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Journal Articles

Identification of T Cell Senescence As a Cell Fate Limiting the Antitumor Activity of 41BB-Costimulated CART Cells

Ismail Can, R. Leo Sakemura, Olivia L. Sirpilla, Claudia Manriquez Roman, Carli M. Stewart, Kun Yun, Truc Huynh, Ekene Ogbodo, Lionel A Kankeu Fonkoua, Jennifer M. Feigin, Omar Gutierrez Ruiz, Long K. Mai, Hong Xia, Brooke L. Kimball, Mehrdad Hefazi, Michael W. Ruff, Elizabeth L. Siegler, H. Atakan Ekiz, Berke Alkan, Fatih Sezer, Saad S. Kenderian
Journal: Blood
Blood (2024) 144 (Supplement 1): 4808.
https://doi.org/10.1182/blood-2024-207818
Published: 2024
Journal Articles

Distinct Functional Impacts of Cytokine Receptor Blockade on CART Cells

Kun Yun, Evandro Bezerra, R. Leo Sakemura, Emmanuel Contreras Guzman, Ismail Can, Omar Gutierrez Ruiz, Ekene Ogbodo, Truc Huynh, Claudia Manriquez Roman, Olivia L. Sirpilla, Carli M. Stewart, Jennifer M. Feigin, Grace E. DeFranco, Sophia Y. Goldberg, Dominic A. Skeele, Long K. Mai, Hong Xia, Brooke L. Kimball, Lionel A Kankeu Fonkoua, Mehrdad Hefazi, Michael W. Ruff, Elizabeth L. Siegler, Saad S. Kenderian
Journal: Blood
Blood (2024) 144 (Supplement 1): 7166.
https://doi.org/10.1182/blood-2024-211119
Published: 2024
Journal Articles

Intrinsic Immunosuppressive Features of Monocytes Suppress CART19 through IL-1 Pathway Modulation in Mantle Cell Lymphoma

Kun Yun, R. Leo Sakemura, Ismail Can, Omar Gutierrez Ruiz, Ekene Ogbodo, Shuwen Zhang, Truc Huynh, Claudia Manriquez Roman, Olivia L. Sirpilla, Carli M. Stewart, James H. Girsch, Jennifer M. Feigin, Long K. Mai, Hong Xia, Brooke L. Kimball, Lionel A Kankeu Fonkoua, Mehrdad Hefazi, Michael W. Ruff, Fariborz Rakhshan Rohakhtar, Vernadette Simon, Elizabeth L. Siegler, Mike Mattie, Sao-Mai Nguyen-Mau, Simone Filosto, Saad S. Kenderian
Journal: Blood
Blood (2024) 144 (Supplement 1): 908.
https://doi.org/10.1182/blood-2024-205905
Published: 2024
Journal Articles

Caspase-1 Inhibition Ameliorates CAR T-Cell Apoptosis and Tumor Cell Pyroptosis to Enhance the Efficacy and Safety of CAR T-Cell Therapy

Wannakorn Khopanlert, Truc Huynh, Brooke L. Kimball, Grace E. DeFranco, Sophia Y. Goldberg, Dominic A. Skeele, Jennifer M. Feigin, James H. Girsch, Olivia L. Sirpilla, Carli M. Stewart, Kun Yun, Claudia Manriquez Roman, Ismail Can, Omar Gutierrez Ruiz, Ekene Ogbodo, Long K. Mai, Hong Xia, Mehrdad Hefazi, Lionel Aurelien Kankeu Fonkoua, Michael W. Ruff, Elizabeth L. Siegler, Saad S. Kenderian, R. Leo Sakemura
Journal: Blood
Blood (2024) 144 (Supplement 1): 907.
https://doi.org/10.1182/blood-2024-202661
Published: 2024
Journal Articles

CD19 occupancy with tafasitamab increases therapeutic index of CART19 cell therapy and diminishes severity of CRS

R. Leo Sakemura, Claudia Manriquez Roman, Paulina Horvei, Elizabeth L. Siegler, James H. Girsch, Olivia L. Sirpilla, Carli M. Stewart, Kun Yun, Ismail Can, Ekene J. Ogbodo, Mohamad M. Adada, Evandro D. Bezerra, Lionel Aurelien Kankeu Fonkoua, Mehrdad Hefazi, Michael W. Ruff, Brooke L. Kimball, Long K. Mai, Truc N. Huynh, Wendy K. Nevala, Kristina Ilieva, Christian Augsberger, Maria Patra-Kneuer, Jürgen Schanzer, Jan Endell, Christina Heitmüller, Stefan Steidl, Sameer A. Parikh, Wei Ding, Neil E. Kay, Grzegorz S. Nowakowski, Saad S. Kenderian
Journal: Blood
Blood (2024) 143 (3): 258–271.
https://doi.org/10.1182/blood.2022018905
Published: 2024
Includes: Supplemental data
Journal Articles

Affinity of Anti-CD19 Antibodies Determines Subsequent CART19 Activation, Apoptosis and CRS in Preclinical Models

R. Leo Sakemura, Claudia Manriquez Roman, Long K. Mai, Brooke L. Kimball, Truc Huynh, Jennifer M. Feigin, James H. Girsch, Olivia L. Sirpilla, Kun Yun, Carli M. Stewart, Omar Gutierrez Ruiz, Ismail Can, Ekene Ogbodo, Lionel Aurelien Kankeu Fonkoua, Mehrdad Hefazi, Michael W. Ruff, Jan Jaehrling, Kristina Ilieva, Maria Patra-Kneuer, Christina Heitmüller, Stefan Steidl, Elizabeth L. Siegler, Saad S. Kenderian
Journal: Blood
Blood (2023) 142 (Supplement 1): 6796.
https://doi.org/10.1182/blood-2023-179408
Published: 2023
Journal Articles

PD-1 Expression in Lymphoma Cells Mediates Cellular Proliferation By Engaging Phosphatase SHP-1/SHP-2

Sutapa Sinha, Tammy Price-Troska, Shulan Tian, R. Leo Sakemura, Huihuang Yan, Justin Boysen, Zhiquan Wang, Xiaosheng Wu, Rong He, Min Shi, Yucai Wang, Eric W Klee, Sameer A. Parikh, Paul J Hampel, Timothy G. Call, Jose F. Leis, Tait D. Shanafelt, Stephen M Ansell, Saad S. Kenderian, Neil E. Kay, Wei Ding
Journal: Blood
Blood (2023) 142 (Supplement 1): 3261.
https://doi.org/10.1182/blood-2023-177755
Published: 2023
Journal Articles

Mutations in the second zinc finger of human EKLF reduce promoter affinity but give rise to benign and disease phenotypes

Belinda K. Singleton, Winnie Lau, Victoria S. S. Fairweather, Nicholas M. Burton, Marieangela C. Wilson, Steve F. Parsons, Ben M. Richardson, Kongtana Trakarnsanga, R. Leo Brady, David J. Anstee, Jan Frayne
Journal: Blood
Blood (2011) 118 (11): 3137–3145.
https://doi.org/10.1182/blood-2011-04-349985
Published: 2011
Includes: Supplemental data
Journal Articles

A Novel EKLF Mutation in a Patient with Dyserythropoietic Anemia: The First Association of EKLF with Disease in Man.

Belinda K Singleton, Victoria SS Fairweather, Winnie Lau, Stephen F Parsons, Nicholas M Burton, Jan Frayne, R. Leo Brady, David J Anstee
Journal: Blood
Blood (2009) 114 (22): 162.
https://doi.org/10.1182/blood.V114.22.162.162
Published: 2009
Journal Articles

The monovalent cation leak in overhydrated stomatocytic red blood cells results from amino acid substitutions in the Rh-associated glycoprotein

Lesley J. Bruce, Hélène Guizouarn, Nicholas M. Burton, Nicole Gabillat, Joyce Poole, Joanna F. Flatt, R. Leo Brady, Franck Borgese, Jean Delaunay, Gordon W. Stewart
Journal: Blood
Blood (2009) 113 (6): 1350–1357.
https://doi.org/10.1182/blood-2008-07-171140
Published: 2009
Includes: Supplemental data
Journal Articles

Mutations in EKLF / KLF1 form the molecular basis of the rare blood group In(Lu) phenotype

Belinda K. Singleton, Nicholas M. Burton, Carole Green, R. Leo Brady, David J. Anstee
Journal: Blood
Blood (2008) 112 (5): 2081–2088.
https://doi.org/10.1182/blood-2008-03-145672
Published: 2008
Includes: Supplemental data
Journal Articles

The Laminin 511/521–binding site on the Lutheran blood group glycoprotein is located at the flexible junction of Ig domains 2 and 3

Tosti J. Mankelow, Nicholas Burton, Fanney O. Stefansdottir, Frances A. Spring, Stephen F. Parsons, Jan S. Pedersen, Cristiano L. P. Oliveira, Donna Lammie, Timothy Wess, Narla Mohandas, Joel Anne Chasis, R. Leo Brady, David J. Anstee
Journal: Blood
Blood (2007) 110 (9): 3398–3406.
https://doi.org/10.1182/blood-2007-06-094748
Published: 2007
Includes: Supplemental data
Journal Articles

Characterisation of the Laminin 10/11 Binding Site on the Lutheran Glycoprotein Suggests a Novel Type of Protein-Protein Interaction.

Tosti J. Mankelow, PhD, Nicholas Burton, B.Sc, Fanney O. Stefansdottir, M.Sc, Frances A. Spring, Ph.D., Stephen F. Parsons, Ph.D., C. Fredrik Gilstring, Ph.D., R. Leo Brady, Ph.D., Mohandas Narla, Ph.D., Joel Anne Chasis, M.D., David J. Anstee, Ph.D.
Journal: Blood
Blood (2006) 108 (11): 1566.
https://doi.org/10.1182/blood.V108.11.1566.1566
Published: 2006
Journal Articles

CD151, the first member of the tetraspanin (TM4) superfamily detected on erythrocytes, is essential for the correct assembly of human basement membranes in kidney and skin

Vanja Karamatic Crew, Nicholas Burton, Alexander Kagan, Carole A. Green, Cyril Levene, Frances Flinter, R. Leo Brady, Geoff Daniels, David J. Anstee
Journal: Blood
Blood (2004) 104 (8): 2217–2223.
https://doi.org/10.1182/blood-2004-04-1512
Published: 2004
Journal Articles

Identification of critical amino-acid residues on the erythroid intercellular adhesion molecule-4 (ICAM-4) mediating adhesion to α V integrins

Tosti J. Mankelow, Frances A. Spring, Stephen F. Parsons, R. Leo Brady, Narla Mohandas, Joel A. Chasis, David J. Anstee
Journal: Blood
Blood (2004) 103 (4): 1503–1508.
https://doi.org/10.1182/blood-2003-08-2792
Published: 2004
Journal Articles

Intercellular adhesion molecule-4 binds α 4 β 1 and α V -family integrins through novel integrin-binding mechanisms: Presented in part as abstracts at the 40th annual meeting of the American Society of Hematology, Miami, FL, December 1998 (Blood 1998;92:589a) and at the annual meeting of the British Blood Transfusion Society, Edinburgh, United Kingdom, September 1999 (Transfus Med 1999;9:[suppl 1]9).

Frances A. Spring, Stephen F. Parsons, Susan Ortlepp, Martin L. Olsson, Richard Sessions, R. Leo Brady, David J. Anstee
Journal: Blood
Blood (2001) 98 (2): 458–466.
https://doi.org/10.1182/blood.V98.2.458
Published: 2001
Journal Articles

Ig VH gene mutational patterns indicate different tumor cell status in human myeloma and monoclonal gammopathy of undetermined significance

SS Sahota, R Leo, TJ Hamblin, FK Stevenson
Journal: Blood
Blood (1996) 87 (2): 746–755.
https://doi.org/10.1182/blood.V87.2.746.bloodjournal872746
Published: 1996
Journal Articles

CD16- CD56+ natural killer cells after bone marrow transplantation

R Jacobs, M Stoll, G Stratmann, R Leo, H Link, RE Schmidt
Journal: Blood
Blood (1992) 79 (12): 3239–3244.
https://doi.org/10.1182/blood.V79.12.3239.3239
Published: 1992