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Issue Archive

Volume 7, Issue 8
April 25 2023
Issue Cover

Table of Contents

STIMULUS REPORT

MAP kinase activating death domain deficiency is a novel cause of impaired lymphocyte cytotoxicity
Kerstin Schütze,Miriam Groß,Kerstin Cornils,Katharina Wustrau,Sonja Schneppenheim,Henning Lenhartz,G. Christoph Korenke,Gritta Janka,Svea Ledig,Ingo Müller,Stephan Ehl,Kai Lehmberg
View Articletitled, MAP kinase activating death domain deficiency is a novel cause of impaired lymphocyte cytotoxicity
Supplemental data

CLINICAL TRIALS AND OBSERVATIONS

Vascular surgery patients with elevated neutrophil-to-lymphocyte ratios have downregulated neutrophil complement RNA expression
Clinical Trials & Observations
Ernest R. Chan,Jasmine Lee,Howard Meyerson,Alona Merkulova,Susan Smith,Feng Lin,Jae S. Cho,Alvin H. Schmaier
View Articletitled, Vascular surgery patients with elevated neutrophil-to-lymphocyte ratios have downregulated neutrophil complement RNA expression
Supplemental data
Safety and efficacy of atezolizumab with rituximab and CHOP in previously untreated diffuse large B-cell lymphoma
Clinical Trials & Observations
Anas Younes,John M. Burke,Bruce D. Cheson,Catherine S. Diefenbach,Silvia Ferrari,Uwe H. Hahn,Eliza A. Hawkes,Cyrus Khan,Izidore S. Lossos,Gerardo Musuraca,Monica Tani,Umberto Vitolo,Sam Yuen,Aparna Raval,Mahesh Shivhare,Tina G. Nielsen,Gila Sellam,Jeff P. Sharman
View Articletitled, Safety and efficacy of atezolizumab with rituximab and CHOP in previously untreated diffuse large B-cell lymphoma
Supplemental data
Open-label pilot study of romiplostim for thrombocytopenia after autologous hematopoietic cell transplantation
Clinical Trials & Observations
Michael Scordo,Leah J. Gilbert,Danielle M. Hanley,Jessica R. Flynn,Sean M. Devlin,Linh K. Nguyen,Josel D. Ruiz,Gunjan L. Shah,Craig S. Sauter,David J. Chung,Heather J. Landau,Oscar B. Lahoud,Richard J. Lin,Parastoo B. Dahi,Miguel-Angel Perales,Sergio A. Giralt,Gerald A. Soff
View Articletitled, Open-label pilot study of romiplostim for thrombocytopenia after autologous hematopoietic cell transplantation
Supplemental data

LYMPHOID NEOPLASIA

Predictors of survival in patients with MALT lymphoma: a retrospective, case-control study
Shunan Qi,Xin Liu,Ariela Noy,Jisun Lee,Sewit Teckie,Carla Hajj,Erel Joffe,Brandon S. Imber,Joachim Yahalom
View Articletitled, Predictors of survival in patients with MALT lymphoma: a retrospective, case-control study
Supplemental data
Dual targeting of aberrant DNA and histone methylation synergistically suppresses tumor cell growth in ATL
Yuki Kurahashi,Tatsuro Watanabe,Yuta Yamamoto,Hiroshi Ureshino,Kazuharu Kamachi,Nao Yoshida-Sakai,Yuki Fukuda-Kurahashi,Satoshi Yamashita,Naoko Hattori,Hideaki Nakamura,Atsushi Kawaguchi,Toshikazu Ushijima,Eisaburo Sueoka,Shinya Kimura
View Articletitled, Dual targeting of aberrant DNA and histone methylation synergistically suppresses tumor cell growth in ATL
Supplemental data
Proinflammatory microenvironment promotes lymphoma progression in mice with high megakaryocyte and TPO levels
Amanda E. Au,Jason Corbin,Marion Lebois,Pradnya Gangatirkar,Fatme Yassinson,Stephanie R. Hyslop,Ping Cannon,Kylie D. Mason,Connie S. N. Li-Wai-Suen,Alexandra L. Garnham,Diane Moujalled,Luisa Cimmino,Warren S. Alexander,Emma C. Josefsson
View Articletitled, Proinflammatory microenvironment promotes lymphoma progression in mice with high megakaryocyte and TPO levels
Supplemental data
Evaluation of 4 prognostic indices in follicular lymphoma treated in first line with immunochemotherapy
Juan Jose Rodríguez-Sevilla,Concepción Fernández-Rodríguez,Leyre Bento,Ramón Diez-Feijóo,Sergio Pinzón,Joan Gibert,Lierni Fernández-Ibarrondo,Marta Lafuente,Ana Ferrer,Blanca Sánchez-González,Eva Gimeno,Juan Sainz,Rafael Ramos,Juan F. García,Lluis Colomo,Beatriz Bellosillo,Antonio Gutiérrez,Antonio Salar
View Articletitled, Evaluation of 4 prognostic indices in follicular lymphoma treated in first line with immunochemotherapy
Supplemental data

MYELOID NEOPLASIA

Rational polypharmacological targeting of FLT3, JAK2, ABL, and ERK1 suppresses the adaptive resistance to FLT3 inhibitors in AML
Mohammad Azhar,Zachary Kincaid,Meenu Kesarwani,Jacob Menke,Joshua Schwieterman,Sekhu Ansari,Angela Reaves,Arhama Ahmed,Rammsha Shehzad,Areeba Khan,Nuha Syed,Noor Amir,Mark Wunderlich,Tahir Latif,William Seibel,Mohammad Azam
View Articletitled, Rational polypharmacological targeting of FLT3, JAK2, ABL, and ERK1 suppresses the adaptive resistance to FLT3 inhibitors in AML
Supplemental data
Long-term proliferation of immature hypoxia-dependent JMML cells supported by a 3D in vitro system
Alice Cani,Caterina Tretti Parenzan,Chiara Frasson,Elena Rampazzo,Pamela Scarparo,Samuela Francescato,Federico Caicci,Vito Barbieri,Antonio Rosato,Simone Cesaro,Marco Zecca,Concetta Micalizzi,Laura Sainati,Martina Pigazzi,Alessandra Biffi,Barbara Buldini,Franco Locatelli,Luca Persano,Riccardo Masetti,Geertruij te Kronnie,Silvia Bresolin
View Articletitled, Long-term proliferation of immature hypoxia-dependent JMML cells supported by a 3D in vitro system
Supplemental data
EVI1 exerts distinct roles in AML via ERG and cyclin D1 promoting a chemoresistant and immune-suppressive environment
Yosuke Masamoto,Akira Chiba,Hideaki Mizuno,Toshiya Hino,Hiroki Hayashida,Tomohiko Sato,Masashige Bando,Katsuhiko Shirahige,Mineo Kurokawa
View Articletitled, EVI1 exerts distinct roles in AML via ERG and cyclin D1 promoting a chemoresistant and immune-suppressive environment
Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

Dynamin-2 deficiency causes age- and sex-dependent neutropenia and myelodysplasia in mice
Alexander J. Willis,Seth J. Corey,Carlos Murga-Zamalloa,Saman S. Karimi,Karam Khaddour,John Quigley,Elizabeth A. Eklund,Yolande Chen
View Articletitled, Dynamin-2 deficiency causes age- and sex-dependent neutropenia and myelodysplasia in mice
Supplemental data

THROMBOSIS AND HEMOSTASIS

Effect of antiplatelet agents and tyrosine kinase inhibitors on oxLDL-mediated procoagulant platelet activity
Tony J. Zheng,Tia C. L. Kohs,Paul A. Mueller,Jiaqing Pang,Stéphanie E. Reitsma,Iván Parra-Izquierdo,Alexander R. Melrose,Liping Yang,Jaewoo Choi,Keith D. Zientek,Denis O. Sviridov,Mark K. Larson,Craig D. Williams,Nathalie Pamir,Joseph J. Shatzel,Ashok P. Reddy,Paul Kievit,Alan T. Remaley,Jan F. Stevens,Monica T. Hinds,Owen J. T. McCarty,Joseph E. Aslan
View Articletitled, Effect of antiplatelet agents and tyrosine kinase inhibitors on oxLDL-mediated procoagulant platelet activity
Supplemental data
Targeting the contact system in a rabbit model of extracorporeal membrane oxygenation
James S. Tweddell,Mousa Kharnaf,Farhan Zafar,Kyle W. Riggs,James A. Reagor,Brett P. Monia,Alexey Revenko,Daniel G. Leino,A. Phillip Owens, III,Janine K. Martin,Benjamin Gourley,Leah Rosenfeldt,Joseph S. Palumbo
View Articletitled, Targeting the contact system in a rabbit model of extracorporeal membrane oxygenation
Supplemental data
Factor VIII mutated with Lys1813Ala within the factor IXa-binding region enhances intrinsic coagulation potential
Yuto Nakajima,Masahiro Takeyama,Akihisa Oda,Naruto Shimonishi,Keiji Nogami
View Articletitled, Factor VIII mutated with Lys1813Ala within the factor IXa-binding region enhances intrinsic coagulation potential
Supplemental data
A transcriptome analysis of basal and stimulated VWF release from endothelial cells derived from patients with type 1 VWD
Robert Kloosterman,Matteo Zago-Schmitt,Julie Grabell,Lisa Thibeault,Patricia A. De Lima,Mackenzie Bowman,Kathrin Tyryshkin,Charles C. T. Hindmarch,Neil Renwick,Paula James
View Articletitled, A transcriptome analysis of basal and stimulated VWF release from endothelial cells derived from patients with type 1 VWD
Supplemental data

TRANSFUSION MEDICINE

Marginal zone B cells are responsible for the production of alloantibodies following platelet transfusion in mice
Adèle Couvidou,Catherine Angénieux,Laurie Ruch,Pierre H. Mangin,Christian Gachet,Blandine Maître
View Articletitled, Marginal zone B cells are responsible for the production of alloantibodies following platelet transfusion in mice
Supplemental data
Sphingosine 1-phosphate has a negative effect on RBC storage quality
Ariel Hay,Travis Nemkov,Fabia Gamboni,Monika Dzieciatkowska,Alicia Key,Matthew Galbraith,Kyle Bartsch,Kaiqi Sun,Yang Xia,Mars Stone,Michael P. Busch,Philip J. Norris,James C. Zimring,Angelo D’Alessandro
View Articletitled, Sphingosine 1-phosphate has a negative effect on RBC storage quality
Supplemental data

TRANSPLANTATION

Impact of GVHD prophylaxis on CMV reactivation and disease after HLA-matched peripheral blood stem cell transplantation
Masumi Ueda Oshima,Hu Xie,Danniel Zamora,Mary E. Flowers,Geoffrey R. Hill,Marco B. Mielcarek,Brenda M. Sandmaier,Ted A. Gooley,Michael J. Boeckh
View Articletitled, Impact of GVHD prophylaxis on CMV reactivation and disease after HLA-matched peripheral blood stem cell transplantation
Supplemental data
Haploidentical vs matched unrelated donors for patients with ALL: donor age matters more than donor type
Rohtesh S. Mehta,David Marin,Amin Alousi,Christopher G. Kanakry,Richard E. Champlin,Katayoun Rezvani,Elizabeth J. Shpall,Kristin Page,Shahinaz M. Gadalla,Daniel Weisdorf,Partow Kebriaei
View Articletitled, Haploidentical vs matched unrelated donors for patients with ALL: donor age matters more than donor type
Supplemental data

RESEARCH LETTERS

Clinical and prognostic impact of STAG2 mutations in myeloid neoplasms: the Mayo Clinic experience
Bahga Katamesh,Ahmad Nanaa,Rong He,David Viswanatha,Phuong Nguyen,Patricia Greipp,Kurt Bessonen,Naseema Gangat,Kebede Begna,Abhishek Mangaonkar,Mrinal Patnaik,William J. Hogan,Ayalew Tefferi,Mark Litzow,Mithun Vinod Shah,Cecilia Arana Yi,James Foran,Talha Badar,Hassan B. Alkhateeb,Aref Al-Kali
View Articletitled, Clinical and prognostic impact of <em>STAG2</em> mutations in myeloid neoplasms: the Mayo Clinic experience
Supplemental data
Valoctocogene roxaparvovec gene transfer in participants with HIV
Clinical Trials & Observations
Margaret V. Ragni,Elaine Majerus,Sylvia Fong,Bridget Yates,Stephen Scheeler,Lisa Razon,Hua Yu,Divya B. Reddy,Tara M. Robinson
View Articletitled, Valoctocogene roxaparvovec gene transfer in participants with HIV
Supplemental data
Barriers to enrollment in clinical trials of patients with aggressive B-cell NHL that progressed after CAR T-cell therapy
Clinical Trials & Observations
Evandro D. Bezerra,Madiha Iqbal,Javier Munoz,Arushi Khurana,Yucai Wang,Matthew J. Maurer,Radhika Bansal,Matthew A. Hathcock,Nora Bennani,Hemant S. Murthy,Allison C. Rosenthal,Jonas Paludo,Jose C. Villasboas,Patrick B. Johnston,Thomas M. Habermann,Stephen M. Ansell,Januario E. Castro,Thomas E. Witzig,Mohamed A. Kharfan-Dabaja,Grzegorz S. Nowakowski,Yi Lin
View Articletitled, Barriers to enrollment in clinical trials of patients with aggressive B-cell NHL that progressed after CAR T-cell therapy
Supplemental data

COMMENTARY

Practical strategies for creating diversity, equity, inclusion, and access in cancer clinical research: DRIVE
Maya N. Birhiray,Ruemu E. Birhiray
View Articletitled, Practical strategies for creating diversity, equity, inclusion, and access in cancer clinical research: DRIVE
Platelet procoagulant membrane dynamics: a key distinction between thrombosis and hemostasis?
Ejaife O. Agbani,Ingeborg Hers,Alastair W. Poole
View Articletitled, Platelet procoagulant membrane dynamics: a key distinction between thrombosis and hemostasis?

ERRATA

Karihtala K, Leivonen S-K, Karjalainen-Lindsberg M-L, et al. Checkpoint protein expression in the tumor microenvironment defines the outcome of classical Hodgkin lymphoma patients. Blood Adv. 2022;6(6):1919-1931.
View Articletitled, Karihtala K, Leivonen S-K, Karjalainen-Lindsberg M-L, et al. Checkpoint protein expression in the tumor microenvironment defines the outcome of classical Hodgkin lymphoma patients. <em>Blood Adv</em>. 2022;6(6):1919-1931.
van Rhee F, Rosenthal A, Kanhai K, et al. Siltuximab is associated with improved progression-free survival in idiopathic multicentric Castleman disease. Blood Adv. 2022;6(16):4773-4781.
View Articletitled, van Rhee F, Rosenthal A, Kanhai K, et al. Siltuximab is associated with improved progression-free survival in idiopathic multicentric Castleman disease. <em>Blood Adv.</em> 2022;6(16):4773-4781.
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Subsequent malignant neoplasms in patients previously treated with anti-CD19 CAR T-cell therapy
Phillips NS, Mulrooney DA, Williams AM, et al. Neurocognitive impairment associated with chronic morbidity in long-term survivors of Hodgkin Lymphoma. Blood Adv. 2023;7(23):7270-7278.
Unleashed monocytic engagement in Sézary syndrome during the combination of anti-CCR4 antibody with type I interferon
A multicenter study of venetoclax-based treatment for patients with Richter transformation of chronic lymphocytic leukemia
Race and ethnicity reporting and representation in hemophilia clinical trials

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