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Journal Articles

Intrinsic Immunosuppressive Features of Monocytes Suppress CART19 through IL-1 Pathway Modulation in Mantle Cell Lymphoma

Kun Yun, R. Leo Sakemura, Ismail Can, Omar Gutierrez Ruiz, Ekene Ogbodo, Shuwen Zhang, Truc Huynh, Claudia Manriquez Roman, Olivia L. Sirpilla, Carli M. Stewart, James H. Girsch, Jennifer M. Feigin, Long K. Mai, Hong Xia, Brooke L. Kimball, Lionel A Kankeu Fonkoua, Mehrdad Hefazi, Michael W. Ruff, Fariborz Rakhshan Rohakhtar, Vernadette Simon, Elizabeth L. Siegler, Mike Mattie, Sao-Mai Nguyen-Mau, Simone Filosto, Saad S. Kenderian
Journal: Blood
Blood (2024) 144 (Supplement 1): 908.
https://doi.org/10.1182/blood-2024-205905
Published: 2024
Journal Articles

Caspase-1 Inhibition Ameliorates CAR T-Cell Apoptosis and Tumor Cell Pyroptosis to Enhance the Efficacy and Safety of CAR T-Cell Therapy

Wannakorn Khopanlert, Truc Huynh, Brooke L. Kimball, Grace E. DeFranco, Sophia Y. Goldberg, Dominic A. Skeele, Jennifer M. Feigin, James H. Girsch, Olivia L. Sirpilla, Carli M. Stewart, Kun Yun, Claudia Manriquez Roman, Ismail Can, Omar Gutierrez Ruiz, Ekene Ogbodo, Long K. Mai, Hong Xia, Mehrdad Hefazi, Lionel Aurelien Kankeu Fonkoua, Michael W. Ruff, Elizabeth L. Siegler, Saad S. Kenderian, R. Leo Sakemura
Journal: Blood
Blood (2024) 144 (Supplement 1): 907.
https://doi.org/10.1182/blood-2024-202661
Published: 2024
Journal Articles

Erythroid Dysplasia in Stag2 Deficient Murine Models Reveals Novel Erythropoietic Function for Stag2 Cohesin

Varun S. Sudunagunta, Yi Chen, Russell Kunes, Edna M. Stewart, Viviana Scoca, John Pantazi, Hongxia Yan, Jane J. Xu, Mohandas Narla, Aaron D. Viny
Journal: Blood
Blood (2024) 144 (Supplement 1): 1070.
https://doi.org/10.1182/blood-2024-208693
Published: 2024
Journal Articles

Distinct Functional Impacts of Cytokine Receptor Blockade on CART Cells

Kun Yun, Evandro Bezerra, R. Leo Sakemura, Emmanuel Contreras Guzman, Ismail Can, Omar Gutierrez Ruiz, Ekene Ogbodo, Truc Huynh, Claudia Manriquez Roman, Olivia L. Sirpilla, Carli M. Stewart, Jennifer M. Feigin, Grace E. DeFranco, Sophia Y. Goldberg, Dominic A. Skeele, Long K. Mai, Hong Xia, Brooke L. Kimball, Lionel A Kankeu Fonkoua, Mehrdad Hefazi, Michael W. Ruff, Elizabeth L. Siegler, Saad S. Kenderian
Journal: Blood
Blood (2024) 144 (Supplement 1): 7166.
https://doi.org/10.1182/blood-2024-211119
Published: 2024
Journal Articles

Identification of T Cell Senescence As a Cell Fate Limiting the Antitumor Activity of 41BB-Costimulated CART Cells

Ismail Can, R. Leo Sakemura, Olivia L. Sirpilla, Claudia Manriquez Roman, Carli M. Stewart, Kun Yun, Truc Huynh, Ekene Ogbodo, Lionel A Kankeu Fonkoua, Jennifer M. Feigin, Omar Gutierrez Ruiz, Long K. Mai, Hong Xia, Brooke L. Kimball, Mehrdad Hefazi, Michael W. Ruff, Elizabeth L. Siegler, H. Atakan Ekiz, Berke Alkan, Fatih Sezer, Saad S. Kenderian
Journal: Blood
Blood (2024) 144 (Supplement 1): 4808.
https://doi.org/10.1182/blood-2024-207818
Published: 2024
Journal Articles

CD19 occupancy with tafasitamab increases therapeutic index of CART19 cell therapy and diminishes severity of CRS

R. Leo Sakemura, Claudia Manriquez Roman, Paulina Horvei, Elizabeth L. Siegler, James H. Girsch, Olivia L. Sirpilla, Carli M. Stewart, Kun Yun, Ismail Can, Ekene J. Ogbodo, Mohamad M. Adada, Evandro D. Bezerra, Lionel Aurelien Kankeu Fonkoua, Mehrdad Hefazi, Michael W. Ruff, Brooke L. Kimball, Long K. Mai, Truc N. Huynh, Wendy K. Nevala, Kristina Ilieva, Christian Augsberger, Maria Patra-Kneuer, Jürgen Schanzer, Jan Endell, Christina Heitmüller, Stefan Steidl, Sameer A. Parikh, Wei Ding, Neil E. Kay, Grzegorz S. Nowakowski, Saad S. Kenderian
Journal: Blood
Blood (2024) 143 (3): 258–271.
https://doi.org/10.1182/blood.2022018905
Published: 2024
Includes: Supplemental data
Journal Articles

Affinity of Anti-CD19 Antibodies Determines Subsequent CART19 Activation, Apoptosis and CRS in Preclinical Models

R. Leo Sakemura, Claudia Manriquez Roman, Long K. Mai, Brooke L. Kimball, Truc Huynh, Jennifer M. Feigin, James H. Girsch, Olivia L. Sirpilla, Kun Yun, Carli M. Stewart, Omar Gutierrez Ruiz, Ismail Can, Ekene Ogbodo, Lionel Aurelien Kankeu Fonkoua, Mehrdad Hefazi, Michael W. Ruff, Jan Jaehrling, Kristina Ilieva, Maria Patra-Kneuer, Christina Heitmüller, Stefan Steidl, Elizabeth L. Siegler, Saad S. Kenderian
Journal: Blood
Blood (2023) 142 (Supplement 1): 6796.
https://doi.org/10.1182/blood-2023-179408
Published: 2023
Journal Articles

CD19 Antigen Occupancy on Cancer Cells with the CD19 Monoclonal Antibody Tafasitamab Improves the Activation, Antitumor Efficacy, and Safety Profile of CART19 Cell Therapy

Reona Leo Sakemura, Claudia Manriquez-Roman, Paulina Horvei, Michelle J. Cox, Truc Huynh, James H. Girsch, Olivia Sirpilla, Kun Yun, Carli M. Stewart, Ismail Can, Ekene J. Ogbodo, Mohamad M. Adada, Lionel A. Kankeu Fonkoua, Mehrdad Hefazi, Michael W. Ruff, Kristina Ilieva-Babinsky, Christian Augsberger, Maria Patra-Kneuer, Christina Heitmüller, Stefan Steidl, Sameer A. Parikh, Wei Ding, Neil E. Kay, Grzegorz S. Nowakowski, Elizabeth L. Siegler, Saad S. Kenderian
Journal: Blood
Blood (2022) 140 (Supplement 1): 2362–2364.
https://doi.org/10.1182/blood-2022-158273
Published: 2022
Journal Articles

Identification of IL-4 As a Key Regulator of CAR T-Cell Exhaustion Using Functional Genomics and Correlates of the Zuma-1 Clinical Trial

Carli M. Stewart, Michelle J. Cox, Reona Leo Sakemura, Ekene J. Ogbodo, Ismail Can, Claudia Manriquez-Roman, Kun Yun, Olivia Sirpilla, James H. Girsch, Truc Huynh, Elizabeth L. Siegler, Jenny J Kim, Mike Mattie, Nathalie Scholler, Simone Filosto, Saad S. Kenderian
Journal: Blood
Blood (2022) 140 (Supplement 1): 4536–4537.
https://doi.org/10.1182/blood-2022-160219
Published: 2022
Journal Articles

Sinusoidal Obstruction Syndrome in Adult Patients with B-Cell Acute Lymphoblastic Leukemia Treated with Inotuzumab Prior to Hematopoietic Stem Cell Transplantation

Vaibhav Agrawal, Hoda Pourhassan, Ni-Chun Tsai, Dat Ngo, Paul B. Koller, Monzr M. Al Malki, Amandeep Salhotra, Haris Ali, Karamjeet S. Sandhu, Shukaib Arslan, Brian J Ball, Salman Otoukesh, Idoroenyi Amanam, Andrew S. Artz, Pamela S. Becker, Forrest M. Stewart, Eileen P. Smith, Peter T. Curtin, Anthony S. Stein, Guido Marcucci, Stephen J Forman, Ryotaro Nakamura, Vinod A. Pullarkat, Ibrahim Aldoss
Journal: Blood
Blood (2022) 140 (Supplement 1): 10449–10450.
https://doi.org/10.1182/blood-2022-165839
Published: 2022
Journal Articles

Long Term Outcomes of Patients with Chronic Myeloid Leukemia Undergoing Allogeneic Hematopoietic Cell Transplantation in the Era of Oral Tyrosine Kinase Inhibitors

Paul B. Koller, Haoyue Shan, Joycelynne Palmer, Peter T. Curtin, Karamjeet S. Sandhu, Vaibhav Agrawal, Ricardo Spielberger, Joshua Mansour, Amanda Blackmon, Salman Otoukesh, Shukaib Arslan, Idoroenyi Amanam, Eileen P. Smith, Forrest M. Stewart, Brian J Ball, Amandeep Salhotra, Ahmed Aribi, Ibrahim Aldoss, Vinod A. Pullarkat, Anthony S. Stein, Andrew S. Artz, Guido Marcucci, Stephen J Forman, Ryotaro Nakamura, Monzr M. Al Malki, David S Snyder, Haris Ali
Journal: Blood
Blood (2022) 140 (Supplement 1): 12945–12946.
https://doi.org/10.1182/blood-2022-170009
Published: 2022
Journal Articles

Chimeric Antigen Receptor Engineering of Mesenchymal Stromal Cells (CAR-MSC) Enhance Immunosuppression and Outcomes in Graft Versus Host Disease (GvHD) Preclinical Models

Olivia Sirpilla, Reona Leo Sakemura, Mehrdad Hefazi, James H. Girsch, Truc Huynh, Michelle J. Cox, Kendall J. Schick, Claudia Manriquez-Roman, Ismail Can, Kun Yun, Carli M. Stewart, Ekene J. Ogbodo, Elizabeth L. Siegler, Saad S. Kenderian
Journal: Blood
Blood (2022) 140 (Supplement 1): 1579–1580.
https://doi.org/10.1182/blood-2022-158872
Published: 2022
Journal Articles

Novel Salvage Therapies Are Highly Effective in Adults with Relapsed/Refractory Acute Lymphoblastic Leukemia (ALL) with Philadelphia (Ph)-like Fusions

Ibrahim Aldoss, Dongyun Yang, Michelle Afkhami, Zhaohui Gu, Sally Mokhtari, Shilpa Shahani, Vaibhav Agrawal, Hoda Pourhassan, Paul B. Koller, Vanina Tomasian, Milhan Telatar, Monzr M. Al Malki, Amandeep Salhotra, Haris Ali, Ahmed Aribi, Karamjeet S. Sandhu, Shukaib Arslan, Brian J Ball, Salman Otoukesh, Idoroenyi Amanam, Andrew S. Artz, Pamela S. Becker, Forrest M. Stewart, Peter T. Curtin, Raju Pillai, Eileen P. Smith, Guido Marcucci, Anthony S. Stein, Stephen J Forman, Ryotaro Nakamura, Vinod A. Pullarkat
Journal: Blood
Blood (2022) 140 (Supplement 1): 6020–6022.
https://doi.org/10.1182/blood-2022-158288
Published: 2022
Journal Articles

Evaluation of 5-Day Vs. 10-Day Decitabine in Combination with Venetoclax in Newly Diagnosed AML Patients Ineligible for Induction Chemotherapy

Jorge M. Ramos Perez, Jose Tinajero, Dat Ngo, Jianying Zhang, Paul B. Koller, Vaibhav Agrawal, Hoda Pourhassan, Monzr M. Al Malki, Amandeep Salhotra, Haris Ali, Ahmed Aribi, Karamjeet S. Sandhu, Shukaib Arslan, Salman Otoukesh, Idoroenyi Amanam, Andrew S. Artz, Pamela S. Becker, Forrest M. Stewart, Eileen P. Smith, Peter Curtin, Stephen J Forman, Ryotaro Nakamura, Vinod A. Pullarkat, Guido Marcucci, Anthony S. Stein, Ibrahim Aldoss, Brian J Ball
Journal: Blood
Blood (2022) 140 (Supplement 1): 9039–9040.
https://doi.org/10.1182/blood-2022-170867
Published: 2022
Journal Articles

Myeloablative Vs Reduced-Intensity Allogeneic Hematopoietic Cell Transplantation in Philadelphia-Chromosome Positive Acute Lymphoblastic Leukemia

Tamer Othman, Paul B. Koller, Ni-Chun Tsai, Hoda Pourhassan, Vaibhav Agrawal, Salman Otoukesh, Idoroenyi Amanam, Dat Ngo, Jason Chen, Monzr M. Al Malki, Amandeep Salhotra, Haris Ali, Ahmed Aribi, Karamjeet S. Sandhu, Shukaib Arslan, Brian J Ball, Forrest M. Stewart, Peter T. Curtin, Andrew S. Artz, David S Snyder, Guido Marcucci, Stephen J Forman, Anthony S. Stein, Ryotaro Nakamura, Vinod A. Pullarkat, Ibrahim Aldoss, Matthew Mei
Journal: Blood
Blood (2022) 140 (Supplement 1): 12819–12820.
https://doi.org/10.1182/blood-2022-164657
Published: 2022
Journal Articles

Differential Susceptibility to Senescence in CART Cells Based on Co-Stimulatory Signaling

Ismail Can, Reona Leo Sakemura, Claudia Manriquez-Roman, Olivia Sirpilla, Carli M. Stewart, Kun Yun, Michelle J. Cox, Truc Huynh, James H. Girsch, Ekene J. Ogbodo, Lionel A. Kankeu Fonkoua, Mehrdad Hefazi, Michael W. Ruff, Justin C. Boysen, Elizabeth L. Siegler, Atakan Ekiz, Saad S. Kenderian, Neil E. Kay
Journal: Blood
Blood (2022) 140 (Supplement 1): 8600–8601.
https://doi.org/10.1182/blood-2022-163446
Published: 2022
Journal Articles

Immunosuppressive Monocyte Modulation of CAR T Cell Functions and Impact on Response to CART19

Kun Yun, Reona Leo Sakemura, Michelle J. Cox, Truc Huynh, Claudia Manriquez-Roman, Olivia Sirpilla, Carli M. Stewart, James H. Girsch, Ekene J. Ogbodo, Ismail Can, Brooke Kimball, Lionel A. Kankeu Fonkoua, Mehrdad Hefazi, Michael W. Ruff, Elizabeth L. Siegler, Mike Mattie, Sao-Mai Nguyen-Mau, Simone Filosto, Saad S. Kenderian
Journal: Blood
Blood (2022) 140 (Supplement 1): 10263–10264.
https://doi.org/10.1182/blood-2022-164706
Published: 2022
Journal Articles

Outcomes Post-Allogeneic Hematopoietic Cell Transplantation Relapse in Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia

Tamer Othman, Ibrahim Aldoss, Ni-Chun Tsai, Hoda Pourhassan, Vaibhav Agrawal, Salman Otoukesh, Idoroenyi Amanam, Dat Ngo, Jason Chen, Monzr M. Al Malki, Amandeep Salhotra, Haris Ali, Ahmed Aribi, Karamjeet S. Sandhu, Shukaib Arslan, Brian J Ball, Forrest M. Stewart, Peter T. Curtin, Andrew S. Artz, David S Snyder, Guido Marcucci, Stephen J Forman, Anthony S. Stein, Ryotaro Nakamura, Vinod A. Pullarkat, Matthew Mei, Paul B. Koller
Journal: Blood
Blood (2022) 140 (Supplement 1): 10568–10570.
https://doi.org/10.1182/blood-2022-163652
Published: 2022
Journal Articles

Challenges of Maintenance Tyrosine Kinase Inhibitor Therapy after Allogeneic Hematopoietic Cell Transplantation in Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia

Tamer Othman, Paul B. Koller, Ni-Chun Tsai, Hoda Pourhassan, Vaibhav Agrawal, Salman Otoukesh, Idoroenyi Amanam, Dat Ngo, Jason Chen, Monzr M. Al Malki, Amandeep Salhotra, Haris Ali, Ahmed Aribi, Karamjeet S. Sandhu, Shukaib Arslan, Brian J. Ball, Forrest M. Stewart, Peter T. Curtin, Andrew S. Artz, David S. Snyder, Guido Marcucci, Stephen J. Forman, Anthony S. Stein, Ryotaro Nakamura, Vinod A. Pullarkat, Ibrahim Aldoss, Matthew Mei
Journal: Blood
Blood (2022) 140 (Supplement 1): 4821–4822.
https://doi.org/10.1182/blood-2022-164639
Published: 2022
Journal Articles

Favorable Modulation of Chimeric Antigen Receptor T Cells Safety and Efficacy By the Non-Covalent BTK Inhibitor Vecabrutinib

Mohamad M. Adada, Reona Sakemura, Michelle J. Cox, Caludia Manriquez-Roman, Elizabeth L. Siegler, Erin E. Tapper, Carli M. Stewart, Kendall J. Schick, Ismail Can, Ekene J. Ogbodo, Evandro D. Bezerra, Lionel A. Kankeu Fonkoua, Mehrdad Hefazi, Michael W. Ruff, Pietro Taverna, Judith A. Fox, Gloria Olivier, Susan L. Slager, Wei Ding, Sameer A. Parikh, Neil E. Kay, Saad S. Kenderian
Journal: Blood
Blood (2021) 138 (Supplement 1): 906.
https://doi.org/10.1182/blood-2021-151073
Published: 2021