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Gretchen Poortinga
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Journal Articles

The Ribosomal Biogenesis Inhibitor CX-5461 Is an Anti-Cancer Therapeutic That Increases Platelet Count in Mice and in Humans

Amandeep Kaur, PhD, Katherine M Hannan, PhD, Samina Nazir, MSc, Kylee H Maclachlan, FRACP,FRCPA, Gretchen Poortinga, PhD, Si Ming Man, PhD, Simon Harrison, MBBS, MRCP, FRCPath, FRACP, PhD, Ross D Hannan, PhD, Elizabeth E. Gardiner, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2360.
https://doi.org/10.1182/blood-2019-121713
Published: 2019
Journal Articles

Novel Combination Therapy Targeting rDNA Transcription and Histone Deacetylation Provides Effective Treatment for Multiple Myeloma, and Synergises in Bortezomib-Resistant MM

Kylee H Maclachlan, BSc, MBChB, FRACP, FRCPA, Andrew Cuddihy, PhD, Nadine Hein, PhD, Carleen Cullinane, PhD, Simon J. Harrison, MBBS,MRCP,FRCPath,FRACP,PhD, Ross Hannan, PhD, Gretchen Poortinga, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1945.
https://doi.org/10.1182/blood-2018-99-113765
Published: 2018
Journal Articles

RNA Polymerase 1 Transcription Inhibitor CX-5461 in Patients with Advanced Hematologic Malignancies: Results of a Phase I First in Human Study

Amit Khot, MBBS, MD MRCP, FRCPath, FRACP, Natalie Brajanovski, BSc, Donald P Cameron, BSc, Gretchen Poortinga, PhD, Elaine Sanij, PhD, John Lim, PharmD, John Soong, MD FCAP, Nadine Hein, PhD, Emma Link, DPhil, Richard B Pearson, PhD, Ross Hannan, Grant A. McArthur, MBBS, PhD BSc, FRACP, Simon J. Harrison, MBBS,MRCP,FRCPath,FRACP,PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3835.
https://doi.org/10.1182/blood.V130.Suppl_1.3835.3835
Published: 2017
Journal Articles

Novel Combination Therapies with the RNA Polymerase I Inhibitor CX-5461 Significantly Improve Efficacy in Multiple Myeloma

Kylee H Maclachlan, FRACP,FRCPA, Andrew Cuddihy, PhD, Nadine Hein, PhD, Carleen Cullinane, PhD, Simon J. Harrison, MBBS,MRCP,FRCPath,FRACP,PhD, Ross Hannan, PhD, Gretchen Poortinga, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1805.
https://doi.org/10.1182/blood.V130.Suppl_1.1805.1805
Published: 2017
Journal Articles

Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population

Nadine Hein, Donald P. Cameron, Katherine M. Hannan, Nhu-Y N. Nguyen, Chun Yew Fong, Jirawas Sornkom, Meaghan Wall, Megan Pavy, Carleen Cullinane, Jeannine Diesch, Jennifer R. Devlin, Amee J. George, Elaine Sanij, Jaclyn Quin, Gretchen Poortinga, Inge Verbrugge, Adele Baker, Denis Drygin, Simon J. Harrison, James D. Rozario, Jason A. Powell, Stuart M. Pitson, Johannes Zuber, Ricky W. Johnstone, Mark A. Dawson, Mark A. Guthridge, Andrew Wei, Grant A. McArthur, Richard B. Pearson, Ross D. Hannan
Journal: Blood
Blood (2017) 129 (21): 2882–2895.
https://doi.org/10.1182/blood-2016-05-718171
Published: 2017
Includes: Supplemental data
Journal Articles

Translational control of c-MYC by rapamycin promotes terminal myeloid differentiation

Meaghan Wall, Gretchen Poortinga, Katherine M. Hannan, Richard B. Pearson, Ross D. Hannan, Grant A. McArthur
Journal: Blood
Blood (2008) 112 (6): 2305–2317.
https://doi.org/10.1182/blood-2007-09-111856
Published: 2008
Includes: Supplemental data
Journal Articles

Inhibiton of mTOR by RAD001 Restores Normal B Cell Differentiation and Prevents B Cell Lymphomas in Eμ- MYC Mice.

Meaghan Wall, Gretchen Poortinga, Daniela Cardozo, Ricky W. Johnstone, Grant A. McArthur
Journal: Blood
Blood (2006) 108 (11): 2498.
https://doi.org/10.1182/blood.V108.11.2498.2498
Published: 2006
Journal Articles

Inhibition of mTOR Reverses the Ability of c-MYC To Block the Differentiation of Murine Granulocytes.

Meaghan Wall, Gretchen Poortinga, Richard B. Pearson, Ross D. Hannan, Grant A. McArthur
Journal: Blood
Blood (2005) 106 (11): 310.
https://doi.org/10.1182/blood.V106.11.310.310
Published: 2005