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Journal Articles

A High-Throughput Screening Approach to Identify Therapeutics for the Treatment of Diamond-Blackfan Anaemia

Lorena Nunez Villacis, Sheren J Al-Obaidi, Piyush Madhamshettiwar, PhD, Nadine Hein, PhD, Jun Chen, MD PhD, Priscilla Soo, Perlita Poh, Megan Pavy, Kaylene J Simpson, PhD, Thomas John Gonda, PhD BSc, Richard B Pearson, PhD, Johan Flygare, MD PhD, Katherine M Hannan, PhD, Amee J George, PhD, Ross Hannan, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3859.
https://doi.org/10.1182/blood-2018-99-114303
Published: 2018
Journal Articles

Small Molecule Screens Identify CDK8-Inhibitors As Candidate Diamond-Blackfan Anemia Drugs

Jun Chen, MD PhD, Kavitha Siva, PhD, Tomasz Rzymski, PhD, Lars Johansson, Thomas Lundbäck, Lorena Nunez Villacis, Fredrik Ek, PhD, Bingrui Wang, Amee J George, PhD, Yang Wan, Lihong Shi, Melissa IIsley, Agatheeswaran Subramaniam, PhD, Mayur Jain, PhD, Shubhranshu Debnath, PhD, Abdul Ghani Alattar, Hanna Axelsson, Milena Mazan, PhD, Eliza Majewska, Ulf R. Tedgard, MD PhD, Marcin W. Wlodarski, MD PhD, Anna-Lena Gustavsson, Roger Olsson, Michal Mikula, Xiaofan Zhu, PhD, Krzysztof Brzózka, PhD, Ross Hannan, PhD, Johan Flygare, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 753.
https://doi.org/10.1182/blood-2018-99-114570
Published: 2018
Journal Articles

Novel Combination Therapy Targeting rDNA Transcription and Histone Deacetylation Provides Effective Treatment for Multiple Myeloma, and Synergises in Bortezomib-Resistant MM

Kylee H Maclachlan, BSc, MBChB, FRACP, FRCPA, Andrew Cuddihy, PhD, Nadine Hein, PhD, Carleen Cullinane, PhD, Simon J. Harrison, MBBS,MRCP,FRCPath,FRACP,PhD, Ross Hannan, PhD, Gretchen Poortinga, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1945.
https://doi.org/10.1182/blood-2018-99-113765
Published: 2018
Journal Articles

RNA Polymerase 1 Transcription Inhibitor CX-5461 in Patients with Advanced Hematologic Malignancies: Results of a Phase I First in Human Study

Amit Khot, MBBS, MD MRCP, FRCPath, FRACP, Natalie Brajanovski, BSc, Donald P Cameron, BSc, Gretchen Poortinga, PhD, Elaine Sanij, PhD, John Lim, PharmD, John Soong, MD FCAP, Nadine Hein, PhD, Emma Link, DPhil, Richard B Pearson, PhD, Ross Hannan, Grant A. McArthur, MBBS, PhD BSc, FRACP, Simon J. Harrison, MBBS,MRCP,FRCPath,FRACP,PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3835.
https://doi.org/10.1182/blood.V130.Suppl_1.3835.3835
Published: 2017
Journal Articles

Novel Combination Therapies with the RNA Polymerase I Inhibitor CX-5461 Significantly Improve Efficacy in Multiple Myeloma

Kylee H Maclachlan, FRACP,FRCPA, Andrew Cuddihy, PhD, Nadine Hein, PhD, Carleen Cullinane, PhD, Simon J. Harrison, MBBS,MRCP,FRCPath,FRACP,PhD, Ross Hannan, PhD, Gretchen Poortinga, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1805.
https://doi.org/10.1182/blood.V130.Suppl_1.1805.1805
Published: 2017