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Issue Archive

Volume 8, Issue 19
October 8 2024
Issue Cover

Table of Contents

INSIDE BLOOD ADVANCES

Bridging radiotherapy before CAR-T therapy in CNS lymphoma
Clinical Trials & Observations
Ulrike Bacher,Thomas Pabst
View Articletitled, Bridging radiotherapy before CAR-T therapy in CNS lymphoma
Adeno-associated virus and hepatocytes: frenemies?
Glenn F. Pierce
View Articletitled, Adeno-associated virus and hepatocytes: frenemies?
CHIP shot: aiming at therapy-induced clonal hematopoiesis
Clinical Trials & Observations
Leo Y. Luo,Alexander G. Bick
View Articletitled, CHIP shot: aiming at therapy-induced clonal hematopoiesis
Hydroxyurea and follicle density in sickle cell
Susan Creary,Chelsea Kebodeaux,Leena Nahata
View Articletitled, Hydroxyurea and follicle density in sickle cell

ADVANCES VIEWPOINTS

What is in a name: defining pediatric refractory ITP
Taizo A. Nakano,Amanda B. Grimes,Robert J. Klaassen,Michele P. Lambert,Cindy Neunert,Jennifer A. Rothman,Kristin A. Shimano,Christina Amend,Megan Askew,Sherif M. Badawy,Jillian M. Baker,Vicky Breakey,Shelley Crary,Monica Davini,Stephanie Fritch Lilla,Megan Gilbert,Taru Hays,Kerry Hege,Kirsty Hillier,Amanda Jacobson-Kelly,Shipra Kaicker,Taylor O. Kim,Manpreet Kochhar,Thierry Leblanc,Marie Martinelli,Mara Nunez,Allison Remiker,Corrina Schultz,Ruchika Sharma,Rachael F. Grace
View Articletitled, What is in a name: defining pediatric refractory ITP
Addressing financial hardship in malignant hematology and hematopoietic cell transplant: a team approach
Salene M. W. Jones,Timothy J. D. Ohlsen,Kristine A. Karvonen,Mohamed Sorror
View Articletitled, Addressing financial hardship in malignant hematology and hematopoietic cell transplant: a team approach

DRUG ADVANCES

Roctavian gene therapy for hemophilia A
Clinical Trials & Observations
Benjamin J. Samelson-Jones,Juliana C. Small,Lindsey A. George
View Articletitled, Roctavian gene therapy for hemophilia A
Supplemental data

REVIEW ARTICLE

Optimizing liver health before and after gene therapy for hemophilia A
Margaret V. Ragni,Henry Mead,Ype P. de Jong,Radoslaw Kaczmarek,Andrew D. Leavitt,Brian Long,Diane J. Nugent,Denise E. Sabatino,Sylvia Fong,Annette von Drygalski,Christopher E. Walsh,Bruce A. Luxon
View Articletitled, Optimizing liver health before and after gene therapy for hemophilia A

CLINICAL TRIALS AND OBSERVATIONS

A.R.R.O.W.2: once- vs twice-weekly carfilzomib, lenalidomide, and dexamethasone in relapsed/refractory multiple myeloma
Clinical Trials & Observations
Meletios A. Dimopoulos,Daniel Coriu,Sosana Delimpasi,Ivan Špička,Terry Upchurch,Belle Fang,Rakhshandra Talpur,Edward Faber,Meral Beksac,Xavier Leleu
View Articletitled, A.R.R.O.W.2: once- vs twice-weekly carfilzomib, lenalidomide, and dexamethasone in relapsed/refractory multiple myeloma
Supplemental data
Alliance A061202: ixazomib, pomalidomide, and dexamethasone for patients with lenalidomide-refractory MM in first relapse
Clinical Trials & Observations
Peter Voorhees,Vera Suman,Yvonne Efebera,Noopur Raje,Sascha Tuchman,Cesar Rodriguez,Jacob Laubach,Misty Bova-Solem,Destin Carlisle,Saad Usmani,Philip McCarthy,Paul G. Richardson
View Articletitled, Alliance A061202: ixazomib, pomalidomide, and dexamethasone for patients with lenalidomide-refractory MM in first relapse
Supplemental data
Health-related quality of life with gilteritinib vs placebo posttransplant for FLT3-ITD+ acute myeloid leukemia
Clinical Trials & Observations
Betty K. Hamilton,Bhavik J. Pandya,Cristina Ivanescu,Dina Elsouda,Mehdi Hamadani,Yi-Bin Chen,Mark J. Levis,Masumi Ueda Oshima,Mark R. Litzow,Robert J. Soiffer,Celalettin Ustun,Alexander E. Perl,Anurag K. Singh,Nancy Geller,Nahla Hasabou,Matt Rosales,David Cella,Laura Corredoira,Carolina Pestana,Mary M. Horowitz,Brent Logan
View Articletitled, Health-related quality of life with gilteritinib vs placebo posttransplant for <em>FLT3-ITD</em><sup><em>+</em></sup> acute myeloid leukemia
Supplemental data
Unexpected diagnosis of WHIM syndrome in refractory autoimmune cytopenia
Clinical Trials & Observations
Yolanda Garcia-Carmona,Jose Chavez,Yael Gernez,Julia T. Geyer,James B. Bussel,Charlotte Cunningham-Rundles
View Articletitled, Unexpected diagnosis of WHIM syndrome in refractory autoimmune cytopenia
Supplemental data

HEALTH SERVICES AND OUTCOMES

CT strain metrics allow for earlier diagnosis of bronchiolitis obliterans syndrome after hematopoietic cell transplant
Husham Sharifi,Christopher D. Bertini,Mansour Alkhunaizi,Maria Hernandez,Zayan Musa,Carlos Borges,Ihsan Turk,Lara Bashoura,Burton F. Dickey,Guang-Shing Cheng,Gregory Yanik,Craig J. Galban,Huawei Henry Guo,Myrna C. B. Godoy,Joseph M. Reinhardt,Eric A. Hoffman,Mario Castro,Gabriela Rondon,Amin M. Alousi,Richard E. Champlin,Elizabeth J. Shpall,Ying Lu,Samuel Peterson,Keshav Datta,Mark R. Nicolls,Joe Hsu,Ajay Sheshadri
View Articletitled, CT strain metrics allow for earlier diagnosis of bronchiolitis obliterans syndrome after hematopoietic cell transplant
Supplemental data

HEMATOPOIESIS AND STEM CELLS

Association of busulfan exposure and outcomes after HCT for patients with an inborn error of immunity
Tim Bognàr,Moises Garcia-Rosa,Arief Lalmohamed,Tayfun Güngör,Mathias Hauri-Hohl,Susan Prockop,Layne Oram,Sung-Yun Pai,Jordan Brooks,Rada M. Savic,Christopher C. Dvorak,Janel R. Long-Boyle,Maja Krajinovic,Henrique Bittencourt,Anne-Charlotte Teyssier,Yves Théorêt,Cary Martinez,Toine C. G. Egberts,Erin Morales,Mary Slatter,Geoffrey D. E. Cuvelier,Robert Chiesa,Robert F. Wynn,Mary Coussons,Maria P. Cicalese,Marc Ansari,Susan E. Long,Christen L. Ebens,Hannah Lust,Sonali Chaudhury,Christa E. Nath,Peter J. Shaw,Steven J. Keogh,M. Y. Eileen C. van der Stoep,Robbert Bredius,Caroline A. Lindemans,Jaap-Jan Boelens,Imke H. Bartelink
View Articletitled, Association of busulfan exposure and outcomes after HCT for patients with an inborn error of immunity
Supplemental data
Impact of cancer therapy on clonal hematopoiesis mutations and subsequent clinical outcomes
Clinical Trials & Observations
Kevin T. Nead,Taebeom Kim,LiJin Joo,Tina L. McDowell,Justin W. Wong,Irenaeus C. C. Chan,Elizabeth Brock,Jing Zhao,Ting Xu,Chad Tang,Chang-Lung Lee,Jun-ichi Abe,Kelly L. Bolton,Zhongxing Liao,Paul A. Scheet,Steven H. Lin
View Articletitled, Impact of cancer therapy on clonal hematopoiesis mutations and subsequent clinical outcomes
Supplemental data
Impact of hydroxyurea on follicle density in patients with sickle cell disease
Tamara Diesch-Furlanetto,Carlos Sanchez,Andrew Atkinson,Corinne Pondarré,Nathalie Dhedin,Bénédicte Neven,Cécile Arnaud,Annie Kamdem,France Pirenne,Gilles Lenaour,Isabelle Brocheriou,Benoit Terris,Françoise Bernaudin,Jean-Hugues Dalle,Catherine Poirot
View Articletitled, Impact of hydroxyurea on follicle density in patients with sickle cell disease
Supplemental data

LYMPHOID NEOPLASIA

A brain organoid/ALL coculture model reveals the AP-1 pathway as critically associated with CNS involvement of BCP-ALL
Philip Gebing,Stefanos Loizou,Sebastian Hänsch,Julian Schliehe-Diecks,Lea Spory,Pawel Stachura,Vera H. Jepsen,Melina Vogt,Aleksandra A. Pandyra,Herui Wang,Zhengping Zhuang,Johannes Zimmermann,Martin Schrappe,Gunnar Cario,Ameera Alsadeq,Denis M. Schewe,Arndt Borkhardt,Lennart Lenk,Ute Fischer,Sanil Bhatia
View Articletitled, A brain organoid/ALL coculture model reveals the AP-1 pathway as critically associated with CNS involvement of BCP-ALL
Supplemental data
CNS bridging radiotherapy achieves rapid cytoreduction before CAR T-cell therapy for aggressive B-cell lymphomas
Clinical Trials & Observations
Gustav Y. Cederquist,Javin Schefflein,Sean M. Devlin,Gunjan L. Shah,Roni Shouval,Harper Hubbeling,Kathryn Tringale,Ana Alarcon Tomas,Beatrice Fregonese,Carla Hajj,Alexander Boardman,Alejandro Luna De Abia,Magdalena Corona,Giulio Cassanello,Parastoo B. Dahi,Richard J. Lin,Paola Ghione,Gilles Salles,Miguel-Angel Perales,M. Lia Palomba,Lorenzo Falchi,Michael Scordo,Christian Grommes,Joachim Yahalom,Brandon S. Imber
View Articletitled, CNS bridging radiotherapy achieves rapid cytoreduction before CAR T-cell therapy for aggressive B-cell lymphomas
Supplemental data

MYELOID NEOPLASIA

Differential inflammatory conditioning of the bone marrow by acute myeloid leukemia and its impact on progression
Valentina R. Minciacchi,Christina Karantanou,Jimena Bravo,Raquel S. Pereira,Costanza Zanetti,Theresa Krack,Rahul Kumar,Katrin Bankov,Sylvia Hartmann,Brian J. P. Huntly,Eshwar Meduri,Wolfram Ruf,Daniela S. Krause
View Articletitled, Differential inflammatory conditioning of the bone marrow by acute myeloid leukemia and its impact on progression
Supplemental data
Real-world treatment patterns and outcomes in relapsed/refractory multiple myeloma (1-3 prior lines): Flatiron database
Binod Dhakal,Hermann Einsele,Jordan M. Schecter,William Deraedt,Nikoletta Lendvai,Ana Slaughter,Carolina Lonardi,Sandhya Nair,Jianming He,Akshay Kharat,Patricia Cost,Satish Valluri,Kwee Yong
View Articletitled, Real-world treatment patterns and outcomes in relapsed/refractory multiple myeloma (1-3 prior lines): Flatiron database
Supplemental data
Altered enhancer-promoter interaction leads to MNX1 expression in pediatric acute myeloid leukemia with t(7;12)(q36;p13)
Dieter Weichenhan,Anna Riedel,Etienne Sollier,Umut H. Toprak,Joschka Hey,Kersten Breuer,Justyna A. Wierzbinska,Aurore Touzart,Pavlo Lutsik,Marion Bähr,Anders Östlund,Tina Nilsson,Susanna Jacobsson,Marcel Edler,Ahmed Waraky,Yvonne Lisa Behrens,Gudrun Göhring,Brigitte Schlegelberger,Clemens Steinek,Hartmann Harz,Heinrich Leonhardt,Anna Dolnik,Dirk Reinhardt,Lars Bullinger,Lars Palmqvist,Daniel B. Lipka,Christoph Plass
View Articletitled, Altered enhancer-promoter interaction leads to <em>MNX1</em> expression in pediatric acute myeloid leukemia with t(7;12)(q36;p13)
Supplemental data

PLASMA CELL DISORDERS

Class II ferroptosis inducers are a novel therapeutic approach for t(4;14)-positive multiple myeloma
Jiasi Zhang,Yuxi Liu,Liping Zuo,Fengjuan Fan,Han Yan,Fei Zhao,Junying Li,Chi Ma,Qun Li,Aoshuang Xu,Jian Xu,Bo Zhang,Yu Hu,Chunyan Sun
View Articletitled, Class II ferroptosis inducers are a novel therapeutic approach for t(4;14)-positive multiple myeloma
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Complete absence of GLUT1 does not impair human terminal erythroid differentiation
Catarina Martins Freire,Nadine R. King,Monika Dzieciatkowska,Daniel Stephenson,Pedro L. Moura,Johannes G. G. Dobbe,Geert J. Streekstra,Angelo D'Alessandro,Ashley M. Toye,Timothy J. Satchwell
View Articletitled, Complete absence of GLUT1 does not impair human terminal erythroid differentiation
Supplemental data

THROMBOSIS AND HEMOSTASIS

Prevalence and characterization of anti-VWF antibodies in a population of patients with type 3 VWD
Crystal L. Perry,Pamela A. Christopherson,Tina A. Agostini,Sandra L. Haberichter,Robert R. Montgomery,Veronica H. Flood
View Articletitled, Prevalence and characterization of anti-VWF antibodies in a population of patients with type 3 VWD
Activated platelets retain and protect most of their factor XIII-A cargo from proteolytic activation and degradation
Yaqiu Sang,Robert H. Lee,Annie Luong,Éva Katona,Claire S. Whyte,Nicholas L. Smith,Alan E. Mast,Matthew J. Flick,Nicola J. Mutch,Wolfgang Bergmeier,Alisa S. Wolberg
View Articletitled, Activated platelets retain and protect most of their factor XIII-A cargo from proteolytic activation and degradation
Supplemental data

RESEARCH LETTERS

Histiocytosis of the orbit and its association with KRAS mutations
Jasmine H. Francis,Rebecca F. Silverman,Julia Canestraro,Dana Bossert,David Della Rocca,Vaios Hatzoglou,David H. Abramson,Eli L. Diamond
View Articletitled, Histiocytosis of the orbit and its association with <em>KRAS</em> mutations
Supplemental data
Immunoglobulins act as predictors of chronicity in pediatric immune thrombocytopenia
Kirsty Hillier,Derek MacMath,Jessica Chumsky,Susan E. Kirk,Candelaria O’Farrell,Taylor Olmsted Kim,Mark Zobeck,Amanda B. Grimes
View Articletitled, Immunoglobulins act as predictors of chronicity in pediatric immune thrombocytopenia
NUP98 is rearranged in 5.0% of adult East Asian patients with AML
Namsoo Kim,Yu Jeong Choi,Hyunsoo Cho,Ji Eun Jang,Seung-Tae Lee,Jaewoo Song,Jong Rak Choi,June-Won Cheong,Haerim Chung,Saeam Shin
View Articletitled, <em>NUP98</em> is rearranged in 5.0% of adult East Asian patients with AML
Supplemental data
  • Cover Image

    Cover Image

    issue cover

    Collapsed z-stack and merge of carboxyfluorescein succinimidyl ester (green), DAPI (red), and anti-MAP2 (blue) staining of cocultured organoids is shown. Magnified images provide enhanced details of the leukemia cells colocalizing with the brain organoid volume, indicating that the leukemic cells sit in a complex network of neurons and their axonal/dendritic connections. See the article by Gebing et al.

All Issues

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