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Journal Articles

Early Relapse in Patients with Newly-Diagnosed Multiple Myeloma: A European Myeloma Network/Harmony Alliance Analysis Including 10843 Patients

Elias K. Mai, Andrea Manubens, Mattia D'Agostino, David A. Cairns, Alessandra Larocca, Juan José Lahuerta Palacios, Ruth Wester, Uta Bertsch, Anders Waage, Elena Zamagni, María-Victoria Mateos, Daniele Dall'Olio, Niels W.C.J. van de Donk, Graham Jackson, Serena Rocchi, Hans Salwender, Joan Bladé, Bronno van der Holt, Gastone Castellani, Katja C. Weisel, Francesca Gay, Sonja Zweegman, Michele Cavo, Jesus Maria Hernandez Rivas, Benedetto Bruno, Gordon Cook, Martin F Kaiser, Hartmut Goldschmidt, Mario Boccadoro, Jesús F. San-Miguel, Pieter Sonneveld
Journal: Blood
Blood (2024) 144 (Supplement 1): 898.
https://doi.org/10.1182/blood-2024-193310
Published: 2024
Journal Articles

Results of the Phase II Randomized Trial EMN15/HOVON147: Carfilzomib-Lenalidomide-Dexamethasone Vs Lenalidomide-Dexamethasone in Patients with High-Risk Smoldering Multiple Myeloma

Annemiek Broijl, Fredrik Schjesvold, Abdel el Yaakoubi, Djamila Issa, Sonja Zweegman, Kon-Siong Jie, Mario Boccadoro, Roman Hajek, Bronno van der Holt, Ruth Wester, Pieter Sonneveld
Journal: Blood
Blood (2024) 144 (Supplement 1): 676.
https://doi.org/10.1182/blood-2024-209809
Published: 2024
Journal Articles

Consolidation Treatment with VRD Followed By Maintenance with Lenalidomide in Multiple Myeloma Improves Overall Survival: Long-Term Follow-up of the EMN02/HOVON95 Randomized Phase 3 Trial

Pieter Sonneveld, Meletios A. Dimopoulos, Meral Beksac, Bronno van der Holt, Francesca Gay, Heinz Ludwig, Sonja Zweegman, Vladimir Maisnar, Maria Teresa Petrucci, Paolo Corradini, Francesca Patriarca, Angelo Belotti, Micol Quaresima, Mariella Grasso, Massimo Offidani, Laura Paris, Anna Marina Liberati, Markus Hansson, Heleen Visser-Wisselaar, Giulia Fumero, Renato Zambello, Paula F Ypma, Anna Pascarella, Niels Frost Andersen, Alexandra Croockewit, Mario Boccadoro, Michele Cavo
Journal: Blood
Blood (2024) 144 (Supplement 1): 674.
https://doi.org/10.1182/blood-2024-197908
Published: 2024
Journal Articles

Phase 3 Study of Teclistamab (Tec) in Combination with Lenalidomide (Len) and Tec Alone Versus Len Alone in Newly Diagnosed Multiple Myeloma (NDMM) As Maintenance Therapy Following Autologous Stem Cell Transplantation (ASCT): Safety Run-in (SRI) Results from the Majestec-4/EMN30 Trial

Elena Zamagni, Tobias Silzle, Ivan Špička, Sabrin Tahri, Sarah Lonergan, Inger S. Nijhof, Antonietta Pia Falcone, Evangelos Terpos, Jakub Radocha, Roberto Mina, Guldane Cengiz Seval, Meral Beksac, Cesar Rodriguez, Marcelo C. Pasquini, Michel Delforge, Vania Hungria, Donna Reece, Philippe Moreau, Yael C. Cohen, Kihyun Kim, Dominik Dytfeld, Jiří Minařík, Irene Strassl, Jelena Bila, Martin Schreder, Janusz Krawczyk, Fredrik Schjesvold, Caroline Cicin-Sain, Christoph Driessen, Gordon Cook, Lugui Qiu, Gonzalo Martin Garate, Agoston Gyula Szabo, Roman Hájek, Marc S. Raab, Silvia Mangiacavalli, Hermann Einsele, Andrew Spencer, Mario Boccadoro, Helen Vassalou, Lixia Pei, Yingqi Shi, Maria Krevvata, Ryan Gruber, Caline Sakabedoyan, Margaret Cobb, Jagoda Jasielec, Himal Amin, Rachel Kobos, Pieter Sonneveld, Niels W.C.J. van de Donk
Journal: Blood
Blood (2024) 144 (Supplement 1): 494.
https://doi.org/10.1182/blood-2024-205608
Published: 2024
Journal Articles

Circulating Tumor Cells As a Biomarker to Identify High-Risk Transplant Eligible Myeloma Patients Treated with Bortezomib, Lenalidomide and Dexamethasone with or without Daratumumab during Induction/Consolidation, and Lenalidomide with or without Daratumumab during Maintenance: Results from the Perseus Study

Luca Bertamini, Cathelijne Fokkema, Paula Rodríguez-Otero, Mark van Duin, Niels W.C.J. Van De Donk, Mattia D'Agostino, Evangelos Terpos, Diego Vieyra, Ricardo M. Attar, Anna Sitthi-Amorn, Robin Carson, Michel Delforge, Christoph Driessen, Roman Hajek, Mario Boccadoro, Hermann Einsele, Annette Vangsted, Vincent H.J. Van Der Velden, Fredrik Schjesvold, Artur Jurczyszyn, Meral Beksac, Andrew Spencer, Annemiek Broijl, Tom Cupedo, Philippe Moreau, Pieter Sonneveld
Journal: Blood
Blood (2024) 144 (Supplement 1): 487.
https://doi.org/10.1182/blood-2024-199550
Published: 2024
Journal Articles

Development and Validation of Novel Machine Learning-Based Risk Scores for Multiple Myeloma: Insights from the Harmony Alliance Big Data Platform

Adrian Mosquera Orgueira, Marta Sonia Gonzalez Perez, Mattia D'Agostino, David A. Cairns, Alessandra Larocca, Juan José Lahuerta Palacios, Ruth Wester, Uta Bertsch, Anders Waage, Elena Zamagni, Carlos Pérez Míguez, Niels W.C.J. Van De Donk, Graham Jackson, Davide Crucitti, Hans Salwender, Daniele Dall'Olio, Gastone Castellani, Manuel Piñeiro Fiel, Sara Bringhen, Sonja Zweegman, Michele Cavo, Jesus Maria Hernandez Rivas, Benedetto Bruno, Gordon Cook, Martin F Kaiser, Hartmut Goldschmidt, Pieter Sonneveld, Jesús F. San-Miguel, Mario Boccadoro, Maria- Victoria Mateos
Journal: Blood
Blood (2024) 144 (Supplement 1): 2226.
https://doi.org/10.1182/blood-2024-201448
Published: 2024
Journal Articles

Health-Related Quality of Life in Transplant-Eligible Patients with Newly Diagnosed Multiple Myeloma: Data from the Perseus Trial of Subcutaneous Daratumumab Combined with Bortezomib, Lenalidomide, and Dexamethasone (D-VRd)

Pieter Sonneveld, Meletios A. Dimopoulos, Mario Boccadoro, Hang Quach, Phoebe Joy Ho, Meral Beksac, Cyrille Hulin, Elisabetta Antonioli, Xavier Leleu, Silvia Mangiacavalli, Aurore Perrot, Michele Cavo, Angelo Belotti, Annemiek Broijl, Francesca Gay, Roberto Mina, Inger S. Nijhof, Niels W.C.J. van de Donk, Eirini Katodritou, Fredrik Schjesvold, Anna Sureda Balari, Laura Rosiñol Dachs, Michel Delforge, Wilfried Roeloffzen, Christoph Driessen, Annette Vangsted, Hermann Einsele, Andrew Spencer, Roman Hajek, Artur Jurczyszyn, Sarah Lonergan, Yanfang Liu, Jianping Wang, Emilie M.J. van Brummelen, Veronique Vanquickelberghe, Anna Sitthi-Amorn, Carla J. de Boer, Robin Carson, Eva G. Katz, Katharine S. Gries, Jiaqi Song, Kai Fai Ho, Paula Rodríguez-Otero, Joan Bladé, Philippe Moreau
Journal: Blood
Blood (2024) 144 (Supplement 1): 2000.
https://doi.org/10.1182/blood-2024-201630
Published: 2024
Journal Articles

Phase 3 Randomized Study of Daratumumab (DARA) + Bortezomib, Lenalidomide, and Dexamethasone (VRd) Versus Vrd Alone in Patients (Pts) with Newly Diagnosed Multiple Myeloma (NDMM) Who Are Eligible for Autologous Stem Cell Transplantation (ASCT): Primary Results of the Perseus Trial

Pieter Sonneveld, Meletios A. Dimopoulos, Mario Boccadoro, Hang Quach, P. Joy Ho, Meral Beksac, Cyrille Hulin, Elisabetta Antonioli, Xavier Leleu, Silvia Mangiacavalli, Aurore Perrot, Michele Cavo, Angelo Belotti, Annemiek Broijl, Francesca Gay, Roberto Mina, Inger S. Nijhof, Niels W.C.J van de Donk, Eirini Katodritou, Fredrik Schjesvold, Anna Sureda Balari, Laura Rosiñol, Michel Delforge, Wilfried Roeloffzen, Tobias Silzle, Annette Vangsted, Hermann Einsele, Andrew Spencer, Roman Hajek, Artur Jurczyszyn, Sarah Lonergan, Tahamtan Ahmadi, Yanfang Liu, Jianping Wang, Diego Vieyra, Emilie M.J. van Brummelen, Veronique Vanquickelberghe, Anna Sitthi-Amorn, Carla J. de Boer, Robin Carson, Paula Rodríguez Otero, Joan Bladé, Philippe Moreau
Journal: Blood
Blood (2023) 142 (Supplement 2): LBA-1.
https://doi.org/10.1182/blood-2023-191911
Published: 2023
Journal Articles

Iberdomide Maintenance after Autologous Stem-Cell Transplantation in Newly Diagnosed MM: First Results of the Phase 2 EMN26 Study

Niels W.C.J. van de Donk, Cyrille Touzeau, Evangelos Terpos, Aurore Perrot, Roberto Mina, Maaike de Ruijter, Elisabetta Antonioli, Eirini Katodritou, Norbert Pescosta, Paulus A.F. Geerts, Cécile Sonntag, Ruth Wester, Angelo Belotti, Silvia Mangiacavalli, Massimo Offidani, Mattia D'Agostino, Mark van Duin, Michele Cavo, Sara Aquino, Alessandra Lombardo, Mark-David Levin, Cyrille Hulin, Mario Boccadoro, Pieter Sonneveld, Francesca Gay
Journal: Blood
Blood (2023) 142 (Supplement 1): 208.
https://doi.org/10.1182/blood-2023-177564
Published: 2023
Journal Articles

Results of the Phase III Randomized Iskia Trial: Isatuximab-Carfilzomib-Lenalidomide-Dexamethasone Vs Carfilzomib-Lenalidomide-Dexamethasone As Pre-Transplant Induction and Post-Transplant Consolidation in Newly Diagnosed Multiple Myeloma Patients

Francesca Gay, Wilfried Roeloffzen, Meletios A. Dimopoulos, Laura Rosiñol, Marjolein van der Klift, Roberto Mina, Albert Oriol Rocafiguera, Eirini Katodritou, Ka Lung Wu, Paula Rodriguez Otero, Roman Hajek, Elisabetta Antonioli, Mark van Duin, Mattia D'Agostino, Joaquin Martinez-Lopez, Elena M. van Leeuwen-Segarceanu, Paola Tacchetti, Niels W.C.J. van de Donk, Katja Weisel, Luděk Pour, Jakub Radocha, Angelo Belotti, Fredrik Schjesvold, Joan Bladé, Hermann Einsele, Pieter Sonneveld, Mario Boccadoro, Annemiek Broijl
Journal: Blood
Blood (2023) 142 (Supplement 1): 4.
https://doi.org/10.1182/blood-2023-177546
Published: 2023
Journal Articles

Carfilzomib-Lenalidomide-Dexamethasone (KRd) Vs. Lenalidomide-Dexamethasone (Rd) in Newly Diagnosed Fit or Intermediate-Fit Multiple Myeloma Patients Not Eligible for Autologous Stem-Cell Transplantation (Phase III EMN20 Trial): Analysis of Sustained Undetectable Minimal Residual Disease (MRD)

Sara Bringhen, Elisabetta Antonioli, Barbara Gamberi, Benedetto Bruno, Daniele Derudas, Patrizia Tosi, Francesca Fazio, Rita Mazza, Sonia Ronconi, Paolo Corradini, Flavia Lotti, Claudia Cellini, Antonietta Pia Falcone, Piero Galieni, Roberto Ria, Angelo Belotti, Donato Mannina, Anna Maria Cafro, Clotilde Cangialosi, Iolanda Donatella Vincelli, Alessandra Lombardo, Alessandra Larocca, Mario Boccadoro, Mattia D'Agostino
Journal: Blood
Blood (2023) 142 (Supplement 1): 205.
https://doi.org/10.1182/blood-2023-177673
Published: 2023
Journal Articles

Genomic and Immune Determinants of Resistance to Anti-CD38 MoAb Based Therapy in Relapsed Multiple Myeloma

Bachisio Ziccheddu, Claudia Giannotta, Mattia D'Agostino, Giuseppe Bertuglia, Elona Saraci, Stefania Oliva, Benjamin Diamond, Niccolò Bolli, Paolo Corradini, David Coffey, Ola Landgren, Benedetto Bruno, Mario Boccadoro, Massimo Massaia, Francesco Maura, Alessandra Larocca
Journal: Blood
Blood (2023) 142 (Supplement 1): 1966.
https://doi.org/10.1182/blood-2023-182301
Published: 2023
Journal Articles

Treatment of Primary Plasma Cell Leukemia with Carfilzomib and Lenalidomide-Based Therapy: Results of the Final Analysis of the Prospective Phase 2 EMN12/HOVON-129 Study for Patients Aged 18-65 Years

Niels W.C.J. Van De Donk, Monique C. Minnema, Bronno van der Holt, Fredrik Schjesvold, Ka Lung Wu, Andrea Capra, Annemiek Broijl, Wilfried W.H. Roeloffzen, Alain Gadisseur, Giuseppe Pietrantuono, Ludek Pour, Vincent H.J. van der Velden, Thomas Lund, Massimo Offidani, Mariella Grasso, Luisa Giaccone, Michele Cavo, Trine Silkjaer, Jo Caers, Sonja Zweegman, Roman Hájek, Reuben Benjamin, Annette Juul Vangsted, Mario Boccadoro, Francesca Gay, Pieter Sonneveld, Pellegrino Musto
Journal: Blood
Blood (2022) 140 (Supplement 1): 4420–4422.
https://doi.org/10.1182/blood-2022-165942
Published: 2022
Journal Articles

Carfilzomib and Lenalidomide for the Treatment of Primary Plasma Cell Leukemia: Final Results of the Prospective Phase 2 EMN12/HOVON-129 Study for Patients Aged ≥66 Years

Pellegrino Musto, Monique C. Minnema, Wilfried W.H. Roeloffzen, Andrea Capra, Bronno van der Holt, Annette Juul Vangsted, Annemiek Broijl, Fredrik Schjesvold, Thomas Lund, Trine Silkjaer, Reuben Benjamin, Mariella Grasso, Ka Lung Wu, Jo Caers, Michele Cavo, Roman Hájek, Benedetto Bruno, Alain Gadisseur, Giuseppe Pietrantuono, Massimo Offidani, Luděk Pour, Pieter Sonneveld, Mario Boccadoro, Niels W.C.J. van de Donk
Journal: Blood
Blood (2022) 140 (Supplement 1): 4409–4411.
https://doi.org/10.1182/blood-2022-156390
Published: 2022
Journal Articles

Pan-Stakeholder Core Outcome Set (COS) Definition for Hematological Malignancies within the Framework of Harmony and Harmony PLUS Projects

Katharina M Lang, Tamás Bereczky, Jan Geissler, Natacha Bolanos, Kathryn E. Morgan, Ananda Plate, Ana Vallejo, Sophie Wintrich, Nick York, Peter Loffelhardt, Brian Huntly, Pieter Sonneveld, Mario Boccadoro, Valeria Santini, Šárka Pospíšilová, Andreas Hochhaus, Tiziano Barbui, Peter Borchmann, Christian Buske, Yann Guillevic, Frederico Calado, Katy Harrison, Dalia Dawoud, Guillermo Sanz, Jesús María Hernández, Ellen De Waal, Martje Barbus, Renate Schulze-Rath, Lars Bullinger
Journal: Blood
Blood (2022) 140 (Supplement 1): 5285–5287.
https://doi.org/10.1182/blood-2022-157549
Published: 2022
Journal Articles

Dedalo: Phase II Study of Daratumumab Plus Pomalidomide and Dexamethasone (DPd) in Patients with Relapsed/Refractory Multiple Myeloma and 17p Deletion

Vittorio Montefusco, Anna Maria Cafro, Gloria Margiotta Casaluci, Francesca Patriarca, Roberto Mina, Mattia D'Agostino, Andrea Capra, Claudia Priola, Anna Benedetta Dalla Palma, Rita Rizzi, Angelo Genua, Maria Teresa Petrucci, Laura Paris, Angelo Belotti, Michele Cavo, Concetta Conticello, Carmelo Carlo-Stella, Mario Boccadoro
Journal: Blood
Blood (2022) 140 (Supplement 1): 10193–10195.
https://doi.org/10.1182/blood-2022-156691
Published: 2022
Journal Articles

DVRd Followed By Ciltacabtagene Autoleucel Versus DVRd Followed By ASCT in Patients with Newly Diagnosed Multiple Myeloma Who Are Transplant Eligible: A Randomized Phase 3 Study ( EM agine/CARTITUDE-6)

Mario Boccadoro, Jesús San-Miguel, Kenshi Suzuki, Niels W.C.J. Van De Donk, Gordon Cook, Andrzej Jakubowiak, Deepu Madduri, Salma Afifi, An-Sofie Stevens, Jordan M. Schecter, William Deraedt, Steven Kuppens, Pankaj Mistry, Lida Pacaud, Erika Florendo, Annemiek Broijl, Francesca Gay, Roberto Mina, Leo Rasche, Philippe Moreau, María-Victoria Mateos, Hermann Einsele, Pieter Sonneveld
Journal: Blood
Blood (2022) 140 (Supplement 1): 4630–4632.
https://doi.org/10.1182/blood-2022-157021
Published: 2022
Journal Articles

Subcutaneous Daratumumab Plus Pomalidomide and Dexamethasone (D-Pd) Versus Pomalidomide and Dexamethasone (Pd) Alone in Patients with Relapsed or Refractory Multiple Myeloma (RRMM): Overall Survival Results from the Phase 3 Apollo Study

Meletios A. Dimopoulos, Evangelos Terpos, Mario Boccadoro, Sosana Delimpasi, Meral Beksac, Eirini Katodritou, Philippe Moreau, Luca Baldini, Argiris Symeonidis, Jelena Bila, Albert Oriol, Maria-Victoria Mateos, Hermann Einsele, Ioannis Orfanidis, Tobias Kampfenkel, Weiping Liu, Michele Kosh, NamPhuong Tran, Robin Carson, Pieter Sonneveld
Journal: Blood
Blood (2022) 140 (Supplement 1): 7272–7274.
https://doi.org/10.1182/blood-2022-163483
Published: 2022
Journal Articles

Co-Occurrence of High-Risk Lesions Is a Consistent Predictor of Ultra-High Risk Multiple Myeloma in Newly Diagnosed and Relapsed/Refractory Patients - Meta-Analysis of 5,808 Trial Patients

Martin F. Kaiser, Pieter Sonneveld, David Cairns, Marc S Raab, Alessandra Larocca, Sarah R Brown, Marc-A. Baertsch, Cong Li, Pellegrino Musto, Kwee Yong, Elias K Mai, Andrea Capra, Gordon Cook, Hartmut Goldschmidt, Mario Boccadoro, Graham Jackson, Niels Weinhold, Francesca Gay
Journal: Blood
Blood (2022) 140 (Supplement 1): 1556–1558.
https://doi.org/10.1182/blood-2022-160130
Published: 2022
Journal Articles

Bortezomib-Melphalan-Prednisone (VMP) Vs. Lenalidomide-Dexamethasone (Rd) in Transplant-Ineligible Real-Life Multiple Myeloma Patients: Updated Results of the Randomized Phase IV Real MM Trial

Sara Bringhen, Mattia D'Agostino, Nicola Giuliani, Irene Attucci, Renato Zambello, Sonia Ronconi, Iolanda Donatella Vincelli, Alessandro Allegra, Giovanna Leonardi, Giuseppe Rossi, Francesco Cattel, Andrea Capra, Piero Galieni, Alessandra Lombardo, Francesca Bonello, Patrizia Tosi, Maide Maria Cavalli, Elisa Sciorsi, Donato Mannina, Roberto Ria, Francesca Patriarca, Michele Cavo, Silvia Mangiacavalli, Giulia Benevolo, Andrea Evangelista, Mario Boccadoro, Benedetto Bruno, Alessandra Larocca
Journal: Blood
Blood (2022) 140 (Supplement 1): 1814–1816.
https://doi.org/10.1182/blood-2022-162178
Published: 2022