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Issue Archive

Volume 4, Issue 17
September 8 2020
Issue Cover

Table of Contents

EXCEPTIONAL CASE REPORT

Ponatinib coronary microangiopathy: novel bedside diagnostic approach and management with N-acetylcysteine
Clinical Trials & Observations
Melinda D. Wu,James Hodovan,Kris Kumar,Bart Moulton,Sven Olson,Aubre Gilbert,Matthew D. Wood,Jonathan R. Lindner
View Articletitled, Ponatinib coronary microangiopathy: novel bedside diagnostic approach and management with <em>N</em>-acetylcysteine
Supplemental data

STIMULUS REPORT

Venous thromboembolism associated with CD19-directed CAR T-cell therapy in large B-cell lymphoma
Clinical Trials & Observations
Hamza Hashmi,Abu-Sayeef Mirza,Alicia Darwin,Constantine Logothetis,Franco Garcia,Anuhya Kommalapati,Rahul S. Mhaskar,Christina Bachmeier,Julio C. Chavez,Bijal Shah,Javier Pinilla-Ibarz,Farhad Khimani,Aleksandr Lazaryan,Hien Liu,Marco L. Davila,Frederick L. Locke,Taiga Nishihori,Michael D. Jain
View Articletitled, Venous thromboembolism associated with CD19-directed CAR T-cell therapy in large B-cell lymphoma
Supplemental data

REVIEW ARTICLE

Enhancing antitumor immunity through checkpoint blockade as a therapeutic strategy in T-cell lymphomas
Alexander Neuwelt,Taha Al-Juhaishi,Eduardo Davila,Bradley Haverkos
View Articletitled, Enhancing antitumor immunity through checkpoint blockade as a therapeutic strategy in T-cell lymphomas

CLINICAL TRIALS AND OBSERVATIONS

Phase 1/2a study of 177Lu-lilotomab satetraxetan in relapsed/refractory indolent non-Hodgkin lymphoma
Clinical Trials & Observations
Arne Kolstad,Tim Illidge,Nils Bolstad,Signe Spetalen,Ulf Madsbu,Caroline Stokke,Johan Blakkisrud,Ayca Løndalen,Noelle O'Rourke,Matthew Beasley,Wojciech Jurczak,Unn-Merete Fagerli,Michal Kaščák,Mike Bayne,Aleš Obr,Jostein Dahle,Lisa Rojkjaer,Veronique Pascal,Harald Holte
View Articletitled, Phase 1/2a study of <sup>177</sup>Lu-lilotomab satetraxetan in relapsed/refractory indolent non-Hodgkin lymphoma
Supplemental data
Sequential response-driven bortezomib-based therapy followed by autologous stem cell transplant in AL amyloidosis
Clinical Trials & Observations
Marco Basset,Paolo Milani,Mario Nuvolone,Francesca Benigna,Lara Rodigari,Andrea Foli,Giampaolo Merlini,Giovanni Palladini
View Articletitled, Sequential response-driven bortezomib-based therapy followed by autologous stem cell transplant in AL amyloidosis
Supplemental data

IMMUNOBIOLOGY AND IMMUNOTHERAPY

Phase 2 multiple-dose study of an FcRn inhibitor, rozanolixizumab, in patients with primary immune thrombocytopenia
Clinical Trials & Observations
Tadeusz Robak,Maciej Kaźmierczak,Isidro Jarque,Vasile Musteata,Jacek Treliński,Nichola Cooper,Peter Kiessling,Ute Massow,Franz Woltering,Rose Snipes,Juan Ke,Grant Langdon,James B. Bussel,Stephen Jolles
View Articletitled, Phase 2 multiple-dose study of an FcRn inhibitor, rozanolixizumab, in patients with primary immune thrombocytopenia
Supplemental data
AMG 701 induces cytotoxicity of multiple myeloma cells and depletes plasma cells in cynomolgus monkeys
Rebecca L. Goldstein,Ana Goyos,Chi-Ming Li,Petra Deegen,Pamela Bogner,Alexander Sternjak,Oliver Thomas,Matthias Klinger,Joachim Wahl,Matthias Friedrich,Benno Rattel,Edwin Lamas,Xiaoshan Min,Athena Sudom,Mozhgan Farshbaf,Angela Coxon,Mercedesz Balazs,Tara Arvedson
View Articletitled, AMG 701 induces cytotoxicity of multiple myeloma cells and depletes plasma cells in cynomolgus monkeys
Supplemental data
Recipient-specific T-cell repertoire reconstitution in the gut following murine hematopoietic cell transplant
Pingping Zheng,John Tamaresis,Govindarajan Thangavelu,Liwen Xu,Xiaoqing You,Bruce R. Blazar,Robert S. Negrin,James L. Zehnder,Bettina P. Iliopoulou,Everett H. Meyer
View Articletitled, Recipient-specific T-cell repertoire reconstitution in the gut following murine hematopoietic cell transplant
Supplemental data
Charge-altering releasable transporters enable phenotypic manipulation of natural killer cells for cancer immunotherapy
Aaron J. Wilk,Nancy Lynn-Benner Weidenbacher,Rosemary Vergara,Ole A. W. Haabeth,Ronald Levy,Robert M. Waymouth,Paul A. Wender,Catherine A. Blish
View Articletitled, Charge-altering releasable transporters enable phenotypic manipulation of natural killer cells for cancer immunotherapy
Supplemental data

LYMPHOID NEOPLASIA

The hematopoietic stem cell marker VNN2 is associated with chemoresistance in pediatric B-cell precursor ALL
Beat Bornhauser,Gunnar Cario,Anna Rinaldi,Thomas Risch,Virginia Rodriguez Martinez,Moritz Schütte,Hans-Jörg Warnatz,Nastassja Scheidegger,Paulina Mirkowska,Martina Temperli,Claudia Möller,Angela Schumich,Michael Dworzak,Andishe Attarbaschi,Monika Brüggemann,Mathias Ritgen,Ester Mejstrikova,Andreas Hofmann,Barbara Buldini,Pamela Scarparo,Giuseppe Basso,Oscar Maglia,Giuseppe Gaipa,Tessa Lara Skroblyn,Quy A. Ngo,Geertruij te Kronnie,Elena Vendramini,Renate Panzer-Grümayer,Malwine Jeanette Barz,Blerim Marovca,Mathias Hauri-Hohl,Felix Niggli,Cornelia Eckert,Martin Schrappe,Martin Stanulla,Martin Zimmermann,Bernd Wollscheid,Marie-Laure Yaspo,Jean-Pierre Bourquin
View Articletitled, The hematopoietic stem cell marker VNN2 is associated with chemoresistance in pediatric B-cell precursor ALL
Supplemental data
The critical role of CD4+ T cells in PD-1 blockade against MHC-II–expressing tumors such as classic Hodgkin lymphoma
Joji Nagasaki,Yosuke Togashi,Takeaki Sugawara,Makiko Itami,Nobuhiko Yamauchi,Junichiro Yuda,Masato Sugano,Yuuki Ohara,Yosuke Minami,Hirohisa Nakamae,Masayuki Hino,Masahiro Takeuchi,Hiroyoshi Nishikawa
View Articletitled, The critical role of CD4<sup>+</sup> T cells in PD-1 blockade against MHC-II–expressing tumors such as classic Hodgkin lymphoma
Supplemental data
Antitumor activity of the dual BET and CBP/EP300 inhibitor NEO2734
Filippo Spriano,Eugenio Gaudio,Luciano Cascione,Chiara Tarantelli,Federica Melle,Giovanna Motta,Valdemar Priebe,Andrea Rinaldi,Gaetanina Golino,Afua Adjeiwaa Mensah,Luca Aresu,Emanuele Zucca,Stefano Pileri,Michael Witcher,Bill Brown,Claes Wahlestedt,Francis Giles,Anastasios Stathis,Francesco Bertoni
View Articletitled, Antitumor activity of the dual BET and CBP/EP300 inhibitor NEO2734
Supplemental data
AKT signaling restrains tumor suppressive functions of FOXO transcription factors and GSK3 kinase in multiple myeloma
Timon A. Bloedjes,Guus de Wilde,Chiel Maas,Eric Eldering,Richard J. Bende,Carel J. M. van Noesel,Steven T. Pals,Marcel Spaargaren,Jeroen E. J. Guikema
View Articletitled, AKT signaling restrains tumor suppressive functions of FOXO transcription factors and GSK3 kinase in multiple myeloma
Supplemental data
The immunomodulatory drugs lenalidomide and pomalidomide enhance the potency of AMG 701 in multiple myeloma preclinical models
Shih-Feng Cho,Liang Lin,Lijie Xing,Yuyin Li,Kenneth Wen,Tengteng Yu,Phillip A. Hsieh,Nikhil Munshi,Joachim Wahl,Katja Matthes,Matthias Friedrich,Tara Arvedson,Kenneth C. Anderson,Yu-Tzu Tai
View Articletitled, The immunomodulatory drugs lenalidomide and pomalidomide enhance the potency of AMG 701 in multiple myeloma preclinical models
Supplemental data
PI3Kδ inhibition reshapes follicular lymphoma–immune microenvironment cross talk and unleashes the activity of venetoclax
Neus Serrat,Martina Guerrero-Hernández,Alba Matas-Céspedes,Anella Yahiaoui,Juan G. Valero,Ferran Nadeu,Guillem Clot,Miriam Di Re,Marc Corbera-Bellalta,Laura Magnano,Alfredo Rivas-Delgado,Anna Enjuanes,Silvia Beà,Maria C. Cid,Elías Campo,Joan Montero,Daniel J. Hodson,Armando López-Guillermo,Dolors Colomer,Stacey Tannheimer,Patricia Pérez-Galán
View Articletitled, PI3Kδ inhibition reshapes follicular lymphoma–immune microenvironment cross talk and unleashes the activity of venetoclax
Supplemental data

THROMBOSIS AND HEMOSTASIS

Effectiveness and safety of rivaroxaban compared with low-molecular-weight heparin in cancer-associated thromboembolism
Clinical Trials & Observations
Olivia S. Costa,Christine G. Kohn,Nicole M. Kuderer,Gary H. Lyman,Thomas J. Bunz,Craig I. Coleman
View Articletitled, Effectiveness and safety of rivaroxaban compared with low-molecular-weight heparin in cancer-associated thromboembolism
von Willebrand factor variant D1472H has no effect in mice with humanized VWF-platelet interactions
Hannah K. Lohmeier,Tricia L. Slobodianuk,Sachiko Kanaji,Sandra L. Haberichter,Robert R. Montgomery,Veronica H. Flood
View Articletitled, von Willebrand factor variant D1472H has no effect in mice with humanized VWF-platelet interactions
Pharmacometric modeling to explore 4F-PCC dosing strategies for VKA reversal in patients with INR below 2
Clinical Trials & Observations
Ravi Sarode,Katsuyuki Fukutake,Masahiro Yasaka,Michael A. Tortorici,Antoinette Mangione,Marc Pfister,Adam Cuker
View Articletitled, Pharmacometric modeling to explore 4F-PCC dosing strategies for VKA reversal in patients with INR below 2
Supplemental data

TRANSPLANTATION

Allogeneic hematopoietic cell transplantation after prior targeted therapy for high-risk chronic lymphocytic leukemia
Haesook T. Kim,Conner J. Shaughnessy,Sharmila C. Rai,Carol Reynolds,Vincent T. Ho,Corey Cutler,John Koreth,Mahasweta Gooptu,Rizwan Romee,Sarah Nikiforow,Philippe Armand,Edwin P. Alyea,Joseph H. Antin,Catherine J. Wu,Robert J. Soiffer,Jerome Ritz,Jennifer R. Brown
View Articletitled, Allogeneic hematopoietic cell transplantation after prior targeted therapy for high-risk chronic lymphocytic leukemia
Supplemental data
Variable CD34+ recovery of cryopreserved allogeneic HPC products: transplant implications during the COVID-19 pandemic
Duncan Purtill,Vicki Antonenas,Paul Chiappini,Daochen Tong,Elizabeth O’Flaherty,Ashish Bajel,Karieshma Kabani,Stephen Larsen,Suikeat Tan,Cheryl Hutchins,David J. Curtis,Glen A. Kennedy,Anne-Marie Watson,LiJun Bai,Matthew Greenwood,David J. Gottlieb,Nada Hamad
View Articletitled, Variable CD34<sup>+</sup> recovery of cryopreserved allogeneic HPC products: transplant implications during the COVID-19 pandemic
Supplemental data
Cord blood CD8+ T-cell expansion following granulocyte transfusions eradicates refractory leukemia
Prashant Hiwarkar,Stuart Adams,Kimberly Gilmour,Ramya Nataraj,Denise Bonney,Kay Poulton,Robert Wynn
View Articletitled, Cord blood CD8<sup>+</sup> T-cell expansion following granulocyte transfusions eradicates refractory leukemia
Supplemental data

VASCULAR BIOLOGY

Integrin VLA-4 as a PET imaging biomarker of hyper-adhesion in transgenic sickle mice
Lydia A. Perkins,Lea Nyiranshuti,Lynda Little-Ihrig,Joseph D. Latoche,Kathryn E. Day,Qin Zhu,Sina Tavakoli,Prithu Sundd,Enrico M. Novelli,Carolyn J. Anderson
View Articletitled, Integrin VLA-4 as a PET imaging biomarker of hyper-adhesion in transgenic sickle mice
Supplemental data
All Issues

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Cardiovascular and genetic determinants of platelet high responsiveness: results from the Gutenberg Health Study
Targeting CD38 with isatuximab and a novel CD38/CD3×CD28 trispecific T-cell engager in older patients with acute myeloid leukemia
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