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Journal Articles

Complement mediates binding and procoagulant effects of ultralarge HIT immune complexes

Sanjay Khandelwal, Ayiesha Barnes, Lubica Rauova, Amrita Sarkar, Ann H. Rux, Serge V. Yarovoi, S. Sergei Zaitsev, John D. Lambris, Sooho S. Myoung, Alexandra Johnson, Grace M. Lee, Madelaine Duarte, Mortimer Poncz, Gowthami M. Arepally, Douglas B. Cines

Blood (2021) 138 (21): 2106–2116.

https://doi.org/10.1182/blood.2020009487

Published: 2021

Includes: Supplemental data

Journal Articles

Incomplete inhibition by eculizumab: mechanistic evidence for residual C5 activity during strong complement activation

Markus J. Harder, Nadine Kuhn, Hubert Schrezenmeier, Britta Höchsmann, Inge von Zabern, Christof Weinstock, Thomas Simmet, Daniel Ricklin, John D. Lambris, Arne Skerra, Markus Anliker, Christoph Q. Schmidt

Blood (2017) 129 (8): 970–980.

https://doi.org/10.1182/blood-2016-08-732800

Published: 2017

Includes: Supplemental data

Journal Articles

Complement C3dg-mediated erythrophagocytosis: implications for paroxysmal nocturnal hemoglobinuria

Zhuoer Lin, Christoph Q. Schmidt, Sophia Koutsogiannaki, Patrizia Ricci, Antonio M. Risitano, John D. Lambris, Daniel Ricklin

Blood (2015) 126 (7): 891–894.

https://doi.org/10.1182/blood-2015-02-625871

Published: 2015

Includes: Supplemental data

Journal Articles

Peptide inhibitors of C3 activation as a novel strategy of complement inhibition for the treatment of paroxysmal nocturnal hemoglobinuria

Antonio M. Risitano, Daniel Ricklin, Yijun Huang, Edimara S. Reis, Hui Chen, Patrizia Ricci, Zhuoer Lin, Caterina Pascariello, Maddalena Raia, Michela Sica, Luigi Del Vecchio, Fabrizio Pane, Florea Lupu, Rosario Notaro, Ranillo R. G. Resuello, Robert A. DeAngelis, John D. Lambris

Blood (2014) 123 (13): 2094–2101.

https://doi.org/10.1182/blood-2013-11-536573

Published: 2014

Includes: Supplemental data

Journal Articles

Preclinical Development and In Vivo Evaluation Of Next-Generation Compstatin Analogs With Improved Systemic Profiles: A Novel Option For The Treatment Of Paroxysmal Nocturnal Hemoglobinuria

Daniel Ricklin, Ph.D., Antonio M. Risitano, MD, PhD, Edimara S. Reis, Ph.D., Patrizia Ricci, Yijun Huang, Ph.D., Zhuoer Lin, Ph.D., Hui Chen, Ph.D., Caterina Pascariello, Maddalena Raia, Luigi Del Vecchio, MD, Fabrizio Pane, MD, Ranillo R. G. Resuello, D.V.M., Robert A. DeAngelis, Ph.D., John D. Lambris, Ph.D.

Blood (2013) 122 (21): 1239.

https://doi.org/10.1182/blood.V122.21.1239.1239

Published: 2013

Journal Articles

Novel Complement Modulators for Paroxysmal Nocturnal Hemoglobinuria: Peptide and Protein Inhibitors of C3 Convertase Prevent Both Surface C3 Deposition and Subsequent Hemolysis of Affected Erythrocytes in Vitro

Antonio M. Risitano, MD, PhD, Patrizia Ricci, Caterina Pascariello, Maddalena Raia, Christoph Q Schmidt, Yingxue Li, Edimara S Reis, Michela Sica, PhD, Rosario Notaro, MD, Luigi Del Vecchio, MD, Fabrizio Pane, Daniel Ricklin, John D Lambris

Blood (2012) 120 (21): 370.

https://doi.org/10.1182/blood.V120.21.370.370

Published: 2012

Journal Articles

Complement-mediated inhibition of neovascularization reveals a point of convergence between innate immunity and angiogenesis

Harald F. Langer, Kyoung-Jin Chung, Valeria V. Orlova, Eun Young Choi, Sunil Kaul, Michael J. Kruhlak, Markella Alatsatianos, Robert A. DeAngelis, Paul A. Roche, Paola Magotti, Xuri Li, Matina Economopoulou, Stavros Rafail, John D. Lambris, Triantafyllos Chavakis

Blood (2010) 116 (22): 4395–4403.

https://doi.org/10.1182/blood-2010-01-261503

Published: 2010

Includes: Supplemental data

Journal Articles

Complement inhibition decreases the procoagulant response and confers organ protection in a baboon model of Escherichia coli sepsis

Robert Silasi-Mansat, Hua Zhu, Narcis I. Popescu, Glenn Peer, Georgia Sfyroera, Paola Magotti, Lacramioara Ivanciu, Cristina Lupu, Tom E. Mollnes, Fletcher B. Taylor, Gary Kinasewitz, John D. Lambris, Florea Lupu

Blood (2010) 116 (6): 1002–1010.

https://doi.org/10.1182/blood-2010-02-269746

Published: 2010

Includes: Supplemental data

Journal Articles

Complement anaphylatoxin C5a contributes to hemodialysis-associated thrombosis

Ioannis Kourtzelis, Maciej M. Markiewski, Michael Doumas, Stavros Rafail, Konstantinos Kambas, Ioannis Mitroulis, Stelios Panagoutsos, Ploumis Passadakis, Vasilios Vargemezis, Paola Magotti, Hongchang Qu, Tom Eirik Mollnes, Konstantinos Ritis, John D. Lambris

Blood (2010) 116 (4): 631–639.

https://doi.org/10.1182/blood-2010-01-264051

Published: 2010

Includes: Supplemental data

Journal Articles

Regulation of Toll-like receptor–mediated inflammatory response by complement in vivo

Xinhua Zhang, Yuko Kimura, Chongyun Fang, Lin Zhou, Georgia Sfyroera, John D. Lambris, Rick A. Wetsel, Takashi Miwa, Wen-Chao Song

Blood (2007) 110 (1): 228–236.

https://doi.org/10.1182/blood-2006-12-063636

Published: 2007

Journal Articles

Functional receptor for C3a anaphylatoxin is expressed by normal hematopoietic stem/progenitor cells, and C3a enhances their homing-related responses to SDF-1

Ryan Reca, Dimitrios Mastellos, Marcin Majka, Leah Marquez, Janina Ratajczak, Silvia Franchini, Aleksandra Glodek, Marek Honczarenko, Lynn A. Spruce, Anna Janowska-Wieczorek, John D. Lambris, Mariusz Z. Ratajczak

Blood (2003) 101 (10): 3784–3793.

https://doi.org/10.1182/blood-2002-10-3233

Published: 2003

Journal Articles

Complement-mediated clearance of erythrocytes: mechanism and delineation of the regulatory roles of Crry and DAF

Hector Molina, Takashi Miwa, Lin Zhou, Brendan Hilliard, Dimitrios Mastellos, Michael A. Maldonado, John D. Lambris, Wen-Chao Song

Blood (2002) 100 (13): 4544–4549.

https://doi.org/10.1182/blood-2002-06-1875

Published: 2002

Journal Articles

Essential role of the C5a receptor in E coli– induced oxidative burst and phagocytosis revealed by a novel lepirudin-based human whole blood model of inflammation

Tom Eirik Mollnes, Ole-Lars Brekke, Michael Fung, Hilde Fure, Dorte Christiansen, Grethe Bergseth, Vibeke Videm, Knut Tore Lappegård, Jörg Köhl, John D. Lambris

Blood (2002) 100 (5): 1869–1877.

https://doi.org/10.1182/blood.V100.5.1869.h81702001869_1869_1877

Published: 2002

Journal Articles

Compstatin Inhibits Complement and Cellular Activation in Whole Blood in Two Models of Extracorporeal Circulation

Bo Nilsson, Rolf Larsson, Jaan Hong, Graciela Elgue, Kristina Nilsson Ekdahl, Arvind Sahu, John D. Lambris

Blood (1998) 92 (5): 1661–1667.

https://doi.org/10.1182/blood.V92.5.1661

Published: 1998

NARROW

Complement mediates binding and procoagulant effects of ultralarge HIT immune complexes

Incomplete inhibition by eculizumab: mechanistic evidence for residual C5 activity during strong complement activation

Complement C3dg-mediated erythrophagocytosis: implications for paroxysmal nocturnal hemoglobinuria

Peptide inhibitors of C3 activation as a novel strategy of complement inhibition for the treatment of paroxysmal nocturnal hemoglobinuria

Preclinical Development and In Vivo Evaluation Of Next-Generation Compstatin Analogs With Improved Systemic Profiles: A Novel Option For The Treatment Of Paroxysmal Nocturnal Hemoglobinuria

Novel Complement Modulators for Paroxysmal Nocturnal Hemoglobinuria: Peptide and Protein Inhibitors of C3 Convertase Prevent Both Surface C3 Deposition and Subsequent Hemolysis of Affected Erythrocytes in Vitro

Complement-mediated inhibition of neovascularization reveals a point of convergence between innate immunity and angiogenesis

Complement inhibition decreases the procoagulant response and confers organ protection in a baboon model of Escherichia coli sepsis

Complement anaphylatoxin C5a contributes to hemodialysis-associated thrombosis

Regulation of Toll-like receptor–mediated inflammatory response by complement in vivo

Functional receptor for C3a anaphylatoxin is expressed by normal hematopoietic stem/progenitor cells, and C3a enhances their homing-related responses to SDF-1

Complement-mediated clearance of erythrocytes: mechanism and delineation of the regulatory roles of Crry and DAF

Essential role of the C5a receptor in E coli– induced oxidative burst and phagocytosis revealed by a novel lepirudin-based human whole blood model of inflammation

Compstatin Inhibits Complement and Cellular Activation in Whole Blood in Two Models of Extracorporeal Circulation

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American Society of Hematology

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American Society of Hematology

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