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Journal Articles

Preclinical Investigation of the p53-MDM2 Antagonist Idasanutlin (RG7388) Demonstrates Significant Activity in High Risk Adult Acute Lymphoblastic Leukemia

Hayden L Bell, Mankaran Singh, MSc, Helen J Blair, PhD, Frederik W. van Delft, MD PhD, Anthony V. Moorman, PhD, John Lunec, PhDMRCR(Hon) FRCPath, Julie Irving, PhD

Blood (2020) 136 (Supplement 1): 38.

https://doi.org/10.1182/blood-2020-139536

Published: 2020

Journal Articles

First Analysis of the UKALL14 Phase 3 Randomised Trial to Determine If the Addition of Rituximab to Standard Induction Chemotherapy Improves EFS in Adults with Precursor B-ALL (CRUK/09/006)

David I Marks, MBBS, PhD FRCPath, Amy A. Kirkwood, MSc, Clare J Rowntree, MBBS, PhD FRCP, FRCPath, Melanie Aguiar, BSc, Katharine E Bailey, MBBS, FRCPath, MA, MRCP, Brendan Beaton, MD, Laura Clifton-Hadley, PhDBSc, Emma Lawrie, BSc, SooWah Lee, MSc, Andrew K McMillan, FRCP, Anthony V. Moorman, PhD, Rachel J. Mitchell, MSc, Pip Patrick, PhDMSc,MA, Tobias F Menne, MD PhD FRCPath, Paul Smith, Bela Wrench, MBBS, MD MRCP, FRCPath, Krisztina Zuborne Alapi, MSc, Adele K. Fielding, MBBS,PhDFRCP,FRCPath

Blood (2019) 134 (Supplement_1): 739.

https://doi.org/10.1182/blood-2019-123374

Published: 2019

Journal Articles

Preliminary Outcomes of Children and Young Adults with Acute Lymphoblastic Leukaemia and Down Syndrome (DS-ALL) on UKALL 2011. Reduction in Treatment-Related Mortality with De-Escalated Therapy

Sara Ghorashian, FRCPath, PhD, Sujith Samarasinghe, Amy A Kirkwood, MSc, Rachael Hough, MD BMBS, FRCP, FRCPath, Clare Rowntree, MD, Sarah Lawson, MD, Nicholas John Goulden, MD PhD MRCPath, Emma Pond, PhD, Pamela R. Kearns, PhDFRCPC, Anthony V. Moorman, PhD, John Moppett, Ajay Vora, MD

Blood (2018) 132 (Supplement 1): 656.

https://doi.org/10.1182/blood-2018-99-118426

Published: 2018

Journal Articles

Acute Neurotoxicity during ALL Therapy Is Associated with Treatment Intensity, Age and Female Sex - an Analysis of SAE Reports from the UKALL 2003 Trial

Qurat-ul-Ain Wahid, Lina Hamadeh, Sheena McGowan, Rachael Hough, MD BMBS, FRCP, FRCPath, Ajay Vora, MD, Anthony V. Moorman, PhD, Christina Halsey, MD PhD

Blood (2018) 132 (Supplement 1): 1379.

https://doi.org/10.1182/blood-2018-99-113267

Published: 2018

Journal Articles

Constitutional Ring Chromosome 21 Predisposes to Acute Lymphoblastic Leukaemia (ALL) with iAMP21

Claire Schwab, Eigil Kjeldsen, MD DMSc, Nyla A. Heerema, PhD, Andrew Carroll, PhD, Matthew Bashton, PhD, Sarra Ryan, PhD, Anthony V. Moorman, PhD, Stephen P. Hunger, MD, Mignon L. Loh, MD, Henrik Hasle, MD PhD, Christine J Harrison, PhD FRCPath

Blood (2017) 130 (Supplement 1): 3978.

https://doi.org/10.1182/blood.V130.Suppl_1.3978.3978

Published: 2017

Journal Articles

The Frequency and Outcome of Ph-like ALL Associated Abnormalities in Childhood Acute Lymphoblastic Leukaemia Treated on MRC UKALL2003

Claire Schwab, Amir Enshaei, PhD, Kathryn G. Roberts, PhD, Lisa J. Russell, PhD, Richard C Harvey, PhD, I-Ming L. Chen, DVM, MS, Cheryl L. Willman, Charles Mullighan, MBBS, MSc, MD, Ajay J. Vora, Anthony V. Moorman, PhD, Christine Harrison

Blood (2016) 128 (22): 2914.

https://doi.org/10.1182/blood.V128.22.2914.2914

Published: 2016

Journal Articles

Improved Diagnosis of Intrachromosomal Amplification of Chromosome 21 (iAMP21) By Copy Number Profiling

Claire Schwab, Paul Sinclair, PhD, Anthony V. Moorman, PhD, Stephen Hunger, MD, Mignon L. Loh, MD, Andrew J. Carroll, PhD, Nyla A. Heerema, PhD, Christine Harrison

Blood (2016) 128 (22): 1733.

https://doi.org/10.1182/blood.V128.22.1733.1733

Published: 2016

Journal Articles

Integrating Genetic Risk Factors with Age, Presenting White Cell Count and MRD Response As Continuous Variables to Predict Relapse in Paediatric Acute Lymphoblastic Leukemia (ALL)

Anthony V. Moorman, PhD, Amir Enshaei, PhD, David O'Connor, MD PhD, Jack Bartram, MD, Jeremy Hancock, PhD, Christine Harrison, Sujith Samarasinghe, MD PhD, John Moppett, MD PhD, Ajay J. Vora, Nicholas Goulden, MD PhD

Blood (2016) 128 (22): 603.

https://doi.org/10.1182/blood.V128.22.603.603

Published: 2016

Journal Articles

Acute Leukemia of Ambiguous Lineage: A Comprehensive Survival Analysis Enables Designing New Treatment Strategies

Ondrej Hrusak, MD PhD, Valerie De Haas, MD PhD, Ales Luks, Iveta Janotova, Ester Mejstrikova, MD PhD, Kirsten Bleckmann, MD, Anja Moricke, MD, Julie Irving, PhD, Benigna Konatkowska, Thomas B. Alexander, MD MPH, Hiroto Inaba, MD PhD, Kjeld Schmiegelow, MD DMSc, Simone Stokley, FRCPath,, Jorge Gabriel Rossi, PhD, Maria Sara Felice, MD PhD, Luciano Dalla-Pozza, MB BS FRACP, Jessa Morales, Michael Dworzak, MD, Barbara Buldini, MD, Giuseppe Basso, Myriam Campbell, Maria Elena Cabrera, Neda Marinov, Sarah Elitzur, MD, Shai Izraeli, MD, Drorit Luria, PhD, Tamar Feuerstein, PhD, Alexandra Kolenova, MD PhD, Peter Svec, Elena Kreminska, Karen R. Rabin, MD, Sophia Polychronopoulou, MD PhD, Elaine da Costa, Hanne Vibeke Marquart, MD PhD, Antonis Kattamis, MD, Richard Ratei, Dirk Reinhardt, MD PhD, Anthony V Moorman, PhD, Martin Schrappe, MD, Jan Stary, MD D.Sc.

Blood (2016) 128 (22): 584.

https://doi.org/10.1182/blood.V128.22.584.584

Published: 2016

Journal Articles

Genomic Landscape of Pediatric Mixed Phenotype Acute Leukemia

Thomas B. Alexander, MD MPH, Zhaohui Gu, PhD, John K Choi, MD, Mignon L. Loh, MD, John Horan, MD MPH, Barbara Buldini, MD, Giuseppe Basso, Sarah Elitzur, MD, C. Michel Zwaan, MD PhD, Valerie de Haas, MD PhD, Allen Eng Juh Yeoh, MD, Dirk Reinhardt, MD PhD, Daisuke Tomizawa, MD, PhD, Tim Lammens, Barbara De Moerloose, MD, Li Zhou, PhD, Hiroki Hori, MD PhD, Anthony V. Moorman, PhD, Andrew S. Moore, MBBS FRACP PhD, Ondrej Hrusak, MD PhD, Soheil Meshinchi, MD PhD, Etan Orgel, MD MS, Meenakshi Devidas, PhD, Stephen P. Hunger, MD, Jamie M Guidry Auvil, Malcolm A. Smith, MD PhD, Tanja M. Davidsen, PhD, Leandro C. Hermida, Patee Gesuwan, Marco A. Marra, PhD, Yussanne Ma, PhD, Andrew J. Mungall, Richard Moore, PhD, Daniela S. Gerhard, PhD, Xueyuan Cao, Lei Shi, PhD, Stanley Pounds, PhD, Hiroto Inaba, MD PhD, Charles Mullighan, MBBS, MSc, MD

Blood (2016) 128 (22): 454.

https://doi.org/10.1182/blood.V128.22.454.454

Published: 2016

Journal Articles

Integration of Minimal Residual Disease with Other Patient Risk Factors Identifies a Population with Very Poor Overall Survival in Pediatric ALL: Results from the UKALL 2003 Trial

David O'Connor, MD PhD, Jack Bartram, MD, Amir Enshaei, PhD, Anthony V Moorman, PhD, Christine Harrison, PhDFRCPath FMedSci, Rachel Wade, MSc, Rachel Clack, MSc, Jeremy Hancock, PhD, Sujith Samarasinghe, MD PhD, John Moppett, MD PhD, Ajay J. Vora, Nicholas Goulden, MD PhD

Blood (2015) 126 (23): 1412.

https://doi.org/10.1182/blood.V126.23.1412.1412

Published: 2015

Journal Articles

Use of Morphological Early Response Data to Predict Relapse in Teenage and Young Adult (TYA) Patients with Acute Lymphoblastic Leukaemia (ALL)

Caroline L Furness, MD, Clare Rowntree, Ajay J. Vora, Amy A Kirkwood, Christopher Mitchell, MBBS, PhD FRCP, Nicholas Goulden, MD PhD, Anthony V. Moorman, PhD, Rachael Hough, MDBMBS,FRCP,FRCPath

Blood (2015) 126 (23): 1415.

https://doi.org/10.1182/blood.V126.23.1415.1415

Published: 2015

Journal Articles

Prognostic Significance and Risk Stratification in Acute Myeloid Leukaemia Patients in the Absence of Successful Cytogenetic Analysis

Lucy Chilton, PhD, Christine Harrison, PhDFRCPath FMedSci, Anthony V. Moorman, PhD, Iona Ashworth, Alan K. Burnett, MD FRCP, David Grimwade, PhD FRCPath, Robert K Hills, MA MSc DPhil

Blood (2015) 126 (23): 1379.

https://doi.org/10.1182/blood.V126.23.1379.1379

Published: 2015

Journal Articles

Clincial and Genetic Landscapes Differ Between IGH-CRLF2 and P2RY8-CRLF2 Acute Lymphoblastic Leukaemia

Lisa Jane Russell, PhD, Lisa Jones, BSc, Amir Enshaei, PhD, Jamie Rutherford, BSc, Stefano Tonin, PhD, Sarra Ryan, PhD, Jeyanthy Eswaran, PhD, Elli Papaemmanuil, PhD, Jose Tubio, PhD, Peter J Campbell, MD PhD, Anthony V Moorman, PhD, Christine Harrison, PhDFRCPath FMedSci

Blood (2015) 126 (23): 1426.

https://doi.org/10.1182/blood.V126.23.1426.1426

Published: 2015

Journal Articles

Acute Leukemias of Ambiguous Lineage; Study on 247 Pediatric Patients

Blood (2015) 126 (23): 252.

https://doi.org/10.1182/blood.V126.23.252.252

Published: 2015

Journal Articles

Long Term Overall Survival of Greater Than 98% in Childhood ALL Patients with Good Risk Features and Low Risk MRD:Â Results from a Large Multi-Center Randomized Controlled Trial, UKALL 2003

Jack Bartram, MD, David O'Connor, MD PhD, Amir Enshaei, PhD, Anthony V Moorman, PhD, Christine Harrison, PhDFRCPath FMedSci, Rachel Wade, MSc, Rachel Clack, MSc, Jeremy Hancock, PhD, Sujith Samarasinghe, MD PhD, John Moppett, MD PhD, Ajay J. Vora, Nicholas Goulden, MD PhD

Blood (2015) 126 (23): 806.

https://doi.org/10.1182/blood.V126.23.806.806

Published: 2015

Journal Articles

Risk Factor Analysis in Paediatric Acute Lymphoblastic Leukaemia with High Hyperdiploidy

Amir Enshaei, PhD, Claire Schwab, Lucy Chilton, PhD, Rachel Wade, MSc, Jeremy Hancock, PhD, Christopher Mitchell, MBBS, PhD FRCP, Sally E Kinsey, Nicholas Goulden, MD PhD, Ajay J. Vora, Christine Harrison, PhDFRCPath FMedSci, Anthony V. Moorman, PhD

Blood (2015) 126 (23): 805.

https://doi.org/10.1182/blood.V126.23.805.805

Published: 2015

Journal Articles

Relapse in Teenage and Young Adult (TYA) Patients Treated on a Pediatric Minimal Residual Disease (MRD) Stratified Protocol Is Associated with a Poor Outcome: Results from UKALL2003

Rob S Sellar, MBChB, FRCPath, Clare Rowntree, PhD, Ajay J. Vora, Caroline L Furness, MD, Nicholas Goulden, MD PhD, Chris Mitchell, FRCPCH, Anthony V. Moorman, PhD, Rachael Hough, MDBMBS,FRCP,FRCPath

Blood (2015) 126 (23): 2493.

https://doi.org/10.1182/blood.V126.23.2493.2493

Published: 2015

Journal Articles

High Frequency and Poor Outcome of Ph-like Acute Lymphoblastic Leukemia in Adults

Blood (2015) 126 (23): 2618.

https://doi.org/10.1182/blood.V126.23.2618.2618

Published: 2015

Journal Articles

No Evidence That PTEN Abnormalities Impact on Outcome in Pediatric Patients with T-Cell Acute Lymphoblastic Leukemia (T-ALL) Treated on the MRC UKALL2003 Trial

Sarah Jenkinson, MSc, Amy A Kirkwood, Nicholas Goulden, MD PhD, Ajay J. Vora, Chris Mitchell, Rachel Wade, Jeremy Hancock, Anthony V. Moorman, PhD, David C Linch, FMedSci, Rosemary E Gale

Blood (2014) 124 (21): 1077.

https://doi.org/10.1182/blood.V124.21.1077.1077

Published: 2014

NARROW

Preclinical Investigation of the p53-MDM2 Antagonist Idasanutlin (RG7388) Demonstrates Significant Activity in High Risk Adult Acute Lymphoblastic Leukemia

First Analysis of the UKALL14 Phase 3 Randomised Trial to Determine If the Addition of Rituximab to Standard Induction Chemotherapy Improves EFS in Adults with Precursor B-ALL (CRUK/09/006)

Preliminary Outcomes of Children and Young Adults with Acute Lymphoblastic Leukaemia and Down Syndrome (DS-ALL) on UKALL 2011. Reduction in Treatment-Related Mortality with De-Escalated Therapy

Acute Neurotoxicity during ALL Therapy Is Associated with Treatment Intensity, Age and Female Sex - an Analysis of SAE Reports from the UKALL 2003 Trial

Constitutional Ring Chromosome 21 Predisposes to Acute Lymphoblastic Leukaemia (ALL) with iAMP21

The Frequency and Outcome of Ph-like ALL Associated Abnormalities in Childhood Acute Lymphoblastic Leukaemia Treated on MRC UKALL2003

Improved Diagnosis of Intrachromosomal Amplification of Chromosome 21 (iAMP21) By Copy Number Profiling

Integrating Genetic Risk Factors with Age, Presenting White Cell Count and MRD Response As Continuous Variables to Predict Relapse in Paediatric Acute Lymphoblastic Leukemia (ALL)

Acute Leukemia of Ambiguous Lineage: A Comprehensive Survival Analysis Enables Designing New Treatment Strategies

Genomic Landscape of Pediatric Mixed Phenotype Acute Leukemia

Integration of Minimal Residual Disease with Other Patient Risk Factors Identifies a Population with Very Poor Overall Survival in Pediatric ALL: Results from the UKALL 2003 Trial

Use of Morphological Early Response Data to Predict Relapse in Teenage and Young Adult (TYA) Patients with Acute Lymphoblastic Leukaemia (ALL)

Prognostic Significance and Risk Stratification in Acute Myeloid Leukaemia Patients in the Absence of Successful Cytogenetic Analysis

Clincial and Genetic Landscapes Differ Between IGH-CRLF2 and P2RY8-CRLF2 Acute Lymphoblastic Leukaemia

Acute Leukemias of Ambiguous Lineage; Study on 247 Pediatric Patients

Long Term Overall Survival of Greater Than 98% in Childhood ALL Patients with Good Risk Features and Low Risk MRD:Â Results from a Large Multi-Center Randomized Controlled Trial, UKALL 2003

Risk Factor Analysis in Paediatric Acute Lymphoblastic Leukaemia with High Hyperdiploidy

Relapse in Teenage and Young Adult (TYA) Patients Treated on a Pediatric Minimal Residual Disease (MRD) Stratified Protocol Is Associated with a Poor Outcome: Results from UKALL2003

High Frequency and Poor Outcome of Ph-like Acute Lymphoblastic Leukemia in Adults

No Evidence That PTEN Abnormalities Impact on Outcome in Pediatric Patients with T-Cell Acute Lymphoblastic Leukemia (T-ALL) Treated on the MRC UKALL2003 Trial

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