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Issue Archive

Volume 4, Issue 6
March 24 2020
Issue Cover

Table of Contents

DRUG ADVANCES

Gilteritinib: potent targeting of FLT3 mutations in AML
Clinical Trials & Observations
Mark Levis,Alexander E. Perl
View Articletitled, Gilteritinib: potent targeting of FLT3 mutations in AML

CLINICAL TRIALS AND OBSERVATIONS

Late effects after ablative allogeneic stem cell transplantation for adolescent and young adult acute myeloid leukemia
Clinical Trials & Observations
Catherine J. Lee,Soyoung Kim,Heather R. Tecca,Stephanie Bo-Subait,Rachel Phelan,Ruta Brazauskas,David Buchbinder,Betty K. Hamilton,Minoo Battiwalla,Navneet S. Majhail,Hillard M. Lazarus,Peter J. Shaw,David I. Marks,Mark R. Litzow,Saurabh Chhabra,Yoshihiro Inamoto,Zachariah DeFilipp,Gerhard C. Hildebrandt,Richard F. Olsson,Kimberly A. Kasow,Jane L. Liesveld,Seth J. Rotz,Sherif M. Badawy,Neel S. Bhatt,Jean A. Yared,Kristin M. Page,Martha L. Arellano,Michael Kent,Nosha Farhadfar,Sachiko Seo,Peiman Hematti,César O. Freytes,Alicia Rovó,Siddhartha Ganguly,Sunita Nathan,Linda Burns,Bronwen E. Shaw,Lori S. Muffly
View Articletitled, Late effects after ablative allogeneic stem cell transplantation for adolescent and young adult acute myeloid leukemia
Supplemental data
Phase 2 trial of montelukast for prevention of pain in sickle cell disease
Clinical Trials & Observations
Joshua J. Field,Adetola Kassim,Amanda Brandow,Stephen H. Embury,Neil Matsui,Karina Wilkerson,Valencia Bryant,Liyun Zhang,Pippa Simpson,Michael R. DeBaun
View Articletitled, Phase 2 trial of montelukast for prevention of pain in sickle cell disease
Supplemental data

LYMPHOID NEOPLASIA

Treatment of MALT lymphoma of the conjunctiva with intralesional rituximab supplemented with autologous serum
Clinical Trials & Observations
Andrés J. M. Ferreri,Marianna Sassone,Elisabetta Miserocchi,Silvia Govi,Caterina Cecchetti,Matteo E. Corti,Silvia Mappa,Luca Arcaini,Francesco Zaja,Giuseppe Todeschini,Donato Mannina,Teresa Calimeri,Salvatore Perrone,Maurilio Ponzoni,Giulio Modorati
View Articletitled, Treatment of MALT lymphoma of the conjunctiva with intralesional rituximab supplemented with autologous serum
The EGFL7-ITGB3-KLF2 axis enhances survival of multiple myeloma in preclinical models
Yousef Salama,Andries Hendrik Heida,Kazuaki Yokoyama,Satoshi Takahashi,Koichi Hattori,Beate Heissig
View Articletitled, The EGFL7-ITGB3-KLF2 axis enhances survival of multiple myeloma in preclinical models
Supplemental data
Genomic profiles and clinical outcomes of de novo blastoid/pleomorphic MCL are distinct from those of transformed MCL
Clinical Trials & Observations
Preetesh Jain,Shaojun Zhang,Rashmi Kanagal-Shamanna,Chi Young Ok,Krystle Nomie,Graciela Nogueras Gonzalez,Omarya Gonzalez-Pagan,Holly A. Hill,Hun Ju Lee,Luis Fayad,Jason Westin,Loretta Nastoupil,Frederick Hagemeister,Wendy Chen,Onyeka Oriabure,Maria Badillo,Changying Jiang,Yao Yixin,Shaoying Li,Guilin Tang,C. Cameron Yin,Keyur P. Patel,Leonard Jeffrey Medeiros,Ranjit Nair,Sairah Ahmed,Swaminathan P. Iyer,Selvi Thirumurthi,Richard Champlin,Guofan Xu,Pan Tinsu,David Santos,Ruiping Wang,Guangchun Han,Jianhua Zhang,Xingzhi Song,Sattva Neelapu,Jorge Romaguera,Andy Futreal,Christopher Flowers,Nathan Fowler,Linghua Wang,Michael L. Wang
View Articletitled, Genomic profiles and clinical outcomes of de novo blastoid/pleomorphic MCL are distinct from those of transformed MCL
Supplemental data
Proteomic profiling of HTLV-1 carriers and ATL patients reveals sTNFR2 as a novel diagnostic biomarker for acute ATL
Carmina Louise Hugo Guerrero,Yoshiko Yamashita,Megumi Miyara,Naoki Imaizumi,Megumi Kato,Shugo Sakihama,Masaki Hayashi,Takashi Miyagi,Kaori Karimata,Junnosuke Uchihara,Kazuiku Ohshiro,Junpei Todoroki,Sawako Nakachi,Satoko Morishima,Kennosuke Karube,Yuetsu Tanaka,Hiroaki Masuzaki,Takuya Fukushima
View Articletitled, Proteomic profiling of HTLV-1 carriers and ATL patients reveals sTNFR2 as a novel diagnostic biomarker for acute ATL
Supplemental data
SAKK38/07 study: integration of baseline metabolic heterogeneity and metabolic tumor volume in DLBCL prognostic model
Clinical Trials & Observations
Luca Ceriani,Giuseppe Gritti,Luciano Cascione,Maria Cristina Pirosa,Angela Polino,Teresa Ruberto,Anastasios Stathis,Andrea Bruno,Alden A. Moccia,Luca Giovanella,Stefanie Hayoz,Sämi Schär,Stefan Dirnhofer,Alessandro Rambaldi,Giovanni Martinelli,Christoph Mamot,Emanuele Zucca
View Articletitled, SAKK38/07 study: integration of baseline metabolic heterogeneity and metabolic tumor volume in DLBCL prognostic model

MYELOID NEOPLASIA

Comprehensive metagenomic analysis of blastic plasmacytoid dendritic cell neoplasm
Jason Nomburg,Susan Bullman,Sun Sook Chung,Katsuhiro Togami,Mark A. Walker,Gabriel K. Griffin,Elizabeth A. Morgan,Nicole R. LeBoeuf,James A. DeCaprio,Matthew Meyerson,Andrew A. Lane
View Articletitled, Comprehensive metagenomic analysis of blastic plasmacytoid dendritic cell neoplasm
Supplemental data
The prognostic impact of FLT3-ITD and NPM1 mutation in adult AML is age-dependent in the population-based setting
Clinical Trials & Observations
Gunnar Juliusson,Martin Jädersten,Stefan Deneberg,Sören Lehmann,Lars Möllgård,Lovisa Wennström,Petar Antunovic,Jörg Cammenga,Fryderyk Lorenz,Emma Ölander,Vladimir Lj Lazarevic,Martin Höglund,for the Swedish AML Registry,for the Swedish AML Registry,for the Swedish AML Registry,for the Swedish AML Registry,for the Swedish AML Registry,for the Swedish AML Registry,for the Swedish AML Registry,for the Swedish AML Registry,for the Swedish AML Registry,for the Swedish AML Registry,for the Swedish AML Registry,for the Swedish AML Registry
View Articletitled, The prognostic impact of <em>FLT3</em>-ITD and <em>NPM1</em> mutation in adult AML is age-dependent in the population-based setting
Supplemental data
Thrombotic, inflammatory, and HIF-regulated genes and thrombosis risk in polycythemia vera and essential thrombocythemia
Radhika Gangaraju,Jihyun Song,Soo Jin Kim,Tsewang Tashi,Brandi N. Reeves,Krishna M. Sundar,Perumal Thiagarajan,Josef T. Prchal
View Articletitled, Thrombotic, inflammatory, and HIF-regulated genes and thrombosis risk in polycythemia vera and essential thrombocythemia
RUNX1-mutated families show phenotype heterogeneity and a somatic mutation profile unique to germline predisposed AML
Anna L. Brown,Peer Arts,Catherine L. Carmichael,Milena Babic,Julia Dobbins,Chan-Eng Chong,Andreas W. Schreiber,Jinghua Feng,Kerry Phillips,Paul P. S. Wang,Thuong Ha,Claire C. Homan,Sarah L. King-Smith,Lesley Rawlings,Cassandra Vakulin,Andrew Dubowsky,Jessica Burdett,Sarah Moore,Grace McKavanagh,Denae Henry,Amanda Wells,Belinda Mercorella,Mario Nicola,Jeffrey Suttle,Ella Wilkins,Xiao-Chun Li,Joelle Michaud,Peter Brautigan,Ping Cannon,Meryl Altree,Louise Jaensch,Miriam Fine,Carolyn Butcher,Richard J. D’Andrea,Ian D. Lewis,Devendra K. Hiwase,Elli Papaemmanuil,Marshall S. Horwitz,Georges Natsoulis,Hugh Y. Rienhoff, Jr,Nigel Patton,Sally Mapp,Rachel Susman,Susan Morgan,Julian Cooney,Mark Currie,Uday Popat,Tilmann Bochtler,Shai Izraeli,Kenneth Bradstock,Lucy A. Godley,Alwin Krämer,Stefan Fröhling,Andrew H. Wei,Cecily Forsyth,Helen Mar Fan,Nicola K. Poplawski,Christopher N. Hahn,Hamish S. Scott
View Articletitled, <em>RUNX1</em>-mutated families show phenotype heterogeneity and a somatic mutation profile unique to germline predisposed AML
Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

Runx1 negatively regulates inflammatory cytokine production by neutrophils in response to Toll-like receptor signaling
Dana C. Bellissimo,Chia-hui Chen,Qin Zhu,Sumedha Bagga,Chung-Tsai Lee,Bing He,Gerald B. Wertheim,Martha Jordan,Kai Tan,G. Scott Worthen,D. Gary Gilliland,Nancy A. Speck
View Articletitled, Runx1 negatively regulates inflammatory cytokine production by neutrophils in response to Toll-like receptor signaling
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Inhibition of complement C1s in patients with cold agglutinin disease: lessons learned from a named patient program
Clinical Trials & Observations
Georg Gelbenegger,Christian Schoergenhofer,Ulla Derhaschnig,Nina Buchtele,Christian Sillaber,Michael Fillitz,Thomas M. Schenk,Shirley D’Sa,Ronwyn Cartwright,James C. Gilbert,Bernd Jilma,Ulrich Jaeger
View Articletitled, Inhibition of complement C1s in patients with cold agglutinin disease: lessons learned from a named patient program
Supplemental data

THROMBOSIS AND HEMOSTASIS

Antibodies that conformationally activate ADAMTS13 allosterically enhance metalloprotease domain function
An-Sofie Schelpe,Anastasis Petri,Elien Roose,Inge Pareyn,Hans Deckmyn,Simon F. De Meyer,James T. B. Crawley,Karen Vanhoorelbeke
View Articletitled, Antibodies that conformationally activate ADAMTS13 allosterically enhance metalloprotease domain function
Supplemental data

TRANSPLANTATION

Heterogeneous impact of cytomegalovirus reactivation on nonrelapse mortality in hematopoietic stem cell transplantation
Clinical Trials & Observations
Satoshi Kaito,Yujiro Nakajima,Konan Hara,Takashi Toya,Tetsuya Nishida,Naoyuki Uchida,Junichi Mukae,Takahiro Fukuda,Yukiyasu Ozawa,Masatsugu Tanaka,Kazuhiro Ikegame,Yuta Katayama,Takuro Kuriyama,Junya Kanda,Yoshiko Atsuta,Masao Ogata,Ayumi Taguchi,Kazuteru Ohashi
View Articletitled, Heterogeneous impact of cytomegalovirus reactivation on nonrelapse mortality in hematopoietic stem cell transplantation
Supplemental data
Regulatory T cells promote alloengraftment in a model of late-gestation in utero hematopoietic cell transplantation
John S. Riley,Lauren E. McClain,John D. Stratigis,Barbara E. Coons,Nicholas J. Ahn,Haiying Li,Stavros P. Loukogeorgakis,Camila G. Fachin,Andre I. B. S. Dias,Alan W. Flake,William H. Peranteau
View Articletitled, Regulatory T cells promote alloengraftment in a model of late-gestation in utero hematopoietic cell transplantation
Supplemental data
Interferon-complement loop in transplant-associated thrombotic microangiopathy
Clinical Trials & Observations
Sonata Jodele,Mario Medvedovic,Nathan Luebbering,Jenny Chen,Christopher E. Dandoy,Benjamin L. Laskin,Stella M. Davies
View Articletitled, Interferon-complement loop in transplant-associated thrombotic microangiopathy
Supplemental data

COMMENTARY

Cold agglutinin–associated B-cell lymphoproliferative disease shows highly recurrent gains of chromosome 3 and 12 or 18
Agnieszka Małecka,Jan Delabie,Ingunn Østlie,Anne Tierens,Ulla Randen,Sigbjørn Berentsen,Geir E. Tjønnfjord,Gunhild Trøen
View Articletitled, Cold agglutinin–associated B-cell lymphoproliferative disease shows highly recurrent gains of chromosome 3 and 12 or 18
Supplemental data

ERRATA

Attarbaschi A, Abla O, Ronceray L, et al. Primary central nervous system lymphoma: initial features, outcome, and late effects in 75 children and adolescents. Blood Adv. 2019;3(24):4291-4297.
View Articletitled, Attarbaschi A, Abla O, Ronceray L, et al. Primary central nervous system lymphoma: initial features, outcome, and late effects in 75 children and adolescents. <em>Blood Adv.</em> 2019;3(24):4291-4297.
Pollyea DA, Amaya M, Strati P, Konopleva MY. Venetoclax for AML: changing the treatment paradigm. Blood Adv. 2019;3(24):4326-4335.
View Articletitled, Pollyea DA, Amaya M, Strati P, Konopleva MY. Venetoclax for AML: changing the treatment paradigm. <em>Blood Adv.</em> 2019;3(24):4326-4335.
Keating AK, Langenhorst J, Wagner JE, et al. The influence of stem cell source on transplant outcomes for pediatric patients with acute myeloid leukemia. Blood Adv. 2019;3(7):1118-1128.
View Articletitled, Keating AK, Langenhorst J, Wagner JE, et al. The influence of stem cell source on transplant outcomes for pediatric patients with acute myeloid leukemia. <em>Blood Adv.</em> 2019;3(7):1118-1128.
Carden MA, Gaddh M, Hoskote A, et al. Rituximab leads to early elimination of circulating CD20+ T and B lymphocytes in patients with iTTP despite ongoing TPEx. Blood Adv. 2020;4(3):477-481.
View Articletitled, Carden MA, Gaddh M, Hoskote A, et al. Rituximab leads to early elimination of circulating CD20<sup>+</sup> T and B lymphocytes in patients with iTTP despite ongoing TPEx. <em>Blood Adv.</em> 2020;4(3):477-481.
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