR T-cell therapy access for US patients with relapsed/refractory DLBCL: a SEER-Medicare data analysis
Andrea P. Chung,Jason T. Shafrin,Sachin Vadgama,Kristen Hurley,Miguel-Angel Perales,Leonard C. Alsfeld,Sanjana Muthukrishnan,Anik R. Patel,Gunjan L. Shah,Richard T. Maziarz
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Supplemental data

LYMPHOID NEOPLASIA

Maintenance therapy with romidepsin after autologous stem-cell transplant for peripheral T-cell lymphoma
Niloufer Khan,Parastoo B. Dahi,Farhad Khimani,Andrei R. Shustov,Mazyar Shadman,Jia Ruan,Alison J. Moskowitz,Andrew D. Zelenetz,Ariela Noy,David J. Straus,Pamela Drullinsky,Audrey Hamilton,Anita Kumar,Craig S. Sauter,Gunjan L. Shah,Matthew J. Matasar,Esther Drill,Theresa Davey,Helen Hancock,Nivetha Ganesan,Natasha Galasso,Koen van Beisen,Sergio Giralt,Steven M. Horwitz
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Supplemental data
TRANSCAR: real-world outcomes of CD19 CAR T-cell therapy in relapsed/refractory transformed indolent lymphomas
Clinical Trials & Observations
Pierre Stephan,Roberta Di Blasi,Louise Roulin,Jean Galtier,Julien Calvani,Véronique Meignin,Marie Donzel,Alexandra Traverse-Glehen,Elsa Poullot,Marie Parrens,Vivien Dupont,Alexandra Marquet,Steven Le Gouill,Roch Houot,Francois-Xavier Gros,François Lemonnier,Emmanuel Bachy,Catherine Thieblemont,Pierre Sesques
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Supplemental data

PLASMA CELL DISORDERS

Sequential BCMA CAR T-cell therapy in refractory multiple myeloma
Tim Richardson,Udo Holtick,Jan-Hendrik Frenking,Hishan Tharmaseelan,Hyatt Balke-Want,Ruth Flümann,Elias Karl Mai,Sandra Sauer,Raphael Teipel,Malte von Bonin,Michael Hallek,Christof Scheid,Philipp Gödel
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PLATELETS AND THROMBOPOIESIS

Elucidating the dynamics of integrin αIIbβ3 from native platelet membranes by cryo-EM with build-and-retrieve method
Xu Han,Zhemin Zhang,Chih-Chia Su,Meinan Lyu,Masaru Miyagi,Edward Yu,Marvin T. Nieman
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Supplemental data
BaR-based cryo-EM of platelet integrin αIIbβ3
Sneha Singh,Arijit Biswas
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RED CELLS, IRON, AND ERYTHROPOIESIS

National Alliance of Sickle Cell Centers consensus standards for transition to adult care in sickle cell disease
Stephanie Howe Guarino,Akshat Jain,Mohan Madisetti,Kenneth Rivlin,Payal C. Desai,Julie Kanter,Sophie Lanzkron,Deepa Manwani
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Supplemental data
A standardized metric to define a successful transition from pediatric to adult care in sickle cell disease
Galia Pollock,Susanna Curtis
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Sex and genotype specificities of microvasculature and muscle remodeling in sub-Saharan sickle cell trait and disease
Léo Blervaque,Pablo Bartolucci,Manon Riccetti,Marion Ravelojaona,Angèle N. Merlet,Mathilde Noguer,Manon Rojo,Christophe Hourdé,Cyril Martin,Vincent Pialoux,Barnabas Gellen,Frédéric Galactéros,Samuel Oyono-Enguéllé,Léonard Féasson,Laurent A. Messonnier,for the SAM and EXDRE Collaborative Study Groups
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Supplemental data

THROMBOSIS AND HEMOSTASIS

Deleting ACC1 in platelets alters phospholipidome and reduces platelet activation and thrombosis in mice
Marie Octave,Laurence Pirotton,Emma de Cartier d’Yves,Alice Marino,Jérôme Ambroise,Martin Giera,Bruno Guigas,Audrey Ginion,Valentine Robaux,Marijke Kuijpers,Constance Baaten,Johan W. M. Heemskerk,Zoltan Nagy,Yotis Senis,Davide Brusa,Caroline Bouzin,Luc Bertrand,Christophe Beauloye,Sandrine Horman
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Supplemental data
Safety and efficacy of apixaban thrombosis prevention in pediatric patients with obesity and acute lymphoblastic leukemia
Vilmarie Rodriguez,Sarah H. O'Brien,Etan Orgel,Corinna L. Schultz,Adam J. Esbenshade,Arteid Memaj,Joshua L. Dyme,Nicholas A. Favatella,Lesley G. Mitchell,on behalf of the PREVAPIX-ALL investigators
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Supplemental data
Weighing the evidence: apixaban for pediatric leukemia
Leslie Raffini,Hilary Whitworth
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TRANSPLANTATION

Refinement of day 28 treatment response criteria for acute GVHD: a collaboration study of the JSTCT and MAGIC
Yu Akahoshi,Yoshihiro Inamoto,Nikolaos Spyrou,Hideki Nakasone,Marcio A. Diniz,Noboru Asada,Francis Ayuk,Hannah K. Choe,Noriko Doki,Tetsuya Eto,Aaron M. Etra,Elizabeth O. Hexner,Nobuhiro Hiramoto,William J. Hogan,Ernst Holler,Keisuke Kataoka,Toshiro Kawakita,Masatsugu Tanaka,Takashi Tanaka,Naoyuki Uchida,Ingrid Vasova,Satoshi Yoshihara,Fumihiko Ishimaru,Takahiro Fukuda,Yi-Bin Chen,Junya Kanda,Ryotaro Nakamura,Yoshiko Atsuta,James L. M. Ferrara,Yoshinobu Kanda,John E. Levine,Takanori Teshima,on behalf of the JSTCT and MAGIC
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Supplemental data

RESEARCH LETTERS

Asciminib for relapsed or refractory Philadelphia chromosome–positive acute lymphoblastic leukemia
Clinical Trials & Observations
Mathilde Chanut,Aurélie Cabannes-Hamy,Marie Balsat,Nassim Sahki,Emmanuel Raffoux,Yosr Hicheri,Bruno Lioure,Lucie Laemmel,Thibaut Leguay,Victoria Cacheux,Maria Pilar Gallego-Hernanz,Andrea Pieragostini,Gabrielle Roth-Guepin,Ludovic Gabellier,Nathalie Denizon,Lise Willems,Quentin Cabrera,Sylvain Chantepie,Valérie Coiteux,Claudie Capdupuy,Martin Carré,Antoine Machet,Juliette Lambert,Sandrine Roux,Franck-Emmanuel Nicolini,Nicolas Boissel,Emmanuelle Clappier,Rathana Kim,Philippe Rousselot
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Supplemental data
PROM1/CD133 marks a proliferative stem cell-like population of blasts in KMT2A rearranged infant ALL
Joe Wilson Cross,Lucy Field,Alastair Smith,Emily Neil,Lucy Hamer,Thomas Jackson,Natalina Elliott,Siobhan Rice,Nicholas Crump,Joe Harman,Rebecca E. Ling,Qingqing Wu,Nouhad El Ouazzani,Rebecca Thomas,Sarah Inglott,Jack Bartram,Owen Smith,Jonathan Bond,Irene Roberts,Thomas A. Milne,Anindita Roy
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Supplemental data
Bing-Neel syndrome: a case series of 46 patients from the United Kingdom
Clinical Trials & Observations
Oliver Tomkins,Jahanzaib Khwaja,Shiwen Koay,Nicole Japzon,Chandrashekar Hoskote,Rajeev Gupta,Robert Baker,Jindriska Lindsay,Charalampia Kyriakou,Michael P. Lunn,Shirley D’Sa
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Serum TARC: a biomarker for early detection or exclusion of relapse in classic Hodgkin lymphoma
Sophie A. Teesink,Lydia Visser,Marcel Nijland,Kylie Keijzer,Anne G. H. Niezink,Bart-Jan Kroesen,Anke van den Berg,Arjan Diepstra,Wouter J. Plattel
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Supplemental data
Platelet glycosylation in myelodysplastic syndromes correlates with disease severity
Katelyn E. Rosenbalm,Tin Long Wong,Donny Hoang,Valerie L. Andersen,George Steinhardt,Shikan Zheng,Elizabeth A. Griffiths,Tongjun Gu,Karin M. Hoffmeister,Joseph T. Y. Lau,Michael J. Nemeth
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Supplemental data
Estimation of benefit to bispecific antibodies in US patients with lymphoma and multiple myeloma
Fausto Alfredo Rios-Olais,Talal Hilal
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Supplemental data
Genetic variation at PPM1H predicts mobilization efficiency in stem cell donors
Yen Phuong La,Daniela Torres Di Bello,Maria Laura Mahecha Escobar,Caterina Cafaro,Stina Wichert,Aitzkoa Lopez de Lapuente Portilla,Björn Nilsson
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Supplemental data
Can baseline cytomegalovirus IgG titers predict cytomegalovirus reactivation after ide-cel therapy?
Taku Kikuchi,Ukyo Kondo,Shotaro Sugita,Miyu Watanabe,Chiaki Matsumoto,Moe Nomura-Yogo,Kodai Kunisada,Haruka Sawada,Kota Sato,Tomomi Takei,Mizuki Ogura,Yu Abe,Kenshi Suzuki,Osamu Hosoya,Tadao Ishida,Nobuhiro Tsukada
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Supplemental data
Long-term outcomes of genome-edited “universal” CAR19 T cells for relapsed/refractory B-ALL at a single pediatric center
Clinical Trials & Observations
Daniela Guardo,Avijeet Kumar Mishra,Hebatalla Rashed,Kimberly Gilmour,Stuart Adams,Danielle Pinner,Martin Sauer,Ajay Vora,Paul Veys,Vesna Pavasovic,Kanchan Rao,Waseem Qasim
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Supplemental data
Gene-edited CAR T cells: going the distance in B-ALL
Clinical Trials & Observations
John A. Ligon,Nirali N. Shah
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LETTER TO THE EDITOR

Comments and concerns on the analysis of DAPS-ITP trial
Aarti Vibhakar,Shaan D. Shah,Ashwin Patel
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  • Cover Image

    Cover Image

    issue cover

    Han et al report the first structural analysis of platelet membrane proteins directly from human platelets. Their structural-omics approach determined the structure integrin αIIbβ3 in its inactivated and intermediate states from resting human platelets. They also uncovered a novel homodimer conformation. The image shows the dimer interface formed by 2 αIIb subunits from 2 individual integrin αIIbβ3 molecules in the intermediate state. The residues at the dimer interface are colored in red. See the article by Han et al.

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