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Journal Articles

Genetic identification of patients with AML older than 60 years achieving long-term survival with intensive chemotherapy

CME Clinical Trials & Observations
Raphael Itzykson, Elise Fournier, Céline Berthon, Christoph Röllig, Thorsten Braun, Alice Marceau-Renaut, Cécile Pautas, Olivier Nibourel, Emilie Lemasle, Jean-Baptiste Micol, Lionel Adès, Delphine Lebon, Jean-Valère Malfuson, Lauris Gastaud, Laure Goursaud, Emmanuel Raffoux, Kevin-James Wattebled, Philippe Rousselot, Xavier Thomas, Sylvain Chantepie, Thomas Cluzeau, Hubert Serve, Nicolas Boissel, Christine Terré, Karine Celli-Lebras, Claude Preudhomme, Christian Thiede, Hervé Dombret, Claude Gardin, Nicolas Duployez
Journal: Blood
Blood (2021) 138 (7): 507–519.
https://doi.org/10.1182/blood.2021011103
Published: 2021
Includes: Supplemental data
Journal Articles

How Morphologic Features Are Shaped By Underlying Somatic Genotype in MDS

Yasunobu Nagata, MD PhD, Ran Zhao, Hassan Awada, Cassandra M Kerr, MS, Abhinav Goyal, Inom Mirzaev, Sunisa Kongkiatkamon, Aziz Nazha, MD, Tomas Radivoyevitch, PhD, Jacob Scott, MD, Mikkael A. Sekeres, MD MS, Brian P. Hobbs, PhD, Jaroslaw P. Maciejewski, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1716.
https://doi.org/10.1182/blood-2019-127285
Published: 2019
Journal Articles

A Personalized Prediction Model to Risk Stratify Patients with Acute Myeloid Leukemia (AML) Using Artificial Intelligence

Jacob Shreve, MD MS, Manja Meggendorfer, PhD, Hassan Awada, MD, Sudipto Mukherjee, MD PhD MPH, Wencke Walter, PhD, Stephan Hutter, PhD, Ahed Makhoul, MD, Cameron Beau Hilton, BA, Nathan Radakovich, BA, Yasunobu Nagata, MD PhD, Yazan Rouphail, Vera Adema, PhD, Cassandra M Kerr, MS, Bhumika J. Patel, MD, Teodora Kuzmanovic, Jaroslaw P. Maciejewski, MD PhD, Claudia Haferlach, MD, Mikkael A. Sekeres, MD MS, Torsten Haferlach, MD, Aziz Nazha, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2091.
https://doi.org/10.1182/blood-2019-128066
Published: 2019
Journal Articles

Predicting Response to Hypomethylating Agents in Patients with Myelodysplastic Syndromes (MDS) Using Artificial Intelligence (AI)

Nathan Radakovich, BA, Mikkael A. Sekeres, MD MS, Cameron Beau Hilton, BA, Sudipto Mukherjee, MD PhD MPH, Jacob Shreve, MD MS, Yazan Rouphail, Rachel Shirley, Vera Adema, PhD, Hassan Awada, MD, Anjali S. Advani, MD, Cassandra M Kerr, MS, Yasunobu Nagata, MD PhD, Yihong Guan, PhD, Teodora Kuzmanovic, BA, Metis Hasipek, PhD, Babal K. Jha, PhD, Jaroslaw P. Maciejewski, MD PhD, Aziz Nazha, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2089.
https://doi.org/10.1182/blood-2019-126275
Published: 2019
Journal Articles

CPX-351 Induces Deep Response and Suppress the Impact of Poor Prognosis Mutations ( TP53, ASXL1, RUNX1 and EVI1 ) Defined By ELN-2017 in t-AML and MRC AML: A Report from a Multicentric French Cohort

Edmond Chiche, Sarah Bertoli, MD PhD, Ramy Rahmé, MD, Jean Baptiste Micol, Florence Pasquier, MD PhD, Pierre Peterlin, Patrice Chevallier, MD, Xavier Thomas, MD PhD, Michael Loschi, MD PhD, Alexis Genthon, Olivier Legrand, MD PhD, Mohamad Mohty, MD PhD, Emmanuel Raffoux, MD, Patrick Auberger, PhD, Alexis Caulier, MD, Magalie Joris, MD, Caroline Bonmati, Gabrielle Roth Guepin, Mathieu Sauvezie, Caroline Lejeune, Arnaud Pigneux, Christian Recher, MD PhD, Lionel Ades, MD PhD, Thomas Cluzeau, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1355.
https://doi.org/10.1182/blood-2019-125623
Published: 2019
Journal Articles

Integrative Study of EZH2 Mutational Status, Copy Number, Protein Expression and H3K27 Trimethylation in AML/MDS Patients

Julia Stomper, Ruth Meier, Tobias Ma, Dietmar Pfeifer, Annette Schmitt-Graeff, Michael Lübbert
Journal: Blood
Blood (2019) 134 (Supplement_1): 1422.
https://doi.org/10.1182/blood-2019-128231
Published: 2019
Journal Articles

DIS3 Mutation in RUNX1-Mutated AML1 Confers a Highly Dismal Prognosis in AML By Repressing Sister Chromatid Cohesion

Christophe Desterke, PhD, Annelise Bennaceur-Griscelli, MD PhD, Ali G Turhan, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1454.
https://doi.org/10.1182/blood-2019-123352
Published: 2019
Journal Articles

The Genetic Architecture of Myeloproliferative Neoplasms-Blast Phase (MPN-BP) Stem Cells

Xiaoli Wang, MD PhD, Raajit K. Rampal, MD PhD, Cing Siang Hu, Noushin Farnoud, PhD, Christopher Famulare, MS, Minal A Patel, MPH, Erin McGovern, BA, Ronald Hoffman, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1677.
https://doi.org/10.1182/blood-2019-128836
Published: 2019
Journal Articles

Effect of Rap-536 on MDS PDX-Murine Models with or without SF3B1 Mutation

Mathieu Meunier, Camille Knosp, Chloe Friedrich, Johanna Zannoni, Jean-Yves Cahn, MD PhD, Olivier Kosmider, PharmD, PhD, Michaela Fontenay, MD PhD, Sophie Park, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1705.
https://doi.org/10.1182/blood-2019-128407
Published: 2019
Journal Articles

Genetics of Monosomy 7 and Del(7q) in MDS Informs Potential Therapeutic Targets

Cassandra M Kerr, MS, Vera Adema, PhD, Wencke Walter, PhD, Stephan Hutter, PhD, Christina A. Snider, BA, Yasunobu Nagata, MD PhD, Manja Meggendorfer, PhD, Claudia Haferlach, MD, Valeria Visconte, PhD, Mikkael A. Sekeres, MD MS, Thomas Laframboise, PhD, Torsten Haferlach, MD, Jaroslaw P. Maciejewski, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1703.
https://doi.org/10.1182/blood-2019-126866
Published: 2019
Journal Articles

Epigenomic Determinants of Transcriptional Activity in ASXL1 -Mutant Chronic Myelomonocytic Leukemia

Moritz Binder, MDMPH, Alexandre Gaspar Maia, PhD, Ryan M. Carr, MD PhD, Christopher Pin, PhD, Kurt Berger, Bonnie Alver, PhD, Keith Robertson, PhD, David Marks, PhD, Martin Fernandez-Zapico, MD, Mrinal M Patnaik, MDMBBS
Journal: Blood
Blood (2019) 134 (Supplement_1): 2987.
https://doi.org/10.1182/blood-2019-123191
Published: 2019
Journal Articles

ASXL1 Mutations Are Associated with Widespread and Distinct DNA Methylation Alterations

Nora E Rahmani, MD, Nandini Ramachandra, Tushar D Bhagat, PhD, Shanisha Gordon, Kith Pradhan, PhD, Bianca Rivera Pena, Mohammad Kazemi, Orsi Giricz, PhD, Shahina Maqbool, Raul Olea, Hamid Dolatshad, Vickram Tittrea, Dharamveer Tatwavedi, Shalini Singh, Andrea Pellagatti, Jacqueline Boultwood, Amit Verma, MBBS
Journal: Blood
Blood (2019) 134 (Supplement_1): 2989.
https://doi.org/10.1182/blood-2019-126850
Published: 2019
Journal Articles

Mutational Type and Configuration of an Individual Gene May Differentially Impact the Clinical and Phenotypic Features

Yasunobu Nagata, MD PhD, Hideki Makishima, MD PhD, Cassandra M Kerr, MS, Bhumika J. Patel, MD, Hassan Awada, Vera Adema, PhD, Valeria Visconte, PhD, Sudipto Mukherjee, MD PhD MPH, Thomas Laframboise, PhD, Aziz Nazha, MD, Tomas Radivoyevitch, PhD, Mikkael A. Sekeres, MD MS, Seishi Ogawa, MD PhD, Jaroslaw P. Maciejewski, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2992.
https://doi.org/10.1182/blood-2019-128893
Published: 2019
Journal Articles

Interrogating the Role of ASXL1 and JAK2 mutations in Myeloproliferative Neoplasms Utilizing Human Pluripotent Stem Cells

Taylor B. Collins, Stephanie A. Luff, PhD, Luis F.Z. Batista, PhD, Christopher M. Sturgeon, PhD, Stephen T. Oh, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2971.
https://doi.org/10.1182/blood-2019-130541
Published: 2019
Journal Articles

Impact of U2AF1 Mutations on Clinical Characteristics and RNA Splicing in Myelodysplastic Syndromes (MDS)

Bing Li, MD, Jinqin Liu, Tiejun Qin, Zefeng Xu, MD, Gang Huang, PhD, Zhijian Xiao, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2979.
https://doi.org/10.1182/blood-2019-126346
Published: 2019
Journal Articles

Distal Enhancer Elements in ASXL1 -Mutant Chronic Myelomonocytic Leukemia

Moritz Binder, MDMPH, Alexandre Gaspar Maia, PhD, Ryan M. Carr, MD PhD, Terra Lasho, PhD, Thomas E. Witzig, MD, Christopher Pin, PhD, Kurt Berger, Bonnie Alver, PhD, Keith Robertson, PhD, David Marks, PhD, Martin Fernandez-Zapico, MD, Mrinal M Patnaik, MDMBBS
Journal: Blood
Blood (2019) 134 (Supplement_1): 2981.
https://doi.org/10.1182/blood-2019-124917
Published: 2019
Journal Articles

Molecular Characterization of Leukemia Evolving from Paroxysmal Nocturnal Hemoglobinuria

Hassan Awada, MD, Shafia Rahman, MBBS, Cassandra M Kerr, MS, Jibran Durrani, Vera Adema, PhD, Ashwin Kishtagari, MBBS, Sunisa Kongkiatkamon, Hetty E. Carraway, MD MBA, Mikkael A. Sekeres, MD MS, Jaroslaw P. Maciejewski, MD PhD, Valeria Visconte, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2499.
https://doi.org/10.1182/blood-2019-131918
Published: 2019
Journal Articles

Mutant ASXL1 Disrupts Paraspeckle Formation through Aberrant Interaction with Nono in Hematopoietic Cells

Yamamoto Keita, MD, Susumu Goyama, MD PhD, Shuhei Asada, MD PhD, Takeshi Fujino, MD, Tomofusa Fukuyama, MD PhD, Yosuke Tanaka, MD, Ayana Kon, MD PhD, Yasuhito Nannya, MD PhD, Seishi Ogawa, MD PhD, Reina Onoguchi, PhD, Nobuyoshi Akimitsu, PhD, Toshio Kitamura, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2514.
https://doi.org/10.1182/blood-2019-125472
Published: 2019
Journal Articles

Single Cell RNA Sequencing Identifies a Crucial Role for ASXL1 in Neutrophil Development

Theodore Braun, MD PhD, Theresa Lusardi, PhD, Trevor Enright, MS, Zachary Schonrock, BS, Cody Coblentz, Hisham Mohamed, PhD, Brian J. Druker, Julia E. Maxson, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 212.
https://doi.org/10.1182/blood-2019-125022
Published: 2019
Journal Articles

BCR-ABL1 p190 in CML: A Minor Breakpoint with a Major Impact

Shady Adnan Awad, MD, Helena Hohtari, MD, Komal Kumar Javarappa, PhD, Tania Brandstoetter, Daehong Kim, Swapnil Potdar, MSc, Caroline A Heckman, PhD, Soili Kytölä, PhD, Kimmo Porkka, Eszter Doma, PhD, Veronika Sexl, MD PhD, Matti Kankainen, PhD, Satu Mustjoki, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 190.
https://doi.org/10.1182/blood-2019-126584
Published: 2019