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Journal Articles

Complement-mediated oxidative damage of red cells impairs response to eculizumab in a G6PD-deficient patient with PNH

Michela Sica, Annamaria Pellecchia, Maria De Angioletti, Giovanni Caocci, Caterina Nannelli, Giorgio La Nasa, Lucio Luzzatto, Rosario Notaro
Journal: Blood
Blood (2020) 136 (26): 3082–3085.
https://doi.org/10.1182/blood.2020007780
Published: 2020
Includes: Supplemental data
Journal Articles

Hematological Response to Eculizumab in Paroxysmal Nocturnal Hemoglobinuria: Application of a Novel Classification to Identify Unmet Clinical Needs and Future Clinical Goals

Pierre-Edouard Debureaux, MD, Fabiana Cacace, Bruno G.P. Silva, MD, Federica Barone, MD, Rodrigo T Calado, MD, Flore Sicre de Fontbrune, Juliette Soret-Dulphy, MD, Patrizia Ricci, Michela Sica, PhD, Rosario Notaro, MD, Phillip Scheinberg, MD, Austin Kulasekararaj, MDMBBS,MRCP,FRCPath, Antonio M. Risitano, MD PhD, Régis Peffault de Latour, MD PhD, Camilla Frieri, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3517.
https://doi.org/10.1182/blood-2019-125917
Published: 2019
Journal Articles

Two Distinct but Functionally Related Autoreactive T Cell Populations in Paroxysmal Nocturnal Hemoglobinuria and Idiopathic Aplastic Anemia: Glycosylphosphatidylinositol-Specific and IFNγ-Producing T Cells

Lucia Gargiulo, PhD, Michela Sica, PhD, Caterina Nannelli, BSc, Lucio Luzzatto, MD, Rosario Notaro, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1166.
https://doi.org/10.1182/blood.V130.Suppl_1.1166.1166
Published: 2017
Journal Articles

CD59 Deficiency Is Critical for C3 Binding on Red Blood Cells of Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) during Anti-C5 Treatment (eculizumab)

MIchela Sica, PhD, Tommaso Rondelli, Patrizia Ricci, PhD, Maria De Angioletti, PhD, Antonio M Risitano, MD PhD, Rosario Notaro, MD
Journal: Blood
Blood (2016) 128 (22): 401.
https://doi.org/10.1182/blood.V128.22.401.401
Published: 2016
Journal Articles

Complement Activation in Paroxysmal Nocturnal Hemoglobinuria (PNH) Causes Oxidative Damage Which May Affect Response to Eculizumab

Michela Sica, PhD, Annamaria Pellecchia, PhD, Margherita Berardi, BS, Lucia Gargiulo, PhD, Tolulase A Olutogun, MD, Giovanni Caocci, MD, Giorgio La Nasa, MD, Maria De Angioletti, PhD, Lucio Luzzatto, MD FRCP, FRCPath, Rosario Notaro, MD
Journal: Blood
Blood (2014) 124 (21): 4397.
https://doi.org/10.1182/blood.V124.21.4397.4397
Published: 2014
Journal Articles

Peptide inhibitors of C3 activation as a novel strategy of complement inhibition for the treatment of paroxysmal nocturnal hemoglobinuria

Antonio M. Risitano, Daniel Ricklin, Yijun Huang, Edimara S. Reis, Hui Chen, Patrizia Ricci, Zhuoer Lin, Caterina Pascariello, Maddalena Raia, Michela Sica, Luigi Del Vecchio, Fabrizio Pane, Florea Lupu, Rosario Notaro, Ranillo R. G. Resuello, Robert A. DeAngelis, John D. Lambris
Journal: Blood
Blood (2014) 123 (13): 2094–2101.
https://doi.org/10.1182/blood-2013-11-536573
Published: 2014
Includes: Supplemental data
Journal Articles

Glycosylphosphatidylinositol-specific, CD1d-restricted T cells in paroxysmal nocturnal hemoglobinuria

Lucia Gargiulo, Maria Papaioannou, Michela Sica, Giulia Talini, Aristeidis Chaidos, Barbara Richichi, Andrei V. Nikolaev, Cristina Nativi, Mark Layton, Josu de la Fuente, Irene Roberts, Lucio Luzzatto, Rosario Notaro, Anastasios Karadimitris
Journal: Blood
Blood (2013) 121 (14): 2753–2761.
https://doi.org/10.1182/blood-2012-11-469353
Published: 2013
Includes: Supplemental data
Journal Articles

Novel Complement Modulators for Paroxysmal Nocturnal Hemoglobinuria: Peptide and Protein Inhibitors of C3 Convertase Prevent Both Surface C3 Deposition and Subsequent Hemolysis of Affected Erythrocytes in Vitro

Antonio M. Risitano, MD, PhD, Patrizia Ricci, Caterina Pascariello, Maddalena Raia, Christoph Q Schmidt, Yingxue Li, Edimara S Reis, Michela Sica, PhD, Rosario Notaro, MD, Luigi Del Vecchio, MD, Fabrizio Pane, Daniel Ricklin, John D Lambris
Journal: Blood
Blood (2012) 120 (21): 370.
https://doi.org/10.1182/blood.V120.21.370.370
Published: 2012
Journal Articles

Autoreactive T Cells From Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) Specifically Recognize Glycosyl- Phosphatidyl-Inositol (GPI)

Lucia Gargiulo, PhD, Michela Sica, PhD, Maria Papaioannou, MD, PhD, Giulia Talini, PhD, Aristeidis Chaidos, MD, PhD, Barbara Richichi, PhD, Andrei V Nikolaev, PhD, Cristina Nativi, PhD, Mark Layton, MD, Josu de la Fuente, MRCP, MRCPCH, FRCPath, Irene Roberts, Lucio Luzzatto, MD, FRCP, FRCPath, Rosario Notaro, MD, Anastasios Karadimitris, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 647.
https://doi.org/10.1182/blood.V120.21.647.647
Published: 2012
Journal Articles

The complement receptor 2/factor H fusion protein TT30 protects paroxysmal nocturnal hemoglobinuria erythrocytes from complement-mediated hemolysis and C3 fragment opsonization

Antonio M. Risitano, Rosario Notaro, Caterina Pascariello, Michela Sica, Luigi del Vecchio, Christopher J. Horvath, Masha Fridkis-Hareli, Carmine Selleri, Margaret A. Lindorfer, Ronald P. Taylor, Lucio Luzzatto, V. Michael Holers
Journal: Blood
Blood (2012) 119 (26): 6307–6316.
https://doi.org/10.1182/blood-2011-12-398792
Published: 2012
Includes: Supplemental data
Journal Articles

HLA B*1402, Cw*0802 Haplotype and DRB1*1501 Allele Are Significantly Increased in Italian Paroxysmal Nocturnal Hemoglobinuria Affected Patients.

Fiorella Alfinito, Elena Cosentini, Rosa Camerlengo, Giuseppe Terrazzano, Michela Sica, Antonio Risitano, Stefania Costagliola, Roberta Della Pepa, Carmela Palladino, Lucio Luzzatto, Bruno Rotoli, Rosario Notaro, Giuseppina Ruggiero
Journal: Blood
Blood (2007) 110 (11): 4035.
https://doi.org/10.1182/blood.V110.11.4035.4035
Published: 2007