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Journal Articles

Synergistic Effect of Tamoxifen and Ruxolitinib Combination in Reducing Disease Burden in Myeloproliferative Neoplasms

Diego A Pereira-Martins, Antonio Bruno Alves-Silva, Manuela Albuquerque De Melo, Natasha Peixoto Fonseca, Isabel Weinhäuser, Fabio Augusto Bueno Perez, Artur Bernardo Ribeiro Bellomi, Lorena Lobo Figueiredo-Pontes, João Agostinho Machado-Neto, Lynn Quek, Prodromos Chatzikyriakou, Gerwin A. Huls, Emanuele Ammatuna, Jan Jacob Schuringa, Fabiola Traina

Blood (2024) 144 (Supplement 1): 4518.

https://doi.org/10.1182/blood-2024-209823

Published: 2024

Journal Articles

Molecular Mechanisms Associated with Autophagy Inhibition to Overcome Resistance to FLT3 Inhibitors

Manuela Albuquerque De Melo, Diego A. Pereira-Martins, Brunno Gilberto Santos Macedo, Livia Bassani Lins de Miranda, Priscila Santos Scheucher, Isabel Weinhäuser, Gerwin Huls, Jan Jacob Schuringa, João Agostinho Machado-Neto, Fabiola Traina

Blood (2024) 144 (Supplement 1): 2752.

https://doi.org/10.1182/blood-2024-203390

Published: 2024

Journal Articles

Impact of Ph-like Gene Signatures on Clinical Outcomes in Adult B-ALL Patients in Resource-Constrained Settings

Keli Lima, César Alexander Ortiz Rojas, Frederico Lisboa Nogueira, Wellington F. Silva, Rita de Cássia Cavaglieri Medeiros, Luciana Nardinelli, Aline de Medeiros Leal, Elvira D. R. P. Velloso, Israel Bendit, Alvaro J Alencar, Charles G. Mullighan, João Agostinho Machado-Neto, Eduardo M. Rego

Blood (2024) 144 (Supplement 1): 2802.

https://doi.org/10.1182/blood-2024-208763

Published: 2024

Journal Articles

Autophagy Induction Constitutes a Targetable Vulnerability in FLT3-Mutant Acute Myeloid Leukemia Cells Treated with FLT3-Inhibitors

Manuela Albuquerque de Melo, Brunno Gilberto Santos Macedo, Natasha Peixoto Fonseca, Priscila Santos Scheucher, Diego A Pereira-Martins, João Agostinho Machado-Neto, Fabiola Traina

Blood (2023) 142 (Supplement 1): 5752.

https://doi.org/10.1182/blood-2023-190724

Published: 2023

Journal Articles

Cephalochromin-Induced Mitochondrial Damage Overcomes Venetoclax-Resistance in Acute Myeloid Leukemia Models

Mariane Cristina Do Nascimento, Diego A Pereira-Martins, Guilherme Augusto Sousa Alcântara, Keli Lima, Hugo Passos Vicari, Marcelo José Pena Ferreira, Leticia Veras Costa-Lotufo, Gerwin A. Huls, Jan Jacob Schuringa, João Agostinho Machado-Neto, Eduardo Magalhães Rego

Blood (2023) 142 (Supplement 1): 5751.

https://doi.org/10.1182/blood-2023-189814

Published: 2023

Journal Articles

Potency and Efficacy of Pharmacological PIP4K2 Inhibitors in Acute Lymphoblastic Leukemia

Keli Lima, Maria Fernanda Lopes Carvalho, Diego A. Pereira-Martins, Wellington F Silva, Mariane Cristina do Nascimento, Lívia Bassani Lins de Miranda, Rita de Cássia Cavaglieri Medeiros, Luciana Nardinelli, Aline de Medeiros Leal, Elvira Deolinda Rodrigues Pereira Velloso, Israel Bendit, Jan Jacob Schuringa, João Agostinho Machado-Neto, Eduardo Magalhães Rego

Blood (2023) 142 (Supplement 1): 5786.

https://doi.org/10.1182/blood-2023-189786

Published: 2023

Journal Articles

Identification of Vulnerabilities for Pharmacological Inhibition of PIP4K2s in Acute Myeloid Leukemia

Keli Lima, Maria Fernanda Lopes Carvalho, Diego A Pereira-Martins, Lívia Bassani Lins de Miranda, Mariane Cristina do Nascimento, Frederico Lisboa Nogueira, Rita de Cássia Cavaglieri Medeiros, Jan Jacob Schuringa, João Agostinho Machado-Neto, Eduardo Magalhães Rego

Blood (2023) 142 (Supplement 1): 5774.

https://doi.org/10.1182/blood-2023-189998

Published: 2023

Journal Articles

Ezrin Is a Potential Druggable Target in Chronic Lymphocytic Leukemia

Jean Carlos Lipreri Da Silva, Felipe Saldanha-Araujo, Raphael Costa Bandeira de Melo, Hugo Passos Vicari, Amandda Évelin Silva De Carvalho, Eduardo M Rego, Valeria Buccheri, João Agostinho Machado-Neto

Blood (2022) 140 (Supplement 1): 12359–12360.

https://doi.org/10.1182/blood-2022-160267

Published: 2022

Journal Articles

Targeting PIP4K2 Lipid Kinases through Thz-P1-2 Reveals Vulnerabilities Related to Mitochondrial Homeostasis and Autophagy in Acute Leukemia

Keli Lima, Diego A Pereira-Martins, Lívia Bassani Lins de Miranda, Juan L Coelho-Silva, Giovana da Silva Leandro, Isabel Weinhäuser, Rita de Cassia Cavaglieri, Wellington F Silva, Aline Medeiros Leal, Ana Paula Alencar de Lima Lange, Elvira Deolinda Rodrigues Pereira Velloso, Emmanuel Griessinger, Jacobien R Hilberink, Gerwin A. Huls, Jan Jacob Schuringa, João Agostinho Machado-Neto, Eduardo M Rego

Blood (2022) 140 (Supplement 1): 5965–5966.

https://doi.org/10.1182/blood-2022-165172

Published: 2022

Journal Articles

Metformin Inhibits STAT3 and MAPK Signaling through AMPK Activation in CSF3R T618I Cells

Natasha Peixoto Fonseca, Bruna Alves Fenerich, Diego A Pereira-Martins, Pedro Manoel Marques Garibaldi, Juan L Coelho-Silva, Antonio Bruno Alves Silva, Jaqueline Cristina Fernandes, Cleide Lucia Silva, Eduardo M Rego, João Agostinho Machado-Neto, Fabiola Traina

Blood (2022) 140 (Supplement 1): 12153–12154.

https://doi.org/10.1182/blood-2022-167392

Published: 2022

Journal Articles

IGF1R-IRS1/2 Pharmacological Inhibitors Act By Distinct Cellular and Molecular Mechanisms and Reveals Vulnerabilities for Treatment of Acute Myeloid Leukemia

Juan L Coelho-Silva, Diego A Pereira-Martins, Virginia Campos Silvestrini, João Agostinho Machado-Neto, Eduardo M Rego, Marcus Smolka, Vitor Marcel Faca, Fabiola Traina

Blood (2021) 138 (Supplement 1): 1869.

https://doi.org/10.1182/blood-2021-153105

Published: 2021

Journal Articles

Irs1 S57X Heterozygous Mutant Mice Display Normal Hematopoiesis and Phenotypic Features, While Homozygous Knockout Exhibit High Fetal or Postnatal Lethality

Bruna Alves Fenerich, BSc, Jaqueline Cristina Fernandes, BSc, MSc, Cleide Lúcia Araújo Silva, MSc, Juan L Coelho-Silva, BSc, MSc, Antonio Bruno Alves Silva, BSc, MSc, Natasha Peixoto Fonseca, B.Sc., M.Sc., João Agostinho Machado-Neto, PhD, Fabiola Traina, MD PhD

Blood (2020) 136 (Supplement 1): 33–34.

https://doi.org/10.1182/blood-2020-139422

Published: 2020

Journal Articles

Molecular-Based Score Inspired on Metabolic Signature Improves Prognostic Stratification for Myelodysplastic Syndrome

Juan L Coelho-Silva, BSc, MSc, Douglas R. A. Silveira, Diego A Pereira-Martins, MSc, César Alexander Ortiz Rojas, BSc, Antonio R. Lucena-Araujo, PhD, Eduardo M Rego, MD PhD, João Agostinho Machado-Neto, PhD, Israel Bendit, MD PhD, Vanderson Rocha, MD PhD, Fabiola Traina, MD PhD

Blood (2019) 134 (Supplement_1): 4257.

https://doi.org/10.1182/blood-2019-132141

Published: 2019

Journal Articles

IGF1R-IRS1/2 Signaling Pathway Is a Potential Target for FLT3-Mutated Acute Myeloid Leukemia

Juan L Coelho-Silva, BSc, MSc, Diego A Pereira-Martins, MSc, Virginia Campos Silvestrini, BSc, MSc, Eduardo M Rego, MD PhD, Vitor Marcel Faca, PhD, João Agostinho Machado-Neto, PhD, Fabiola Traina, MD PhD

Blood (2019) 134 (Supplement_1): 2689.

https://doi.org/10.1182/blood-2019-132129

Published: 2019

Journal Articles

Metformin Suppress Cellular and Molecular Processes Related to Maintenance and Proliferation of Myeloproliferative Neoplasm Stem Cell

Juan L Coelho-Silva, BSc, MSc, Thiago Mantello Bianco, MSc, Antonio Bruno Alves Silva, BSc, Diego Antonio Pereira-Martins, M.Sc., Natasha Peixoto Fonseca, B.Sc., M.Sc., Isabel Weinhäuser, MSc, Eduardo M Rego, MD PhD, Fernando Chahud, MD PhD, João Agostinho Machado-Neto, PhD, Lorena Lobo Figueiredo-Pontes, MD PhD, Fabiola Traina, MD PhD

Blood (2019) 134 (Supplement_1): 1682.

https://doi.org/10.1182/blood-2019-132115

Published: 2019

Journal Articles

Clinical Impact and Therapeutic Opportunity of Insulin Receptor Substrates 1/2 in Acute Myeloid Leukemia

Juan Luiz Coelho-Silva, BSc, MSc, Diego Antonio Pereira-Martins, MSc, Josiane Lilian Schiavinato, PhD, Eduardo Magalhães Rego, MD PhD, João Agostinho Machado-Neto, BSc, Fabiola Traina, MD PhD

Blood (2018) 132 (Supplement 1): 1512.

https://doi.org/10.1182/blood-2018-99-119156

Published: 2018

Journal Articles

Autophagy Inhibition Potentiates Ruxolitinib-Induced Apoptosis in JAK2 V617F Cells

João Agostinho Machado-Neto, BSc, Juan Luiz Coelho-Silva, BSc, MSc, Fábio Pires de Souza Santos, MD PhD, Priscila Santos Scheucher, PhD, Paulo Vidal Campregher, MD PhD, Nelson Hamerschlak, MD PhD, Eduardo Magalhães Rego, MDPhD, Fabiola Traina, MD PhD

Blood (2018) 132 (Supplement 1): 1788.

https://doi.org/10.1182/blood-2018-99-119651

Published: 2018

Journal Articles

The Pharmacological IGF1R-IRS1/2 Inhibitor NT157 Presents Multiple Anti-Neoplastic Effects in Myeloproliferative Neoplasms

Bruna Alves Fenerich, BSc, João Agostinho Machado-Neto, BSc, Ana Paula Nunes Rodrigues Alves, MSc, Paula De Melo Campos, MD PhD, Jaqueline Cristina Fernandes, BSc, MSc, Juan Luiz Coelho-Silva, BSc, MSc, Renata Scopim Ribeiro, BSc, MSc, Fernanda B da Silva, BSc and MSc, Priscila Santos Scheucher, PhD, Lorena Lobo Figueiredo-Pontes, MD PhD, Eduardo Magalhães Rego, MDPhD, Fabiola Traina, MD PhD

Blood (2017) 130 (Supplement 1): 1253.

https://doi.org/10.1182/blood.V130.Suppl_1.1253.1253

Published: 2017

Journal Articles

IGF Signaling Predicts Outcomes and Is a Promising Target Therapy for Acute Myeloid Leukemia

Juan Luiz Coelho-Silva, BSc, MSc, João Agostinho Machado-Neto, BSc, Jaqueline Cristina Fernandes, BSc, MSc, Ana Silvia G de Lima, PhD, Priscila Santos Scheucher, PhD, Eduardo Magalhães Rego, MDPhD, Fabiola Traina, MD PhD

Blood (2017) 130 (Supplement 1): 3966.

https://doi.org/10.1182/blood.V130.Suppl_1.3966.3966

Published: 2017

Journal Articles

DNMT3A Is Highly Expressed in Bone Marrow Cells from Acute Myeloid Leukemia Patients

Renata Scopim Ribeiro, BSc, MSc, João Agostinho Machado-Neto, BSc, Paula De Melo Campos, MD PhD, Christopher A. Eide, Samantha L Savage, Irene Lorand-Metze, MD PhD, Cristina E. Tognon, PhD, Fernando Ferreira Costa, MD PhD, Brian J. Druker, MD, Sara Teresinha Olalla Saad, MD PhD, Fabiola Traina, MD PhD

Blood (2017) 130 (Supplement 1): 3969.

https://doi.org/10.1182/blood.V130.Suppl_1.3969.3969

Published: 2017

NARROW

Synergistic Effect of Tamoxifen and Ruxolitinib Combination in Reducing Disease Burden in Myeloproliferative Neoplasms

Molecular Mechanisms Associated with Autophagy Inhibition to Overcome Resistance to FLT3 Inhibitors

Impact of Ph-like Gene Signatures on Clinical Outcomes in Adult B-ALL Patients in Resource-Constrained Settings

Autophagy Induction Constitutes a Targetable Vulnerability in FLT3-Mutant Acute Myeloid Leukemia Cells Treated with FLT3-Inhibitors

Cephalochromin-Induced Mitochondrial Damage Overcomes Venetoclax-Resistance in Acute Myeloid Leukemia Models

Potency and Efficacy of Pharmacological PIP4K2 Inhibitors in Acute Lymphoblastic Leukemia

Identification of Vulnerabilities for Pharmacological Inhibition of PIP4K2s in Acute Myeloid Leukemia

Ezrin Is a Potential Druggable Target in Chronic Lymphocytic Leukemia

Targeting PIP4K2 Lipid Kinases through Thz-P1-2 Reveals Vulnerabilities Related to Mitochondrial Homeostasis and Autophagy in Acute Leukemia

Metformin Inhibits STAT3 and MAPK Signaling through AMPK Activation in CSF3R T618I Cells

IGF1R-IRS1/2 Pharmacological Inhibitors Act By Distinct Cellular and Molecular Mechanisms and Reveals Vulnerabilities for Treatment of Acute Myeloid Leukemia

Irs1 S57X Heterozygous Mutant Mice Display Normal Hematopoiesis and Phenotypic Features, While Homozygous Knockout Exhibit High Fetal or Postnatal Lethality

Molecular-Based Score Inspired on Metabolic Signature Improves Prognostic Stratification for Myelodysplastic Syndrome

IGF1R-IRS1/2 Signaling Pathway Is a Potential Target for FLT3-Mutated Acute Myeloid Leukemia

Metformin Suppress Cellular and Molecular Processes Related to Maintenance and Proliferation of Myeloproliferative Neoplasm Stem Cell

Clinical Impact and Therapeutic Opportunity of Insulin Receptor Substrates 1/2 in Acute Myeloid Leukemia

Autophagy Inhibition Potentiates Ruxolitinib-Induced Apoptosis in JAK2 V617F Cells

The Pharmacological IGF1R-IRS1/2 Inhibitor NT157 Presents Multiple Anti-Neoplastic Effects in Myeloproliferative Neoplasms

IGF Signaling Predicts Outcomes and Is a Promising Target Therapy for Acute Myeloid Leukemia

DNMT3A Is Highly Expressed in Bone Marrow Cells from Acute Myeloid Leukemia Patients

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American Society of Hematology

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ASH Publications

American Society of Hematology

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