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Journal Articles

Inhibition of ATR Potentiates Acute Myeloid Leukemia Cells to the RNA Pol I Transcription Inhibitor CX-5461

Margaret Shatara, MD, Tingting Wang, Xinyu Li, Holly Edwards, BS, Jeffrey W. Taub, MD, Hai Lin, MD, Yubin Ge, PhD

Blood (2018) 132 (Supplement 1): 5224.

https://doi.org/10.1182/blood-2018-99-113937

Published: 2018

Journal Articles

RNA Polymerase 1 Transcription Inhibitor CX-5461 in Patients with Advanced Hematologic Malignancies: Results of a Phase I First in Human Study

Amit Khot, MBBS, MD MRCP, FRCPath, FRACP, Natalie Brajanovski, BSc, Donald P Cameron, BSc, Gretchen Poortinga, PhD, Elaine Sanij, PhD, John Lim, PharmD, John Soong, MD FCAP, Nadine Hein, PhD, Emma Link, DPhil, Richard B Pearson, PhD, Ross Hannan, Grant A. McArthur, MBBS, PhD BSc, FRACP, Simon J. Harrison, MBBS,MRCP,FRCPath,FRACP,PhD

Blood (2017) 130 (Supplement 1): 3835.

https://doi.org/10.1182/blood.V130.Suppl_1.3835.3835

Published: 2017

Journal Articles

Novel Combination Therapies with the RNA Polymerase I Inhibitor CX-5461 Significantly Improve Efficacy in Multiple Myeloma

Kylee H Maclachlan, FRACP,FRCPA, Andrew Cuddihy, PhD, Nadine Hein, PhD, Carleen Cullinane, PhD, Simon J. Harrison, MBBS,MRCP,FRCPath,FRACP,PhD, Ross Hannan, PhD, Gretchen Poortinga, PhD

Blood (2017) 130 (Supplement 1): 1805.

https://doi.org/10.1182/blood.V130.Suppl_1.1805.1805

Published: 2017

Journal Articles

Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population

Blood (2017) 129 (21): 2882–2895.

https://doi.org/10.1182/blood-2016-05-718171

Published: 2017

Includes: Supplemental data

Journal Articles

A New Insight into Pediatric Leukemia: Che-1 Involvement in Oncogenic c-Myc Signaling

Valentina Folgiero, PhD, Cristina Sorino, PhD, Valentina Bertaina, PhD, Francesca De Nicola, PhD, Frauke Goeman, PhD, Paolo Romania, PhD, Matteo Pallocca, PhD, Doriana Fruci, PhD, Alice Bertaina, MD PhD, Luciana Vinti, MD, Maurizio Fanciulli, PhD, Franco Locatelli, MD

Blood (2016) 128 (22): 5267.

https://doi.org/10.1182/blood.V128.22.5267.5267

Published: 2016

Journal Articles

RNA Polymerase I Inhibition with CX-5461 As a Novel Strategy to Target MYC in Multiple Myeloma

Hans Lee, MD, Hua Wang, PhD, Heather Lin, M.S., Veera Baladandayuthapani, PhD, Jin He, Richard Julian Jones, PhD, Isere Kuiatse, PhD, Dongmin Gu, MD, PhD, Zhiqiang Wang, PhD, Sean O'Brien, PhD, Jonathan J Keats, PhD, Jing Yang, PhD, Richard Eric Davis, MD, Robert Z. Orlowski, PhD, MD

Blood (2015) 126 (23): 3010.

https://doi.org/10.1182/blood.V126.23.3010.3010

Published: 2015

Journal Articles

High Resolution Mapping of Active RNA Polymerases Identifies KIT As a Target of BET Inhibitors in t(8;21) AML

Yue Zhao, PhD, Phillip Liu, PhD, Peggy Scherle, PhD, Reid Huber, PhD, Michael R. Savona, MD, Scott Hiebert, PhD

Blood (2015) 126 (23): 1225.

https://doi.org/10.1182/blood.V126.23.1225.1225

Published: 2015

Journal Articles

Repositioning of Quinacrine for Treatment of Acute Myeloid Leukemia

Anna Eriksson, MD PhD, Albin Osterros, MD, Sadia Hassan, PhD, Joachim Gullbo, MD PhD, Linda Rickardson, PhD, Malin Jarvius, PhD, Peter Nygren, MD Prof., Marten Fryknas, PhD, Martin Hoglund, MD PhD, Rolf Larsson, MD PhD

Blood (2014) 124 (21): 3609.

https://doi.org/10.1182/blood.V124.21.3609.3609

Published: 2014

Journal Articles

Collapse of Ribosome Biogenesis Induces Rapid Erythroblast Differentiation

Anna Raimbault, Celia Floquet, PhD, Boris Guyot, Ulku Cuhadar, Olivier Kosmider, MD PhD, Francois Morle, PhD, Patrick Mayeux, PhD, Michaela Fontenay, MD PhD

Blood (2014) 124 (21): 2671.

https://doi.org/10.1182/blood.V124.21.2671.2671

Published: 2014

Journal Articles

Interaction of TIF-90 and filamin A in the regulation of rRNA synthesis in leukemic cells

Le Xuan Truong Nguyen, Steven M. Chan, Tri Duc Ngo, Aparna Raval, Kyeong Kyu Kim, Ravindra Majeti, Beverly S. Mitchell

Blood (2014) 124 (4): 579–589.

https://doi.org/10.1182/blood-2013-12-544726

Published: 2014

Includes: Supplemental data

Journal Articles

CX-5461, a Novel RNA Polymerase I Inhibitor, Is Active Against Wild-Type and Mutant p53 Myeloma Models

Hans C. Lee, MD, Hua Wang, Ph.D., Bing-Zong Li, M.D., Ph.D., Zhiqiang Wang, Ph.D., Richard Julian Jones, Ph.D., Dongmin Gu, M.D., Ph.D., Sean O'Brien, Ph.D., Richard E. Davis, M.D., Robert Z. Orlowski, M.D., Ph.D.

Blood (2013) 122 (21): 4438.

https://doi.org/10.1182/blood.V122.21.4438.4438

Published: 2013

Journal Articles

Inhibition Of RNA Polymerase I Transcription By CX-5461 As a Therapeutic Strategy For The Cancer-Specific Activation Of p53 In Highly Refractory Haematological Malignancies

Nadine Hein, PhD, Sean O'Brien, Ph.D., Denis Drygin, PhD, Simon J. Harrison, MBBS MRCP (uk) MRCPath (uk) PhD, Amit Khot, MD, FRCPath, MBBS, MRCP, Carleen Cullinane, PhD, Matthews Geoff, PhD, Marta Chesi, PhD, Peter Leif Bergsagel, MD, Johannes Zuber, MD, Scott W. Lowe, Ph.D., Ricky W Johnstone, PhD, Rick Pearson, PhD, Grant A. McArthur, MD, PhD, FRACP, MBBS, Ross D Hannan, PhD

Blood (2013) 122 (21): 3941.

https://doi.org/10.1182/blood.V122.21.3941.3941

Published: 2013

Journal Articles

Single Arm, Multi-Center, Phase II Study Of Clofarabine In Chinese Pediatric Patients With Refractory Or Relapsed Acute Lymphoblastic Leukemia

Leping Zhang, Xin Du, MD, Yan Li, MD, Zhen Cai, MD, PhD, Kang Yu, MD, Fenlai Tan, MD, PhD, Yi Fang, MD, Xiaojun Huang, MD, Jin Lu, MD

Blood (2013) 122 (21): 5016.

https://doi.org/10.1182/blood.V122.21.5016.5016

Published: 2013

Journal Articles

Activation Of Akt Enhances Ribosomal RNA Synthesis In AML Cells Through a Novel Isoform Of TIF-1A and Inhibition Of Filamin A Cleavage

Le Xuan Truong Nguyen, PhD, Min Huang, Steven M. Chan, MD, PhD, Ravi Majeti, MD, PhD, Beverly S. Mitchell

Blood (2013) 122 (21): 1266.

https://doi.org/10.1182/blood.V122.21.1266.1266

Published: 2013

Journal Articles

Inhibition of RNA Polymerase I Transcription by CX-5461 As a Therapeutic Strategy for the Cancer-Specific Activation of p53 in MLL-Rearranged Acute Myeloid Leukemias

Nadine Hein, PhD, Megan J Bywater, PhD, Kim Stanley, BSc, Inge Verbrugge, PhD, Carlene Cullinane, PhD, Adele Baker, PhD, Hannes Zuber, PhD, Amy Rappaport, PhD, Denis Drygin, PhD, Nanni Huser, PhD, Josh Bliesath, PhD, David M Ryckman, PhD, William G Rice, PhD, Scott W Lowe, PhD, Ricky W Johnstone, PhD, Richard B Pearson, PhD, Grant A. McArthur, MD, PhD, FRACP, MBBS, Ross D Hannan, PhD

Blood (2011) 118 (21): 1548.

https://doi.org/10.1182/blood.V118.21.1548.1548

Published: 2011

Journal Articles

High-Resolution Genome Wide Copy Number Alteration (CNA) and Loss of Heterozigosity (LOH) Analysis in Chronic Myeloid Leukemia (CML) Shows That High and Intermediate Sokal Risk Pts (Pts) Have Multiple Losses Targeting Genes Involved in DNA Repair.

Simona Soverini, PhD, Sabrina Colarossi, Alessandra Gnani, Annalisa Astolfi, Serena Formica, Fausto Castagnetti, Francesca Palandri, Gabriele Gugliotta, Angela Poerio, Ilaria Iacobucci, Marilina Amabile, Giulia Marzocchi, Simona Luatti, Carolina Terragna, Sandra Durante, Nicoletta Testoni, Gianantonio Rosti, Michele Baccarani, Giovanni Martinelli

Blood (2009) 114 (22): 3262.

https://doi.org/10.1182/blood.V114.22.3262.3262

Published: 2009

Journal Articles

Clofarabine in Children with Refractory/Relapsed Acute Leukemia: Results of 2 Phase II Open Label Studies.

Sima Jeha, Bassem Razzouk, Paul Gaynon, Michael Rytting, Richard Kadota, Susan Rheingold, Lori Luchtman-Jones, Robert Arceci, Peter Steinherz

Blood (2006) 108 (11): 4460.

https://doi.org/10.1182/blood.V108.11.4460.4460

Published: 2006

NARROW

Inhibition of ATR Potentiates Acute Myeloid Leukemia Cells to the RNA Pol I Transcription Inhibitor CX-5461

RNA Polymerase 1 Transcription Inhibitor CX-5461 in Patients with Advanced Hematologic Malignancies: Results of a Phase I First in Human Study

Novel Combination Therapies with the RNA Polymerase I Inhibitor CX-5461 Significantly Improve Efficacy in Multiple Myeloma

Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population

A New Insight into Pediatric Leukemia: Che-1 Involvement in Oncogenic c-Myc Signaling

RNA Polymerase I Inhibition with CX-5461 As a Novel Strategy to Target MYC in Multiple Myeloma

High Resolution Mapping of Active RNA Polymerases Identifies KIT As a Target of BET Inhibitors in t(8;21) AML

Repositioning of Quinacrine for Treatment of Acute Myeloid Leukemia

Collapse of Ribosome Biogenesis Induces Rapid Erythroblast Differentiation

Interaction of TIF-90 and filamin A in the regulation of rRNA synthesis in leukemic cells

CX-5461, a Novel RNA Polymerase I Inhibitor, Is Active Against Wild-Type and Mutant p53 Myeloma Models

Inhibition Of RNA Polymerase I Transcription By CX-5461 As a Therapeutic Strategy For The Cancer-Specific Activation Of p53 In Highly Refractory Haematological Malignancies

Single Arm, Multi-Center, Phase II Study Of Clofarabine In Chinese Pediatric Patients With Refractory Or Relapsed Acute Lymphoblastic Leukemia

Activation Of Akt Enhances Ribosomal RNA Synthesis In AML Cells Through a Novel Isoform Of TIF-1A and Inhibition Of Filamin A Cleavage

Inhibition of RNA Polymerase I Transcription by CX-5461 As a Therapeutic Strategy for the Cancer-Specific Activation of p53 in MLL-Rearranged Acute Myeloid Leukemias

High-Resolution Genome Wide Copy Number Alteration (CNA) and Loss of Heterozigosity (LOH) Analysis in Chronic Myeloid Leukemia (CML) Shows That High and Intermediate Sokal Risk Pts (Pts) Have Multiple Losses Targeting Genes Involved in DNA Repair.

Clofarabine in Children with Refractory/Relapsed Acute Leukemia: Results of 2 Phase II Open Label Studies.

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American Society of Hematology

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American Society of Hematology

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