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Journal Articles

Synergistic Effect of Tamoxifen and Ruxolitinib Combination in Reducing Disease Burden in Myeloproliferative Neoplasms

Diego A Pereira-Martins, Antonio Bruno Alves-Silva, Manuela Albuquerque De Melo, Natasha Peixoto Fonseca, Isabel Weinhäuser, Fabio Augusto Bueno Perez, Artur Bernardo Ribeiro Bellomi, Lorena Lobo Figueiredo-Pontes, João Agostinho Machado-Neto, Lynn Quek, Prodromos Chatzikyriakou, Gerwin A. Huls, Emanuele Ammatuna, Jan Jacob Schuringa, Fabiola Traina

Blood (2024) 144 (Supplement 1): 4518.

https://doi.org/10.1182/blood-2024-209823

Published: 2024

Journal Articles

Metabolism-Related Features Identify the Combination Metformin Plus NAMPT Inhibitors As a Selective Treatment Strategy in Acute Myeloid Leukemia

Isabel Weinhaeuser, Diego Pereira-Martins, Dominique Sternadt, Emmanuel F Griessinger, Douglas RA Silveira, Juan L Coelho-Silva, Antonio Bruno Alves-Silva, Ayşegül Erdem, Bruno Koza Lino Duarte, Lynn Quek, Fabiola Traina, Sara Teresinha Olalla Saad, Jacobien R Hilberink, Emanuele Ammatuna, Eduardo Magalhães Rego, Geert A. Huls, Antonio R Lucena-Araujo, Jan Jacob Schuringa

Blood (2023) 142 (Supplement 1): 294.

https://doi.org/10.1182/blood-2023-186061

Published: 2023

Journal Articles

Metformin Inhibits STAT3 and MAPK Signaling through AMPK Activation in CSF3R T618I Cells

Natasha Peixoto Fonseca, Bruna Alves Fenerich, Diego A Pereira-Martins, Pedro Manoel Marques Garibaldi, Juan L Coelho-Silva, Antonio Bruno Alves Silva, Jaqueline Cristina Fernandes, Cleide Lucia Silva, Eduardo M Rego, João Agostinho Machado-Neto, Fabiola Traina

Blood (2022) 140 (Supplement 1): 12153–12154.

https://doi.org/10.1182/blood-2022-167392

Published: 2022

Journal Articles

Irs1 S57X Heterozygous Mutant Mice Display Normal Hematopoiesis and Phenotypic Features, While Homozygous Knockout Exhibit High Fetal or Postnatal Lethality

Bruna Alves Fenerich, BSc, Jaqueline Cristina Fernandes, BSc, MSc, Cleide Lúcia Araújo Silva, MSc, Juan L Coelho-Silva, BSc, MSc, Antonio Bruno Alves Silva, BSc, MSc, Natasha Peixoto Fonseca, B.Sc., M.Sc., João Agostinho Machado-Neto, PhD, Fabiola Traina, MD PhD

Blood (2020) 136 (Supplement 1): 33–34.

https://doi.org/10.1182/blood-2020-139422

Published: 2020

Journal Articles

Metformin Suppress Cellular and Molecular Processes Related to Maintenance and Proliferation of Myeloproliferative Neoplasm Stem Cell

Juan L Coelho-Silva, BSc, MSc, Thiago Mantello Bianco, MSc, Antonio Bruno Alves Silva, BSc, Diego Antonio Pereira-Martins, M.Sc., Natasha Peixoto Fonseca, B.Sc., M.Sc., Isabel Weinhäuser, MSc, Eduardo M Rego, MD PhD, Fernando Chahud, MD PhD, João Agostinho Machado-Neto, PhD, Lorena Lobo Figueiredo-Pontes, MD PhD, Fabiola Traina, MD PhD

Blood (2019) 134 (Supplement_1): 1682.

https://doi.org/10.1182/blood-2019-132115

Published: 2019

Journal Articles

Efficacy of the Pan-Bcl-2 Inhibitor (Obatoclax) As a Single Agent to Treat Myeloproliferative Neoplasm in JAK2V617F Murine Transplantation Model

Thiago Mantello Bianco, MSc, Juan L Coelho-Silva, BSc, MSc, Diego A Pereira-Martins, MSc, Priscila Santos Scheucher, PhD, Isabel Weinhäuser, MSc, Antonio Bruno Alves Silva, BSc, Cleide Lucia Silva, MSc, Ann Mullally, MD, Susumu S Kobayashi, MD PhD, Eduardo M Rego, MD PhD, Fabiola Traina, MD PhD, Lorena Lobo Figueiredo-Pontes, MD PhD

Blood (2019) 134 (Supplement_1): 2977.

https://doi.org/10.1182/blood-2019-131023

Published: 2019

Journal Articles

Clinical Significance of NOTCH1 mutations in Chronic Lymphocytic Leukemia.

Giovanni Del Poeta, Michele Dal Bo, Maria Ilaria Del Principe, Federico Pozzo, Dario Ragusa, Francesca Maria Rossi, Annalisa Biagi, Antonella Zucchetto, Riccardo Bomben, Massimo Degan, Antonio Bruno, Pietro Bulian, MD, Davide Rossi, MD, Paolo de Fabritiis, Sergio Amadori, Gianluca Gaidano, Valter Gattei, MD

Blood (2012) 120 (21): 2870.

https://doi.org/10.1182/blood.V120.21.2870.2870

Published: 2012

Journal Articles

The Amount of Mitochondrial Apoptosis Exerts Prognostic Impact on Normal Karyotype Acute Myeloid Leukemia.

Giovanni Del Poeta, Maria Ilaria Del Principe, Francesco Buccisano, Luca Maurillo, Benedetta Neri, Licia Ottaviani, Fabrizio Luciano, Daniela Piccioni, Maria Irno Consalvo, Emanuele Ammatuna, Antonio Bruno, Paolo de Fabritiis, Valter Gattei, Adriano Venditti, Francesco Lo Coco, Sergio Amadori

Blood (2008) 112 (11): 1481.

https://doi.org/10.1182/blood.V112.11.1481.1481

Published: 2008

Journal Articles

Multidrug Resistance Proteins Overexpression Worsen the Favorable Clinical Impact of an Elevated Spontaneous Apoptosis in Acute Myeloid Leukemia (AML).

Giovanni Del Poeta, Maria Ilaria Del Principe, Francesco Buccisano, Adriano Venditti, Luca Maurillo, Emanuele Ammatuna, Antonio Bruno, Benedetta Neri, Chiara Sarlo, Francesco Lo Coco, Paolo de Fabritiis, Sergio Amadori

Blood (2006) 108 (11): 2315.

https://doi.org/10.1182/blood.V108.11.2315.2315

Published: 2006

Journal Articles

Clinical significance of ZAP-70 protein expression in B-cell chronic lymphocytic leukemia

Blood (2006) 108 (3): 853–861.

https://doi.org/10.1182/blood-2005-12-4986

Published: 2006

Journal Articles

Clinical Relevance of Spontaneous Apoptosis Is Independent from Multidrug Resistance in Acute Myeloid Leukemia (AML).

Giovanni Del Poeta, MD, Maria Ilaria Del Principe, MD, Adriano Venditti, MD, Francesco Buccisano, MD, Luca Maurillo, MD, Carla Mazzone, MD, Benedetta Neri, MD, Maria Irno Consalvo, PhD, Antonio Bruno, PhD, Francesco Lo Coco, MD, Valter Gattei, MD, Sergio Amadori, MD

Blood (2005) 106 (11): 333.

https://doi.org/10.1182/blood.V106.11.333.333

Published: 2005

Journal Articles

Spontaneous Apoptosis and Proliferation Predict Disease Progression within ZAP-70 Negative B-Cell Chronic Lymphocytic Leukemia (B-CLL).

Giovanni Del Poeta, MD, Maria Ilaria Del Principe, MD, Pasquale Niscola, MD, Luca Maurillo, MD, Adriano Venditti, MD, Francesco Buccisano, MD, Maria Irno Consalvo, PhD, Carla Mazzone, MD, Paola Panetta, PhD, Massimo Degan, PhD, Irene Pasqua, PhD, Antonio Bruno, PhD, Valter Gattei, MD, Francesco Lo Coco, MD, Sergio Amadori, MD

Blood (2005) 106 (11): 1197.

https://doi.org/10.1182/blood.V106.11.1197.1197

Published: 2005

Journal Articles

Clinical Significance of Apoptosis Is Independent from Proliferation in Acute Myeloid Leukemia (AML).

Giovanni Del Poeta, M.D., Maria Ilaria Del Principe, M.D., Adriano Venditti, M.D., Luca Maurillo, M.D., Francesco Buccisano, M.D., Maria Irno Consalvo, Ph.D., Carla Mazzone, M.D., Maria Christina Cox, M.D., Antonio Bruno, M.D., Francesco Lo Coco, M.D., Sergio Amadori, M.D.

Blood (2004) 104 (11): 198.

https://doi.org/10.1182/blood.V104.11.198.198

Published: 2004

Journal Articles

Amount of spontaneous apoptosis detected by Bax/Bcl-2 ratio predicts outcome in acute myeloid leukemia (AML): Presented in part at the 42nd annual meeting of the American Society of Hematology, San Francisco, CA, December 1-5, 2000. 46

Giovanni Del Poeta, Adriano Venditti, Maria Ilaria Del Principe, Luca Maurillo, Francesco Buccisano, Anna Tamburini, Maria Christina Cox, Annibale Franchi, Antonio Bruno, Carla Mazzone, Paola Panetta, Giovanna Suppo, Mario Masi, Sergio Amadori

Blood (2003) 101 (6): 2125–2131.

https://doi.org/10.1182/blood-2002-06-1714

Published: 2003

Journal Articles

Biological Features of Acute Myeloid Leukemia in the Elderly

Adriano Venditti, Giovanni Del Poeta, Francesco Buccisano, Anna Tamburini, Maria Christina Cox-Froncillo, Antonio Bruno, Beatrice Del Moro, Anna Maria Epiceno, M. Masi, Sergio Amadori, Roberto Stasi

Blood (1998) 92 (2): 697–699.

https://doi.org/10.1182/blood.V92.2.697

Published: 1998

Journal Articles

Minimally Differentiated Acute Myeloid Leukemia (AML-M0): Comparison of 25 Cases With Other French-American-British Subtypes

Adriano Venditti, Giovanni Del Poeta, Francesco Buccisano, Anna Tamburini, M. Christina Cox, Roberto Stasi, Antonio Bruno, Germano Aronica, Laura Maffei, Giovanna Suppo, Maria Domenica Simone, Laura Forte, Valeria Cordero, Massimiliano Postorino, Vincenza Tufilli, Giancarlo Isacchi, Mario Masi, Giuseppe Papa, Sergio Amadori

Blood (1997) 89 (2): 621–629.

https://doi.org/10.1182/blood.V89.2.621

Published: 1997

Journal Articles

Biological Pattern of AML-M0 Versus AML-M1: Response

Adriano Venditti, Giovanni Del Poeta, Francesco Buccisano, Anna Tamburini, Germano Aronica, Antonio Bruno, M. Christina Cox-Froncillo, Laura Maffei, M. Domenica Simone, Giuseppe Papa, Sergio Amadori

Blood (1997) 89 (1): 345.

https://doi.org/10.1182/blood.V89.1.345

Published: 1997

NARROW

Synergistic Effect of Tamoxifen and Ruxolitinib Combination in Reducing Disease Burden in Myeloproliferative Neoplasms

Metabolism-Related Features Identify the Combination Metformin Plus NAMPT Inhibitors As a Selective Treatment Strategy in Acute Myeloid Leukemia

Metformin Inhibits STAT3 and MAPK Signaling through AMPK Activation in CSF3R T618I Cells

Irs1 S57X Heterozygous Mutant Mice Display Normal Hematopoiesis and Phenotypic Features, While Homozygous Knockout Exhibit High Fetal or Postnatal Lethality

Metformin Suppress Cellular and Molecular Processes Related to Maintenance and Proliferation of Myeloproliferative Neoplasm Stem Cell

Efficacy of the Pan-Bcl-2 Inhibitor (Obatoclax) As a Single Agent to Treat Myeloproliferative Neoplasm in JAK2V617F Murine Transplantation Model

Clinical Significance of NOTCH1 mutations in Chronic Lymphocytic Leukemia.

The Amount of Mitochondrial Apoptosis Exerts Prognostic Impact on Normal Karyotype Acute Myeloid Leukemia.

Multidrug Resistance Proteins Overexpression Worsen the Favorable Clinical Impact of an Elevated Spontaneous Apoptosis in Acute Myeloid Leukemia (AML).

Clinical significance of ZAP-70 protein expression in B-cell chronic lymphocytic leukemia

Clinical Relevance of Spontaneous Apoptosis Is Independent from Multidrug Resistance in Acute Myeloid Leukemia (AML).

Spontaneous Apoptosis and Proliferation Predict Disease Progression within ZAP-70 Negative B-Cell Chronic Lymphocytic Leukemia (B-CLL).

Clinical Significance of Apoptosis Is Independent from Proliferation in Acute Myeloid Leukemia (AML).

Amount of spontaneous apoptosis detected by Bax/Bcl-2 ratio predicts outcome in acute myeloid leukemia (AML): Presented in part at the 42nd annual meeting of the American Society of Hematology, San Francisco, CA, December 1-5, 2000. 46

Biological Features of Acute Myeloid Leukemia in the Elderly

Minimally Differentiated Acute Myeloid Leukemia (AML-M0): Comparison of 25 Cases With Other French-American-British Subtypes

Biological Pattern of AML-M0 Versus AML-M1: Response

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