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Journal Articles

Safety and Efficacy of Filanesib in Combination with Pomalidomide and Dexamethasone in Refractory MM Patients. Phase Ib/II Pomdefil Clinical Trial Conducted By the Spanish MM Group

Enrique M. Ocio, MD PhD, Cristina Motlló, MD, Paula Rodriguez-Otero, MD PhD, Joaquín Martínez-López, MD PhD, Javier De La Rubia, Mieke Ptaszynski, Brian Tunquist, Ramon Garcia-Sanz, MD PhD, Albert Oriol, Juan José Lahuerta, MD PhD, Jesús San-Miguel, MD PhD, Maria-Victoria Mateos, MD PhD
Journal: Blood
Blood (2016) 128 (22): 4503.
https://doi.org/10.1182/blood.V128.22.4503.4503
Published: 2016
Journal Articles

Filanesib Primarily Initiates the Apoptotic Program By Activating Bax through a Calpain-Dependent Mechanism

Susana Hernández-García, Lorena González-Méndez, Irena Misiewicz-Krzeminska, Esperanza Macarena Algarín, Ana Alicia López-Iglesias, Laura San-Segundo, Montserrat Martín-Sánchez, Teresa Paíno, Norma C Gutierrez, Mercedes Garayoa, Brian Tunquist, Maria-Victoria Mateos, Enrique M Ocio
Journal: Blood
Blood (2015) 126 (23): 5353.
https://doi.org/10.1182/blood.V126.23.5353.5353
Published: 2015
Journal Articles

Phase 2 Study of Carfilzomib (CFZ) with or without Filanesib (FIL) in Patients with Advanced Multiple Myeloma (MM)

Jeffrey A Zonder, MD, Saad Usmani, Emma C. Scott, MD, Craig C. Hofmeister, MD, Nikoletta Lendvai, MDPhD, Jesus G. Berdeja, MD, Larry D. Anderson, Jr., MD PhD, Parameswaran Hari, MBBS, MD MRCP, Seema Singhal, MD, Gregory Orloff, MD, Michael Craig, MD, Jason Valent, MD, Wes Lee, Lowell Hart, J Hrom, Stephano Tarantolo, Edward Faber, DO, Gary J Schiller, MD, Jennifer Schreiber, BS, Colleen Oliver, MSc, Selena A Rush, BS, Brian Tunquist, Mieke Ptaszynski, Noopur S. Raje, MD
Journal: Blood
Blood (2015) 126 (23): 728.
https://doi.org/10.1182/blood.V126.23.728.728
Published: 2015
Journal Articles

Mechanisms Underlying the Synergistic Interaction of Filanesib with Pomalidomide and Dexamethasone (FPD) in Multiple Myeloma

Susana Hernández-García, Laura San-Segundo, Lorena González-Méndez, Montserrat Martín-Sánchez, Luis A Corchete, Teresa Paíno, Ana Alicia López-Iglesias, Esperanza Macarena Algarín, Mercedes Garayoa, Brian Tunquist, Norma C Gutierrez, Maria-Victoria Mateos, MD PhD, Enrique M Ocio
Journal: Blood
Blood (2015) 126 (23): 1801.
https://doi.org/10.1182/blood.V126.23.1801.1801
Published: 2015
Journal Articles

Filanesib (ARRY-520) Demonstrates Potent and Rapid Activity in Preclinical Models of MM, Dependent on Bcl-2 Family Expression, and Synergistic with Dexamethasone and IMiDs

Susana Hernández-García, Laura San-Segundo, Lorena González-Méndez, Teresa Paíno, PhD, Ana Alicia López-Iglesias, MD, Montserrat Martín-Sánchez, Mercedes Garayoa, PhD BS, Michael J Humphries, PhD, Brian Tunquist, PhD BS, Maria-Victoria Mateos, Enrique M Ocio, MD PhD
Journal: Blood
Blood (2014) 124 (21): 4710.
https://doi.org/10.1182/blood.V124.21.4710.4710
Published: 2014
Journal Articles

ARRY-520 Combined With Pomalidomide Displays Enhanced Anti-Tumor Activity In Preclinical Models Of Multiple Myeloma

Michael J Humphries, PhD, Deborah Anderson, Lance Williams, Rob Rieger, Brian Tunquist, PhD, Duncan Walker, PhD
Journal: Blood
Blood (2013) 122 (21): 3167.
https://doi.org/10.1182/blood.V122.21.3167.3167
Published: 2013
Journal Articles

Identification of Alpha 1-Acid Glycoprotein (AAG) As a Potential Patient Selection Biomarker for Improved Clinical Activity of the Novel KSP Inhibitor ARRY-520 in Relapsed and Refractory Multiple Myeloma (MM)

Brian Tunquist, Karin Brown, Gary Hingorani, Sagar Lonial, MD, Jonathan L. Kaufman, MD, Jeffrey A. Zonder, MD, Adam D Cohen, MD, William I. Bensinger, MD, Robert Z. Orlowski, M.D., Ph.D., Jatin J. Shah, M.D., Brandi Hilder, Ann Marie Ptaszynski, MD, Kevin Koch, Kevin Litwiler, Duncan Walker
Journal: Blood
Blood (2012) 120 (21): 1868.
https://doi.org/10.1182/blood.V120.21.1868.1868
Published: 2012
Journal Articles

Combination of the KSP Inhibitor ARRY-520 with Bortezomib or Revlimid Causes Sustained Tumor Regressions and Significantly Increased Time to Regrowth in Models of Multiple Myeloma.

Richard Woessner, Brian Tunquist, April Cox, Sumeet Rana, Duncan Walker, Patrice A. Lee
Journal: Blood
Blood (2009) 114 (22): 2858.
https://doi.org/10.1182/blood.V114.22.2858.2858
Published: 2009