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Journal Articles

Characterization and Prognostic Relevance of Circulating Microvesicles in Chronic Lymphocytic Leukemia

Luciana De Luca, Giovanni D'Arena, MD, Vittorio Simeon, PhD, Stefania Trino, PhD, Ilaria Laurenzana, PhD, Antonella Caivano, Francesco La Rocca, Oreste Villani, MD, Giovanna Mansueto, MD, Silvia Deaglio, MD PhD, Idanna Innocenti, MD, Luca Laurenti, Stefano Molica, MD, Giuseppe Pietrantuono, MD, Angelo De Stradis, Luigi Del Vecchio, MD, Pellegrino Musto, MD

Blood (2016) 128 (22): 4375.

https://doi.org/10.1182/blood.V128.22.4375.4375

Published: 2016

Journal Articles

A Pyrazolo[3,4-d]Pyrimidine Compound Reduces Fyn Phosphorylation and Induces Apoptosis in Large Granular Lymphocyte Leukemia Cells

Ilaria Laurenzana, PhD, Antonella Caivano, Francesco La Rocca, Stefania Trino, PhD, Luciana De Luca, Francesca D'Alessio, Cristina Tintori, PhD, Vittorio Simeon, PhD, Antonio Traficante, Antonella Teramo, PhD, Renato Zambello, Gianpietro Semenzato, Silvia Schenone, Maurizio Botta, PhD, Pellegrino Musto, Luigi Del Vecchio, MD

Blood (2015) 126 (23): 3254.

https://doi.org/10.1182/blood.V126.23.3254.3254

Published: 2015

Journal Articles

High Serum Levels of Extracellular Vesicles which Express Specific Markers of Malignancy Are Released in Patients with Various Types of Hematological Neoplastic Disorders

Antonella Caivano, Luciana De Luca, Ilaria Laurenzana, Francesco La Rocca, Vittorio Simeon, Stefania Trino, Annalisa Morano, Fiorella D'Auria, Pellegrino Musto, MD, Luigi Del Vecchio

Blood (2014) 124 (21): 2917.

https://doi.org/10.1182/blood.V124.21.2917.2917

Published: 2014

Journal Articles

Exposure of Cord Blood Hematopoietic Stem Cells to Bone Marrow Mesenchimal Cells-Derived Microvesicles Induces Cell Survival and Inhibition of Differentiation

Luciana De Luca, Stefania Trino, Vittorio Simeon, Ilaria Laurenzana, Stefania Raimondo, Marina Podestà, Michele Santodirocco, Lazzaro Di Mauro, Francesco La Rocca, Antonella Caivano, Annalisa Morano, Luigi Del Vecchio, Francesco Frassoni, Daniela Cilloni, Pellegrino Musto, MD

Blood (2014) 124 (21): 4364.

https://doi.org/10.1182/blood.V124.21.4364.4364

Published: 2014

Journal Articles

Peptide inhibitors of C3 activation as a novel strategy of complement inhibition for the treatment of paroxysmal nocturnal hemoglobinuria

Antonio M. Risitano, Daniel Ricklin, Yijun Huang, Edimara S. Reis, Hui Chen, Patrizia Ricci, Zhuoer Lin, Caterina Pascariello, Maddalena Raia, Michela Sica, Luigi Del Vecchio, Fabrizio Pane, Florea Lupu, Rosario Notaro, Ranillo R. G. Resuello, Robert A. DeAngelis, John D. Lambris

Blood (2014) 123 (13): 2094–2101.

https://doi.org/10.1182/blood-2013-11-536573

Published: 2014

Includes: Supplemental data

Journal Articles

The Interferon Score Towards Interferon Alpha Tailored Therapy In Essential Thrombocythemia

Novella Pugliese, MD, Novella Pugliese, MD, Concetta Quintarelli, PhD, Biagio De Angelis, PhD, Luana Marano, Santa Errichiello, PhD, Nicola Esposito, Maddalena Raia, Claudio Cerchione, Luigi Del Vecchio, MD, Marco Picardi, MD, Vincenzo Martinelli, MD, Fabrizio Pane

Blood (2013) 122 (21): 4073.

https://doi.org/10.1182/blood.V122.21.4073.4073

Published: 2013

Journal Articles

Preclinical Development and In Vivo Evaluation Of Next-Generation Compstatin Analogs With Improved Systemic Profiles: A Novel Option For The Treatment Of Paroxysmal Nocturnal Hemoglobinuria

Daniel Ricklin, Ph.D., Antonio M. Risitano, MD, PhD, Edimara S. Reis, Ph.D., Patrizia Ricci, Yijun Huang, Ph.D., Zhuoer Lin, Ph.D., Hui Chen, Ph.D., Caterina Pascariello, Maddalena Raia, Luigi Del Vecchio, MD, Fabrizio Pane, MD, Ranillo R. G. Resuello, D.V.M., Robert A. DeAngelis, Ph.D., John D. Lambris, Ph.D.

Blood (2013) 122 (21): 1239.

https://doi.org/10.1182/blood.V122.21.1239.1239

Published: 2013

Journal Articles

Circulating Megakaryocyte-Derived Cells Detected by Flow Cytometry As Marker of Aggressive Neoplasms of Megakaryocytic Lineage in Acute Megakaryoblastic Leukemia and Allied Malignancies Presenting As Primary Myelofibrosis

Serena Marotta, Giovanna Giagnuolo, Giulia Scalia, Maddalena Raia, Santina Basile, Giuseppe Ciancia, Guido Pettinato, Fabrizio Pane, Gennaro de Rosa, Luigi Del Vecchio, MD, Antonio M. Risitano, MD, PhD

Blood (2012) 120 (21): 1461.

https://doi.org/10.1182/blood.V120.21.1461.1461

Published: 2012

Journal Articles

Cellular Composition and Clonal Evolution of 295 Type III PNH Clones: An Italian Multi-Laboratory Study

Blood (2012) 120 (21): 3482.

https://doi.org/10.1182/blood.V120.21.3482.3482

Published: 2012

Journal Articles

Novel Complement Modulators for Paroxysmal Nocturnal Hemoglobinuria: Peptide and Protein Inhibitors of C3 Convertase Prevent Both Surface C3 Deposition and Subsequent Hemolysis of Affected Erythrocytes in Vitro

Antonio M. Risitano, MD, PhD, Patrizia Ricci, Caterina Pascariello, Maddalena Raia, Christoph Q Schmidt, Yingxue Li, Edimara S Reis, Michela Sica, PhD, Rosario Notaro, MD, Luigi Del Vecchio, MD, Fabrizio Pane, Daniel Ricklin, John D Lambris

Blood (2012) 120 (21): 370.

https://doi.org/10.1182/blood.V120.21.370.370

Published: 2012

Journal Articles

The complement receptor 2/factor H fusion protein TT30 protects paroxysmal nocturnal hemoglobinuria erythrocytes from complement-mediated hemolysis and C3 fragment opsonization

Antonio M. Risitano, Rosario Notaro, Caterina Pascariello, Michela Sica, Luigi del Vecchio, Christopher J. Horvath, Masha Fridkis-Hareli, Carmine Selleri, Margaret A. Lindorfer, Ronald P. Taylor, Lucio Luzzatto, V. Michael Holers

Blood (2012) 119 (26): 6307–6316.

https://doi.org/10.1182/blood-2011-12-398792

Published: 2012

Includes: Supplemental data

Journal Articles

SHP-1 expression accounts for resistance to imatinib treatment in Philadelphia chromosome–positive cells derived from patients with chronic myeloid leukemia

Blood (2011) 118 (13): 3634–3644.

https://doi.org/10.1182/blood-2011-03-341073

Published: 2011

Includes: Supplemental data

Journal Articles

C3-Mediated Extravascular Hemolysis In Paroxysmal Nocturnal Hemoglobinuria: An In Vitro Model to Dissect Complement C3 Activation Comparing the Effects of Complement Inhibitors Eculizumab, 3E7 and TT30 on C3 Fragment Processing and Hemolysis of PNH Erythrocytes

Antonio M. Risitano, MD, PhD, Caterina Pascariello, Luigi Del Vecchio, MD, Christopher J Horvath, DVM, MS, DACVP, Masha Fridkis-Hareli, PhD, V. Michael Holers, MD, Margaret A Lindorfer, PhD, Ronald P Taylor, PhD

Blood (2010) 116 (21): 637.

https://doi.org/10.1182/blood.V116.21.637.637

Published: 2010

Journal Articles

JAK2V617F Mutation Persists IN Blasts and Mature CELLS of Transformed- JAK2V617F-POSITIVE-MYELOPROLIFERATIVE Neoplasia: A European LEUKEMIA NET (ENL) STUDY

Ciro R Rinaldi, MD, Paola Rinaldi, Adele Alagia, Marica Gemei, Luigi Del Vecchio, MD, Bruno Martino, Giorgina Specchia, Anna Candoni, Luigi Gugliotta, MD, Alessandro M. Vannucchi, MD, Tiziano Barbui, MD, Fabrizio Pane, MD

Blood (2010) 116 (21): 4090.

https://doi.org/10.1182/blood.V116.21.4090.4090

Published: 2010

Journal Articles

CD34 + cells from AML with mutated NPM1 harbor cytoplasmic mutated nucleophosmin and generate leukemia in immunocompromised mice

Blood (2010) 116 (19): 3907–3922.

https://doi.org/10.1182/blood-2009-08-238899

Published: 2010

Includes: Supplemental data

Journal Articles

Reduced Expression Level of SHP1 Gives An Additive Survival Advantage to the Ph+ Cells of Chronic Myeloid Leukemia (CML) Patients and Provides a Novel Pretreatment Predictor of Major Molecular Response Achievement in CML Patients.

Blood (2009) 114 (22): 2212.

https://doi.org/10.1182/blood.V114.22.2212.2212

Published: 2009

Journal Articles

Trisomy of Chromosome 7: a Novel Cytogenetic Abnormality in a Paediatric Case of Mixed Acute Leukemia.

Rosanna Parasole, Laura Vicari, Fara Petruzziello, Anna Leszl, Giuseppe Menna, M. Tarsitano, Luigi Del Vecchio, MD, Giulia Scalia, Giovanna Maisto, Giuseppe Basso, Vincenzo Poggi, Nicoletta Marra

Blood (2009) 114 (22): 4121.

https://doi.org/10.1182/blood.V114.22.4121.4121

Published: 2009

Journal Articles

Subcutaneous Alemtuzumab Is a Safe and Effective Treatment for Global or Single-Lineage Immune-Mediated Marrow Failures: a Survey from the EBMT-WPSAA

Antonio M. Risitano, MD, PhD, Elisa Seneca, Ludovica Marando, Bianca Serio, Carmine Selleri, Giulia Scalia, Luigi Del Vecchio, MD, Annapaola Iori, M.D., Alexander Kulagin, Sebastien Maury, Joerg Halter, Vikas Gupta, MD, MRCP, MRCPath, Andrea Bacigalupo, MD, Gerard Socié, Andre Tichelli, Judith Marsh, Hubert Schrezenmeier, Jakob R. Passweg, MD, MS, Bruno Rotoli

Blood (2008) 112 (11): 1042.

https://doi.org/10.1182/blood.V112.11.1042.1042

Published: 2008

Journal Articles

A decreased Level of Shp1 provides an additive survival advantage to the Ph+ Cells of CML Patients and may account for Resistance to Imatinib Treatment

Nicola Esposito, PhD, Irene Colavita, PhD, Fabrizio Quarantelli, PhD, Barbara Izzo, PhD, Luigia Luciano, MD, Luigi Del Vecchio, MD, Timothy Hughes, Jerald Radich, Domenico Russo, MD, Simona Soverini, PhD, Ilaria Iacobucci, PhD, Giovanni Martinelli, MD, Giuseppe Saglio, MD, Junia Melo, MD, PhD, Margherita Ruoppolo, PhD, Thea Kalebic, Fabrizio Pane, MD

Blood (2008) 112 (11): 3186.

https://doi.org/10.1182/blood.V112.11.3186.3186

Published: 2008

Journal Articles

CD200: a New Target for Immunotherapy in Hematologic Malignancies.

Lorenzo Brunetti, Giovanna Abate, Marisa Gorrese, Maddalena Raia, Caterina Pascariello, Giulia Scalia, Bruno Rotoli, Luigi Del Vecchio

Blood (2008) 112 (11): 1598.

https://doi.org/10.1182/blood.V112.11.1598.1598

Published: 2008

NARROW

Characterization and Prognostic Relevance of Circulating Microvesicles in Chronic Lymphocytic Leukemia

A Pyrazolo[3,4-d]Pyrimidine Compound Reduces Fyn Phosphorylation and Induces Apoptosis in Large Granular Lymphocyte Leukemia Cells

High Serum Levels of Extracellular Vesicles which Express Specific Markers of Malignancy Are Released in Patients with Various Types of Hematological Neoplastic Disorders

Exposure of Cord Blood Hematopoietic Stem Cells to Bone Marrow Mesenchimal Cells-Derived Microvesicles Induces Cell Survival and Inhibition of Differentiation

Peptide inhibitors of C3 activation as a novel strategy of complement inhibition for the treatment of paroxysmal nocturnal hemoglobinuria

The Interferon Score Towards Interferon Alpha Tailored Therapy In Essential Thrombocythemia

Preclinical Development and In Vivo Evaluation Of Next-Generation Compstatin Analogs With Improved Systemic Profiles: A Novel Option For The Treatment Of Paroxysmal Nocturnal Hemoglobinuria

Circulating Megakaryocyte-Derived Cells Detected by Flow Cytometry As Marker of Aggressive Neoplasms of Megakaryocytic Lineage in Acute Megakaryoblastic Leukemia and Allied Malignancies Presenting As Primary Myelofibrosis

Cellular Composition and Clonal Evolution of 295 Type III PNH Clones: An Italian Multi-Laboratory Study

Novel Complement Modulators for Paroxysmal Nocturnal Hemoglobinuria: Peptide and Protein Inhibitors of C3 Convertase Prevent Both Surface C3 Deposition and Subsequent Hemolysis of Affected Erythrocytes in Vitro

The complement receptor 2/factor H fusion protein TT30 protects paroxysmal nocturnal hemoglobinuria erythrocytes from complement-mediated hemolysis and C3 fragment opsonization

SHP-1 expression accounts for resistance to imatinib treatment in Philadelphia chromosome–positive cells derived from patients with chronic myeloid leukemia

C3-Mediated Extravascular Hemolysis In Paroxysmal Nocturnal Hemoglobinuria: An In Vitro Model to Dissect Complement C3 Activation Comparing the Effects of Complement Inhibitors Eculizumab, 3E7 and TT30 on C3 Fragment Processing and Hemolysis of PNH Erythrocytes

JAK2V617F Mutation Persists IN Blasts and Mature CELLS of Transformed- JAK2V617F-POSITIVE-MYELOPROLIFERATIVE Neoplasia: A European LEUKEMIA NET (ENL) STUDY

CD34 + cells from AML with mutated NPM1 harbor cytoplasmic mutated nucleophosmin and generate leukemia in immunocompromised mice

Reduced Expression Level of SHP1 Gives An Additive Survival Advantage to the Ph+ Cells of Chronic Myeloid Leukemia (CML) Patients and Provides a Novel Pretreatment Predictor of Major Molecular Response Achievement in CML Patients.

Trisomy of Chromosome 7: a Novel Cytogenetic Abnormality in a Paediatric Case of Mixed Acute Leukemia.

Subcutaneous Alemtuzumab Is a Safe and Effective Treatment for Global or Single-Lineage Immune-Mediated Marrow Failures: a Survey from the EBMT-WPSAA

A decreased Level of Shp1 provides an additive survival advantage to the Ph+ Cells of CML Patients and may account for Resistance to Imatinib Treatment

CD200: a New Target for Immunotherapy in Hematologic Malignancies.

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American Society of Hematology

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American Society of Hematology

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