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        Truncation of 3′ CCND1 by t(11;22) leads to negative SP4 CCND1 immunohistochemistry in blastoid mantle cell lymphoma
        
        
            
        
    
        
                
            
    
    
    
        
        
     
    
                    
        
                    
                
            
    
    
    
        
        
     
    
                     
    
                     
    
                    
        
        
        
                    
        
        Immune reconstitution and infectious complications following axicabtagene ciloleucel therapy for large B-cell lymphoma
        
        
            
        
    
        
                
            
    
    
    
        
                    
        
        Clinical predictors of poor outcomes in patients with sickle cell disease and COVID-19 infection
        
        
            
        
    
        
                
            
    
    
    
        
                    
        
        αβ T-cell graft depletion for allogeneic HSCT in adults with hematological malignancies
        
        
            
        
    
        
                
            
    
    
    
        
                    
        
        Allogeneic hematopoietic stem cell transplantation in leukocyte adhesion deficiency type I and III
        
        
            
        
    
        
                
            
    
    
    
        
        
     
    
                    
        
                    
                
            
    
    
    
        
                    
                
            
    
    
    
        
        
     
    
                    
        
        
        
     
    
                    
        
        
                    
                
            
    
    
    
        
                    
        
        Clinicopathological features of adult T-cell leukemia/lymphoma with HTLV-1–infected Hodgkin and Reed-Sternberg–like cells
        
        
            
        
    
        
                
            
    
    
    
        
        
     
    
                    
        
        
                    
                
            
    
    
    
        
        
                    
        
        Real-life experience with CPX-351 and impact on the outcome of high-risk AML patients: a multicentric French cohort
        
        
            
        
    
        
                
            
    
    
    
        
        
     
    
                    
        
        
     
    
                    
        
        
        
                    
        
        Plasma fibrinolysis, inflammatory markers, and postthrombotic syndrome: preliminary findings from the Kids-DOTT Biobank
        
        
            
        
    
        
    
            
                
            
    
    
    
        
        
     
    
                    
        
                    
        
        A pragmatic multi-institutional approach to understanding transplant-associated thrombotic microangiopathy after stem cell transplant
        
        
            
        
    
        
                
            
    
    
    
        
        
     
    
                    
                    
                
            
    
    
    
        
        
     
    
 
    
            
    
        
    
         
 
    
    
        
    
            
    
        
    
    
    
        
    
    
    
            
    
                    
 
    
    
 
    
    
    
        
    
    
    
            
        
            
    
        
        
    
             
            
             
            
             
        
    
 
    
    
 
    
    
        
    
    
    
            
    
                    
 
    
    
 
    
    
 
    
    
    
    
        
    Issue Archive
January 12 2021
    
    In this Issue
    
    Table of Contents
EDITORIALS
BLOOD ADVANCES TALK
CLINICAL GUIDELINES
ASH ISTH NHF WFH 2021 guidelines on the diagnosis of von Willebrand disease
            Paula D. James,Nathan T. Connell,Barbara Ameer,Jorge Di Paola,Jeroen Eikenboom,Nicolas Giraud,Sandra Haberichter,Vicki Jacobs-Pratt,Barbara Konkle,Claire McLintock,Simon McRae,Robert R. Montgomery,James S. O’Donnell,Nikole Scappe,Robert Sidonio, Jr,Veronica H. Flood,Nedaa Husainat,Mohamad A. Kalot,Reem A. Mustafa
            
        
    
            ASH ISTH NHF WFH 2021 guidelines on the management of von Willebrand disease
            Nathan T. Connell,Veronica H. Flood,Romina Brignardello-Petersen,Rezan Abdul-Kadir,Alice Arapshian,Susie Couper,Jean M. Grow,Peter Kouides,Michael Laffan,Michelle Lavin,Frank W. G. Leebeek,Sarah H. O’Brien,Margareth C. Ozelo,Alberto Tosetto,Angela C. Weyand,Paula D. James,Mohamad A. Kalot,Nedaa Husainat,Reem A. Mustafa
            
        
    
            DRUG ADVANCES
EXCEPTIONAL CASE REPORT
        
        Truncation of 3′ CCND1 by t(11;22) leads to negative SP4 CCND1 immunohistochemistry in blastoid mantle cell lymphoma
        
        
            
        
                    
                        Clinical Trials & Observations
                    
        
            
    
        
            Fumiyo Maekawa,Chiyuki Kishimori,Miho Nakagawa,Kayo Takeoka,Katsuhiro Fukutsuka,Masahiko Hayashida,Futoshi Iioka,Masakazu Fujimoto,Kengo Takeuchi,Hirokazu Nakamine,Hitoshi Ohno
            
        
    
            STIMULUS REPORT
Pre-HCT mosaicism increases relapse risk and lowers survival in acute lymphoblastic leukemia patients post–unrelated HCT
            Yiwen Wang,Weiyin Zhou,Junke Wang,Ezgi Karaesmen,Hancong Tang,Philip L. McCarthy,Marcelo C. Pasquini,Youjin Wang,Lisa J. McReynolds,Hormuzd A. Katki,Mitchell J. Machiela,Meredith Yeager,Loreall Pooler,Xin Sheng,Christopher A. Haiman,David Van Den Berg,Stephen R. Spellman,Tao Wang,Michelle Kuxhausen,Stephen J. Chanock,Stephanie J. Lee,Alyssa I. Clay-Gilmour,Theresa E. Hahn,Shahinaz M. Gadalla,Lara E. Sucheston-Campbell
            
        
    
            REVIEW ARTICLE
SYSTEMATIC REVIEW
CLINICAL TRIALS AND OBSERVATIONS
        
        Immune reconstitution and infectious complications following axicabtagene ciloleucel therapy for large B-cell lymphoma
        
        
            
        
                    
                        Clinical Trials & Observations
                    
        
            
    
        
            John H. Baird,David J. Epstein,John S. Tamaresis,Zachary Ehlinger,Jay Y. Spiegel,Juliana Craig,Gursharan K. Claire,Matthew J. Frank,Lori Muffly,Parveen Shiraz,Everett Meyer,Sally Arai,Janice (Wes) Brown,Laura Johnston,Robert Lowsky,Robert S. Negrin,Andrew R. Rezvani,Wen-Kai Weng,Theresa Latchford,Bita Sahaf,Crystal L. Mackall,David B. Miklos,Surbhi Sidana
            
        
    
            
        
        Clinical predictors of poor outcomes in patients with sickle cell disease and COVID-19 infection
        
        
            
        
                    
                        Clinical Trials & Observations
                    
        
            
    
        
            Caterina P. Minniti,Ahmar U. Zaidi,Mehdi Nouraie,Deepa Manwani,Gary D. Crouch,Andrew S. Crouch,Michael U. Callaghan,Sarah Carpenter,Charleen Jacobs,Jin Han,Jena Simon,Jeffrey Glassberg,Victor R. Gordeuk,Elizabeth S. Klings
            
        
    
            
        
        αβ T-cell graft depletion for allogeneic HSCT in adults with hematological malignancies
        
        
            
        
                    
                        Clinical Trials & Observations
                    
        
            
    
        
            Moniek A. de Witte,Anke Janssen,Klaartje Nijssen,Froso Karaiskaki,Luuk Swanenberg,Anna van Rhenen,Rick Admiraal,Lotte van der Wagen,Monique C. Minnema,Eefke Petersen,Reinier A. P. Raymakers,Kasper Westinga,Trudy Straetemans,Constantijn J. M. Halkes,Jaap-Jan Boelens,Jürgen Kuball
            
        
    
            
        
        Allogeneic hematopoietic stem cell transplantation in leukocyte adhesion deficiency type I and III
        
        
            
        
                    
                        Clinical Trials & Observations
                    
        
            
    
        
            Shahrzad Bakhtiar,on behalf of the Pediatric Diseases Working Party and the Inborn Errors Working Party of EBMT,Emilia Salzmann-Manrique,on behalf of the Pediatric Diseases Working Party and the Inborn Errors Working Party of EBMT,Henric-Jan Blok,on behalf of the Pediatric Diseases Working Party and the Inborn Errors Working Party of EBMT,Dirk-Jan Eikema,on behalf of the Pediatric Diseases Working Party and the Inborn Errors Working Party of EBMT,Sheree Hazelaar,on behalf of the Pediatric Diseases Working Party and the Inborn Errors Working Party of EBMT,Mouhab Ayas,on behalf of the Pediatric Diseases Working Party and the Inborn Errors Working Party of EBMT,Amos Toren,on behalf of the Pediatric Diseases Working Party and the Inborn Errors Working Party of EBMT,Gal Goldstein,on behalf of the Pediatric Diseases Working Party and the Inborn Errors Working Party of EBMT,Despina Moshous,on behalf of the Pediatric Diseases Working Party and the Inborn Errors Working Party of EBMT,Franco Locatelli,on behalf of the Pediatric Diseases Working Party and the Inborn Errors Working Party of EBMT,Pietro Merli,on behalf of the Pediatric Diseases Working Party and the Inborn Errors Working Party of EBMT,Gerard Michel,on behalf of the Pediatric Diseases Working Party and the Inborn Errors Working Party of EBMT,Gülyüz Öztürk,on behalf of the Pediatric Diseases Working Party and the Inborn Errors Working Party of EBMT,Ansgar Schulz,on behalf of the Pediatric Diseases Working Party and the Inborn Errors Working Party of EBMT,Carsten Heilmann,on behalf of the Pediatric Diseases Working Party and the Inborn Errors Working Party of EBMT,Marianne Ifversen,on behalf of the Pediatric Diseases Working Party and the Inborn Errors Working Party of EBMT,Rob F. Wynn,on behalf of the Pediatric Diseases Working Party and the Inborn Errors Working Party of EBMT,Olga Aleinikova,on behalf of the Pediatric Diseases Working Party and the Inborn Errors Working Party of EBMT,Yves Bertrand,on behalf of the Pediatric Diseases Working Party and the Inborn Errors Working Party of EBMT,Abdelghani Tbakhi,on behalf of the Pediatric Diseases Working Party and the Inborn Errors Working Party of EBMT,Paul Veys,on behalf of the Pediatric Diseases Working Party and the Inborn Errors Working Party of EBMT,Musa Karakukcu,on behalf of the Pediatric Diseases Working Party and the Inborn Errors Working Party of EBMT,Alphan Kupesiz,on behalf of the Pediatric Diseases Working Party and the Inborn Errors Working Party of EBMT,Ardeshir Ghavamzadeh,on behalf of the Pediatric Diseases Working Party and the Inborn Errors Working Party of EBMT,Rupert Handgretinger,on behalf of the Pediatric Diseases Working Party and the Inborn Errors Working Party of EBMT,Emel Unal,on behalf of the Pediatric Diseases Working Party and the Inborn Errors Working Party of EBMT,Antonio Perez-Martinez,on behalf of the Pediatric Diseases Working Party and the Inborn Errors Working Party of EBMT,Muge Gokce,on behalf of the Pediatric Diseases Working Party and the Inborn Errors Working Party of EBMT,Fulvio Porta,on behalf of the Pediatric Diseases Working Party and the Inborn Errors Working Party of EBMT,Tekin Aksu,on behalf of the Pediatric Diseases Working Party and the Inborn Errors Working Party of EBMT,Gülsün Karasu,on behalf of the Pediatric Diseases Working Party and the Inborn Errors Working Party of EBMT,Isabel Badell,on behalf of the Pediatric Diseases Working Party and the Inborn Errors Working Party of EBMT,Per Ljungman,on behalf of the Pediatric Diseases Working Party and the Inborn Errors Working Party of EBMT,Elena Skorobogatova,on behalf of the Pediatric Diseases Working Party and the Inborn Errors Working Party of EBMT,Akif Yesilipek,on behalf of the Pediatric Diseases Working Party and the Inborn Errors Working Party of EBMT,Tsila Zuckerman,on behalf of the Pediatric Diseases Working Party and the Inborn Errors Working Party of EBMT,Robbert R. G. Bredius,on behalf of the Pediatric Diseases Working Party and the Inborn Errors Working Party of EBMT,Polina Stepensky,on behalf of the Pediatric Diseases Working Party and the Inborn Errors Working Party of EBMT,Bella Shadur,on behalf of the Pediatric Diseases Working Party and the Inborn Errors Working Party of EBMT,Mary Slatter,on behalf of the Pediatric Diseases Working Party and the Inborn Errors Working Party of EBMT,Andrew R. Gennery,on behalf of the Pediatric Diseases Working Party and the Inborn Errors Working Party of EBMT,Michael H. Albert,on behalf of the Pediatric Diseases Working Party and the Inborn Errors Working Party of EBMT,Peter Bader,on behalf of the Pediatric Diseases Working Party and the Inborn Errors Working Party of EBMT,Arjan Lankester,on behalf of the Pediatric Diseases Working Party and the Inborn Errors Working Party of EBMT
            
        
    
            HEMATOPOIESIS AND STEM CELLS
A robust approach for the generation of functional hematopoietic progenitor cell lines to model leukemic transformation
            Eszter Doma,Isabella Maria Mayer,Tania Brandstoetter,Barbara Maurer,Reinhard Grausenburger,Ingeborg Menzl,Markus Zojer,Andrea Hoelbl-Kovacic,Leif Carlsson,Gerwin Heller,Karoline Kollmann,Veronika Sexl
            
        
    
            Tryptophan metabolism is dysregulated in individuals with Fanconi anemia
            Allison L. Bartlett,Lindsey Romick-Rosendale,Adam Nelson,Sheyar Abdullah,Nathan Luebbering,Jamen Bartlett,Marion Brusadelli,Joseph S. Palumbo,Kelly Lake,Bridget Litts,Alexandra Duell,Annette Urbanski,Adam Lane,Kasiani C. Myers,Susanne I. Wells,Stella M. Davies
            
        
    
            IMMUNOBIOLOGY AND IMMUNOTHERAPY
LYMPHOID NEOPLASIA
Inhibition of B-cell receptor signaling disrupts cell adhesion in mantle cell lymphoma via RAC2
            Wenjun Wu,Weige Wang,Carrie A. Franzen,Hui Guo,Jimmy Lee,Yan Li,Madina Sukhanova,Dong Sheng,Girish Venkataraman,Mei Ming,Pin Lu,Anhui Gao,Chunmei Xia,Jia Li,Liang Leo Zhang,Vivian Changying Jiang,Michael L. Wang,Jorge Andrade,Xiaoyan Zhou,Y. Lynn Wang
            
        
    
            
        
        Clinicopathological features of adult T-cell leukemia/lymphoma with HTLV-1–infected Hodgkin and Reed-Sternberg–like cells
        
        
            
        
                    
                        Clinical Trials & Observations
                    
        
            
    
        
            Kennosuke Karube,Mitsuyoshi Takatori,Shugo Sakihama,Yuma Tsuruta,Takashi Miyagi,Kazuho Morichika,Sakiko Kitamura,Norihiro Nakada,Masaki Hayashi,Shohei Tomori,Iwao Nakazato,Kazuiku Ohshiro,Naoki Imaizumi,Yara Yukie Kikuti,Naoya Nakamura,Satoko Morishima,Hiroaki Masuzaki,Takuya Fukushima
            
        
    
            MYELOID NEOPLASIA
Modulation of IL-6/STAT3 signaling axis in CD4+FOXP3− T cells represents a potential antitumor mechanism of azacitidine
            Eleftheria Lamprianidou,Chryssoula Kordella,Anastasiya Kazachenka,Emmanouela Zoulia,Elsa Bernard,Anastasia Filia,Stamatia Laidou,Panayiotis Garantziotis,Theodoros P. Vassilakopoulos,Sotirios G. Papageorgiou,Vassiliki Pappa,Athanasios G. Galanopoulos,Nora Viniou,Evangelia Nakou,Lydia Kalafati,Anastasia Chatzidimitriou,George Kassiotis,Elli Papaemmanuil,Ioannis Mitroulis,Ioannis Kotsianidis
            
        
    
            
        
        Real-life experience with CPX-351 and impact on the outcome of high-risk AML patients: a multicentric French cohort
        
        
            
        
                    
                        Clinical Trials & Observations
                    
        
            
    
        
            Edmond Chiche,Ramy Rahmé,Sarah Bertoli,Pierre-Yves Dumas,Jean-Baptiste Micol,Yosr Hicheri,Florence Pasquier,Pierre Peterlin,Patrice Chevallier,Xavier Thomas,Michael Loschi,Alexis Genthon,Ollivier Legrand,Mohamad Mohty,Emmanuel Raffoux,Patrick Auberger,Alexis Caulier,Magalie Joris,Caroline Bonmati,Gabrielle Roth-Guepin,Caroline Lejeune,Arnaud Pigneux,Norbert Vey,Christian Recher,Lionel Ades,Thomas Cluzeau
            
        
    
            RED CELLS, IRON, AND ERYTHROPOIESIS
THROMBOSIS AND HEMOSTASIS
        
        Plasma fibrinolysis, inflammatory markers, and postthrombotic syndrome: preliminary findings from the Kids-DOTT Biobank
        
        
            
        
                    
                        Clinical Trials & Observations
                    
        
            
    
        
    
            TRANSPLANTATION
        
        A pragmatic multi-institutional approach to understanding transplant-associated thrombotic microangiopathy after stem cell transplant
        
        
            
        
                    
                        Clinical Trials & Observations
                    
        
            
    
        
            Christopher E. Dandoy,Seth Rotz,Priscila Badia Alonso,Anna Klunk,Catherine Desmond,John Huber,Hannah Ingraham,Christine Higham,Christopher C. Dvorak,Christine Duncan,Michelle Schoettler,Leslie Lehmann,Maria Cancio,James Killinger,Blachy Davila,Rachel Phelan,Kris M. Mahadeo,Sajad Khazal,Nahal Lalefar,Madhav Vissa,Kasiani Myers,Greg Wallace,Adam Nelson,Pooja Khandelwal,Deepika Bhatla,Nicholas Gloude,Eric Anderson,Jeffrey Huo,Philip Roehrs,Jeffery J. Auletta,Ranjit Chima,Adam Lane,Stella M. Davies,Sonata Jodele
            
        
    
            COMMENTARIES
Piezo1-xerocytosis red cell metabolome shows impaired glycolysis and increased hemoglobin oxygen affinity
            Laurent Kiger,Lydie Oliveira,Corinne Guitton,Laurence Bendélac,Kaldoun Ghazal,Valérie Proulle,Frédéric Galacteros,Christophe Junot,François Fenaille,Paul-Henri Roméo,Loic Garçon,Véronique Picard
            
        
    
            - 
        
            Cover Image
        
        Cover Image![issue cover]()  COVER FIGURE 
 Artist’s rendition of an antibody response to a viral infection. ID 159331151 © Igor Zakharevich | Dreamstime.com.
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