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Issue Archive

Volume 5, Issue 1
January 12 2021
Issue Cover

Table of Contents

EDITORIALS

100 Already?
Robert S. Negrin
View Articletitled, 100 Already?
Creating an international network for science and clinical progress: democratizing dissemination of advances in global hematology
Leslie S. Kean
View Articletitled, Creating an international network for science and clinical progress: democratizing dissemination of advances in global hematology
Navigating a new terrain: how Twitter is changing hematologists
Ahmar U. Zaidi,Alexander K. Glaros,Angela C. Weyand
View Articletitled, Navigating a new terrain: how Twitter is changing hematologists

BLOOD ADVANCES TALK

Concizumab: a novel anti-TFPI therapeutic for hemophilia
Clinical Trials & Observations
Amy D. Shapiro
View Articletitled, Concizumab: a novel anti-TFPI therapeutic for hemophilia
Supplemental data

CLINICAL GUIDELINES

ASH ISTH NHF WFH 2021 guidelines on the diagnosis of von Willebrand disease
Paula D. James,Nathan T. Connell,Barbara Ameer,Jorge Di Paola,Jeroen Eikenboom,Nicolas Giraud,Sandra Haberichter,Vicki Jacobs-Pratt,Barbara Konkle,Claire McLintock,Simon McRae,Robert R. Montgomery,James S. O’Donnell,Nikole Scappe,Robert Sidonio, Jr,Veronica H. Flood,Nedaa Husainat,Mohamad A. Kalot,Reem A. Mustafa
View Articletitled, ASH ISTH NHF WFH 2021 guidelines on the diagnosis of von Willebrand disease
Supplemental data
ASH ISTH NHF WFH 2021 guidelines on the management of von Willebrand disease
Nathan T. Connell,Veronica H. Flood,Romina Brignardello-Petersen,Rezan Abdul-Kadir,Alice Arapshian,Susie Couper,Jean M. Grow,Peter Kouides,Michael Laffan,Michelle Lavin,Frank W. G. Leebeek,Sarah H. O’Brien,Margareth C. Ozelo,Alberto Tosetto,Angela C. Weyand,Paula D. James,Mohamad A. Kalot,Nedaa Husainat,Reem A. Mustafa
View Articletitled, ASH ISTH NHF WFH 2021 guidelines on the management of von Willebrand disease
Supplemental data

DRUG ADVANCES

The use of luspatercept for thalassemia in adults
Clinical Trials & Observations
Maria Domenica Cappellini,Ali T. Taher
View Articletitled, The use of luspatercept for thalassemia in adults

EXCEPTIONAL CASE REPORT

Truncation of 3′ CCND1 by t(11;22) leads to negative SP4 CCND1 immunohistochemistry in blastoid mantle cell lymphoma
Clinical Trials & Observations
Fumiyo Maekawa,Chiyuki Kishimori,Miho Nakagawa,Kayo Takeoka,Katsuhiro Fukutsuka,Masahiko Hayashida,Futoshi Iioka,Masakazu Fujimoto,Kengo Takeuchi,Hirokazu Nakamine,Hitoshi Ohno
View Articletitled, Truncation of 3′ <em>CCND1</em> by t(11;22) leads to negative SP4 CCND1 immunohistochemistry in blastoid mantle cell lymphoma
Supplemental data

STIMULUS REPORT

Pre-HCT mosaicism increases relapse risk and lowers survival in acute lymphoblastic leukemia patients post–unrelated HCT
Yiwen Wang,Weiyin Zhou,Junke Wang,Ezgi Karaesmen,Hancong Tang,Philip L. McCarthy,Marcelo C. Pasquini,Youjin Wang,Lisa J. McReynolds,Hormuzd A. Katki,Mitchell J. Machiela,Meredith Yeager,Loreall Pooler,Xin Sheng,Christopher A. Haiman,David Van Den Berg,Stephen R. Spellman,Tao Wang,Michelle Kuxhausen,Stephen J. Chanock,Stephanie J. Lee,Alyssa I. Clay-Gilmour,Theresa E. Hahn,Shahinaz M. Gadalla,Lara E. Sucheston-Campbell
View Articletitled, Pre-HCT mosaicism increases relapse risk and lowers survival in acute lymphoblastic leukemia patients post–unrelated HCT
Supplemental data

REVIEW ARTICLE

Overcoming resistance to targeted therapies in chronic lymphocytic leukemia
Sigrid S. Skånland,Anthony R. Mato
View Articletitled, Overcoming resistance to targeted therapies in chronic lymphocytic leukemia

SYSTEMATIC REVIEW

A systematic review of antithrombotic treatment of venous thromboembolism in patients with myeloproliferative neoplasms
Eva N. Hamulyák,Joost G. Daams,Frank W. G. Leebeek,Bart J. Biemond,Peter A. W. te Boekhorst,Saskia Middeldorp,Mandy N. Lauw
View Articletitled, A systematic review of antithrombotic treatment of venous thromboembolism in patients with myeloproliferative neoplasms
Supplemental data

CLINICAL TRIALS AND OBSERVATIONS

Longitudinal effect of disease-modifying therapy on tricuspid regurgitant velocity in children with sickle cell anemia
Clinical Trials & Observations
Parul Rai,Vijaya M. Joshi,Jason F. Goldberg,Amber M. Yates,Victoria I. Okhomina,Rhiannon Penkert,Kenneth I. Ataga,Guolian Kang,Jane S. Hankins
View Articletitled, Longitudinal effect of disease-modifying therapy on tricuspid regurgitant velocity in children with sickle cell anemia
Supplemental data
UCD with MCD-like inflammatory state: surgical excision is highly effective
Clinical Trials & Observations
Miao-yan Zhang,Ming-nan Jia,Jia Chen,Jun Feng,Xin-xin Cao,Dao-bin Zhou,David C. Fajgenbaum,Lu Zhang,Jian Li
View Articletitled, UCD with MCD-like inflammatory state: surgical excision is highly effective
Immune reconstitution and infectious complications following axicabtagene ciloleucel therapy for large B-cell lymphoma
Clinical Trials & Observations
John H. Baird,David J. Epstein,John S. Tamaresis,Zachary Ehlinger,Jay Y. Spiegel,Juliana Craig,Gursharan K. Claire,Matthew J. Frank,Lori Muffly,Parveen Shiraz,Everett Meyer,Sally Arai,Janice (Wes) Brown,Laura Johnston,Robert Lowsky,Robert S. Negrin,Andrew R. Rezvani,Wen-Kai Weng,Theresa Latchford,Bita Sahaf,Crystal L. Mackall,David B. Miklos,Surbhi Sidana
View Articletitled, Immune reconstitution and infectious complications following axicabtagene ciloleucel therapy for large B-cell lymphoma
Supplemental data
Clinical predictors of poor outcomes in patients with sickle cell disease and COVID-19 infection
Clinical Trials & Observations
Caterina P. Minniti,Ahmar U. Zaidi,Mehdi Nouraie,Deepa Manwani,Gary D. Crouch,Andrew S. Crouch,Michael U. Callaghan,Sarah Carpenter,Charleen Jacobs,Jin Han,Jena Simon,Jeffrey Glassberg,Victor R. Gordeuk,Elizabeth S. Klings
View Articletitled, Clinical predictors of poor outcomes in patients with sickle cell disease and COVID-19 infection
Supplemental data
αβ T-cell graft depletion for allogeneic HSCT in adults with hematological malignancies
Clinical Trials & Observations
Moniek A. de Witte,Anke Janssen,Klaartje Nijssen,Froso Karaiskaki,Luuk Swanenberg,Anna van Rhenen,Rick Admiraal,Lotte van der Wagen,Monique C. Minnema,Eefke Petersen,Reinier A. P. Raymakers,Kasper Westinga,Trudy Straetemans,Constantijn J. M. Halkes,Jaap-Jan Boelens,Jürgen Kuball
View Articletitled, αβ T-cell graft depletion for allogeneic HSCT in adults with hematological malignancies
Supplemental data
Allogeneic hematopoietic stem cell transplantation in leukocyte adhesion deficiency type I and III
Clinical Trials & Observations
Shahrzad Bakhtiar,Emilia Salzmann-Manrique,Henric-Jan Blok,Dirk-Jan Eikema,Sheree Hazelaar,Mouhab Ayas,Amos Toren,Gal Goldstein,Despina Moshous,Franco Locatelli,Pietro Merli,Gerard Michel,Gülyüz Öztürk,Ansgar Schulz,Carsten Heilmann,Marianne Ifversen,Rob F. Wynn,Olga Aleinikova,Yves Bertrand,Abdelghani Tbakhi,Paul Veys,Musa Karakukcu,Alphan Kupesiz,Ardeshir Ghavamzadeh,Rupert Handgretinger,Emel Unal,Antonio Perez-Martinez,Muge Gokce,Fulvio Porta,Tekin Aksu,Gülsün Karasu,Isabel Badell,Per Ljungman,Elena Skorobogatova,Akif Yesilipek,Tsila Zuckerman,Robbert R. G. Bredius,Polina Stepensky,Bella Shadur,Mary Slatter,Andrew R. Gennery,Michael H. Albert,Peter Bader,Arjan Lankester,on behalf of the Pediatric Diseases Working Party and the Inborn Errors Working Party of EBMT
View Articletitled, Allogeneic hematopoietic stem cell transplantation in leukocyte adhesion deficiency type I and III
Supplemental data

HEMATOPOIESIS AND STEM CELLS

A robust approach for the generation of functional hematopoietic progenitor cell lines to model leukemic transformation
Eszter Doma,Isabella Maria Mayer,Tania Brandstoetter,Barbara Maurer,Reinhard Grausenburger,Ingeborg Menzl,Markus Zojer,Andrea Hoelbl-Kovacic,Leif Carlsson,Gerwin Heller,Karoline Kollmann,Veronika Sexl
View Articletitled, A robust approach for the generation of functional hematopoietic progenitor cell lines to model leukemic transformation
Supplemental data
Tryptophan metabolism is dysregulated in individuals with Fanconi anemia
Allison L. Bartlett,Lindsey Romick-Rosendale,Adam Nelson,Sheyar Abdullah,Nathan Luebbering,Jamen Bartlett,Marion Brusadelli,Joseph S. Palumbo,Kelly Lake,Bridget Litts,Alexandra Duell,Annette Urbanski,Adam Lane,Kasiani C. Myers,Susanne I. Wells,Stella M. Davies
View Articletitled, Tryptophan metabolism is dysregulated in individuals with Fanconi anemia

IMMUNOBIOLOGY AND IMMUNOTHERAPY

Polarized mitochondria as guardians of NK cell fitness
Laura Surace,Jean-Marc Doisne,Pedro Escoll,Solenne Marie,Valerie Dardalhon,Carys Croft,Anna Thaller,Davide Topazio,Angelo Sparaneo,Antonia Cama,Olimpia Musumeci,Aurelio d’Ecclesia,Carmen Buchrieser,Naomi Taylor,James P. Di Santo
View Articletitled, Polarized mitochondria as guardians of NK cell fitness
Supplemental data
Medullary stromal cells synergize their production and capture of CCL21 for T-cell emigration from neonatal mouse thymus
Kieran D. James,Daniel F. Legler,Vladimir Purvanov,Izumi Ohigashi,Yousuke Takahama,Sonia M. Parnell,Andrea J. White,William E. Jenkinson,Graham Anderson
View Articletitled, Medullary stromal cells synergize their production and capture of CCL21 for T-cell emigration from neonatal mouse thymus
Supplemental data

LYMPHOID NEOPLASIA

Notch activation is pervasive in SMZL and uncommon in DLBCL: implications for Notch signaling in B-cell tumors
Vignesh Shanmugam,Jeffrey W. Craig,Laura K. Hilton,Matthew H. Nguyen,Christopher K. Rushton,Kian Fahimdanesh,Scott Lovitch,Ben Ferland,David W. Scott,Jon C. Aster
View Articletitled, Notch activation is pervasive in SMZL and uncommon in DLBCL: implications for Notch signaling in B-cell tumors
Supplemental data
Inhibition of B-cell receptor signaling disrupts cell adhesion in mantle cell lymphoma via RAC2
Wenjun Wu,Weige Wang,Carrie A. Franzen,Hui Guo,Jimmy Lee,Yan Li,Madina Sukhanova,Dong Sheng,Girish Venkataraman,Mei Ming,Pin Lu,Anhui Gao,Chunmei Xia,Jia Li,Liang Leo Zhang,Vivian Changying Jiang,Michael L. Wang,Jorge Andrade,Xiaoyan Zhou,Y. Lynn Wang
View Articletitled, Inhibition of B-cell receptor signaling disrupts cell adhesion in mantle cell lymphoma via RAC2
Supplemental data
Clinicopathological features of adult T-cell leukemia/lymphoma with HTLV-1–infected Hodgkin and Reed-Sternberg–like cells
Clinical Trials & Observations
Kennosuke Karube,Mitsuyoshi Takatori,Shugo Sakihama,Yuma Tsuruta,Takashi Miyagi,Kazuho Morichika,Sakiko Kitamura,Norihiro Nakada,Masaki Hayashi,Shohei Tomori,Iwao Nakazato,Kazuiku Ohshiro,Naoki Imaizumi,Yara Yukie Kikuti,Naoya Nakamura,Satoko Morishima,Hiroaki Masuzaki,Takuya Fukushima
View Articletitled, Clinicopathological features of adult T-cell leukemia/lymphoma with HTLV-1–infected Hodgkin and Reed-Sternberg–like cells
Supplemental data

MYELOID NEOPLASIA

Somatic GATA2 mutations define a subgroup of myeloid malignancy patients at high risk for invasive fungal disease
Rahul S. Vedula,Matthew P. Cheng,Christine E. Ronayne,Dimitrios Farmakiotis,Vincent T. Ho,Sophia Koo,Francisco M. Marty,R. Coleman Lindsley,Tyler D. Bold
View Articletitled, Somatic GATA2 mutations define a subgroup of myeloid malignancy patients at high risk for invasive fungal disease
Supplemental data
Modulation of IL-6/STAT3 signaling axis in CD4+FOXP3− T cells represents a potential antitumor mechanism of azacitidine
Eleftheria Lamprianidou,Chryssoula Kordella,Anastasiya Kazachenka,Emmanouela Zoulia,Elsa Bernard,Anastasia Filia,Stamatia Laidou,Panayiotis Garantziotis,Theodoros P. Vassilakopoulos,Sotirios G. Papageorgiou,Vassiliki Pappa,Athanasios G. Galanopoulos,Nora Viniou,Evangelia Nakou,Lydia Kalafati,Anastasia Chatzidimitriou,George Kassiotis,Elli Papaemmanuil,Ioannis Mitroulis,Ioannis Kotsianidis
View Articletitled, Modulation of IL-6/STAT3 signaling axis in CD4<sup>+</sup>FOXP3<sup>−</sup> T cells represents a potential antitumor mechanism of azacitidine
Supplemental data
The metabolic reprogramming in acute myeloid leukemia patients depends on their genotype and is a prognostic marker
Caroline Lo Presti,Florence Fauvelle,Marie-Christine Jacob,Julie Mondet,Pascal Mossuz
View Articletitled, The metabolic reprogramming in acute myeloid leukemia patients depends on their genotype and is a prognostic marker
Supplemental data
Real-life experience with CPX-351 and impact on the outcome of high-risk AML patients: a multicentric French cohort
Clinical Trials & Observations
Edmond Chiche,Ramy Rahmé,Sarah Bertoli,Pierre-Yves Dumas,Jean-Baptiste Micol,Yosr Hicheri,Florence Pasquier,Pierre Peterlin,Patrice Chevallier,Xavier Thomas,Michael Loschi,Alexis Genthon,Ollivier Legrand,Mohamad Mohty,Emmanuel Raffoux,Patrick Auberger,Alexis Caulier,Magalie Joris,Caroline Bonmati,Gabrielle Roth-Guepin,Caroline Lejeune,Arnaud Pigneux,Norbert Vey,Christian Recher,Lionel Ades,Thomas Cluzeau
View Articletitled, Real-life experience with CPX-351 and impact on the outcome of high-risk AML patients: a multicentric French cohort
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Dynamic changes in murine erythropoiesis from birth to adulthood: implications for the study of murine models of anemia
Lixiang Chen,Jie Wang,Jing Liu,Hua Wang,Christopher D. Hillyer,Lionel Blanc,Xiuli An,Narla Mohandas
View Articletitled, Dynamic changes in murine erythropoiesis from birth to adulthood: implications for the study of murine models of anemia
Supplemental data
Hematologic indices in individuals with pathogenic germline DICER1 variants
Clinical Trials & Observations
Lauren M. Vasta,Nicholas E. Khan,Cecilia P. Higgs,Laura A. Harney,Ann G. Carr,Anne K. Harris,Kris Ann P. Schultz,Mary L. McMaster,Douglas R. Stewart
View Articletitled, Hematologic indices in individuals with pathogenic germline <em>DICER1</em> variants
Supplemental data

THROMBOSIS AND HEMOSTASIS

HIGH-2-LOW risk model to predict venous thromboembolism in allogeneic transplant patients after platelet engraftment
Clinical Trials & Observations
Kylee L. Martens,Wilson L. da Costa, Jr,Christopher I. Amos,Chris Davis,Madeline Kesten,Stephanie J. Lee,Neil A. Zakai,David A. Garcia,Ang Li
View Articletitled, HIGH-2-LOW risk model to predict venous thromboembolism in allogeneic transplant patients after platelet engraftment
Supplemental data
Plasma levels of von Willebrand factor and future risk of incident venous thromboembolism
Clinical Trials & Observations
Magnus S. Edvardsen,Kristian Hindberg,Ellen-Sofie Hansen,Vânia M. Morelli,Thor Ueland,Pål Aukrust,Sigrid K. Brækkan,Line H. Evensen,John-Bjarne Hansen
View Articletitled, Plasma levels of von Willebrand factor and future risk of incident venous thromboembolism
Plasma fibrinolysis, inflammatory markers, and postthrombotic syndrome: preliminary findings from the Kids-DOTT Biobank
Clinical Trials & Observations
Marisol Betensky,Ernest K. Amankwah,Stephanie Brandal,Allen D. Everett,Neil A. Goldenberg
View Articletitled, Plasma fibrinolysis, inflammatory markers, and postthrombotic syndrome: preliminary findings from the Kids-DOTT Biobank
Supplemental data

TRANSPLANTATION

A pragmatic multi-institutional approach to understanding transplant-associated thrombotic microangiopathy after stem cell transplant
Clinical Trials & Observations
Christopher E. Dandoy,Seth Rotz,Priscila Badia Alonso,Anna Klunk,Catherine Desmond,John Huber,Hannah Ingraham,Christine Higham,Christopher C. Dvorak,Christine Duncan,Michelle Schoettler,Leslie Lehmann,Maria Cancio,James Killinger,Blachy Davila,Rachel Phelan,Kris M. Mahadeo,Sajad Khazal,Nahal Lalefar,Madhav Vissa,Kasiani Myers,Greg Wallace,Adam Nelson,Pooja Khandelwal,Deepika Bhatla,Nicholas Gloude,Eric Anderson,Jeffrey Huo,Philip Roehrs,Jeffery J. Auletta,Ranjit Chima,Adam Lane,Stella M. Davies,Sonata Jodele
View Articletitled, A pragmatic multi-institutional approach to understanding transplant-associated thrombotic microangiopathy after stem cell transplant
Supplemental data

COMMENTARIES

Geographic prevalence variation and phenotype penetrance in porphyria: insights from a Chinese population database
Pei Li,Dhiman Maitra,Ning Kuo,Herbert L. Bonkovsky,M. Bishr Omary
View Articletitled, Geographic prevalence variation and phenotype penetrance in porphyria: insights from a Chinese population database
Supplemental data
Piezo1-xerocytosis red cell metabolome shows impaired glycolysis and increased hemoglobin oxygen affinity
Laurent Kiger,Lydie Oliveira,Corinne Guitton,Laurence Bendélac,Kaldoun Ghazal,Valérie Proulle,Frédéric Galacteros,Christophe Junot,François Fenaille,Paul-Henri Roméo,Loic Garçon,Véronique Picard
View Articletitled, Piezo1-xerocytosis red cell metabolome shows impaired glycolysis and increased hemoglobin oxygen affinity
Supplemental data
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