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Journal Articles

FXII inhibition: multipronged benefits

Helen Philippou

Blood (2021) 138 (2): 107–109.

https://doi.org/10.1182/blood.2021011032

Published: 2021

Journal Articles

Single Cell Transcriptomic Analysis of the Multiple Myeloma Bone Marrow Identifies a Unique Inflammatory Stromal Cell Population Associated with TNF Signaling

Madelon M.E. de Jong, MD, Zoltan Kellermayer, MD PhD, Natalie Papazian, M Duin, Annemiek Broyl, MD PhD, Pieter Sonneveld, Tom Cupedo

Blood (2019) 134 (Supplement_1): 690.

https://doi.org/10.1182/blood-2019-123012

Published: 2019

Journal Articles

Dnmt3a Mutation Confers a Selective Advantage Specifically to Cells within the Long-Term Hematopoietic Stem Cell (LT-HSC) Compartment

Elizabeth Eudy, BS, Matthew Loberg, BA, Rebecca Bell, BA, Tim Stearns, Jennifer Trowbridge, PhD

Blood (2019) 134 (Supplement_1): 448.

https://doi.org/10.1182/blood-2019-124540

Published: 2019

Journal Articles

Loss of METTL3 Mediated m6A RNA Modification Results in Double-Stranded RNA Induced Innate Immune Response and Hematopoietic Failure

Blood (2019) 134 (Supplement_1): 450.

https://doi.org/10.1182/blood-2019-130442

Published: 2019

Journal Articles

The Low Number of Mucosal-Associated Invariant T Cells in the Graft Was Associated with Occurrence of Gut Graft-Versus-Host Disease

Gao Mengge, Yan Hong, Yuqian Sun, MD, Jun Kong, MD, Chenhua Yan, PhD, Zhidong Wang, PhD, Yu Wang, Xiaojun Huang, MD, Xiaosu Zhao, PhD

Blood (2019) 134 (Supplement_1): 2001.

https://doi.org/10.1182/blood-2019-127722

Published: 2019

Journal Articles

Evidence of Endothelial Dysfunction and Activation of RhoA/Rho Kinase Pathway in Inflammatory Bowel Disease

Jaime Pereira, MD, Claudia G Saez, PhD, Manuel Alvarez, MD, Felipe Silva, MD, Nixa Olivares, Jose G Valenzuela, Antonia Pastore, Diego Mezzano, MD

Blood (2019) 134 (Supplement_1): 3641.

https://doi.org/10.1182/blood-2019-126033

Published: 2019

Journal Articles

Combining CAR Engineering and CIS Checkpoint Deletion in NK Cells for the Treatment of B Cell Hematologic Malignancies

Blood (2019) 134 (Supplement_1): 1936.

https://doi.org/10.1182/blood-2019-126739

Published: 2019

Journal Articles

Acute Inflammation Induces Lactate Release By Bone Marrow Neutrophils That Promotes Their Mobilization Via Endothelial GPR81 Signaling

Eman Khatib-Massalha, MSc, Suditi Bhattacharya, MSc, Hassan Massalha, PhD, Karin Golan, PhD, Orit Kollet, PhD, Anju Kumari, PhD, Francesca Avemaria, PhD, Tomer Itkin, PhD, Shiri Gur-Cohen, PhD, Abraham Avigdor, MD, Shalev Itzkovitz, PhD, Stefan Offermanns, MD PhD, Amiram Ariel, PhD, Ronen Alon, PhD, Tsvee Lapidot, PhD

Blood (2019) 134 (Supplement_1): 3582.

https://doi.org/10.1182/blood-2019-123248

Published: 2019

Journal Articles

Inflammation Response Cytokines IFN-γ and IL-10 Regulate Monocyte Subset Differentiation

Hui Zhong, PhD, Weili Bao, Yunfeng Liu, PhD, Karina Yazdanbakhsh, PhD

Blood (2019) 134 (Supplement_1): 3586.

https://doi.org/10.1182/blood-2019-129515

Published: 2019

Journal Articles

Heme Overload Triggers Xanthine Oxidase Release and Mediates the Inflammatory Response

Heidi M Schmidt, BSE, Eric Kelley, PhD, Adam Straub, PhD

Blood (2019) 134 (Supplement_1): 3529.

https://doi.org/10.1182/blood-2019-130274

Published: 2019

Journal Articles

High Molecular Weight Kininogen but Not Factor XII Deficiency Attenuates Acetaminophen-Induced Liver Injury in Mice

Michael Wayne Henderson, MSc, Erica Sparkenbaugh, PhD BS, Denis Noubouossie, MD PhD, Reiner Mailer, Thomas Renne, MD PhD, Keith R McCrae, MD, Nigel S. Key, MBChB, FRCP, Rafal Pawlinski, PhD

Blood (2019) 134 (Supplement_1): 3621.

https://doi.org/10.1182/blood-2019-127206

Published: 2019

Journal Articles

Bone Marrow Plasma Cell Burden in Gaucher Disease Correlates with Local Macrophage Infiltration and May be Altered By Disease Treatment

Monika Klimkowska, MD PhD, Maciej J. Machaczka, MD PhD

Blood (2019) 134 (Supplement_1): 3593.

https://doi.org/10.1182/blood-2019-131343

Published: 2019

Journal Articles

Disease Model of Atherosclerosis Using Werner Syndrome Patient-Derived Induced Pluripotent Stem Cells Reveals Excessive Inflammatory Response Against Ox-LDL

Sudip Kumar Paul, MSc, Masamitsu Sone, PhD, Hisaya Kato, MD PhD, Yoshiro Maezawa, MD PhD, Yasuo Ouchi, PhD, Koutaro Yokote, MD PhD, Koji Eto, MD, Naoya Takayama, MD PhD

Blood (2019) 134 (Supplement_1): 3615.

https://doi.org/10.1182/blood-2019-123919

Published: 2019

Journal Articles

Composite Copy Number Variation in CDK4 , CDKN2A and RB1 Predisposes Mantle Cell Lymphoma to Expansion of PD1+ Tumor Cells and Resistance to CDK4/6 Inhibitor Therapy as Revealed by Integrative Longitudinal scRNA-seq

Maurizio Di Liberto, PhD, Yang Hu, PhD, Xiangao Huang, PhD, Christina Y. Lee, MD, Kevin Wang, B.S., Nancy L. Bartlett, MD, LeAnn Ridling, Kristie A. Blum, MD, Kami J. Maddocks, MD, Steven I Park, MD, Jia Ruan, MD PhD, Kenneth Eng, B.S., Lorenzo Galluzzi, PhD, John P. Leonard, MD, Peter Martin, FRCPC, MD MS, Olivier Elemento, PhD, Selina Chen-Kiang, PhD

Blood (2019) 134 (Supplement_1): 1492.

https://doi.org/10.1182/blood-2019-130944

Published: 2019

Journal Articles

Bnz-1, a Selective γ-Chain Cytokine Inhibitor Has Clinical Activity in Patients with Cutaneous T Cell Lymphoma By Selectively Blocking IL-2, IL-15 and IL-9 Signaling: Results of a Multicenter, Open-Label Phase 1 Trial

Christiane Querfeld, MD PhD, Basem M. William, MRCP,MD, Jonathan E. Brammer, MD, Lubomir Sokol, MD PhD, Yutaka Tagaya, MD PhD, Paul Frohna, MD PhD PharmD, Nazli Azimi, PhD PharmD, Jasmine M. Zain, MD

Blood (2019) 134 (Supplement_1): 1557.

https://doi.org/10.1182/blood-2019-129201

Published: 2019

Journal Articles

Transcriptomic and Metabolomic Profiling Identifies Calcium-Dependent Signaling Mechanisms As a Novel and Exploitable Target to Overcome Anti-CD20 Resistance in Non-Hodgkin Lymphoma (NHL)

Ravi Dashnamoorthy, PhD, Saheli Sarkar, PhD, Afshin Beheshti, PhD, Maisarah Mokhtar, B.S, Tali Konry, PhD, Michael Levin, PhD, Andrew M. Evens, DO, MSc

Blood (2019) 134 (Supplement_1): 1511.

https://doi.org/10.1182/blood-2019-126539

Published: 2019

Journal Articles

Alterations in Secretome and Transcriptome of Bone Marrow Derived MSCs in Patients with Diffuse Large B-Cell Lymphoma without Bone Marrow Involvement

Nataliya A. Petinati, MD PhD, Natalia Sats, PhD, Nina J. Drize, PhD, Irina Malyants, Victoria Shender, PhD, Ksenia Anufrieva, PhD, Polina Shneider, Tatiana Grigorieva, PhD, Georgiy Arapidi, PhD, Maria Lagarkova, PhD, Ekaterina A. Fastova, MD, Aminat A. Magomedova, MD PhD, Sergey K. Kravchenko, MD PhD, Valeriy G. Savchenko, MD PhD

Blood (2019) 134 (Supplement_1): 1514.

https://doi.org/10.1182/blood-2019-122431

Published: 2019

Journal Articles

Alliance A041701 - a Randomized Phase 2/3 Study of Conventional Chemotherapy +/- Uproleselan (GMI-1271) in Older Adults with Acute Myeloid Leukemia (AML) Receiving Intensive Induction Chemotherapy

Geoffrey L. Uy, MD, Jun Yin, PhD, Heidi D. Klepin, MD, Shira Dinner, MD, Anthony J. Jaslowski, MD, Stephen A. Strickland, MD, Jane L. Liesveld, MD, John C. Byrd, MD, Richard M. Stone, MD

Blood (2019) 134 (Supplement_1): 1366.

https://doi.org/10.1182/blood-2019-127142

Published: 2019

Journal Articles

Deciphering Molecular Heterogeneity in Pediatric AML Using a Cancer Vs Normal Transcriptomic Approach

Barbara Depreter, PhD PharmD, Mattias Hofmans, MD, Eva Terras, Anne Uyttebroeck, MD, An Van Damme, MD, Alina Ferster, MD, Jutte Van der Werff Ten Bosch, MD, Marie-Françoise Dresse, MD PhD, Karl Vandepoele, PhD, Barbara De Moerloose, MD PhD, Jan Philippé, MD PhD, Tim Lammens, PhD

Blood (2019) 134 (Supplement_1): 1457.

https://doi.org/10.1182/blood-2019-125538

Published: 2019

Journal Articles

Functional Calcitriol/Vitamin D Receptor Signaling in Chronic Lymphocytic Leukemia

Marina Gerousi, Fotis Psomopoulos, Kostantia Kotta, Niki Stavroyianni, Achilles Anagnostopoulos, Ioannis Kotsianidis, Stavroula Ntoufa, Kostas Stamatopoulos

Blood (2019) 134 (Supplement_1): 3019.

https://doi.org/10.1182/blood-2019-127910

Published: 2019

NARROW

FXII inhibition: multipronged benefits

Single Cell Transcriptomic Analysis of the Multiple Myeloma Bone Marrow Identifies a Unique Inflammatory Stromal Cell Population Associated with TNF Signaling

Dnmt3a Mutation Confers a Selective Advantage Specifically to Cells within the Long-Term Hematopoietic Stem Cell (LT-HSC) Compartment

Loss of METTL3 Mediated m6A RNA Modification Results in Double-Stranded RNA Induced Innate Immune Response and Hematopoietic Failure

The Low Number of Mucosal-Associated Invariant T Cells in the Graft Was Associated with Occurrence of Gut Graft-Versus-Host Disease

Evidence of Endothelial Dysfunction and Activation of RhoA/Rho Kinase Pathway in Inflammatory Bowel Disease

Combining CAR Engineering and CIS Checkpoint Deletion in NK Cells for the Treatment of B Cell Hematologic Malignancies

Acute Inflammation Induces Lactate Release By Bone Marrow Neutrophils That Promotes Their Mobilization Via Endothelial GPR81 Signaling

Inflammation Response Cytokines IFN-γ and IL-10 Regulate Monocyte Subset Differentiation

Heme Overload Triggers Xanthine Oxidase Release and Mediates the Inflammatory Response

High Molecular Weight Kininogen but Not Factor XII Deficiency Attenuates Acetaminophen-Induced Liver Injury in Mice

Bone Marrow Plasma Cell Burden in Gaucher Disease Correlates with Local Macrophage Infiltration and May be Altered By Disease Treatment

Disease Model of Atherosclerosis Using Werner Syndrome Patient-Derived Induced Pluripotent Stem Cells Reveals Excessive Inflammatory Response Against Ox-LDL

Composite Copy Number Variation in CDK4 , CDKN2A and RB1 Predisposes Mantle Cell Lymphoma to Expansion of PD1+ Tumor Cells and Resistance to CDK4/6 Inhibitor Therapy as Revealed by Integrative Longitudinal scRNA-seq

Bnz-1, a Selective γ-Chain Cytokine Inhibitor Has Clinical Activity in Patients with Cutaneous T Cell Lymphoma By Selectively Blocking IL-2, IL-15 and IL-9 Signaling: Results of a Multicenter, Open-Label Phase 1 Trial

Transcriptomic and Metabolomic Profiling Identifies Calcium-Dependent Signaling Mechanisms As a Novel and Exploitable Target to Overcome Anti-CD20 Resistance in Non-Hodgkin Lymphoma (NHL)

Alterations in Secretome and Transcriptome of Bone Marrow Derived MSCs in Patients with Diffuse Large B-Cell Lymphoma without Bone Marrow Involvement

Alliance A041701 - a Randomized Phase 2/3 Study of Conventional Chemotherapy +/- Uproleselan (GMI-1271) in Older Adults with Acute Myeloid Leukemia (AML) Receiving Intensive Induction Chemotherapy

Deciphering Molecular Heterogeneity in Pediatric AML Using a Cancer Vs Normal Transcriptomic Approach

Functional Calcitriol/Vitamin D Receptor Signaling in Chronic Lymphocytic Leukemia

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American Society of Hematology

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American Society of Hematology

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