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Volume 130, Issue 22

November 30 2017

In this Issue

INSIDE BLOOD COMMENTARIES
PERSPECTIVE
BLOOD SPOTLIGHT
REVIEW ARTICLES
CLINICAL TRIALS AND OBSERVATIONS
IMMUNOBIOLOGY AND IMMUNOTHERAPY
LYMPHOID NEOPLASIA
MYELOID NEOPLASIA
LETTER TO BLOOD
BLOOD WORK

Table of Contents

INSIDE BLOOD COMMENTARIES

INSIDE BLOOD COMMENTARY

First targeted therapy in multiple myeloma
Clinical Trials & Observations

K. Martin Kortüm,Hermann Einsele

View Articletitled, First targeted therapy in multiple myeloma

INSIDE BLOOD COMMENTARY

The ecosystem of classical Hodgkin lymphoma

Christian Steidl

View Articletitled, The ecosystem of classical Hodgkin lymphoma

PERSPECTIVE

Clonality in context: hematopoietic clones in their marrow environment

James N. Cooper,Neal S. Young

View Articletitled, Clonality in context: hematopoietic clones in their marrow environment

BLOOD SPOTLIGHT

Gemtuzumab ozogamicin for acute myeloid leukemia

Frederick R. Appelbaum,Irwin D. Bernstein

View Articletitled, Gemtuzumab ozogamicin for acute myeloid leukemia

REVIEW ARTICLES

Targeting novel mechanisms of pain in sickle cell disease

Huy Tran,Mihir Gupta,Kalpna Gupta

View Articletitled, Targeting novel mechanisms of pain in sickle cell disease

Advances in the diagnosis and treatment of Von Willebrand disease

Ruchika Sharma,Veronica H. Flood

View Articletitled, Advances in the diagnosis and treatment of Von Willebrand disease

CLINICAL TRIALS AND OBSERVATIONS

Promising efficacy and acceptable safety of venetoclax plus bortezomib and dexamethasone in relapsed/refractory MM
Clinical Trials & Observations

Philippe Moreau,Asher Chanan-Khan,Andrew W. Roberts,Amit B. Agarwal,Thierry Facon,Shaji Kumar,Cyrille Touzeau,Elizabeth A. Punnoose,Jaclyn Cordero,Wijith Munasinghe,Jia Jia,Ahmed Hamed Salem,Kevin J. Freise,Joel D. Leverson,Sari Heitner Enschede,Jeremy A. Ross,Paulo C. Maciag,Maria Verdugo,Simon J. Harrison

View Articletitled, Promising efficacy and acceptable safety of venetoclax plus bortezomib and dexamethasone in relapsed/refractory MM

Supplemental data

Efficacy of venetoclax as targeted therapy for relapsed/refractory t(11;14) multiple myeloma
Clinical Trials & Observations

Shaji Kumar,Jonathan L. Kaufman,Cristina Gasparetto,Joseph Mikhael,Ravi Vij,Brigitte Pegourie,Lofti Benboubker,Thierry Facon,Martine Amiot,Philippe Moreau,Elizabeth A. Punnoose,Stefanie Alzate,Martin Dunbar,Tu Xu,Suresh K. Agarwal,Sari Heitner Enschede,Joel D. Leverson,Jeremy A. Ross,Paulo C. Maciag,Maria Verdugo,Cyrille Touzeau

View Articletitled, Efficacy of venetoclax as targeted therapy for relapsed/refractory t(11;14) multiple myeloma

Supplemental data

IMMUNOBIOLOGY AND IMMUNOTHERAPY

A CD200R-CD28 fusion protein appropriates an inhibitory signal to enhance T-cell function and therapy of murine leukemia

Shannon K. Oda,Andrew W. Daman,Nicolas M. Garcia,Felecia Wagener,Thomas M. Schmitt,Xiaoxia Tan,Aude G. Chapuis,Philip D. Greenberg

View Articletitled, A CD200R-CD28 fusion protein appropriates an inhibitory signal to enhance T-cell function and therapy of murine leukemia

Supplemental data

LYMPHOID NEOPLASIA

Topological analysis reveals a PD-L1-associated microenvironmental niche for Reed-Sternberg cells in Hodgkin lymphoma

Christopher D. Carey,Daniel Gusenleitner,Mikel Lipschitz,Margaretha G. M. Roemer,Edward C. Stack,Evisa Gjini,Xihao Hu,Robert Redd,Gordon J. Freeman,Donna Neuberg,F. Stephen Hodi,Xiaole Shirley Liu,Margaret A. Shipp,Scott J. Rodig

View Articletitled, Topological analysis reveals a PD-L1-associated microenvironmental niche for Reed-Sternberg cells in Hodgkin lymphoma

Supplemental data

MYELOID NEOPLASIA

Chd7 deficiency delays leukemogenesis in mice induced by Cbfb-MYH11

Tao Zhen,Erika M. Kwon,Ling Zhao,Jingmei Hsu,R. Katherine Hyde,Ying Lu,Lemlem Alemu,Nancy A. Speck,P. Paul Liu

View Articletitled, <em>Chd7</em> deficiency delays leukemogenesis in mice induced by <em>Cbfb-MYH11</em>

Supplemental data

LETTER TO BLOOD

Analysis of ITGB2 rare germ line variants in chronic lymphocytic leukemia

Grace Tiao,M. Reina Improgo,Eugen Tausch,Stacey M. Fernandes,Jasmin Bahlo,Sandra Robrecht,Kirsten Fischer,Michael Hallek,Stephan Stilgenbauer,Adam Kiezun,Gad Getz,Jennifer R. Brown

View Articletitled, Analysis of <em>ITGB2</em> rare germ line variants in chronic lymphocytic leukemia

Supplemental data

BLOOD WORK

The unused iron

Armin Rashidi,Scott Gilles

View Articletitled, The unused iron

Cover Image

Cover Image

Multiplex immunofluorescence image (40× resolution) of a case of classical Hodgkin lymphoma stained with 4′,6-diamidino-2-phenylindole (DAPI) (blue, for nuclei), anti-CD68 (magenta), and anti–PD-1 (yellow) and showing a CD68⁺ tumor-associated macrophage in contact with a PD-1⁺ T cell. See the article by Carey et al on page 2420.
Front Matter
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