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Paula Rodriguez-Otero, MD PhD
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Journal Articles

HORIZON (OP-106) Versus MAMMOTH: An Indirect Comparison of Efficacy Outcomes for Patients with Relapsed/Refractory Multiple Myeloma Refractory (RRMM) to Anti-CD38 Monoclonal Antibody Therapy Treated with Melflufen Plus Dexamethasone Versus Conventional Agents

Joan Blade Creixenti, María-Victoria Mateos, MD PhD, Albert Oriol, Alessandra Larocca, Michele Cavo, Paula Rodríguez-Otero, MD PhD, Xavier Leleu, MD, Maxim Norkin, MD PhD, Omar Nadeem, MD, John W. Hiemenz, MD, Hani Hassoun, MD, Cyrille Touzeau, Adrián Alegre Amor, MD PhD, Agne Paner, MD, Christopher Maisel, MD, Amitabha Mazumder, MD, Anastasios Raptis, MD, Noemí Puig, MD PhD, Stojan Zavisic, BSc, Marcus Thuresson, PhD, Johan Harmenberg, MD PhD, Paul G. Richardson, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 2–4.
https://doi.org/10.1182/blood-2020-137164
Published: 2020
Journal Articles

HORIZON (OP-106): Melflufen Plus Dexamethasone (dex) in 55 Patients (pts) with Relapsed/Refractory Multiple Myeloma (RRMM) with Extramedullary Disease (EMD)-Subgroup Analysis

Paul G. Richardson, MD, María-Victoria Mateos, MD PhD, Albert Oriol, Alessandra Larocca, Michele Cavo, Paula Rodríguez-Otero, MD PhD, Xavier Leleu, MD, Maxim Norkin, MD PhD, Omar Nadeem, MD, John W. Hiemenz, MD, Hani Hassoun, MD, Cyrille Touzeau, Adrián Alegre Amor, MD PhD, Agne Paner, MD, Christopher Maisel, MD, Amitabha Mazumder, MD, Anastasios Raptis, MD, Noemí Puig, MD PhD, Elena Zamagni, Marcus Thuresson, PhD, Johan Harmenberg, MD PhD, Olof Harlin, VMD, PhD, Joan Blade Creixenti
Journal: Blood
Blood (2020) 136 (Supplement 1): 15–17.
https://doi.org/10.1182/blood-2020-137118
Published: 2020
Journal Articles

HORIZON (OP-106): Melflufen Plus Dexamethasone (dex) in Patients (pts) with Relapsed/Refractory Multiple Myeloma (RRMM) Exposed to Prior Alkylator Therapy-Subgroup Analysis

Paula Rodríguez-Otero, MD PhD, María-Victoria Mateos, MD PhD, Albert Oriol, Alessandra Larocca, Joan Blade Creixenti, Michele Cavo, Xavier Leleu, MD, Maxim Norkin, MD PhD, Omar Nadeem, MD, John W. Hiemenz, MD, Hani Hassoun, MD, Cyrille Touzeau, Adrián Alegre Amor, MD PhD, Agne Paner, MD, Christopher Maisel, MD, Amitabha Mazumder, MD, Anastasios Raptis, MD, Noemí Puig, MD PhD, Marcus Thuresson, PhD, Johan Harmenberg, MD PhD, Olof Harlin, VMD, PhD, Paul G. Richardson, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 22–23.
https://doi.org/10.1182/blood-2020-136466
Published: 2020
Journal Articles

HORIZON (OP-106): Melflufen Plus Dexamethasone in Patients with Relapsed/Refractory Multiple Myeloma-Age Subgroup Analysis of Elderly Patients

Alessandra Larocca, Paul G. Richardson, MD, Albert Oriol, Joan Blade Creixenti, Michele Cavo, Paula Rodríguez-Otero, MD PhD, Xavier Leleu, MD, Maxim Norkin, MD PhD, Omar Nadeem, MD, John W. Hiemenz, MD, Hani Hassoun, MD, Cyrille Touzeau, Adrián Alegre Amor, MD PhD, Agne Paner, MD, Christopher Maisel, MD, Amitabha Mazumder, MD, Anastasios Raptis, MD, Noemí Puig, MD PhD, Marcus Thuresson, PhD, Johan Harmenberg, MD PhD, Bengt Gustavsson, Dr MDSci, MSc Pharm, María-Victoria Mateos, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 44–46.
https://doi.org/10.1182/blood-2020-136856
Published: 2020
Journal Articles

KarMMa-3: A Phase 3 Study of Idecabtagene Vicleucel (ide-cel, bb2121), a BCMA-Directed CAR T Cell Therapy Vs Standard Regimens in Relapsed and Refractory Multiple Myeloma

Michel Delforge, MDPhD, Rachid C. Baz, MD, Michele Cavo, Natalie S. Callander, MD, Armin Ghobadi, MD, Paula Rodriguez-Otero, MD PhD, María-Victoria Mateos, MD PhD, Monica Massaro, MPH, Li Ding, Payal Patel, Gianfranco Pittari, MD PhD, Steven Novick, MDPhD, Sergio A. Giralt, MD, Jesus G. Berdeja, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 24–25.
https://doi.org/10.1182/blood-2020-137156
Published: 2020
Journal Articles

Dose- and Schedule-Dependent Immunomodulatory Effects of the Novel Celmod Agent CC-92480 in Patients with Relapsed/Refractory Multiple Myeloma

Lilly Wong, Manisha Lamba, María Dolores Jiménez Nuñez, Daniel Bauer, Paul G. Richardson, MD, Nizar J. Bahlis, MD, Annette J. Vangsted, Karthik Ramasamy, Suzanne Trudel, Joaquín Martínez-Lopez, María-Victoria Mateos, Paula Rodriguez-Otero, MD PhD, Sagar Lonial, MD FACP, Rakesh Popat, Albert Oriol, Chatchada Karanes, Robert Z. Orlowski, MDPhD, Jesus G. Berdeja, MD, Michael Pourdehnad, Daniel W. Pierce
Journal: Blood
Blood (2020) 136 (Supplement 1): 47–48.
https://doi.org/10.1182/blood-2020-137161
Published: 2020
Journal Articles

Dreamm-5 Platform Trial: Belantamab Mafodotin (Belamaf) in Combination with Four Different Novel Agents in Patients with Relapsed/Refractory Multiple Myeloma (RRMM)

Paul G. Richardson, MD, Ajay Nooka, MDMPH, Hang Quach, MDFRACP,FRCPA,MBBS, Suzanne Trudel, MD, David Routledge, Kevin Song, MD, Hareth Nahi, MD, Sofia Paul, Josephine Khan, Maria Brouch, Geraldine Ferron-Brady, PhD, Anne Yeakey, MD, Chris Shelton, Rocio Montes de Oca, PhD, L. Mary Smith, Ellie Im, Christoph M Ahlers, Elaine M Paul, Beata Holkova, Ira Gupta, MD, Brandon E. Kremer, MD PhD, Paula Rodriguez-Otero, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 1–2.
https://doi.org/10.1182/blood-2020-139182
Published: 2020
Journal Articles

Safety and Preliminary Efficacy Results from a Phase Ib/II Study of Cobimetinib As a Single Agent and in Combination with Venetoclax with or without Atezolizumab in Patients with Relapsed/Refractory Multiple Myeloma

Fredrik Schjesvold, Vincent Ribrag, MD, Paula Rodriguez-Otero, MD PhD, Pawel J. Robak, MDPhD, Markus Hansson, MD, Roman Hajek, Adrián Alegre Amor, MD PhD, Joaquin Martinez-López, Maika Onishi, Jorge D. Gallo, Aparna Raval, Sameer Deshpande, Vikram Malhi, Wan-Jen Hong, MD, Marc S. Raab, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 45–46.
https://doi.org/10.1182/blood-2020-135845
Published: 2020
Journal Articles

First Results of Iberdomide (IBER; CC-220) in Combination with Dexamethasone (DEX) and Daratumumab (DARA) or Bortezomib (BORT) in Patients with Relapsed/Refractory Multiple Myeloma (RRMM)

Niels W.C.J. van de Donk, MD PhD, Rakesh Popat, Jeremy Larsen, Monique C. Minnema, Sundar Jagannath, MD, Albert Oriol, Jeffrey Zonder, Paul G. Richardson, MD, Paula Rodriguez-Otero, MD PhD, Ashraf Z. Badros, MD, Edward Stadtmauer, Sara Bringhen, MD, Erica Campagnaro, MD, David S. Siegel, MD PhD, Barbara Gamberi, Mercedes Gironella Mesa, Pieter Sonneveld, MD PhD, Tuong Vi Nguyen, Antonia Di Micco, April Sorrell, Min Chen, Michael Amatangelo, Elisabeth Kueenburg, Sagar Lonial, MD FACP
Journal: Blood
Blood (2020) 136 (Supplement 1): 16–17.
https://doi.org/10.1182/blood-2020-137743
Published: 2020
Journal Articles

Preclinical and Translational Support for Clinical Development of Iberdomide in Combination with Proteasome Inhibitors: Mechanism of Synergy in Clinical Trial CC-220-MM-001

Michael Amatangelo, Chad Bjorklund, Jian Kang, Archana Mukhopadhyay, María Dolores Jiménez Nuñez, Lilly Wong, William Pierceall, Sagar Lonial, MD FACP, Niels W.C.J. van de Donk, Rakesh Popat, Sundar Jagannath, MD, Jeffrey Zonder, Monique C. Minnema, Albert Oriol, Jeremy Larsen, Ashraf Z. Badros, MD, Paula Rodriguez-Otero, MD PhD, Pieter Sonneveld, MD PhD, Tuong Vi Nguyen, Kevin Hong, April Sorrell, Anjan Thakurta
Journal: Blood
Blood (2020) 136 (Supplement 1): 8–9.
https://doi.org/10.1182/blood-2020-137710
Published: 2020
Journal Articles

Preclinical and Translational Data Support Development of Iberdomide in Combination with CD38- and SLAMF7-Directed Monoclonal Antibodies: Evidence for Rational Combinations

Michael Amatangelo, Chad Bjorklund, Peilin Ma, Krista Wollerman, William Pierceall, Sagar Lonial, MD FACP, Niels W.C.J. van de Donk, MD PhD, Rakesh Popat, Sundar Jagannath, MD, Jeffrey Zonder, Monique C. Minnema, Albert Oriol, Jeremy Larsen, Ashraf Z. Badros, MD, Paula Rodriguez-Otero, MD PhD, Pieter Sonneveld, MD PhD, Tuong Vi Nguyen, Kevin Hong, April Sorrell, Anjan Thakurta
Journal: Blood
Blood (2020) 136 (Supplement 1): 9–10.
https://doi.org/10.1182/blood-2020-137667
Published: 2020
Journal Articles

Subcutaneous Daratumumab (DARA SC) Plus Standard-of-Care (SoC) Regimens in Multiple Myeloma (MM) across Lines of Therapy in the Phase 2 Pleiades Study: Initial Results of the Dara SC Plus Carfilzomib/Dexamethasone (D-Kd) Cohort, and Updated Results for the Dara SC Plus Bortezomib/Melphalan/Prednisone (D-VMP) and Dara SC Plus Lenalidomide/Dexamethasone (D-Rd) Cohorts

Philippe Moreau, MD, Ajai Chari, Mathias Haenel, MD, Albert Oriol, Paula Rodriguez-Otero, MD PhD, Helen McCarthy, PhD FRCPath, Kenshi Suzuki, MD PhD, Vania T. M. Hungria, MD PhD, Anna Sureda Balari, MD PhD, Lauriane Clement-Filliatre, MD, Cyrille Hulin, MD, Hila Magen, MD, Shinsuke Iida, MD PhD, Vladimir Maisnar, MD, Lionel Karlin, MD, Luděk Pour, MD, Cyrille Touzeau, Shiyi Yang, Michele Kosh, Maria Delioukina, Christoph Heuck, Hartmut Goldschmidt, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 28–30.
https://doi.org/10.1182/blood-2020-134935
Published: 2020
Journal Articles

Efficacy and Safety of Idecabtagene Vicleucel (ide-cel, bb2121) in Elderly Patients with Relapsed and Refractory Multiple Myeloma: KarMMa Subgroup Analysis

Jesus G. Berdeja, MD, Noopur S. Raje, MD, David S. Siegel, MD PhD, Yi Lin, MD PhD, Larry D. Anderson, Jr., MD PhD, Paula Rodriguez-Otero, MD PhD, Salomon Manier, MD PhD, Hermann Einsele, MD, Michele Cavo, Anna Truppel-Hartmann, MD, Everton Rowe, PhD, Jill Sanford, MS, Julie Wang, PharmD, PhD, Timothy B. Campbell, MD PhD, Sundar Jagannath, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 16–17.
https://doi.org/10.1182/blood-2020-134322
Published: 2020
Journal Articles

Curative Strategy for High-Risk Smoldering Myeloma (GEM-CESAR): Carfilzomib, Lenalidomide and Dexamethasone (KRd) As Induction Followed By HDT-ASCT, Consolidation with Krd and Maintenance with Rd

Maria-Victoria Mateos, MD, Joaquin Martinez Lopez, MD PhD, Paula Rodriguez-Otero, MD PhD, Enrique M Ocio, MD, Marta Sonia Gonzalez, MD, Albert Oriol, MD, Norma Gutierrez, MD PhD, Bruno Paiva, PhD, Rafael Rios, Laura Rosinol, MD PhD, Miguel Angel Alvarez, MD, Maria Jose Calasanz, BSc, PhD, Joan Bargay, MD PhD, Ana Pilar Gonzalez, PhD, Fernando Escalante, Dr., Rafael Martínez, Noemi Puig, MD PhD, Javier de la Rubia, Ana Isabel Teruel, MD, Maria Teresa Cedena, Felipe De Arriba, PhD, Luis Palomera, Miguel T Hernández, Javier Lopez Jimenez, Jesús Martín, Esther Piensa, Aránzazu García-Mateo, Veronica González, Joan Blade, MD, Juan Jose Lahuerta, Jesus F. San Miguel, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 402.
https://doi.org/10.1182/blood.V130.Suppl_1.402.402
Published: 2017
Journal Articles

Safety and Efficacy of Filanesib in Combination with Pomalidomide and Dexamethasone in Refractory MM Patients. Phase Ib/II Pomdefil Clinical Trial Conducted By the Spanish MM Group

Enrique M. Ocio, MDPhD, Cristina Motllo, Paula Rodriguez-Otero, MD PhD, Joaquin Martinez-Lopez, MD PhD, Javier de la Rubia, Jesús Martín, Joan Bladé, MD PhD, María-Dolores García-Malo, Luis Palomera, Aránzazu García-Mateo, Felipe De Arriba, PhD, Ramón García-Sanz, MD, Albert Oriol, MD, Juan-José Lahuerta, Jesus F. San Miguel, MD, Maria-Victoria Mateos, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1873.
https://doi.org/10.1182/blood.V130.Suppl_1.1873.1873
Published: 2017
Journal Articles

A Phase Ib Study of Isatuximab in Combination with Bortezomib, Cyclophosphamide, and Dexamethasone (VCDI) in Patients with Newly Diagnosed Multiple Myeloma Non-Eligible for Transplantation

Enrique M. Ocio, MDPhD, Sara Bringhen, MD, Stefania Oliva, MD, Paula Rodriguez-Otero, MD PhD, Dheepak Kanagavel, MD PhD, Corina Oprea, MD, Vivian Wei, Severine Doroumian, Joaquin Martinez-Lopez, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3160.
https://doi.org/10.1182/blood.V130.Suppl_1.3160.3160
Published: 2017
Journal Articles

High-Throughput Characterization and New Insight into the Role of Tumor Associated Macrophages (TAMs) in Multiple Myeloma (MM)

Paula Arana, Aintzane Zabaleta, Marta Lasa, Patricia Maiso, PhD, Diego Alignani, Tomas Jelinek, MD, Victor Segura, PhD, Wouter van den Bossche, Cristina Teodosio, Daniela Damasceno, Paula Rodriguez-Otero, MD PhD, Felipe Prosper, MD, Maria-Victoria Mateos, MD PhD, Juan Jose Lahuerta, Joan Bladé, Jacques J.M. van Dongen, MD PhD, Jesus San Miguel, MD PhD, Alberto Orfao, MD PhD, Bruno Paiva, PhD
Journal: Blood
Blood (2016) 128 (22): 482.
https://doi.org/10.1182/blood.V128.22.482.482
Published: 2016
Journal Articles

Non-Invasive Genetic Profiling Is Highly Applicable in Multiple Myeloma (MM) through Characterization of Circulating Tumor Cells (CTCs)

Leire Burgos, Diego Alignani, Juan-Jose Garces, Lourdes Ortiz, Tomas Jelinek, MD, Victor Segura, PhD, Luzalba Sanoja, Maria-Jose Calasanz, Xabier Agirre, PhD, Felipe Prosper, MD, Paula Rodriguez-Otero, MD PhD, Rafael Rios, Joaquin Martinez-Lopez, Luis Palomera, MD PhD, Maria Teresa Zudaire, Rafael Del Orbe, MD, Jacques J.M. van Dongen, MD PhD, Alberto Orfao, MD PhD, Bruno Paiva, PhD, Jesus San Miguel, MD PhD
Journal: Blood
Blood (2016) 128 (22): 801.
https://doi.org/10.1182/blood.V128.22.801.801
Published: 2016
Journal Articles

Safety and Efficacy of Filanesib in Combination with Pomalidomide and Dexamethasone in Refractory MM Patients. Phase Ib/II Pomdefil Clinical Trial Conducted By the Spanish MM Group

Enrique M. Ocio, MD PhD, Cristina Motlló, MD, Paula Rodriguez-Otero, MD PhD, Joaquín Martínez-López, MD PhD, Javier De La Rubia, Mieke Ptaszynski, Brian Tunquist, Ramon Garcia-Sanz, MD PhD, Albert Oriol, Juan José Lahuerta, MD PhD, Jesús San-Miguel, MD PhD, Maria-Victoria Mateos, MD PhD
Journal: Blood
Blood (2016) 128 (22): 4503.
https://doi.org/10.1182/blood.V128.22.4503.4503
Published: 2016
Journal Articles

New Insights into the Mechanism of Action (MoA) of First-in-Class IgG-Based Bcma T-Cell Bispecific Antibody (TCB) for the Treatment of Multiple Myeloma (MM)

Laura Moreno, Aintzane Zabaleta, Diego Alignani, Marta Lasa, Patricia Maiso, PhD, Tomas Jelinek, MD, Victor Segura, PhD, Jose Antonio Delgado, Paula Rodriguez-Otero, MD PhD, Felipe Prosper, MD, Klaus Strein, MD PhD, Minh Diem Vu, PhD, Jesus San Miguel, MD PhD, Bruno Paiva, PhD
Journal: Blood
Blood (2016) 128 (22): 2096.
https://doi.org/10.1182/blood.V128.22.2096.2096
Published: 2016