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Volume 132, Issue 10

September 6 2018

In this Issue

BLOOD COMMENTARIES
PLENARY PAPER
PERSPECTIVE
BLOOD SPOTLIGHT
CLINICAL TRIALS AND OBSERVATIONS
HEMATOPOIESIS AND STEM CELLS
LYMPHOID NEOPLASIA
THROMBOSIS AND HEMOSTASIS
BLOOD WORK

Table of Contents

BLOOD COMMENTARIES

Red Cells, Iron, and Erythropoiesis

Heme, whence come thy carbon building blocks?

Tracey A. Rouault

View Articletitled, Heme, whence come thy carbon building blocks?

CLINICAL TRIALS AND OBSERVATIONS

CART19 in Hodgkin lymphoma: are we driving the right model?
Clinical Trials & Observations

Catherine S. Diefenbach

View Articletitled, CART19 in Hodgkin lymphoma: are we driving the right model?

Lymphoid Neoplasia

A miRaculous new therapy in myeloma?

Lawrence H. Boise

View Articletitled, A miRaculous new therapy in myeloma?

THROMBOSIS AND HEMOSTASIS

ADAMTS-13 in traumatic brain injury?

Rosemary Kozar

View Articletitled, ADAMTS-13 in traumatic brain injury?

PLENARY PAPER

Red Cells, Iron, and Erythropoiesis

Glutamine via α-ketoglutarate dehydrogenase provides succinyl-CoA for heme synthesis during erythropoiesis

Joseph S. Burch,Jason R. Marcero,John Alan Maschek,James E. Cox,Laurie K. Jackson,Amy E. Medlock,John D. Phillips,Harry A. Dailey, Jr

View Articletitled, Glutamine via α-ketoglutarate dehydrogenase provides succinyl-CoA for heme synthesis during erythropoiesis

Supplemental data

PERSPECTIVE

Insight into origins, mechanisms, and utility of DNA methylation in B-cell malignancies

Christopher C. Oakes,Jose I. Martin-Subero

View Articletitled, Insight into origins, mechanisms, and utility of DNA methylation in B-cell malignancies

BLOOD SPOTLIGHT

BCL-2 inhibition in AML: an unexpected bonus?
Clinical Trials & Observations

Marina Konopleva,Anthony Letai

View Articletitled, BCL-2 inhibition in AML: an unexpected bonus?

CLINICAL TRIALS AND OBSERVATIONS

CALGB 50604: risk-adapted treatment of nonbulky early-stage Hodgkin lymphoma based on interim PET
Clinical Trials & Observations

David J. Straus,Sin-Ho Jung,Brandelyn Pitcher,Lale Kostakoglu,John C. Grecula,Eric D. Hsi,Heiko Schöder,Leslie L. Popplewell,Julie E. Chang,Craig H. Moskowitz,Nina Wagner-Johnston,John P. Leonard,Jonathan W. Friedberg,Brad S. Kahl,Bruce D. Cheson,Nancy L. Bartlett

View Articletitled, CALGB 50604: risk-adapted treatment of nonbulky early-stage Hodgkin lymphoma based on interim PET

Supplemental data

Nonviral RNA chimeric antigen receptor–modified T cells in patients with Hodgkin lymphoma
Clinical Trials & Observations Brief Report

Jakub Svoboda,Susan R. Rheingold,Saar I. Gill,Stephan A. Grupp,Simon F. Lacey,Irina Kulikovskaya,Megan M. Suhoski,J. Joseph Melenhorst,Brandon Loudon,Anthony R. Mato,Sunita Dwivedy Nasta,Daniel J. Landsburg,Matthew R. Youngman,Bruce L. Levine,David L. Porter,Carl H. June,Stephen J. Schuster

View Articletitled, Nonviral RNA chimeric antigen receptor–modified T cells in patients with Hodgkin lymphoma

HEMATOPOIESIS AND STEM CELLS

Phosphatidylinositol transfer proteins regulate megakaryocyte TGF-β1 secretion and hematopoiesis in mice

Maegan Capitano,Liang Zhao,Scott Cooper,Chelsea Thorsheim,Aae Suzuki,Xinxin Huang,Alexander L. Dent,Michael S. Marks,Charles S. Abrams,Hal E. Broxmeyer

View Articletitled, Phosphatidylinositol transfer proteins regulate megakaryocyte TGF-β1 secretion and hematopoiesis in mice

Supplemental data

LYMPHOID NEOPLASIA

Noncovalent inhibition of C481S Bruton tyrosine kinase by GDC-0853: a new treatment strategy for ibrutinib-resistant CLL

Sean D. Reiff,Elizabeth M. Muhowski,Daphne Guinn,Amy Lehman,Catherine A. Fabian,Carolyn Cheney,Rose Mantel,Lisa Smith,Amy J. Johnson,Wendy B. Young,Adam R. Johnson,Lichuan Liu,John C. Byrd,Jennifer A. Woyach

View Articletitled, Noncovalent inhibition of C481S Bruton tyrosine kinase by GDC-0853: a new treatment strategy for ibrutinib-resistant CLL

Therapeutic vulnerability of multiple myeloma to MIR17PTi, a first-in-class inhibitor of pri-miR-17-92

Eugenio Morelli,Lavinia Biamonte,Cinzia Federico,Nicola Amodio,Maria Teresa Di Martino,Maria Eugenia Gallo Cantafio,Martina Manzoni,Francesca Scionti,Mehmet Kemal Samur,Annamaria Gullà,Maria Angelica Stamato,Maria Rita Pitari,Daniele Caracciolo,Settimio Sesti,Niels M. Frandsen,Marco Rossi,Antonino Neri,Mariateresa Fulciniti,Nikhil C. Munshi,Pierosandro Tagliaferri,Pierfrancesco Tassone

View Articletitled, Therapeutic vulnerability of multiple myeloma to MIR17PTi, a first-in-class inhibitor of pri-miR-17-92

Supplemental data

THROMBOSIS AND HEMOSTASIS

Blood-induced bone loss in murine hemophilic arthropathy is prevented by blocking the iRhom2/ADAM17/TNF-α pathway

Coline Haxaire,Narine Hakobyan,Tania Pannellini,Camila Carballo,David McIlwain,Tak W. Mak,Scott Rodeo,Suchitra Acharya,Daniel Li,Jackie Szymonifka,Xiangqian Song,Sébastien Monette,Alok Srivastava,Jane E. Salmon,Carl P. Blobel

View Articletitled, Blood-induced bone loss in murine hemophilic arthropathy is prevented by blocking the iRhom2/ADAM17/TNF-α pathway

Supplemental data

von Willebrand factor enhances microvesicle-induced vascular leakage and coagulopathy in mice with traumatic brain injury

Yingang Wu,Wei Liu,Yuan Zhou,Tristan Hilton,Zilong Zhao,Wei Liu,Min Wang,Jason Yeon,Katie Houck,Perumal Thiagarajan,Fangyi Zhang,Fu-Dong Shi,Xiaoping Wu,Min Li,Jing-fei Dong,Jianning Zhang

View Articletitled, von Willebrand factor enhances microvesicle-induced vascular leakage and coagulopathy in mice with traumatic brain injury

Supplemental data

BLOOD WORK

Spindle cell lesion in the bone marrow

Samuel Guzman,Sumire Kitahara

View Articletitled, Spindle cell lesion in the bone marrow

Multiple subperiosteal bone resorption in adult T-cell leukemia/lymphoma

Takefumi Katsuragi,Junichi Tsukada

View Articletitled, Multiple subperiosteal bone resorption in adult T-cell leukemia/lymphoma

Cover Image

Cover Image

Hemophilic arthropathy (HA) is a major cause of disability in hemophilia A patients. The authors show that tumor necrosis factor-α and its upstream regulators, iRhom2 and ADAM17, have a pivotal role in synovitis and bone loss in HA. This is evidenced by osteoclasts (red) resorbing bone (blue). See the article by Haxaire et al on page 1064.
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Doubling down on GPRC5D in multiple myeloma

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